N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus
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{"title"=>"N-linked glycans are assembled on highly reduced dolichol phosphate carriers in the hyperthermophilic archaea Pyrococcus furiosus", "type"=>"journal", "authors"=>[{"first_name"=>"Michelle M.", "last_name"=>"Chang", "scopus_author_id"=>"26326746700"}, {"first_name"=>"Barbara", "last_name"=>"Imperiali", "scopus_author_id"=>"7006256007"}, {"first_name"=>"Jerry", "last_name"=>"Eichler", "scopus_author_id"=>"7102232277"}, {"first_name"=>"Ziqiang", "last_name"=>"Guan", "scopus_author_id"=>"7202541986"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203", "pui"=>"605586159", "doi"=>"10.1371/journal.pone.0130482", "scopus"=>"2-s2.0-84939528651", "sgr"=>"84939528651", "issn"=>"19326203", "pmid"=>"26098850"}, "id"=>"81a9eafa-a14b-32b4-8ac6-805c411b8903", "abstract"=>"In all three domains of life, N-glycosylation begins with the assembly of glycans on phos-phorylated polyisoprenoid carriers. Like eukaryotes, archaea also utilize phosphorylated dolichol for this role, yet whereas the assembled oligosaccharide is transferred to target pro-teins from dolichol pyrophosphate in eukaryotes, archaeal N-linked glycans characterized to date are derived from a dolichol monophosphate carrier, apart from a single example. In this study, glycan-charged dolichol phosphate from the hyperthermophile Pyrococcus furio-sus was identified and structurally characterized. Normal and reverse phase liquid chroma-tography-electrospray ionization mass spectrometry revealed the existence of dolichol phosphate charged with the heptasaccharide recently described in in vitro studies of N-gly-cosylation on this species. As with other described archaeal dolichol phosphates, the α-and ω-terminal isoprene subunits of the P. furiosus lipid are saturated, in contrast to eukaryal phosphodolichols that present only a saturated α-position isoprene subunit. Inter-estingly, an additional 1-4 of the 12-14 isoprene subunits comprising P. furiosus dolichol phosphate are saturated, making this lipid not only the longest archaeal dolichol phosphate described to date but also the most highly saturated.", "link"=>"http://www.mendeley.com/research/nlinked-glycans-assembled-highly-reduced-dolichol-phosphate-carriers-hyperthermophilic-archaea-pyroc", "reader_count"=>10, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>3, "Chemistry"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2129899"], "description"=>"<p>A. The mass spectrum of the RPLC fraction with a retention time of 8.5–9.5 min contains [M-2H]<sup>2-</sup> peaks of <i>m/z</i> 1046.592, 1081.120 and 1114.637, corresponding to heptasaccharide-charged C<sub>60</sub>, C<sub>65</sub> and C<sub>70</sub> DolP, respectively. The <sup>13</sup>C<sub>1</sub>-containing isotopic and monoisotopic [M-2H]<sup>2-</sup> peaks of heptasaccharide-charged C<sub>65</sub> DolP are indicated. The inset shows [M-2H]<sup>2-</sup> peaks of <i>m/z</i> 914.551, 948.575 and 979.583, corresponding to C<sub>60</sub>, C<sub>65</sub> and C<sub>70</sub> DolP attached to the pentasaccharide precursor of the complete heptasaccharide, as well as [M-2H]<sup>2-</sup> peaks of <i>m/z</i> 980.585, 1014.089 and 1048.116, corresponding to C<sub>60</sub>, C<sub>65</sub> and C<sub>70</sub> DolP attached to the hexasaccharide precursor of the same heptasaccharide. B. The chemical structure (based on the N-linked glycan) and MS/MS fragmentation scheme are shown in the panel top. The MS/MS spectrum of the [M-2H]<sup>2-</sup> peak of <i>m/z</i> 1081.12 corresponding to heptasaccharide-charged C<sub>65</sub> DolP is presented in the panel bottom. The arrows indicating x10 and x15 reflect magnification of the ion peaks in the corresponding region of <i>m/z</i> values on the spectrum.</p>", "links"=>[], "tags"=>["dolichol phosphate", "Reduced Dolichol Phosphate Carriers", "phosphorylated polyisoprenoid carriers", "phosphorylated dolichol", "isoprene", "Hyperthermophilic Archaea Pyrococcus furiosus", "eukaryal phosphodolichols", "subunit", "dolichol pyrophosphate", "dolichol monophosphate carrier", "furiosus dolichol phosphate", "furiosus lipid", "target proteins", "archaeal dolichol phosphates", "archaeal dolichol phosphate", "hyperthermophile Pyrococcus furiosus"], "article_id"=>1457466, "categories"=>["Uncategorised"], "users"=>["Michelle M. Chang", "Barbara Imperiali", "Jerry Eichler", "Ziqiang Guan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130482.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_P_furiosus_contains_heptasaccharide_charged_DolP_/1457466", "title"=>"<i>P</i>. <i>furiosus</i> contains heptasaccharide-charged DolP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 04:14:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/2129900"], "description"=>"<p>The predicted chemical structures and calculated masses of C<sub>65</sub> DolP charged with the mono-, di-, tri-, tetra-, penta-, hexasaccharide-, and the complete heptasaccharide are shown (top to bottom, respectively).</p>", "links"=>[], "tags"=>["dolichol phosphate", "Reduced Dolichol Phosphate Carriers", "phosphorylated polyisoprenoid carriers", "phosphorylated dolichol", "isoprene", "Hyperthermophilic Archaea Pyrococcus furiosus", "eukaryal phosphodolichols", "subunit", "dolichol pyrophosphate", "dolichol monophosphate carrier", "furiosus dolichol phosphate", "furiosus lipid", "target proteins", "archaeal dolichol phosphates", "archaeal dolichol phosphate", "hyperthermophile Pyrococcus furiosus"], "article_id"=>1457467, "categories"=>["Uncategorised"], "users"=>["Michelle M. Chang", "Barbara Imperiali", "Jerry Eichler", "Ziqiang Guan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130482.g002", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_glycan_charged_DolP_species_detected_in_the_P_furiosus_lipid_extract_/1457467", "title"=>"The glycan-charged DolP species detected in the <i>P</i>. <i>furiosus</i> lipid extract.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 04:14:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/2129901"], "description"=>"<p>A. The MS spectrum of the NPLC fraction with a retention time of 14–14.5 min contains [M-H]<sup>-</sup> ion peaks corresponding to N-acetylhexosamine-linked C<sub>6o</sub>, C<sub>65</sub> and C<sub>70</sub> DolP (<i>m/z</i> 1126.871, 1194.934 and 1262.995, respectively). Each DolP species includes 7–11 unsaturated isoprene subunits. B. Zoomed-in spectrum of N-acetylhexosamine-charged C<sub>65</sub> DolP [M-H]<sup>-</sup> ion peaks showing the varying degree of dolichol saturation. Peaks corresponding to species containing dolichol that includes 2–6 saturated bonds are indicated accordingly. C. MS/MS spectrum of the [M-H]<sup>-</sup> ion of C<sub>65</sub> DolP at <i>m/z</i> 1194.934. The fragmentation scheme (inset) shows the distribution of the saturated bonds (mostly near the ω-terminus).</p>", "links"=>[], "tags"=>["dolichol phosphate", "Reduced Dolichol Phosphate Carriers", "phosphorylated polyisoprenoid carriers", "phosphorylated dolichol", "isoprene", "Hyperthermophilic Archaea Pyrococcus furiosus", "eukaryal phosphodolichols", "subunit", "dolichol pyrophosphate", "dolichol monophosphate carrier", "furiosus dolichol phosphate", "furiosus lipid", "target proteins", "archaeal dolichol phosphates", "archaeal dolichol phosphate", "hyperthermophile Pyrococcus furiosus"], "article_id"=>1457468, "categories"=>["Uncategorised"], "users"=>["Michelle M. Chang", "Barbara Imperiali", "Jerry Eichler", "Ziqiang Guan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130482.g003", "stats"=>{"downloads"=>4, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_P_furiosus_DolP_is_highly_saturated_/1457468", "title"=>"<i>P</i>. <i>furiosus</i> DolP is highly saturated.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-22 04:14:16"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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