Using ClinicalTrials.gov to Supplement Information in Ophthalmology Conference Abstracts about Trial Outcomes: A Comparison Study
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{"title"=>"Using ClinicalTrials.gov to supplement information in ophthalmology conference abstracts about trial outcomes: A comparison study", "type"=>"journal", "authors"=>[{"first_name"=>"Roberta W.", "last_name"=>"Scherer", "scopus_author_id"=>"23768576000"}, {"first_name"=>"Lynn", "last_name"=>"Huynh", "scopus_author_id"=>"55965987100"}, {"first_name"=>"Ann Margret", "last_name"=>"Ervin", "scopus_author_id"=>"23481923000"}, {"first_name"=>"Kay", "last_name"=>"Dickersin", "scopus_author_id"=>"7005562566"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"605585690", "sgr"=>"84939246872", "doi"=>"10.1371/journal.pone.0130619", "scopus"=>"2-s2.0-84939246872", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "pmid"=>"26107924"}, "id"=>"fcff857b-7dcb-3c81-aeae-7109d8de46e6", "abstract"=>"BACKGROUND: Including results from unpublished randomized controlled trials (RCTs) in a systematic review may ameliorate the effect of publication bias in systematic review results. Unpublished RCTs are sometimes described in abstracts presented at conferences, included in trials registers, or both. Trial results may not be available in a trials register and abstracts describing RCT results often lack study design information. Complementary information from a trials register record may be sufficient to allow reliable inclusion of an unpublished RCT only available as an abstract in a systematic review.\\n\\nMETHODS: We identified 496 abstracts describing RCTs presented at the 2007 to 2009 Association for Research in Vision and Ophthalmology (ARVO) meetings; 154 RCTs were registered in ClinicalTrials.gov. Two persons extracted verbatim primary and non-primary outcomes reported in the abstract and ClinicalTrials.gov record. We compared each abstract outcome with all ClinicalTrials.gov outcomes and coded matches as complete, partial, or no match.\\n\\nRESULTS: We identified 800 outcomes in 152 abstracts (95 primary [51 abstracts] and 705 [141 abstracts] non-primary outcomes). No outcomes were reported in 2 abstracts. Of 95 primary outcomes, 17 (18%) agreed completely, 53 (56%) partially, and 25 (26%) had no match with a ClinicalTrials.gov primary or non-primary outcome. Among 705 non-primary outcomes, 56 (8%) agreed completely, 205 (29%) agreed partially, and 444 (63%) had no match with a ClinicalTrials.gov primary or non-primary outcome. Among the 258 outcomes partially agreeing, we found additional information on the time when the outcome was measured more often in ClinicalTrials.gov than in the abstract (141/258 (55%) versus 55/258 (21%)). We found no association between the presence of non-matching \"new\" outcomes and year of registration, time to registry update, industry sponsorship, or multi-center status.\\n\\nCONCLUSION: Conference abstracts may be a valuable source of information about results for outcomes of unpublished RCTs that have been registered in ClinicalTrials.gov. Complementary additional descriptive information may be present for outcomes reported in both sources. However, ARVO abstract authors also present outcomes not reported in ClinicalTrials.gov and these may represent analyses not originally planned.", "link"=>"http://www.mendeley.com/research/using-clinicaltrialsgov-supplement-information-ophthalmology-conference-abstracts-about-trial-outcom", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2146813"], "description"=>"<p>The number of primary outcomes (n = 95) that were reported in an abstract are shown in gray bars and non-primary outcomes (n = 705) in white bars.</p>", "links"=>[], "tags"=>["496 abstracts", "ClinicalTrials.gov record", "258 outcomes", "2 abstracts", "lack study design information", "ARVO", "2009 Association", "trial results", "Ophthalmology Conference Abstracts", "Comparison Study BackgroundIncluding results", "Unpublished RCTs", "review results", "trial outcomes", "trials registers", "Complementary information", "industry sponsorship", "154 RCTs", "publication bias", "ClinicalTrials.gov outcomes", "RCT results", "Supplement Information", "800 outcomes"], "article_id"=>1462181, "categories"=>["Uncategorised"], "users"=>["Roberta W. Scherer", "Lynn Huynh", "Ann-Margret Ervin", "Kay Dickersin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130619.g002", "stats"=>{"downloads"=>6, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_primary_and_non_primary_outcomes_/1462181", "title"=>"Distribution of primary and non-primary outcomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-24 03:14:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/2146814"], "description"=>"<p>Abstract outcomes from 40 abstracts reporting primary outcomes that completely agree with the outcome in <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> are shown in green, those partially agree are shown in yellow, and those that do not match any outcome are in red.</p>", "links"=>[], "tags"=>["496 abstracts", "ClinicalTrials.gov record", "258 outcomes", "2 abstracts", "lack study design information", "ARVO", "2009 Association", "trial results", "Ophthalmology Conference Abstracts", "Comparison Study BackgroundIncluding results", "Unpublished RCTs", "review results", "trial outcomes", "trials registers", "Complementary information", "industry sponsorship", "154 RCTs", "publication bias", "ClinicalTrials.gov outcomes", "RCT results", "Supplement Information", "800 outcomes"], "article_id"=>1462182, "categories"=>["Uncategorised"], "users"=>["Roberta W. Scherer", "Lynn Huynh", "Ann-Margret Ervin", "Kay Dickersin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130619.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Agreement_between_primary_outcomes_reported_in_abstracts_with_primary_outcome_reported_in_ClinicalTrials_gov_/1462182", "title"=>"Agreement between primary outcomes reported in abstracts with primary outcome reported in ClinicalTrials.gov.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-24 03:14:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/2146812"], "description"=>"<p>The flow chart shows the number of outcomes by abstract and level of agreement with outcomes in the <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> register. Primary outcomes are shown on the left and non-primary outcomes on the right. Both primary and non-primary outcomes were compared with the outcome in the Primary Outcome Field of <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> first. Unmatched outcomes were then compared with all other outcomes reported in the <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> record. The number of abstract outcomes that completely agreed with the outcome in <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> is shown in green, that partially agreed is shown in yellow and that were not matched to any outcome in red. <a href=\"http://CT.gov\" target=\"_blank\">CT.gov</a> = <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a></p>", "links"=>[], "tags"=>["496 abstracts", "ClinicalTrials.gov record", "258 outcomes", "2 abstracts", "lack study design information", "ARVO", "2009 Association", "trial results", "Ophthalmology Conference Abstracts", "Comparison Study BackgroundIncluding results", "Unpublished RCTs", "review results", "trial outcomes", "trials registers", "Complementary information", "industry sponsorship", "154 RCTs", "publication bias", "ClinicalTrials.gov outcomes", "RCT results", "Supplement Information", "800 outcomes"], "article_id"=>1462180, "categories"=>["Uncategorised"], "users"=>["Roberta W. Scherer", "Lynn Huynh", "Ann-Margret Ervin", "Kay Dickersin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130619.g001", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_/1462180", "title"=>"Flow chart.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-24 03:14:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/2146815", "https://ndownloader.figshare.com/files/2146816"], "description"=>"<div><p>Background</p><p>Including results from unpublished randomized controlled trials (RCTs) in a systematic review may ameliorate the effect of publication bias in systematic review results. Unpublished RCTs are sometimes described in abstracts presented at conferences, included in trials registers, or both. Trial results may not be available in a trials register and abstracts describing RCT results often lack study design information. Complementary information from a trials register record may be sufficient to allow reliable inclusion of an unpublished RCT only available as an abstract in a systematic review.</p><p>Methods</p><p>We identified 496 abstracts describing RCTs presented at the 2007 to 2009 Association for Research in Vision and Ophthalmology (ARVO) meetings; 154 RCTs were registered in <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a>. Two persons extracted verbatim primary and non-primary outcomes reported in the abstract and <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> record. We compared each abstract outcome with all <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> outcomes and coded matches as complete, partial, or no match.</p><p>Results</p><p>We identified 800 outcomes in 152 abstracts (95 primary [51 abstracts] and 705 [141 abstracts] non-primary outcomes). No outcomes were reported in 2 abstracts. Of 95 primary outcomes, 17 (18%) agreed completely, 53 (56%) partially, and 25 (26%) had no match with a <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> primary or non-primary outcome. Among 705 non-primary outcomes, 56 (8%) agreed completely, 205 (29%) agreed partially, and 444 (63%) had no match with a <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> primary or non-primary outcome. Among the 258 outcomes partially agreeing, we found additional information on the time when the outcome was measured more often in <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> than in the abstract (141/258 (55%) versus 55/258 (21%)). We found no association between the presence of non-matching “new” outcomes and year of registration, time to registry update, industry sponsorship, or multi-center status.</p><p>Conclusion</p><p>Conference abstracts may be a valuable source of information about results for outcomes of unpublished RCTs that have been registered in <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a>. Complementary additional descriptive information may be present for outcomes reported in both sources. However, ARVO abstract authors also present outcomes not reported in <a href=\"http://www.clinicaltrials.gov\" target=\"_blank\">ClinicalTrials.gov</a> and these may represent analyses not originally planned.</p></div>", "links"=>[], "tags"=>["496 abstracts", "ClinicalTrials.gov record", "258 outcomes", "2 abstracts", "lack study design information", "ARVO", "2009 Association", "trial results", "Ophthalmology Conference Abstracts", "Comparison Study BackgroundIncluding results", "Unpublished RCTs", "review results", "trial outcomes", "trials registers", "Complementary information", "industry sponsorship", "154 RCTs", "publication bias", "ClinicalTrials.gov outcomes", "RCT results", "Supplement Information", "800 outcomes"], "article_id"=>1462183, "categories"=>["Uncategorised"], "users"=>["Roberta W. Scherer", "Lynn Huynh", "Ann-Margret Ervin", "Kay Dickersin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0130619.s001", "https://dx.doi.org/10.1371/journal.pone.0130619.s002"], "stats"=>{"downloads"=>6, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Using_ClinicalTrials_gov_to_Supplement_Information_in_Ophthalmology_Conference_Abstracts_about_Trial_Outcomes_A_Comparison_Study_/1462183", "title"=>"Using ClinicalTrials.gov to Supplement Information in Ophthalmology Conference Abstracts about Trial Outcomes: A Comparison Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-06-24 03:14:32"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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