Intermittent Androgen Suppression: Estimating Parameters for Individual Patients Based on Initial PSA Data in Response to Androgen Deprivation Therapy
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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2148189"], "description"=>"<p>Comparison between the classifications by medical doctors (MD) and the classifications of mathematical models by fitting the first half cycles (MMH) only using the proposed method (the p-value: 0.80).</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463168, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t008", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_classifications_by_medical_doctors_MD_and_the_classifications_of_mathematical_models_by_fitting_the_first_half_cycles_MMH_only_using_the_proposed_method_the_p_value_0_80_/1463168", "title"=>"Comparison between the classifications by medical doctors (MD) and the classifications of mathematical models by fitting the first half cycles (MMH) only using the proposed method (the p-value: 0.80).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148187"], "description"=>"<p>Comparison between the classifications obtained by the proposed method with the first one and half cycles (MM1H) and the classifications by mathematical models using the fitting method of Ref. [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.ref015\" target=\"_blank\">15</a>] (MM[<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.ref015\" target=\"_blank\">15</a>]) (p-value: 0.029).</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463166, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t006", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_classifications_obtained_by_the_proposed_method_with_the_first_one_and_half_cycles_MM1H_and_the_classifications_by_mathematical_models_using_the_fitting_method_of_Ref_15_MM_15_p_value_0_029_/1463166", "title"=>"Comparison between the classifications obtained by the proposed method with the first one and half cycles (MM1H) and the classifications by mathematical models using the fitting method of Ref. [15] (MM[15]) (p-value: 0.029).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148184"], "description"=>"<p>Comparison between the classifications obtained by the proposed method with the whole data (MMWD) using the classifications by mathematical models using the fitting method of Ref. [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.ref015\" target=\"_blank\">15</a>] (MM[<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.ref015\" target=\"_blank\">15</a>]) (p-value < 0.001).</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463163, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t003", "stats"=>{"downloads"=>3, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_classifications_obtained_by_the_proposed_method_with_the_whole_data_MMWD_using_the_classifications_by_mathematical_models_using_the_fitting_method_of_Ref_15_MM_15_p_value_/1463163", "title"=>"Comparison between the classifications obtained by the proposed method with the whole data (MMWD) using the classifications by mathematical models using the fitting method of Ref. [15] (MM[15]) (p-value < 0.001).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148183"], "description"=>"<p>MD and MMWD correspond to classifications by medical doctors and those by mathematical models with the whole data, respectively (the p-value < 0.001).</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463162, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_obtained_by_the_proposed_method_/1463162", "title"=>"Results obtained by the proposed method.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148178"], "description"=>"<p>These criteria used here were originally proposed in Ref. [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.ref030\" target=\"_blank\">30</a>].</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463157, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Classification_of_patients_for_intermittent_androgen_suppression_using_the_mathematical_model_of_Ref_15_/1463157", "title"=>"Classification of patients for intermittent androgen suppression using the mathematical model of Ref. [15].", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148191"], "description"=>"<div><p>When a physician decides on a treatment and its schedule for a specific patient, information gained from prior patients and experience in the past is taken into account. A more objective way to make such treatment decisions based on actual data would be useful to the clinician. Although there are many mathematical models proposed for various diseases, so far there is no mathematical method that accomplishes optimization of the treatment schedule using the information gained from past patients or “rapid learning” technology. In an attempt to use this approach, we integrate the information gained from patients previously treated with intermittent androgen suppression (IAS) with that from a current patient by first fitting the time courses of clinical data observed from the previously treated patients, then constructing the prior information of the parameter values of the mathematical model, and finally, maximizing the posterior probability for the parameters of the current patient using the prior information. Although we used data from prostate cancer patients, the proposed method is general, and thus can be applied to other diseases once an appropriate mathematical model is established for that disease.</p></div>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463170, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intermittent_Androgen_Suppression_Estimating_Parameters_for_Individual_Patients_Based_on_Initial_PSA_Data_in_Response_to_Androgen_Deprivation_Therapy_/1463170", "title"=>"Intermittent Androgen Suppression: Estimating Parameters for Individual Patients Based on Initial PSA Data in Response to Androgen Deprivation Therapy", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148186"], "description"=>"<p>Comparison between the classifications by medical doctors (MD) and those by the proposed method with the first one and half cycles (MM1H) (the p-value: 0.005).</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463165, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t005", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_classifications_by_medical_doctors_MD_and_those_by_the_proposed_method_with_the_first_one_and_half_cycles_MM1H_the_p_value_0_005_/1463165", "title"=>"Comparison between the classifications by medical doctors (MD) and those by the proposed method with the first one and half cycles (MM1H) (the p-value: 0.005).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148185"], "description"=>"<p>Comparison between the classifications obtained by the proposed method with the whole data (MMWD) and those obtained by the proposed method with the first one and half cycles (MM1H) (the p-value < 0.001).</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463164, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t004", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_classifications_obtained_by_the_proposed_method_with_the_whole_data_MMWD_and_those_obtained_by_the_proposed_method_with_the_first_one_and_half_cycles_MM1H_the_p_value_lt_0_001_/1463164", "title"=>"Comparison between the classifications obtained by the proposed method with the whole data (MMWD) and those obtained by the proposed method with the first one and half cycles (MM1H) (the p-value < 0.001).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148182"], "description"=>"<p>MD and MM [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.ref015\" target=\"_blank\">15</a>] correspond to classifications by medical doctors and those by mathematical models using the fitting method of Ref. [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.ref015\" target=\"_blank\">15</a>], respectively (the p-value obtained by Fisher’s exact test implemented in R (we applied the same method for obtaining the p-values in the other tables): 0.13). For example, there were 35 patients who were classified to “Without relapse” by medical doctors and were classified to “Type (i)” by the mathematical models using the original method of Ref. [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.ref015\" target=\"_blank\">15</a>].</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463161, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_obtained_by_the_original_method_used_in_Ref_15_/1463161", "title"=>"Results obtained by the original method used in Ref. [15].", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148180"], "description"=>"<p>In this figure, we fitted first one and half cycles to predict the following cycles. Panels (a), (b), and (c) correspond to examples of Type (i), Type (ii), and Type (iii) patients, respectively. In each panel, the blue solid line shows the fitting and the prediction under IAS, the blue vertical dash-dotted line shows the point switching between the fitting and the prediction, and the green dashed line shows the simulation under CAS, and the red crosses show the actually observed values of PSA levels.</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463159, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fitting_and_prediction_with_the_proposed_method_/1463159", "title"=>"Fitting and prediction with the proposed method.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148181"], "description"=>"<p>In this figure, we fitted the first half cycle of IAS. To interpret the figure, please see the caption of <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130372#pone.0130372.g002\" target=\"_blank\">Fig 2</a>.</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463160, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fitting_and_prediction_using_the_proposed_method_/1463160", "title"=>"Fitting and prediction using the proposed method.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148190"], "description"=>"<p>The artificial data were generated by simulating the treatment schedule of the off-treatment period of 16 weeks followed by the first half cycle of IAS (the p-value: 0.18).</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463169, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t009", "stats"=>{"downloads"=>5, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_classifications_used_for_generating_the_artificial_data_MM_and_those_obtained_by_fitting_the_artificial_data_for_the_mathematical_model_using_the_proposed_method_MMAD_/1463169", "title"=>"Comparison between the classifications used for generating the artificial data (MM) and those obtained by fitting the artificial data for the mathematical model using the proposed method (MMAD).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2148188"], "description"=>"<p>Comparison between the classifications obtained by the proposed method with the whole data (MMWD) and those obtained by the proposed method with the first half cycles (MMH) (the p-value: 0.10).</p>", "links"=>[], "tags"=>["parameter values", "prostate cancer patients", "androgen deprivation therapy", "information", "Initial PSA Data", "androgen suppression", "objective way", "Intermittent Androgen Suppression", "data", "ias", "Individual Patients", "time courses", "treatment decisions", "treatment schedule", "model"], "article_id"=>1463167, "categories"=>["Uncategorised"], "users"=>["Yoshito Hirata", "Kai Morino", "Koichiro Akakura", "Celestia S. Higano", "Nicholas Bruchovsky", "Teresa Gambol", "Susan Hall", "Gouhei Tanaka", "Kazuyuki Aihara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130372.t007", "stats"=>{"downloads"=>2, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_classifications_obtained_by_the_proposed_method_with_the_whole_data_MMWD_and_those_obtained_by_the_proposed_method_with_the_first_half_cycles_MMH_the_p_value_0_10_/1463167", "title"=>"Comparison between the classifications obtained by the proposed method with the whole data (MMWD) and those obtained by the proposed method with the first half cycles (MMH) (the p-value: 0.10).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-24 04:49:33"}

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  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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