Mortality in Children with Optic Pathway Glioma Treated with Up-Front BB-SFOP Chemotherapy
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{"title"=>"Mortality in children with optic pathway glioma treated with up-front BB-SFOP chemotherapy", "type"=>"journal", "authors"=>[{"first_name"=>"Josué", "last_name"=>"Rakotonjanahary", "scopus_author_id"=>"55924221000"}, {"first_name"=>"Emilie", "last_name"=>"De Carli", "scopus_author_id"=>"25822340300"}, {"first_name"=>"Matthieu", "last_name"=>"Delion", "scopus_author_id"=>"26421612400"}, {"first_name"=>"Chantal", "last_name"=>"Kalifa", "scopus_author_id"=>"7005893605"}, {"first_name"=>"Jacques", "last_name"=>"Grill", "scopus_author_id"=>"56230796400"}, {"first_name"=>"François", "last_name"=>"Doz", "scopus_author_id"=>"7006535031"}, {"first_name"=>"Pierre", "last_name"=>"Leblond", "scopus_author_id"=>"35264642300"}, {"first_name"=>"Anne Isabelle", "last_name"=>"Bertozzi", "scopus_author_id"=>"8688666600"}, {"first_name"=>"Xavier", "last_name"=>"Rialland", "scopus_author_id"=>"6603829528"}, {"first_name"=>"Claire", "last_name"=>"Alapetite", "scopus_author_id"=>"6701617696"}, {"first_name"=>"Nicolas", "last_name"=>"André", "scopus_author_id"=>"35301855700"}, {"first_name"=>"Valérie", "last_name"=>"Bernier", "scopus_author_id"=>"15126806800"}, {"first_name"=>"Franck", "last_name"=>"Bourdeaut", "scopus_author_id"=>"6602456207"}, {"first_name"=>"Christian", "last_name"=>"Carrié", "scopus_author_id"=>"54790559600"}, {"first_name"=>"Pascal", "last_name"=>"Chastagner", "scopus_author_id"=>"55523225500"}, {"first_name"=>"Cécile", "last_name"=>"Conter", "scopus_author_id"=>"55213868100"}, {"first_name"=>"Christelle", "last_name"=>"Dufour", "scopus_author_id"=>"23466493100"}, {"first_name"=>"Natacha", "last_name"=>"Entz-Werlé", "scopus_author_id"=>"6602099223"}, {"first_name"=>"Dominique Figarella", "last_name"=>"Branger", "scopus_author_id"=>"56784335200"}, {"first_name"=>"Fanny", "last_name"=>"Fouyssac", "scopus_author_id"=>"23481777600"}, {"first_name"=>"Didier", "last_name"=>"Frappaz", "scopus_author_id"=>"7006004483"}, {"first_name"=>"Jean Claude", "last_name"=>"Gentet", "scopus_author_id"=>"7007121807"}, {"first_name"=>"Karien", "last_name"=>"Guichardet", "scopus_author_id"=>"56310914700"}, {"first_name"=>"Jean Louis", "last_name"=>"Habrand", "scopus_author_id"=>"7005282526"}, {"first_name"=>"Claire", "last_name"=>"Hoyoux", "scopus_author_id"=>"7004461863"}, {"first_name"=>"Céline", "last_name"=>"Icher", "scopus_author_id"=>"24576746400"}, {"first_name"=>"Justine", "last_name"=>"Kanold", "scopus_author_id"=>"6603797385"}, {"first_name"=>"Véronique", "last_name"=>"Laithier", "scopus_author_id"=>"6603430490"}, {"first_name"=>"Véronique", "last_name"=>"Mosseri", "scopus_author_id"=>"7003779315"}, {"first_name"=>"Xavier", "last_name"=>"Muracciole", "scopus_author_id"=>"6603610847"}, {"first_name"=>"Laetitia", "last_name"=>"Padovani", "scopus_author_id"=>"6701767106"}, {"first_name"=>"Anne", "last_name"=>"Pagnier", "scopus_author_id"=>"14424534300"}, {"first_name"=>"Gilles", "last_name"=>"Palenzuela", "scopus_author_id"=>"6505520741"}, {"first_name"=>"Yves", "last_name"=>"Perel", "scopus_author_id"=>"7006235084"}, {"first_name"=>"Dominique", "last_name"=>"Plantaz", "scopus_author_id"=>"56217116700"}, {"first_name"=>"Eric", "last_name"=>"Sariban", "scopus_author_id"=>"7006769331"}, {"first_name"=>"Pascale", "last_name"=>"Schneider", "scopus_author_id"=>"7402107694"}, {"first_name"=>"Christine", "last_name"=>"Soler", "scopus_author_id"=>"7004873364"}, {"first_name"=>"C.", "last_name"=>"Chappé", "scopus_author_id"=>"37025701000"}, {"first_name"=>"N.", "last_name"=>"Sirvent", "scopus_author_id"=>"7003578039"}, {"first_name"=>"C.", "last_name"=>"Berger", "scopus_author_id"=>"35444246800"}, {"first_name"=>"P.", "last_name"=>"Lutz", "scopus_author_id"=>"55243649200"}, {"first_name"=>"P.", "last_name"=>"Blouin", "scopus_author_id"=>"6602703074"}, {"first_name"=>"C.", "last_name"=>"Piguet", "scopus_author_id"=>"7007044415"}, {"first_name"=>"P.", "last_name"=>"Lemoine", "scopus_author_id"=>"56783806100"}, {"first_name"=>"F.", "last_name"=>"Millot", "scopus_author_id"=>"7006201993"}, {"first_name"=>"O.", "last_name"=>"Minckes", "scopus_author_id"=>"6602987008"}, {"first_name"=>"F.", "last_name"=>"Demeocq", "scopus_author_id"=>"7005419377"}, {"first_name"=>"F.", "last_name"=>"De Vathaire", "scopus_author_id"=>"55613231775"}, {"first_name"=>"E.", "last_name"=>"Berardi", "scopus_author_id"=>"56536511300"}, {"first_name"=>"S.", "last_name"=>"Chalal", "scopus_author_id"=>"56784204500"}, {"first_name"=>"C.", "last_name"=>"Alberti", "scopus_author_id"=>"7006093385"}, {"first_name"=>"I.", "last_name"=>"Pellier", "scopus_author_id"=>"6603102583"}, {"first_name"=>"S.", "last_name"=>"Proust", "scopus_author_id"=>"57189412324"}, {"first_name"=>"P.", "last_name"=>"Mercier", "scopus_author_id"=>"8201496700"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84939444523", "sgr"=>"84939444523", "pui"=>"605586372", "pmid"=>"26098902", "doi"=>"10.1371/journal.pone.0127676"}, "id"=>"2a414c7f-3a66-3ba9-8327-e307fac4a453", "abstract"=>"Background In terms of overall survival (OS), limited data are available for the very long-term outcomes of children treated for optic pathway glioma (OPG) with up-front chemotherapy. Therefore, we undertook this study with the aim of clarifying long-term OS and causes of death in these patients. Methods We initiated and analyzed a historical cohort study of 180 children with OPG treated in France with BB-SFOP chemotherapy between 1990 and 2004. The survival distributions were estimated using Kaplan-Meier method. The effect of potential risk factors on the risk of death was described using Cox regression analysis. Results The OS was 95% [95% CI: 90.6-97.3] 5 years after diagnosis and significantly decreased over time without ever stabilizing: 91.6%at 10 years [95% CI: 86.5-94.8], 80.7% at 15 years [95% CI: 72.7-86.8] and 75.5% [95% CI: 65.6-83] at 18 years. Tumor progression was the most common cause of death (65%). Age and intracranial hypertension at diagnosis were significantly associated with a worse prognosis. Risk of death was increased by 3.1[95% CI: 1.5-6.2] (p=0.002) for patients less than 1 year old at diagnosis and by 5.2[95% CI: 1.5- 17.6] (p=0.007) for patients with initial intracranial hypertension. Boys without diencephalic syndrome had a better prognosis (HR: 0.3 [95% CI: 0.1-0.8], p=0.007). This study shows that i) in children with OPG, OS is not as favorable as previously described and ii) patients can be classified into 2 groups depending on risk factors (age, intracranial hypertension, sex and diencephalic syndrome) with an OS rate of 50.4% at 18 years [95% CI: 31.4-66.6] in children with the worst prognosis. These findings could justify, depending on the initial risk, a different therapeutic approach to this tumor with more aggres- sive treatment (especially chemotherapy) in patients with high risk factors.", "link"=>"http://www.mendeley.com/research/mortality-children-optic-pathway-glioma-treated-upfront-bbsfop-chemotherapy", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>4, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>5, "Student > Master"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>4, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>5, "Student > Master"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>13, "Psychology"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"France"=>1, "Spain"=>1, "India"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2128715"], "description"=>"<p>* The candidate risk factors were: age at diagnosis (< 1 year), sex, intracranial hypertension at diagnosis, diencephalic syndrome, NF1 status, and subsequent treatment (chemotherapy, radiotherapy and initial partial surgery). Interaction terms used: gender with age at diagnosis, gender with NF1 status, gender with DS at diagnosis.</p><p>Multivariate Cox regression analysis of factors associated with Overall Survival in patients with OPG.</p>", "links"=>[], "tags"=>["risk factors", "hr", "diencephalic syndrome", "opg", "Optic Pathway Glioma Treated", "chemotherapy", "ci", "Cox regression analysis.ResultsThe OS", "prognosis", "intracranial hypertension", "diagnosis"], "article_id"=>1456480, "categories"=>["Uncategorised"], "users"=>["Josué Rakotonjanahary", "Emilie De Carli", "Matthieu Delion", "Chantal Kalifa", "Jacques Grill", "Francois Doz", "Pierre Leblond", "Anne-Isabelle Bertozzi", "Xavier Rialland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127676.t003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_Cox_regression_analysis_of_factors_associated_with_Overall_Survival_in_patients_with_OPG_/1456480", "title"=>"Multivariate Cox regression analysis of factors associated with Overall Survival in patients with OPG.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-22 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128718", "https://ndownloader.figshare.com/files/2128719", "https://ndownloader.figshare.com/files/2128720", "https://ndownloader.figshare.com/files/2128721", "https://ndownloader.figshare.com/files/2128722", "https://ndownloader.figshare.com/files/2128723"], "description"=>"<div><p>Background</p><p>In terms of overall survival (OS), limited data are available for the very long-term outcomes of children treated for optic pathway glioma (OPG) with up-front chemotherapy. Therefore, we undertook this study with the aim of clarifying long-term OS and causes of death in these patients.</p><p>Methods</p><p>We initiated and analyzed a historical cohort study of 180 children with OPG treated in France with BB-SFOP chemotherapy between 1990 and 2004. The survival distributions were estimated using Kaplan-Meier method. The effect of potential risk factors on the risk of death was described using Cox regression analysis.</p><p>Results</p><p>The OS was 95% [95% CI: 90.6-97.3] 5 years after diagnosis and significantly decreased over time without ever stabilizing: 91.6% at 10 years [95% CI: 86.5-94.8], 80.7% at 15 years [95% CI: 72.7-86.8] and 75.5% [95% CI: 65.6-83] at 18 years. Tumor progression was the most common cause of death (65%). Age and intracranial hypertension at diagnosis were significantly associated with a worse prognosis. Risk of death was increased by 3.1[95% CI: 1.5-6.2] (p=0.002) for patients less than 1 year old at diagnosis and by 5.2[95% CI: 1.5-17.6] (p=0.007) for patients with initial intracranial hypertension. Boys without diencephalic syndrome had a better prognosis (HR: 0.3 [95% CI: 0.1-0.8], p=0.007).</p><p>Conclusions</p><p>This study shows that i) in children with OPG, OS is not as favorable as previously described and ii) patients can be classified into 2 groups depending on risk factors (age, intracranial hypertension, sex and diencephalic syndrome) with an OS rate of 50.4% at 18 years [95% CI: 31.4-66.6] in children with the worst prognosis. These findings could justify, depending on the initial risk, a different therapeutic approach to this tumor with more aggressive treatment (especially chemotherapy) in patients with high risk factors.</p></div>", "links"=>[], "tags"=>["risk factors", "hr", "diencephalic syndrome", "opg", "Optic Pathway Glioma Treated", "chemotherapy", "ci", "Cox regression analysis.ResultsThe OS", "prognosis", "intracranial hypertension", "diagnosis"], "article_id"=>1456483, "categories"=>["Uncategorised"], "users"=>["Josué Rakotonjanahary", "Emilie De Carli", "Matthieu Delion", "Chantal Kalifa", "Jacques Grill", "Francois Doz", "Pierre Leblond", "Anne-Isabelle Bertozzi", "Xavier Rialland"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0127676.s001", "https://dx.doi.org/10.1371/journal.pone.0127676.s002", "https://dx.doi.org/10.1371/journal.pone.0127676.s003", "https://dx.doi.org/10.1371/journal.pone.0127676.s004", "https://dx.doi.org/10.1371/journal.pone.0127676.s005", "https://dx.doi.org/10.1371/journal.pone.0127676.s006"], "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mortality_in_Children_with_Optic_Pathway_Glioma_Treated_with_Up_Front_BB_SFOP_Chemotherapy_/1456483", "title"=>"Mortality in Children with Optic Pathway Glioma Treated with Up-Front BB-SFOP Chemotherapy", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-06-22 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128707"], "description"=>"<p>Overall Survival for the whole population with optic pathway glioma.</p>", "links"=>[], "tags"=>["risk factors", "hr", "diencephalic syndrome", "opg", "Optic Pathway Glioma Treated", "chemotherapy", "ci", "Cox regression analysis.ResultsThe OS", "prognosis", "intracranial hypertension", "diagnosis"], "article_id"=>1456472, "categories"=>["Uncategorised"], "users"=>["Josué Rakotonjanahary", "Emilie De Carli", "Matthieu Delion", "Chantal Kalifa", "Jacques Grill", "Francois Doz", "Pierre Leblond", "Anne-Isabelle Bertozzi", "Xavier Rialland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127676.g001", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_Survival_for_the_whole_population_with_optic_pathway_glioma_/1456472", "title"=>"Overall Survival for the whole population with optic pathway glioma.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128710"], "description"=>"<p>Overall survival according to age at diagnosis (A), NF1 status (B), presence of DS (C) or intracranial hypertension (IH) (D) at diagnosis.</p>", "links"=>[], "tags"=>["risk factors", "hr", "diencephalic syndrome", "opg", "Optic Pathway Glioma Treated", "chemotherapy", "ci", "Cox regression analysis.ResultsThe OS", "prognosis", "intracranial hypertension", "diagnosis"], "article_id"=>1456475, "categories"=>["Uncategorised"], "users"=>["Josué Rakotonjanahary", "Emilie De Carli", "Matthieu Delion", "Chantal Kalifa", "Jacques Grill", "Francois Doz", "Pierre Leblond", "Anne-Isabelle Bertozzi", "Xavier Rialland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127676.g002", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_survival_according_to_age_at_diagnosis_A_NF1_status_B_presence_of_DS_C_or_intracranial_hypertension_IH_D_at_diagnosis_/1456475", "title"=>"Overall survival according to age at diagnosis (A), NF1 status (B), presence of DS (C) or intracranial hypertension (IH) (D) at diagnosis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128712"], "description"=>"<p>Overall survival according to the number of risk factors present at diagnosis: whole population (A), 0 or 1 risk factor (B), 2 or more risk factors (C).</p>", "links"=>[], "tags"=>["risk factors", "hr", "diencephalic syndrome", "opg", "Optic Pathway Glioma Treated", "chemotherapy", "ci", "Cox regression analysis.ResultsThe OS", "prognosis", "intracranial hypertension", "diagnosis"], "article_id"=>1456477, "categories"=>["Uncategorised"], "users"=>["Josué Rakotonjanahary", "Emilie De Carli", "Matthieu Delion", "Chantal Kalifa", "Jacques Grill", "Francois Doz", "Pierre Leblond", "Anne-Isabelle Bertozzi", "Xavier Rialland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127676.g003", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_survival_according_to_the_number_of_risk_factors_present_at_diagnosis_whole_population_A_0_or_1_risk_factor_B_2_or_more_risk_factors_C_/1456477", "title"=>"Overall survival according to the number of risk factors present at diagnosis: whole population (A), 0 or 1 risk factor (B), 2 or more risk factors (C).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128713"], "description"=>"<p><sup>1</sup> Diencephalic syndrome was defined as failure to thrive and a diagnostic weight between the 2<sup>nd</sup> and 5<sup>th</sup> percentile.</p><p><sup>2</sup> Intracranial hypertension was defined by clinical symptoms associated with radiological hydrocephalus.</p><p>Characteristics of patients at diagnosis.</p>", "links"=>[], "tags"=>["risk factors", "hr", "diencephalic syndrome", "opg", "Optic Pathway Glioma Treated", "chemotherapy", "ci", "Cox regression analysis.ResultsThe OS", "prognosis", "intracranial hypertension", "diagnosis"], "article_id"=>1456478, "categories"=>["Uncategorised"], "users"=>["Josué Rakotonjanahary", "Emilie De Carli", "Matthieu Delion", "Chantal Kalifa", "Jacques Grill", "Francois Doz", "Pierre Leblond", "Anne-Isabelle Bertozzi", "Xavier Rialland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127676.t001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_patients_at_diagnosis_/1456478", "title"=>"Characteristics of patients at diagnosis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-22 02:48:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128714"], "description"=>"<p>* Reference for HR</p><p>Overall Survival distributions and Hazard Ratios depending on the clinical data at diagnosis and treatments (p values according to univariate Cox regression analysis).</p>", "links"=>[], "tags"=>["risk factors", "hr", "diencephalic syndrome", "opg", "Optic Pathway Glioma Treated", "chemotherapy", "ci", "Cox regression analysis.ResultsThe OS", "prognosis", "intracranial hypertension", "diagnosis"], "article_id"=>1456479, "categories"=>["Uncategorised"], "users"=>["Josué Rakotonjanahary", "Emilie De Carli", "Matthieu Delion", "Chantal Kalifa", "Jacques Grill", "Francois Doz", "Pierre Leblond", "Anne-Isabelle Bertozzi", "Xavier Rialland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0127676.t002", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_Survival_distributions_and_Hazard_Ratios_depending_on_the_clinical_data_at_diagnosis_and_treatments_p_values_according_to_univariate_Cox_regression_analysis_/1456479", "title"=>"Overall Survival distributions and Hazard Ratios depending on the clinical data at diagnosis and treatments (p values according to univariate Cox regression analysis).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-22 02:48:53"}

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  • {"unique-ip"=>"63", "full-text"=>"68", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"61", "full-text"=>"72", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"73", "full-text"=>"80", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"56", "full-text"=>"62", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"82", "full-text"=>"89", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"57", "full-text"=>"61", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"68", "full-text"=>"69", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"56", "full-text"=>"63", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"58", "full-text"=>"67", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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