Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men
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{"title"=>"Genital cytomegalovirus replication predicts syphilis acquisition among HIV-1 infected men who have sex with men", "type"=>"journal", "authors"=>[{"first_name"=>"Sara", "last_name"=>"Gianella", "scopus_author_id"=>"14041676800"}, {"first_name"=>"Davey M.", "last_name"=>"Smith", "scopus_author_id"=>"55722955800"}, {"first_name"=>"Eric S.", "last_name"=>"Daar", "scopus_author_id"=>"7006098438"}, {"first_name"=>"Michael P.", "last_name"=>"Dube", "scopus_author_id"=>"56715072900"}, {"first_name"=>"Andrea", "last_name"=>"Lisco", "scopus_author_id"=>"6506279010"}, {"first_name"=>"Christophe", "last_name"=>"Vanpouille", "scopus_author_id"=>"6507734655"}, {"first_name"=>"Leonid", "last_name"=>"Margolis", "scopus_author_id"=>"7102677602"}, {"first_name"=>"Richard H.", "last_name"=>"Haubrich", "scopus_author_id"=>"7003333798"}, {"first_name"=>"Sheldon R.", "last_name"=>"Morris", "scopus_author_id"=>"14042205100"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84936760295", "scopus"=>"2-s2.0-84936760295", "pui"=>"605098142", "pmid"=>"26061824", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0130410"}, "id"=>"4c6d146a-8fe0-3e89-a8cc-710ca111a20c", "abstract"=>"<sec id=\"sec001\"> <title>Objective</title> <p>Sexually transmitted infections (STI) are common among HIV-infected men who have sex with men (MSM). While behavioral factors are important in STI acquisition, other biological factors such as immune modulation due to chronic viral infection may further predispose to STI acquisition.</p> </sec> <sec id=\"sec002\"> <title>Design</title> <p>Post Hoc analysis including data collected over 12 months of follow-up from 131 HIV-infected MSM receiving antiretroviral therapy and screened for incident bacterial STI every 3 months.</p> </sec> <sec id=\"sec003\"> <title>Methods</title> <p>Genital secretions collected at baseline were used to measure herpesvirus replication and inflammatory cytokines. Baseline predictors of STI were determined using survival analysis of time to incident STI.</p> </sec> <sec id=\"sec004\"> <title>Results</title> <p>All participants were seropositive for cytomegalovirus (CMV), and 52% had detectable genital CMV at baseline. Thirty-five individuals acquired STI during follow-up, sometimes with multiple pathogen (17 syphilis, 21 gonorrhea, 14 chlamydia). Syphilis acquisition was associated with genital CMV replication at baseline (19.1% CMV-shedders versus 4.8% non-shedders, <italic>p</italic>=0.03) and younger age (<italic>p</italic>=0.02). Lower seminal MCP-1 was associated with higher seminal CMV levels and with syphilis acquisition (<italic>p</italic>&lt;0.01). For syphilis acquisition, in multivariable Cox-Proportional Hazard model adjusted hazard rates were 3.56 (95%CI:1.00–12.73) for baseline CMV replication and 2.50 (0.92–6.77) for younger age.</p> </sec> <sec id=\"sec005\"> <title>Conclusions</title> <p>This post hoc analysis suggest that CMV-associated decrease in seminal MCP-1 levels might predispose HIV-infected MSM to syphilis acquisition, but not other STI. Future studies should determine underlying mechanisms and if a causal association exists.</p> </sec>", "link"=>"http://www.mendeley.com/research/genital-cytomegalovirus-replication-predicts-syphilis-acquisition-among-hiv1-infected-men-sex-men", "reader_count"=>7, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2106359"], "description"=>"<p><u>Legend</u>: n (%): number (percentage) of participants; MSM: men who have sex with men; HIV: Human immunodeficiency virus; ART: antiretroviral therapy; IQR: interquartile range; HHV: Human Herpesviruses; CMV: cytomegalovirus; EBV: Epstein-Barr virus; HSV-1 and -2: Herpes simplex virus type 1 and type 2; HHV-6/-7/-8: human herpesvirus type 6/type 7/type 8.</p><p>Demographics and co-infections at baseline.</p>", "links"=>[], "tags"=>["STI acquisition.DesignPost Hoc analysis", "measure herpesvirus replication", "syphilis acquisition", "3 months.MethodsGenital secretions", "Genital Cytomegalovirus Replication Predicts Syphilis Acquisition", "baseline CMV replication", "incident STI.ResultsAll participants", "ci", "MSM", "hiv", "mcp"], "article_id"=>1445696, "categories"=>["Biological Sciences"], "users"=>["Sara Gianella", "Davey M. Smith", "Eric S. Daar", "Michael P. Dubé", "Andrea Lisco", "Christophe Vanpouille", "Leonid Margolis", "Richard H. Haubrich", "Sheldon R. Morris"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130410.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographics_and_co_infections_at_baseline_/1445696", "title"=>"Demographics and co-infections at baseline.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-10 04:31:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/2106357"], "description"=>"<p>Kaplan Meier curve of time to incident syphilis during follow-up in subjects with detectable seminal CMV DNA (in green, N = 68) and without detectable seminal CMV DNA (in pink, N = 63) at baseline.</p>", "links"=>[], "tags"=>["STI acquisition.DesignPost Hoc analysis", "measure herpesvirus replication", "syphilis acquisition", "3 months.MethodsGenital secretions", "Genital Cytomegalovirus Replication Predicts Syphilis Acquisition", "baseline CMV replication", "incident STI.ResultsAll participants", "ci", "MSM", "hiv", "mcp"], "article_id"=>1445694, "categories"=>["Biological Sciences"], "users"=>["Sara Gianella", "Davey M. Smith", "Eric S. Daar", "Michael P. Dubé", "Andrea Lisco", "Christophe Vanpouille", "Leonid Margolis", "Richard H. Haubrich", "Sheldon R. Morris"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130410.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meier_of_Syphilis_Cases_/1445694", "title"=>"Kaplan Meier of Syphilis Cases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-10 04:31:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/2106360"], "description"=>"<p><u>Legend:</u> n (%): number (percentage) of participants; HR: hazard ratio; IQR: interquartile range; 95% CI: 95% confidence intervals; HIV: Human immunodeficiency virus, ART: antiretroviral therapy; CMV: cytomegalovirus; EBV: Epstein-Barr virus; HSV-1 and -2: Herpes simplex virus type 1 and type 2; HHV-6/-7/-8: human herpesvirus type 6/type 7/type 8. In <b>bold:</b> significant <i>p</i>-values (<i>p</i><0.1).</p><p>Factors associated with incident syphilis.</p>", "links"=>[], "tags"=>["STI acquisition.DesignPost Hoc analysis", "measure herpesvirus replication", "syphilis acquisition", "3 months.MethodsGenital secretions", "Genital Cytomegalovirus Replication Predicts Syphilis Acquisition", "baseline CMV replication", "incident STI.ResultsAll participants", "ci", "MSM", "hiv", "mcp"], "article_id"=>1445697, "categories"=>["Biological Sciences"], "users"=>["Sara Gianella", "Davey M. Smith", "Eric S. Daar", "Michael P. Dubé", "Andrea Lisco", "Christophe Vanpouille", "Leonid Margolis", "Richard H. Haubrich", "Sheldon R. Morris"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130410.t002", "stats"=>{"downloads"=>2, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Factors_associated_with_incident_syphilis_/1445697", "title"=>"Factors associated with incident syphilis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-10 04:31:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/2106358"], "description"=>"<p>CMV shedding (panel A) and syphilis acquisition (panel B) were both associated with LOWER seminal MCP-1 levels (Mann Whitney test).</p>", "links"=>[], "tags"=>["STI acquisition.DesignPost Hoc analysis", "measure herpesvirus replication", "syphilis acquisition", "3 months.MethodsGenital secretions", "Genital Cytomegalovirus Replication Predicts Syphilis Acquisition", "baseline CMV replication", "incident STI.ResultsAll participants", "ci", "MSM", "hiv", "mcp"], "article_id"=>1445695, "categories"=>["Biological Sciences"], "users"=>["Sara Gianella", "Davey M. Smith", "Eric S. Daar", "Michael P. Dubé", "Andrea Lisco", "Christophe Vanpouille", "Leonid Margolis", "Richard H. Haubrich", "Sheldon R. Morris"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130410.g002", "stats"=>{"downloads"=>4, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genital_MCP_1_levels_CMV_shedding_and_syphilis_acquisition_/1445695", "title"=>"Genital MCP-1 levels, CMV shedding and syphilis acquisition.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-10 04:31:22"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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