Silencing of Cholinergic Basal Forebrain Neurons Using Archaerhodopsin Prolongs Slow-Wave Sleep in Mice
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Silencing of cholinergic basal forebrain neurons using archaerhodopsin prolongs slow-wave sleep in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Yu Feng", "last_name"=>"Shi", "scopus_author_id"=>"56020817700"}, {"first_name"=>"Yong", "last_name"=>"Han", "scopus_author_id"=>"56309201500"}, {"first_name"=>"Yun Ting", "last_name"=>"Su", "scopus_author_id"=>"57161489600"}, {"first_name"=>"Jun Hua", "last_name"=>"Yang", "scopus_author_id"=>"57161510900"}, {"first_name"=>"Yan Qin", "last_name"=>"Yu", "scopus_author_id"=>"7406253532"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84941668934", "pui"=>"608635387", "sgr"=>"84941668934", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "issn"=>"19326203", "pmid"=>"26151909", "doi"=>"10.1371/journal.pone.0130130"}, "id"=>"4c630600-5607-34c2-912d-944902a0cf68", "abstract"=>"The basal forebrain (BF) plays a crucial role in cortical activation. Our previous study showed that activation of cholinergic BF neurons alone is sufficient to suppress slow-wave sleep (SWS) and promote wakefulness and rapid-eye-movement (REM) sleep. However, the exact role of silencing cholinergic BF neurons in the sleep-wake cycle remains unclear. We inhibitied the cholinergic BF neurons genetically targeted with archaerhodopsin (Arch) with yellow light to clarify the role of cholinergic BF neurons in the sleep-wake cycle. Bilateral inactivation of cholinergic BF neurons genetically targeted with archaerhodopsin prolonged SWS and decreased the probability of awakening from SWS in mice. However, silencing these neurons changed neither the duration of wakefulness or REM sleep, nor the probability of transitions to other sleep-wake episodes from wakefulness or REM sleep. Furthermore, silencing these neurons for 6 h within the inactive or active period increased the duration of SWS at the expense of the duration of wakefulness, as well as increasing the number of prolonged SWS episodes (120-240 s). The lost wakefulness was compensated by a delayed increase of wakefulness, so the total duration of SWS and wakefulness during 24 h was kept stable. Our results indicate that the main effect of these neurons is to terminate SWS, whereas wakefulness or REM sleep may be determined by co-operation of the cholinergic BF neurons with other arousal-sleep control systems.", "link"=>"http://www.mendeley.com/research/silencing-cholinergic-basal-forebrain-neurons-using-archaerhodopsin-prolongs-slowwave-sleep-mice", "reader_count"=>21, "reader_count_by_academic_status"=>{"Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>6, "Student > Master"=>1, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>6, "Student > Master"=>1, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>3, "Neuroscience"=>5, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>5}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"France"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84941668934"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84941668934?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84941668934&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84941668934&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84941668934", "dc:identifier"=>"SCOPUS_ID:84941668934", "eid"=>"2-s2.0-84941668934", "dc:title"=>"Silencing of cholinergic basal forebrain neurons using archaerhodopsin prolongs slow-wave sleep in mice", "dc:creator"=>"Shi Y.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"10", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-07-01", "prism:coverDisplayDate"=>"July 2015", "prism:doi"=>"10.1371/journal.pone.0130130", "citedby-count"=>"19", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Zhejiang University School of Medicine", "affiliation-city"=>"Hangzhou", "affiliation-country"=>"China"}], "pubmed-id"=>"26151909", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0130130", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0130130", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"80", "xml_views"=>"10", "html_views"=>"510"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"94"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"9"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2166693"], "description"=>"<p><b>(A</b>) Diagram of heterozygous mice with conditional expression of Arch-GFP after recombination of the Stop-loxP gene and ChAT-Cre recombinase. (<b>B</b>) PCR analysis. Ai35D heterozygous mice had one 242-bp and one 246-bp band, while WT mice had only one 242-bp band. The positive Cre band was at 350-bp.</p>", "links"=>[], "tags"=>["rem", "duration", "sws", "wakefulness", "Cholinergic Basal Forebrain Neurons", "Bilateral inactivation", "cholinergic BF neurons", "6 h", "basal forebrain", "24 h"], "article_id"=>1476720, "categories"=>["Biological Sciences"], "users"=>["Yu-Feng Shi", "Yong Han", "Yun-Ting Su", "Jun-Hua Yang", "Yan-Qin Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130130.g001", "stats"=>{"downloads"=>9, "page_views"=>350, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Recombination_of_Ai35D_and_ChAT_Cre_mice_/1476720", "title"=>"Recombination of Ai35D and ChAT-Cre mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-07 03:22:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/2166694"], "description"=>"<p>(<b>A</b>–<b>C)</b> Representative photomicrographs of the BF depicting Arch-GFP expression (<b>A</b>, green), ChAT immunoreactivity (<b>B</b>, red), and overlaid images (<b>C</b>) from a ChAT-Arch mouse. Scale bars, 50 μm. (<b>D)</b> Statistics of the total co-expression of GFP and ChAT immunofluorescence from ChAT-Arch mice (n = 5) in 30-μm sections from the rostral-to-caudal ends of the BF (anteroposterior, -0.4 to -0.8). Cell counts are represented as mean ± s.e.m. <b>(E)</b> Yellow light inhibits the activity of Arch-expressing cholinergic BF neurons. Action potentials recorded under current-clamp from a neuron expressing Arch-GFP in a BF slice in response to 20 Hz yellow light pulse trains (20 ms per pulse) or continuous yellow light for 30 s (upper trace). Action potentials recorded under current-clamp from a neuron expressing Arch-GFP in a BF slice in response to 20 Hz yellow light pulse trains (20 ms per pulse) or continuous yellow light for 60 s (lower trace). (<b>F</b>) Representative photomicrographs of Arch-GFP expression in BF from a ChAT-Arch mouse. White arrow indicated a fiberoptic lesion track. 3V, 3rd ventricle; D3V, dorsal 3rd ventricle. Scale bars, 200 μm.</p>", "links"=>[], "tags"=>["rem", "duration", "sws", "wakefulness", "Cholinergic Basal Forebrain Neurons", "Bilateral inactivation", "cholinergic BF neurons", "6 h", "basal forebrain", "24 h"], "article_id"=>1476721, "categories"=>["Biological Sciences"], "users"=>["Yu-Feng Shi", "Yong Han", "Yun-Ting Su", "Jun-Hua Yang", "Yan-Qin Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130130.g002", "stats"=>{"downloads"=>2, "page_views"=>58, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Specific_and_efficient_expression_of_Arch_GFP_in_cholinergic_BF_neurons_of_ChAT_Arch_mice_/1476721", "title"=>"Specific and efficient expression of Arch-GFP in cholinergic BF neurons of ChAT-Arch mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-07 03:22:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/2166695"], "description"=>"<p>(<b>A</b>–<b>D)</b> Left panel, representative EEG and EMG recordings showing that photoinhibition (yellow bars, continuous yellow light for 30 s) applied during waking (<b>B</b>), SWS (<b>C</b>), or REM sleep (<b>D</b>) in a ChAT-Arch mouse and during waking (<b>A</b>) in a wild-type mouse. Right panel, relative cortical EEG power (0.38-Hz binned frequencies, 30-s duration) at baseline (black trace) and after the onset of photostimulation (yellow trace) in ChAT-Arch mice. n = 3 mice, 10 stimulations per mouse in <b>A</b>–<b>D</b>. <i>p</i> >0.05, two-tailed Student’s t test between baseline and ChAT-Arch mice with bilateral inactivation of cholinergic BF neurons.</p>", "links"=>[], "tags"=>["rem", "duration", "sws", "wakefulness", "Cholinergic Basal Forebrain Neurons", "Bilateral inactivation", "cholinergic BF neurons", "6 h", "basal forebrain", "24 h"], "article_id"=>1476722, "categories"=>["Biological Sciences"], "users"=>["Yu-Feng Shi", "Yong Han", "Yun-Ting Su", "Jun-Hua Yang", "Yan-Qin Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130130.g003", "stats"=>{"downloads"=>4, "page_views"=>48, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Photoinhibition_of_cholinergic_BF_neurons_during_wakefulness_SWS_and_REM_sleep_in_the_inactive_period_/1476722", "title"=>"Photoinhibition of cholinergic BF neurons during wakefulness, SWS, and REM sleep in the inactive period.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-07 03:22:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/2166696"], "description"=>"<p>(<b>A</b>, <b>C)</b> Duration of individual SWS episodes at baseline and 30-s unilateral or bilateral continuous inactivation during the inactive period (<b>A</b>) and active period (<b>C</b>). (<b>B</b>, <b>D)</b> Duration of individual REM sleep episodes at baseline and 30-s unilateral or bilateral continuous inactivation during the inactive period (<b>B</b>) and active period (<b>D</b>). The experiments were performed from 13:00 to 17:00 during the inactive period and from 22:00 to 02:00 during the active period. The baseline was determined by analyzing the duration of individual SWS or REM sleep episodes about the same time on the day before inactivation. n = 5 mice, *<i>p</i> <0.05, **<i>p</i> <0.01, two-way ANOVA between stimulation condition and animal type followed by Tukey’s <i>post-hoc</i> test.</p>", "links"=>[], "tags"=>["rem", "duration", "sws", "wakefulness", "Cholinergic Basal Forebrain Neurons", "Bilateral inactivation", "cholinergic BF neurons", "6 h", "basal forebrain", "24 h"], "article_id"=>1476723, "categories"=>["Biological Sciences"], "users"=>["Yu-Feng Shi", "Yong Han", "Yun-Ting Su", "Jun-Hua Yang", "Yan-Qin Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130130.g004", "stats"=>{"downloads"=>1, "page_views"=>43, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Silencing_of_cholinergic_BF_neurons_prolongs_SWS_duration_but_does_not_affect_REM_sleep_/1476723", "title"=>"Silencing of cholinergic BF neurons prolongs SWS duration but does not affect REM sleep.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-07 03:22:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/2166697"], "description"=>"<p>(<b>A</b>, <b>D)</b> Percentage probability of transition to wakefulness or REM sleep or maintained SWS from SWS within a single 30-s unilateral or bilateral continuous inactivation in the inactive period (<b>A</b>) and the active period (<b>D</b>). (<b>B</b>, <b>E)</b> Percentage probability of transition to SWS or maintained wakefulness from wakefulness within a single 30-s unilateral or bilateral continuous inactivation in the inactive period (<b>B</b>) and the active period (<b>E</b>). (<b>C</b>, <b>F)</b> Percentage probability of transition to wakefulness or maintained REM sleep from REM sleep within a single 30-s unilateral or bilateral continuous inactivation in the inactive period (<b>C</b>) and the active period (<b>F</b>). n = 6 mice, *<i>p</i> <0.05, **<i>p</i> <0.01, ***<i>p</i> <0.001, one-way ANOVA for unilateral or bilateral continuous inactivation compared with control followed by Tukey <i>post-hoc</i> test.</p>", "links"=>[], "tags"=>["rem", "duration", "sws", "wakefulness", "Cholinergic Basal Forebrain Neurons", "Bilateral inactivation", "cholinergic BF neurons", "6 h", "basal forebrain", "24 h"], "article_id"=>1476724, "categories"=>["Biological Sciences"], "users"=>["Yu-Feng Shi", "Yong Han", "Yun-Ting Su", "Jun-Hua Yang", "Yan-Qin Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130130.g005", "stats"=>{"downloads"=>0, "page_views"=>39, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Silencing_of_cholinergic_BF_neurons_reduces_transitions_from_SWS_but_does_not_affect_transitions_from_wakefulness_and_REM_sleep_/1476724", "title"=>"Silencing of cholinergic BF neurons reduces transitions from SWS but does not affect transitions from wakefulness and REM sleep.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-07 03:22:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/2166699"], "description"=>"<p><b>(A</b>, <b>B)</b> Time the ChAT-Arch mice spent in wakefulness, SWS, and REM sleep during 24 h with 6-h inactivation (continuous, 60 s, once every 2 min) in the inactive period (13:00–19:00) (<b>A</b>) and the active period (19:00–01:00) (<b>B</b>). Each symbol represents the hourly mean time in each stage. The baseline was determined by analyzing the hourly mean time in each stage on the day before inactivation. <b>(C, D)</b> Percentage of total times the ChAT-Arch mice spent in wakefulness, SWS, and REM sleep during 24 h with and without light inactivation. n = 6 mice, *<i>p</i> <0.05, **<i>p</i> <0.01, two-tailed Student’s t test between baseline and with light inactivation.</p>", "links"=>[], "tags"=>["rem", "duration", "sws", "wakefulness", "Cholinergic Basal Forebrain Neurons", "Bilateral inactivation", "cholinergic BF neurons", "6 h", "basal forebrain", "24 h"], "article_id"=>1476726, "categories"=>["Biological Sciences"], "users"=>["Yu-Feng Shi", "Yong Han", "Yun-Ting Su", "Jun-Hua Yang", "Yan-Qin Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130130.g006", "stats"=>{"downloads"=>0, "page_views"=>44, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Six_hour_inactivation_of_cholinergic_BF_neurons_during_the_inactive_or_active_period_/1476726", "title"=>"Six-hour inactivation of cholinergic BF neurons during the inactive or active period.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-07 03:22:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/2166701"], "description"=>"<p><b>(A, B)</b> Numbers of episodes of wakefulness, SWS, and REM sleep during 6 h with and without light inactivation. n = 5 ChAT-Arch mice. <b>(C</b>, <b>D)</b> Durations of episodes of wakefulness, SWS, and REM sleep during 6 h with and without light inactivation. n = 5 ChAT-Arch mice. <b>(E, F)</b> Numbers of episodes of wakefulness during 6 h with and without light inactivation. n = 5 ChAT-Arch mice. <b>(G, H)</b> Numbers of episodes of SWS during 6 h with and without light inactivation. n = 5 ChAT-Arch mice. **<i>p</i> <0.01, ***<i>p</i> <0.001, two-tailed Student’s t test between baseline and with light inactivation.</p>", "links"=>[], "tags"=>["rem", "duration", "sws", "wakefulness", "Cholinergic Basal Forebrain Neurons", "Bilateral inactivation", "cholinergic BF neurons", "6 h", "basal forebrain", "24 h"], "article_id"=>1476728, "categories"=>["Biological Sciences"], "users"=>["Yu-Feng Shi", "Yong Han", "Yun-Ting Su", "Jun-Hua Yang", "Yan-Qin Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130130.g007", "stats"=>{"downloads"=>0, "page_views"=>49, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SWS_episode_duration_increases_during_6_h_inactivation_of_cholinergic_BF_neurons_during_the_active_period_/1476728", "title"=>"SWS episode duration increases during 6-h inactivation of cholinergic BF neurons during the active period.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-07 03:22:55"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime | Further Information

Loading … Spinner
There are currently no alerts