Distribution and Morphology of Calcium-Binding Proteins Immunoreactive Neurons following Chronic Tungsten Multielectrode Implants
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{"title"=>"Distribution and morphology of calcium-binding proteins immunoreactive neurons following chronic tungsten multielectrode implants", "type"=>"journal", "authors"=>[{"first_name"=>"Marco Aurelio M.", "last_name"=>"Freire", "scopus_author_id"=>"57193482124"}, {"first_name"=>"Jean", "last_name"=>"Faber", "scopus_author_id"=>"53163586200"}, {"first_name"=>"Nelson Alessandretti M.", "last_name"=>"Lemos", "scopus_author_id"=>"22135559700"}, {"first_name"=>"Jose Ronaldo", "last_name"=>"Santos", "scopus_author_id"=>"54414901400"}, {"first_name"=>"Pedro França", "last_name"=>"Cavalcanti", "scopus_author_id"=>"56494705200"}, {"first_name"=>"Ramon Hypolito", "last_name"=>"Lima", "scopus_author_id"=>"23975833800"}, {"first_name"=>"Edgard", "last_name"=>"Morya", "scopus_author_id"=>"6506185708"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84939207432", "pui"=>"605586247", "doi"=>"10.1371/journal.pone.0130354", "sgr"=>"84939207432", "pmid"=>"26098896"}, "id"=>"4b45e266-1e24-3990-8e7b-14da5d39d694", "abstract"=>"The development of therapeutic approaches to improve the life quality of people suffering from different types of body paralysis is a current major medical challenge. Brain-machine interface (BMI) can potentially help reestablishing lost sensory and motor functions, allowing patients to use their own brain activity to restore sensorimotor control of paralyzed body parts. Chronic implants of multielectrodes, employed to record neural activity directly from the brain parenchyma, constitute the fundamental component of a BMI. However, before this technique may be effectively available to human clinical trials, it is essential to characterize its long-term impact on the nervous tissue in animal models. In the present study we evaluated how chronic implanted tungsten microelectrode arrays impact the distribution and morphology of interneurons reactive to calcium-binding proteins calbindin (CB), calretinin (CR) and parvalbumin (PV) across the rat's motor cortex. Our results revealed that chronic microelectrode arrays were well tolerated by the nervous tissue, with recordings remaining viable for up to 6 months after implantation. Furthermore, neither the morphology nor the distribution of inhibitory neurons were broadly impacted. Moreover, restricted microglial activation was observed on the implanted sites. On the whole, our results confirm and expand the notion that tungsten multielectrodes can be deemed as a feasible candidate to future human BMI studies.", "link"=>"http://www.mendeley.com/research/distribution-morphology-calciumbinding-proteins-immunoreactive-neurons-following-chronic-tungsten-mu", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>5, "Student > Bachelor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>5, "Student > Bachelor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>4, "Neuroscience"=>2, "Sports and Recreations"=>1, "Physics and Astronomy"=>1, "Psychology"=>1, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>5}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2128826"], "description"=>"<p>Notice that there is no evidence of alteration in both morphology and pattern of reactivity of calbindin (CB)- (a), calretinin (CR)- (b) and parvalbumin (PV)-positive neurons (c) when implanted and contralateral hemispheres are compared. Left column of the figure: implanted hemisphere; right column of the figure: contralateral hemisphere, adopted as control. Scale bar: 50 μm.</p>", "links"=>[], "tags"=>["morphology", "BMI studies", "microelectrode arrays", "motor functions", "body parts", "Animal models", "life quality", "microglial activation", "sensorimotor control", "Chronic implants", "brain parenchyma", "pv", "Chronic Tungsten Multielectrode Implants", "tungsten multielectrodes", "6 months", "cb", "cr", "tissue", "body paralysis", "brain activity", "tungsten microelectrode arrays impact", "interneurons reactive"], "article_id"=>1456574, "categories"=>["Uncategorised"], "users"=>["Marco Aurelio M. Freire", "Jean Faber", "Nelson Alessandretti M. Lemos", "Jose Ronaldo Santos", "Pedro França Cavalcanti", "Ramon Hypolito Lima", "Edgard Morya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130354.g006", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Morphology_of_neurons_reactive_to_calcium_binding_proteins_CBP_in_implanted_and_contralateral_hemispheres_/1456574", "title"=>"Morphology of neurons reactive to calcium binding proteins (CBP) in implanted and contralateral hemispheres.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:55:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128823"], "description"=>"<p>(a). Nissl staining shows the well-defined location of the electrode track (arrow), revealing a small loss of tissue. (b). It was possible to attest the absence of vacuolization and pyctonic profiles in all time points evaluated. The tissue around electrode implants presented a similar aspect to their contralateral counterpart. Black squares in lower magnification pictures indicate the regions where enlargements were obtained in all groups. Left column of the figure: implanted hemisphere; right column of the figure: contralateral hemisphere, adopted as control. Scale bar: 100 μm (lower magnification); 200 μm (enlargements).</p>", "links"=>[], "tags"=>["morphology", "BMI studies", "microelectrode arrays", "motor functions", "body parts", "Animal models", "life quality", "microglial activation", "sensorimotor control", "Chronic implants", "brain parenchyma", "pv", "Chronic Tungsten Multielectrode Implants", "tungsten multielectrodes", "6 months", "cb", "cr", "tissue", "body paralysis", "brain activity", "tungsten microelectrode arrays impact", "interneurons reactive"], "article_id"=>1456571, "categories"=>["Uncategorised"], "users"=>["Marco Aurelio M. Freire", "Jean Faber", "Nelson Alessandretti M. Lemos", "Jose Ronaldo Santos", "Pedro França Cavalcanti", "Ramon Hypolito Lima", "Edgard Morya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130354.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_General_pattern_of_implant_sites_/1456571", "title"=>"General pattern of implant sites.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:55:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128822"], "description"=>"<p>(a). Measurement of the SNR average among all time points revealed an increase in this parameter after 3 months of implant as compared to 1 month of implantation. In latter survival time (6 months after the array implant), quality of recordings decreased as compared to previous time point, though a good SNR still had been identified (standard deviation threshold: SNR>std(SNR) = 1; and SNRn = 5 animals by time point); values expressed as mean ± SEM. (b). Temporal variation of the neuronal number in each group during its time of implant, comparing the first and the last week of array implantation in all survival times, in relationship to Threshold rate (Hz) adopted to assess SNR (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130354#sec002\" target=\"_blank\">Material and Methods</a>). There was an improvement in the number of neuronal units from 1 month to 3 months of implant. In latter survival time (6 months of implant) number of recorded cells decreased (<i>n</i> = 5 animals by time point).</p>", "links"=>[], "tags"=>["morphology", "BMI studies", "microelectrode arrays", "motor functions", "body parts", "Animal models", "life quality", "microglial activation", "sensorimotor control", "Chronic implants", "brain parenchyma", "pv", "Chronic Tungsten Multielectrode Implants", "tungsten multielectrodes", "6 months", "cb", "cr", "tissue", "body paralysis", "brain activity", "tungsten microelectrode arrays impact", "interneurons reactive"], "article_id"=>1456570, "categories"=>["Uncategorised"], "users"=>["Marco Aurelio M. Freire", "Jean Faber", "Nelson Alessandretti M. Lemos", "Jose Ronaldo Santos", "Pedro França Cavalcanti", "Ramon Hypolito Lima", "Edgard Morya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130354.g002", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Signal_to_noise_ratio_SNR_of_cortical_neurons_recorded_from_all_animals_across_distinct_survival_times_/1456570", "title"=>"Signal-to-noise ratio (SNR) of cortical neurons recorded from all animals across distinct survival times.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:55:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128825"], "description"=>"<p>Quantitative analysis revealed that the number of calbindin (CB)- (a), calretinin (CR)- (b) and parvalbumin (PV)-reactive neurons (c) did not differ significantly when implanted and contralateral sides were compared. Distinct colors (blue: contralateral hemisphere; green: implanted hemisphere) were adopted to provide a better identification of both control and implanted groups in all time points evaluated. The boxes correspond to the 25th and 75th percentiles (bottom and top of the boxes, respectively), the median values are indicated by the red horizontal line inside each box, the whiskers point out the minimum and maximum values and the crosses represent the outliers.</p>", "links"=>[], "tags"=>["morphology", "BMI studies", "microelectrode arrays", "motor functions", "body parts", "Animal models", "life quality", "microglial activation", "sensorimotor control", "Chronic implants", "brain parenchyma", "pv", "Chronic Tungsten Multielectrode Implants", "tungsten multielectrodes", "6 months", "cb", "cr", "tissue", "body paralysis", "brain activity", "tungsten microelectrode arrays impact", "interneurons reactive"], "article_id"=>1456573, "categories"=>["Uncategorised"], "users"=>["Marco Aurelio M. Freire", "Jean Faber", "Nelson Alessandretti M. Lemos", "Jose Ronaldo Santos", "Pedro França Cavalcanti", "Ramon Hypolito Lima", "Edgard Morya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130354.g005", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_calcium_binding_proteins_reactive_neurons_across_implanted_and_contralateral_hemispheres_/1456573", "title"=>"Distribution of calcium-binding proteins-reactive neurons across implanted and contralateral hemispheres.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:55:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128824"], "description"=>"<p>Chronic presence of electrodes did not affect the general cell distribution of calbindin (CB)- (a), calretinin (CR)- (b) and parvalbumin (PV)- (c) reactive neurons even after 6 months of implant. Left column of the figure: implanted hemisphere (arrows point to electrode tracks); right column of the figure: contralateral hemisphere, adopted as control. Scale bar: 100 μm.</p>", "links"=>[], "tags"=>["morphology", "BMI studies", "microelectrode arrays", "motor functions", "body parts", "Animal models", "life quality", "microglial activation", "sensorimotor control", "Chronic implants", "brain parenchyma", "pv", "Chronic Tungsten Multielectrode Implants", "tungsten multielectrodes", "6 months", "cb", "cr", "tissue", "body paralysis", "brain activity", "tungsten microelectrode arrays impact", "interneurons reactive"], "article_id"=>1456572, "categories"=>["Uncategorised"], "users"=>["Marco Aurelio M. Freire", "Jean Faber", "Nelson Alessandretti M. Lemos", "Jose Ronaldo Santos", "Pedro França Cavalcanti", "Ramon Hypolito Lima", "Edgard Morya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130354.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Calcium_binding_proteins_immunoreactivity_across_implanted_sites_/1456572", "title"=>"Calcium-binding proteins immunoreactivity across implanted sites.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:55:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128821"], "description"=>"<p>(a). General aspect of a 32 channel microelectrode array. (b). Details of the electrode array being implanted through the skull window on primary motor cortex, relative to bregma (marked with a black dot). Scale bars: 3.5 mm (a and b).</p>", "links"=>[], "tags"=>["morphology", "BMI studies", "microelectrode arrays", "motor functions", "body parts", "Animal models", "life quality", "microglial activation", "sensorimotor control", "Chronic implants", "brain parenchyma", "pv", "Chronic Tungsten Multielectrode Implants", "tungsten multielectrodes", "6 months", "cb", "cr", "tissue", "body paralysis", "brain activity", "tungsten microelectrode arrays impact", "interneurons reactive"], "article_id"=>1456569, "categories"=>["Uncategorised"], "users"=>["Marco Aurelio M. Freire", "Jean Faber", "Nelson Alessandretti M. Lemos", "Jose Ronaldo Santos", "Pedro França Cavalcanti", "Ramon Hypolito Lima", "Edgard Morya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130354.g001", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multielectrode_apparatus_coordinates_adopted_to_implant_and_surgical_procedure_/1456569", "title"=>"Multielectrode apparatus, coordinates adopted to implant and surgical procedure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:55:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/2128827"], "description"=>"<p>(a). Electrode implantation sites (arrows) were identified as a well-defined strip of microglial labeling, especially in latter survival time point. (b). Iba1-reactive microglial cells with a hypertrophic morphology were observed only in the vicinity of implants, whilst microglial cells presented a non-activated morphology in the contralateral hemisphere, possessing stellate non-hypertrophic cell bodies and thin and elongated processes. Activated microglial cells were not observed far from implant sites neither in contralateral hemispheres. White squares in lower magnification pictures indicate the regions where enlargements were obtained in all groups. Left column of the figure: implanted hemisphere; right column of the figure: contralateral hemisphere, adopted as control. Scale bar: 100 μm (lower magnification); 25 μm (enlargements).</p>", "links"=>[], "tags"=>["morphology", "BMI studies", "microelectrode arrays", "motor functions", "body parts", "Animal models", "life quality", "microglial activation", "sensorimotor control", "Chronic implants", "brain parenchyma", "pv", "Chronic Tungsten Multielectrode Implants", "tungsten multielectrodes", "6 months", "cb", "cr", "tissue", "body paralysis", "brain activity", "tungsten microelectrode arrays impact", "interneurons reactive"], "article_id"=>1456575, "categories"=>["Uncategorised"], "users"=>["Marco Aurelio M. Freire", "Jean Faber", "Nelson Alessandretti M. Lemos", "Jose Ronaldo Santos", "Pedro França Cavalcanti", "Ramon Hypolito Lima", "Edgard Morya"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130354.g007", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microglial_immunoreactivity_across_electrode_tracks_/1456575", "title"=>"Microglial immunoreactivity across electrode tracks.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 02:55:43"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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