Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping
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{"title"=>"Dissecting allele architecture of early onset IBD using high-density genotyping", "type"=>"journal", "authors"=>[{"first_name"=>"Shervin", "last_name"=>"Rabizadeh", "scopus_author_id"=>"16140342400"}, {"first_name"=>"Joshua", "last_name"=>"Noe", "scopus_author_id"=>"26028089700"}, {"first_name"=>"Scott", "last_name"=>"Snapper", "scopus_author_id"=>"7003969189"}, {"first_name"=>"Anthony", "last_name"=>"Otley", "scopus_author_id"=>"6603463473"}, {"first_name"=>"Stanley", "last_name"=>"Cohen", "scopus_author_id"=>"55242194000"}, {"first_name"=>"Maria", "last_name"=>"Oliva-Hemker", "scopus_author_id"=>"6603255996"}, {"first_name"=>"Barbara", "last_name"=>"Kirschner", "scopus_author_id"=>"7006378146"}, {"first_name"=>"Patel", "last_name"=>"Ashish", "scopus_author_id"=>"55449639000"}, {"first_name"=>"David", "last_name"=>"Ziring", "scopus_author_id"=>"14424649300"}, {"first_name"=>"Jonathan", "last_name"=>"Evans", "scopus_author_id"=>"55724929100"}, {"first_name"=>"Susan", "last_name"=>"Baker", "scopus_author_id"=>"55628588466"}, {"first_name"=>"David J.", "last_name"=>"Cutler", "scopus_author_id"=>"35354177500"}, {"first_name"=>"Michael E.", "last_name"=>"Zwick", "scopus_author_id"=>"7007024749"}, {"first_name"=>"David T.", "last_name"=>"Okou", "scopus_author_id"=>"6503919938"}, {"first_name"=>"Sampath", "last_name"=>"Prahalad", "scopus_author_id"=>"6604044779"}, {"first_name"=>"Thomas", "last_name"=>"Walters", "scopus_author_id"=>"12805551700"}, {"first_name"=>"Stephen L.", "last_name"=>"Guthery", "scopus_author_id"=>"6603369156"}, {"first_name"=>"Marla", "last_name"=>"Dubinsky", "scopus_author_id"=>"7003310173"}, {"first_name"=>"Robert", "last_name"=>"Baldassano", "scopus_author_id"=>"7003934246"}, {"first_name"=>"Wallace V.", "last_name"=>"Crandall", "scopus_author_id"=>"7003565046"}, {"first_name"=>"Joel", "last_name"=>"Rosh", "scopus_author_id"=>"57201272574"}, {"first_name"=>"James", "last_name"=>"Markowitz", "scopus_author_id"=>"7102165629"}, {"first_name"=>"Michael", "last_name"=>"Stephens", "scopus_author_id"=>"8373869600"}, {"first_name"=>"Richard", "last_name"=>"Kellermayer", "scopus_author_id"=>"6602623020"}, {"first_name"=>"Marian", "last_name"=>"Pfefferkorn", "scopus_author_id"=>"6603915871"}, {"first_name"=>"Melvin B.", "last_name"=>"Heyman", "scopus_author_id"=>"7102238098"}, {"first_name"=>"Neal", "last_name"=>"LeLeiko", "scopus_author_id"=>"7004491305"}, {"first_name"=>"David", "last_name"=>"Mack", "scopus_author_id"=>"7102096227"}, {"first_name"=>"Dedrick", "last_name"=>"Moulton", "scopus_author_id"=>"7005424106"}, {"first_name"=>"Michael D.", "last_name"=>"Kappelman", "scopus_author_id"=>"8343817000"}, {"first_name"=>"Archana", "last_name"=>"Kumar", "scopus_author_id"=>"56297772200"}, {"first_name"=>"Jarod", "last_name"=>"Prince", "scopus_author_id"=>"56779576200"}, {"first_name"=>"Promita", "last_name"=>"Bose", "scopus_author_id"=>"55361047200"}, {"first_name"=>"Kajari", "last_name"=>"Mondal", "scopus_author_id"=>"7004865986"}, {"first_name"=>"Dhanya", "last_name"=>"Ramachandran", "scopus_author_id"=>"57190445912"}, {"first_name"=>"John F.", "last_name"=>"Bohnsack", "scopus_author_id"=>"7004428275"}, {"first_name"=>"Anne M.", "last_name"=>"Griffiths", "scopus_author_id"=>"23070897000"}, {"first_name"=>"Yael", "last_name"=>"Haberman", "scopus_author_id"=>"8409408800"}, {"first_name"=>"Jonah", "last_name"=>"Essers", "scopus_author_id"=>"13103000000"}, {"first_name"=>"Susan D.", "last_name"=>"Thompson", "scopus_author_id"=>"7403233264"}, {"first_name"=>"Bruce", "last_name"=>"Aronow", "scopus_author_id"=>"7005740105"}, {"first_name"=>"David J.", "last_name"=>"Keljo", "scopus_author_id"=>"6701919021"}, {"first_name"=>"Jeffrey S.", "last_name"=>"Hyams", "scopus_author_id"=>"7102153409"}, {"first_name"=>"Lee A.", "last_name"=>"Denson", "scopus_author_id"=>"6701786907"}, {"first_name"=>"Subra", "last_name"=>"Kugathasan", "scopus_author_id"=>"6603770341"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84939133461", "sgr"=>"84939133461", "doi"=>"10.1371/journal.pone.0128074", "pui"=>"605586360", "pmid"=>"26098103", "issn"=>"19326203"}, "id"=>"0493d4d7-7bc0-35a8-9354-57da6a7e4f73", "abstract"=>"BACKGROUND: The inflammatory bowel diseases (IBD) are common, complex disorders in which genetic and environmental factors are believed to interact leading to chronic inflammatory responses against the gut microbiota. Earlier genetic studies performed in mostly adult population of European descent identified 163 loci affecting IBD risk, but most have relatively modest effect sizes, and altogether explain only ~20% of the genetic susceptibility. Pediatric onset represents about 25% of overall incident cases in IBD, characterized by distinct disease physiology, course and risks. The goal of this study is to compare the allelic architecture of early onset IBD with adult onset in population of European descent.\\n\\nMETHODS: We performed a fine mapping association study of early onset IBD using high-density Immunochip genotyping on 1008 pediatric-onset IBD cases (801 Crohn's disease; 121 ulcerative colitis and 86 IBD undetermined) and 1633 healthy controls. Of the 158 SNP genotypes obtained (out of the 163 identified in adult onset), this study replicated 4% (5 SNPs out of 136) of the SNPs identified in the Crohn's disease (CD) cases and 0.8% (1 SNP out of 128) in the ulcerative colitis (UC) cases. Replicated SNPs implicated the well known NOD2 and IL23R. The point estimate for the odds ratio (ORs) for NOD2 was above and outside the confidence intervals reported in adult onset. A polygenic liability score weakly predicted the age of onset for a larger collection of CD cases (p< 0.03, R2= 0.007), but not for the smaller number of UC cases.\\n\\nCONCLUSIONS: The allelic architecture of common susceptibility variants for early onset IBD is similar to that of adult onset. This immunochip genotyping study failed to identify additional common variants that may explain the distinct phenotype that characterize early onset IBD. A comprehensive dissection of genetic loci is necessary to further characterize the genetic architecture of early onset IBD.", "link"=>"http://www.mendeley.com/research/dissecting-allele-architecture-early-onset-ibd-using-highdensity-genotyping", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. 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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2129925", "https://ndownloader.figshare.com/files/2129926", "https://ndownloader.figshare.com/files/2129927", "https://ndownloader.figshare.com/files/2129928", "https://ndownloader.figshare.com/files/2129929", "https://ndownloader.figshare.com/files/2129930", "https://ndownloader.figshare.com/files/2129931", "https://ndownloader.figshare.com/files/2129932", "https://ndownloader.figshare.com/files/2129933", "https://ndownloader.figshare.com/files/2129934", "https://ndownloader.figshare.com/files/2129935", "https://ndownloader.figshare.com/files/2129936", "https://ndownloader.figshare.com/files/2129937"], "description"=>"<div><p>Background</p><p>The inflammatory bowel diseases (IBD) are common, complex disorders in which genetic and environmental factors are believed to interact leading to chronic inflammatory responses against the gut microbiota. Earlier genetic studies performed in mostly adult population of European descent identified 163 loci affecting IBD risk, but most have relatively modest effect sizes, and altogether explain only ~20% of the genetic susceptibility. Pediatric onset represents about 25% of overall incident cases in IBD, characterized by distinct disease physiology, course and risks. The goal of this study is to compare the allelic architecture of early onset IBD with adult onset in population of European descent.</p><p>Methods</p><p>We performed a fine mapping association study of early onset IBD using high-density Immunochip genotyping on 1008 pediatric-onset IBD cases (801 Crohn’s disease; 121 ulcerative colitis and 86 IBD undetermined) and 1633 healthy controls. Of the 158 SNP genotypes obtained (out of the 163 identified in adult onset), this study replicated 4% (5 SNPs out of 136) of the SNPs identified in the Crohn’s disease (CD) cases and 0.8% (1 SNP out of 128) in the ulcerative colitis (UC) cases. Replicated SNPs implicated the well known <i>NOD2</i> and <i>IL23R</i>. The point estimate for the odds ratio (ORs) for <i>NOD2</i> was above and outside the confidence intervals reported in adult onset. A polygenic liability score weakly predicted the age of onset for a larger collection of CD cases (p< 0.03, R<sup>2</sup>= 0.007), but not for the smaller number of UC cases.</p><p>Conclusions</p><p>The allelic architecture of common susceptibility variants for early onset IBD is similar to that of adult onset. This immunochip genotyping study failed to identify additional common variants that may explain the distinct phenotype that characterize early onset IBD. A comprehensive dissection of genetic loci is necessary to further characterize the genetic architecture of early onset IBD.</p></div>", "links"=>[], "tags"=>["or", "immunochip genotyping study", "onset IBD", "mapping association study", "Dissecting Allele Architecture", "NOD 2", "polygenic liability score", "adult onset", "158 SNP genotypes", "UC cases.ConclusionsThe allelic architecture", "il", "23R"], "article_id"=>1457488, "categories"=>["Uncategorised"], "users"=>["David J. Cutler", "Michael E. Zwick", "David T. Okou", "Sampath Prahalad", "Thomas Walters", "Stephen L. Guthery", "Marla Dubinsky", "Robert Baldassano", "Wallace V. Crandall", "Joel Rosh", "James Markowitz", "Michael Stephens", "Richard Kellermayer", "Marian Pfefferkorn", "Melvin B. Heyman", "Neal Leleiko", "David Mack", "Dedrick Moulton", "Michael D. Kappelman", "Archana Kumar", "Jarod Prince", "Promita Bose", "Kajari Mondal", "Dhanya Ramachandran", "John F. Bohnsack", "Anne M. Griffiths", "Yael Haberman", "Jonah Essers", "Susan D. Thompson", "Bruce Aronow", "David J. Keljo", "Jeffrey S. Hyams", "Lee A. Denson", "Subra Kugathasan"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0128074.s001", "https://dx.doi.org/10.1371/journal.pone.0128074.s002", "https://dx.doi.org/10.1371/journal.pone.0128074.s003", "https://dx.doi.org/10.1371/journal.pone.0128074.s004", "https://dx.doi.org/10.1371/journal.pone.0128074.s005", "https://dx.doi.org/10.1371/journal.pone.0128074.s006", "https://dx.doi.org/10.1371/journal.pone.0128074.s007", "https://dx.doi.org/10.1371/journal.pone.0128074.s008", "https://dx.doi.org/10.1371/journal.pone.0128074.s009", "https://dx.doi.org/10.1371/journal.pone.0128074.s010", "https://dx.doi.org/10.1371/journal.pone.0128074.s011", "https://dx.doi.org/10.1371/journal.pone.0128074.s012", "https://dx.doi.org/10.1371/journal.pone.0128074.s013"], "stats"=>{"downloads"=>11, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dissecting_Allele_Architecture_of_Early_Onset_IBD_Using_High_Density_Genotyping_/1457488", "title"=>"Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-06-22 04:10:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/2129859"], "description"=>"<p>The horizontal black line represent the thresholds of <i>P</i> = 3.57 x 10<sup>–7</sup> for Bonferroni significance</p>", "links"=>[], "tags"=>["or", "immunochip genotyping study", "onset IBD", "mapping association study", "Dissecting Allele Architecture", "NOD 2", "polygenic liability score", "adult onset", "158 SNP genotypes", "UC cases.ConclusionsThe allelic architecture", "il", "23R"], "article_id"=>1457429, "categories"=>["Uncategorised"], "users"=>["David J. Cutler", "Michael E. Zwick", "David T. Okou", "Sampath Prahalad", "Thomas Walters", "Stephen L. Guthery", "Marla Dubinsky", "Robert Baldassano", "Wallace V. Crandall", "Joel Rosh", "James Markowitz", "Michael Stephens", "Richard Kellermayer", "Marian Pfefferkorn", "Melvin B. Heyman", "Neal Leleiko", "David Mack", "Dedrick Moulton", "Michael D. Kappelman", "Archana Kumar", "Jarod Prince", "Promita Bose", "Kajari Mondal", "Dhanya Ramachandran", "John F. Bohnsack", "Anne M. Griffiths", "Yael Haberman", "Jonah Essers", "Susan D. Thompson", "Bruce Aronow", "David J. Keljo", "Jeffrey S. Hyams", "Lee A. Denson", "Subra Kugathasan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0128074.g001", "stats"=>{"downloads"=>2, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Manhattan_plot_of_SNP_association_p_values_result_for_CD_vs_controls_within_pediatric_onset_IBD_/1457429", "title"=>"Manhattan plot of SNP association p-values result for CD vs controls within pediatric onset IBD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 04:10:52"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"48", "full-text"=>"60", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"38", "full-text"=>"35", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"39", "full-text"=>"27", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"31", "full-text"=>"37", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"35", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"30", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"28", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"32", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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