Skin Barrier Function and Staphylococcus aureus Colonization in Vestibulum Nasi and Fauces in Healthy Infants and Infants with Eczema: A Population-Based Cohort Study
Publication Date
June 12, 2015
Journal
PLOS ONE
Authors
Teresa Løvold Berents, Karin Cecilie Lødrup Carlsen, Petter Mowinckel, Håvard Ove Skjerven, et al
Volume
10
Issue
6
Pages
e0130145
DOI
https://dx.plos.org/10.1371/journal.pone.0130145
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0130145
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26070153
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466520
Europe PMC
http://europepmc.org/abstract/MED/26070153
Web of Science
000356327000142
Scopus
84936107554
Mendeley
http://www.mendeley.com/research/skin-barrier-function-staphylococcus-aureus-colonization-vestibulum-nasi-fauces-healthy-infants-infa
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Mendeley | Further Information

{"title"=>"Skin barrier function and Staphylococcus aureus colonization in vestibulum nasi and fauces in healthy infants and infants with eczema: A population-based cohort study", "type"=>"journal", "authors"=>[{"first_name"=>"Teresa Løvold", "last_name"=>"Berents", "scopus_author_id"=>"6506400050"}, {"first_name"=>"Karin Cecilie Lødrup", "last_name"=>"Carlsen", "scopus_author_id"=>"6603838951"}, {"first_name"=>"Petter", "last_name"=>"Mowinckel", "scopus_author_id"=>"6603940379"}, {"first_name"=>"Håvard Ove", "last_name"=>"Skjerven", "scopus_author_id"=>"55761651300"}, {"first_name"=>"Bente", "last_name"=>"Kvenshagen", "scopus_author_id"=>"16245156900"}, {"first_name"=>"Leif Bjarte", "last_name"=>"Rolfsjord", "scopus_author_id"=>"55761645300"}, {"first_name"=>"Maria", "last_name"=>"Bradley", "scopus_author_id"=>"12781970000"}, {"first_name"=>"Agne", "last_name"=>"Lieden", "scopus_author_id"=>"6504147521"}, {"first_name"=>"Kai Håkon", "last_name"=>"Carlsen", "scopus_author_id"=>"22133339200"}, {"first_name"=>"Peter", "last_name"=>"Gaustad", "scopus_author_id"=>"7006172825"}, {"first_name"=>"Petter", "last_name"=>"Gjersvik", "scopus_author_id"=>"7004886087"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"26070153", "scopus"=>"2-s2.0-84936107554", "pui"=>"605092421", "doi"=>"10.1371/journal.pone.0130145", "sgr"=>"84936107554"}, "id"=>"ee32dc7b-b57f-3b4e-bea6-4925cd2ed5f1", "abstract"=>"Atopic eczema (AE) is associated with Staphylococcus aureus (S. aureus) colonization and skin barrier dysfunction, often measured by increased transepidermal water loss (TEWL). In the present study, the primary aim was to see whether S. aureus colonization in the vestibu- lum nasi and/or fauces was associated with increased TEWL in infants with healthy skin and infants with eczema. Secondarily, we aimed to investigate whether TEWLmeasure- ments on non-lesional skin on the lateral upper arm is equivalent to volar forearm in infants. In 167 of 240 infants, recruited from the general population, TEWL measurements on the lateral upper arm and volar forearm, using a DermaLab USB, fulfilled our environmental re- quirements. The mean of three TEWL measurements from each site was used for analysis. The infants were diagnosed with no eczema (n = 110), possible AE (n = 28) or AE (n = 29). DNA samples were analysed for mutations in the filaggrin gene (FLG). Bacterial cultures were reported positive with the identification of at least one culture with S. aureus from vesti- bulum nasi and/or fauces. S. aureus colonization, found in 89 infants (53%), was not associ- ated with increased TEWL(i.e. TEWL in the upper quartile), neither on the lateral upper arm or volar forearm (p = 0.08 and p = 0.98, respectively), nor with AE (p = 0.10) or FLG mutation (p = 0.17). TEWL was significantly higher on both measuring sites in infants with AE com- pared to infants with possible AE and no eczema. FLG mutation was significantly associat- ed with increased TEWL, with a 47% difference in TEWL.We conclude that S. aureus in vestibulum nasi and/or fauces was not associated with TEWL, whereas TEWL measure- ments on the lateral upper arm and volar forearm appear equally appropriate in infants", "link"=>"http://www.mendeley.com/research/skin-barrier-function-staphylococcus-aureus-colonization-vestibulum-nasi-fauces-healthy-infants-infa", "reader_count"=>21, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>1, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>1, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>2, "Mathematics"=>1, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>2, "Unspecified"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Korea (South)"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2109289"], "description"=>"<p>Transepidermal water loss (TEWL) in 167 infants, recruited from the general population in Oslo and Fredrikstad, Norway, with no eczema, possible atopic eczema (AE) and AE. Measurements were performed three times and recorded as mean g/m<sup>2</sup>h<sup>-1</sup> each site. Results are given as estimated mean (95% CI) from robust regression analysis.</p><p><sup>a</sup>p<0.001 AE vs. possible AE. There was no significant difference between possible AE and no eczema.</p><p>Transepidermal water loss (TEWL).</p>", "links"=>[], "tags"=>["infant", "TEWL measurements", "aureus colonization", "vestibulum nasi", "FLG mutation", "volar forearm", "dna", "transepidermal water loss", "USB", "skin barrier function", "skin barrier dysfunction", "ae", "Staphylococcus aureus Colonization"], "article_id"=>1448037, "categories"=>["Biological Sciences"], "users"=>["Teresa Løvold Berents", "Karin Cecilie Lødrup Carlsen", "Petter Mowinckel", "Håvard Ove Skjerven", "Bente Kvenshagen", "Leif Bjarte Rolfsjord", "Maria Bradley", "Agne Liedén", "Kai-Håkon Carlsen", "Peter Gaustad", "Petter Gjersvik"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130145.t002", "stats"=>{"downloads"=>7, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transepidermal_water_loss_TEWL_/1448037", "title"=>"Transepidermal water loss (TEWL).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-12 03:45:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2109287"], "description"=>"<p>Boxplot showing <i>filaggrin</i> (<i>FLG</i>) mutation identified in 14 (8%) of 167 infants recruited from the general population and transepidermal water loss (TEWL; g/m<sup>2</sup>h<sup>-1</sup>) on the lateral upper arm. <i>FLG</i> mutations were associated with increased TEWL (p = 0.006).</p>", "links"=>[], "tags"=>["infant", "TEWL measurements", "aureus colonization", "vestibulum nasi", "FLG mutation", "volar forearm", "dna", "transepidermal water loss", "USB", "skin barrier function", "skin barrier dysfunction", "ae", "Staphylococcus aureus Colonization"], "article_id"=>1448035, "categories"=>["Biological Sciences"], "users"=>["Teresa Løvold Berents", "Karin Cecilie Lødrup Carlsen", "Petter Mowinckel", "Håvard Ove Skjerven", "Bente Kvenshagen", "Leif Bjarte Rolfsjord", "Maria Bradley", "Agne Liedén", "Kai-Håkon Carlsen", "Peter Gaustad", "Petter Gjersvik"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130145.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transepidermal_waterloss_and_filaggrin_mutation_/1448035", "title"=>"Transepidermal waterloss and <i>filaggrin</i> mutation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-12 03:45:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2109288"], "description"=>"<p>Characteristics of 240 infants, recruited from the general population in Oslo and Fredrikstad, Norway, of whom 167 were included and 73 excluded from the analyses. Exclusions were done due to crying during the measuring transepidermal water loss (n = 7) and/or measuring conditions not fulfilling strict environmental criteria for humidity and/or temperature (n = 66). All values are given as number (percentage), unless otherwise stated.</p><p>Characteristics.</p>", "links"=>[], "tags"=>["infant", "TEWL measurements", "aureus colonization", "vestibulum nasi", "FLG mutation", "volar forearm", "dna", "transepidermal water loss", "USB", "skin barrier function", "skin barrier dysfunction", "ae", "Staphylococcus aureus Colonization"], "article_id"=>1448036, "categories"=>["Biological Sciences"], "users"=>["Teresa Løvold Berents", "Karin Cecilie Lødrup Carlsen", "Petter Mowinckel", "Håvard Ove Skjerven", "Bente Kvenshagen", "Leif Bjarte Rolfsjord", "Maria Bradley", "Agne Liedén", "Kai-Håkon Carlsen", "Peter Gaustad", "Petter Gjersvik"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130145.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_/1448036", "title"=>"Characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-12 03:45:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2109285"], "description"=>"<p>Boxplot showing <i>Staphylococcus aureus</i> (<i>S</i>. <i>aureus</i>) colonization in vestibulum nasi and/or fauces in 89 (53%) of 167 infants recruited from the general population was not significantly associated with the estimated mean transepidermal waterloss (TEWL; g/m<sup>2</sup>h<sup>-1</sup>) on the lateral upper arm.</p>", "links"=>[], "tags"=>["infant", "TEWL measurements", "aureus colonization", "vestibulum nasi", "FLG mutation", "volar forearm", "dna", "transepidermal water loss", "USB", "skin barrier function", "skin barrier dysfunction", "ae", "Staphylococcus aureus Colonization"], "article_id"=>1448033, "categories"=>["Biological Sciences"], "users"=>["Teresa Løvold Berents", "Karin Cecilie Lødrup Carlsen", "Petter Mowinckel", "Håvard Ove Skjerven", "Bente Kvenshagen", "Leif Bjarte Rolfsjord", "Maria Bradley", "Agne Liedén", "Kai-Håkon Carlsen", "Peter Gaustad", "Petter Gjersvik"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130145.g001", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Staphylococcus_aureus_colonization_and_transepidermal_waterloss_/1448033", "title"=>"<i>Staphylococcus aureus</i> colonization and transepidermal waterloss.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-12 03:45:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/2109291", "https://ndownloader.figshare.com/files/2109292", "https://ndownloader.figshare.com/files/2109293"], "description"=>"<div><p>Atopic eczema (AE) is associated with <i>Staphylococcus aureus</i> (<i>S</i>. <i>aureus</i>) colonization and skin barrier dysfunction, often measured by increased transepidermal water loss (TEWL). In the present study, the primary aim was to see whether <i>S</i>. <i>aureus</i> colonization in the vestibulum nasi and/or fauces was associated with increased TEWL in infants with healthy skin and infants with eczema. Secondarily, we aimed to investigate whether TEWL measurements on non-lesional skin on the lateral upper arm is equivalent to volar forearm in infants. In 167 of 240 infants, recruited from the general population, TEWL measurements on the lateral upper arm and volar forearm, using a DermaLab USB, fulfilled our environmental requirements. The mean of three TEWL measurements from each site was used for analysis. The infants were diagnosed with no eczema (n = 110), possible AE (n = 28) or AE (n = 29). DNA samples were analysed for mutations in the <i>filaggrin</i> gene (<i>FLG)</i>. Bacterial cultures were reported positive with the identification of at least one culture with <i>S</i>. <i>aureus</i> from vestibulum nasi and/or fauces. <i>S</i>. <i>aureus</i> colonization, found in 89 infants (53%), was not associated with increased TEWL (i.e. TEWL in the upper quartile), neither on the lateral upper arm or volar forearm (p = 0.08 and p = 0.98, respectively), nor with AE (p = 0.10) or <i>FLG</i> mutation (p = 0.17). TEWL was significantly higher on both measuring sites in infants with AE compared to infants with possible AE and no eczema. <i>FLG</i> mutation was significantly associated with increased TEWL, with a 47% difference in TEWL. We conclude that <i>S</i>. <i>aureus</i> in vestibulum nasi and/or fauces was not associated with TEWL, whereas TEWL measurements on the lateral upper arm and volar forearm appear equally appropriate in infants.</p></div>", "links"=>[], "tags"=>["infant", "TEWL measurements", "aureus colonization", "vestibulum nasi", "FLG mutation", "volar forearm", "dna", "transepidermal water loss", "USB", "skin barrier function", "skin barrier dysfunction", "ae", "Staphylococcus aureus Colonization"], "article_id"=>1448039, "categories"=>["Biological Sciences"], "users"=>["Teresa Løvold Berents", "Karin Cecilie Lødrup Carlsen", "Petter Mowinckel", "Håvard Ove Skjerven", "Bente Kvenshagen", "Leif Bjarte Rolfsjord", "Maria Bradley", "Agne Liedén", "Kai-Håkon Carlsen", "Peter Gaustad", "Petter Gjersvik"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0130145.s001", "https://dx.doi.org/10.1371/journal.pone.0130145.s002", "https://dx.doi.org/10.1371/journal.pone.0130145.s003"], "stats"=>{"downloads"=>12, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Skin_Barrier_Function_and_Staphylococcus_aureus_Colonization_in_Vestibulum_Nasi_and_Fauces_in_Healthy_Infants_and_Infants_with_Eczema_A_Population_Based_Cohort_Study/1448039", "title"=>"Skin Barrier Function and <i>Staphylococcus aureus</i> Colonization in Vestibulum Nasi and Fauces in Healthy Infants and Infants with Eczema: A Population-Based Cohort Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-06-12 03:45:25"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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