Clinical Implications of iNOS Levels in Triple-Negative Breast Cancer Responding to Neoadjuvant Chemotherapy
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{"title"=>"Clinical Implications of iNOS Levels in Triple-Negative Breast Cancer Responding to Neoadjuvant Chemotherapy", "type"=>"journal", "authors"=>[{"first_name"=>"Zining", "last_name"=>"Jin"}, {"first_name"=>"Wenqian", "last_name"=>"Wang"}, {"first_name"=>"Nan", "last_name"=>"Jiang"}, {"first_name"=>"Lei", "last_name"=>"Zhang"}, {"first_name"=>"Yiming", "last_name"=>"Li"}, {"first_name"=>"Xiaoyin", "last_name"=>"Xu"}, {"first_name"=>"Shouliang", "last_name"=>"Cai"}, {"first_name"=>"Liang", "last_name"=>"Wei"}, {"first_name"=>"Xuhong", "last_name"=>"Liu"}, {"first_name"=>"Guanglei", "last_name"=>"Chen"}, {"first_name"=>"Yizhen", "last_name"=>"Zhou"}, {"first_name"=>"Cheng", "last_name"=>"Liu"}, {"first_name"=>"Zhan", "last_name"=>"Li"}, {"first_name"=>"Feng", "last_name"=>"Jin"}, {"first_name"=>"Bo", "last_name"=>"Chen"}], "year"=>2015, "source"=>"PLOS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0130286", "pmid"=>"26196284", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"bca29fb0-2dbf-3b3f-917e-4813f2893472", "abstract"=>"Triple-negative breast cancer is a high-risk breast cancer with poor survival rate. To date, there is a lack of targeted therapy for this type of cancer. One unique phenomenon is that inflammatory breast cancer is frequently triple negative. However, it is still ambiguous how inflammation influences triple-negative breast cancer growth and responding to chemotherapy. Herein, we investigated the levels of inflammation-associated enzyme, iNOS, in 20 triple-negative breast cancer patients' tumors, and examined its correlation with patients' responses to platinum-based neoadjuvant chemotherapy. Our studies showed that triple-negative breast cancer patients with attenuated iNOS levels in tumor cells after treatment showed better responses to platinum-based neoadjuvant chemotherapy than other triple-negative breast cancer patients. Our further in vitro studies confirmed that induction of proper levels of NO increased the resistance to cisplatin in triple-negative MDA-MB-231 cells. Our data suggest that aberrant high level of iNOS/NO are associated with less effectiveness of platinum-based neoadjuvant chemotherapy in triple-negative breast cancer. Therefore, we propose to monitor iNOS levels as a new predictor for triple-negative breast cancer patient's response to platinum-based neoadjuvant chemotherapy. Moreover, iNOS/NO is considered as a potential target for combination therapy with platinum drugs for triple-negative breast cancer.", "link"=>"http://www.mendeley.com/research/clinical-implications-inos-levels-triplenegative-breast-cancer-responding-neoadjuvant-chemotherapy", "reader_count"=>5, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"China"=>1}, "group_count"=>0}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/2184821"], "description"=>"<p>Asterisk indicates p<0.01.</p>", "links"=>[], "tags"=>["chemotherapy", "breast cancer", "attenuated iNOS levels", "neoadjuvant"], "article_id"=>1490442, "categories"=>["Biological Sciences"], "users"=>["Zining Jin", "Wenqian Wang", "Nan Jiang", "Lei Zhang", "Yiming Li", "Xiaoyin Xu", "Shouliang Cai", "Liang Wei", "Xuhong Liu", "Guanglei Chen", "Yizhen Zhou", "Cheng Liu", "Zhan Li", "Feng Jin", "Bo Chen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130286.g007", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_presence_of_DETA_NONOate_reverse_the_inhibitory_effect_of_cisplatin_on_MDA_MB_231_cells_/1490442", "title"=>"The presence of DETA NONOate reverse the inhibitory effect of cisplatin on MDA-MB-231 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-21 03:20:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2184837", "https://ndownloader.figshare.com/files/2184838"], "description"=>"<div><p>Triple-negative breast cancer is a high-risk breast cancer with poor survival rate. To date, there is a lack of targeted therapy for this type of cancer. One unique phenomenon is that inflammatory breast cancer is frequently triple negative. However, it is still ambiguous how inflammation influences triple-negative breast cancer growth and responding to chemotherapy. Herein, we investigated the levels of inflammation-associated enzyme, iNOS, in 20 triple-negative breast cancer patients’ tumors, and examined its correlation with patients’ responses to platinum-based neoadjuvant chemotherapy. Our studies showed that triple-negative breast cancer patients with attenuated iNOS levels in tumor cells after treatment showed better responses to platinum-based neoadjuvant chemotherapy than other triple-negative breast cancer patients. Our further <i>in vitro</i> studies confirmed that induction of proper levels of NO increased the resistance to cisplatin in triple-negative MDA-MB-231 cells. Our data suggest that aberrant high level of iNOS/NO are associated with less effectiveness of platinum-based neoadjuvant chemotherapy in triple-negative breast cancer. Therefore, we propose to monitor iNOS levels as a new predictor for triple-negative breast cancer patient’s response to platinum-based neoadjuvant chemotherapy. Moreover, iNOS/NO is considered as a potential target for combination therapy with platinum drugs for triple-negative breast cancer.</p></div>", "links"=>[], "tags"=>["chemotherapy", "breast cancer", "attenuated iNOS levels", "neoadjuvant"], "article_id"=>1490454, "categories"=>["Biological Sciences"], "users"=>["Zining Jin", "Wenqian Wang", "Nan Jiang", "Lei Zhang", "Yiming Li", "Xiaoyin Xu", "Shouliang Cai", "Liang Wei", "Xuhong Liu", "Guanglei Chen", "Yizhen Zhou", "Cheng Liu", "Zhan Li", "Feng Jin", "Bo Chen"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0130286.s001", "https://dx.doi.org/10.1371/journal.pone.0130286.s002"], "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_Implications_of_iNOS_Levels_in_Triple_Negative_Breast_Cancer_Responding_to_Neoadjuvant_Chemotherapy_/1490454", "title"=>"Clinical Implications of iNOS Levels in Triple-Negative Breast Cancer Responding to Neoadjuvant Chemotherapy", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-07-21 03:20:05"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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