Genetic Influence on Slope Variability in a Childhood Reflexive Attention Task
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{"title"=>"Genetic influence on slope variability in a childhood reflexive attention task", "type"=>"journal", "authors"=>[{"first_name"=>"Rebecca A.", "last_name"=>"Lundwall", "scopus_author_id"=>"54971866100"}, {"first_name"=>"Jeffrey K.", "last_name"=>"Watkins", "scopus_author_id"=>"56780958000"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"605585919", "pmid"=>"26102342", "doi"=>"10.1371/journal.pone.0130668", "issn"=>"19326203", "scopus"=>"2-s2.0-84939244145", "sgr"=>"84939244145", "isbn"=>"1932-6203"}, "id"=>"09b40581-391e-3f72-a282-c9b76e9e41bb", "abstract"=>"Individuals are not perfectly consistent, and interindividual variability is a common feature in all varieties of human behavior. Some individuals respond more variably than others, however, and this difference may be important to understanding how the brain works. In this paper, we explore genetic contributions to response time (RT) slope variability on a reflexive attention task. We are interested in such variability because we believe it is an important part of the overall picture of attention that, if understood, has the potential to improve intervention for those with attentional deficits. Genetic association studies are valuable in discovering biological pathways of variability and several studies have found such associations with a sustained attention task. Here, we expand our knowledge to include a reflexive attention task. We ask whether specific candidate genes are associated with interindividual variability on a childhood reflexive attention task in 9-16 year olds. The genetic makers considered are on 11 genes: APOE, BDNF, CHRNA4, COMT, DRD4, HTR4, IGF2, MAOA, SLC5A7, SLC6A3, and SNAP25. We find significant associations with variability with markers on nine and we discuss the results in terms of neurotransmitters associated with each gene and the characteristics of the associated measures from the reflexive attention task.", "link"=>"http://www.mendeley.com/research/genetic-influence-slope-variability-childhood-reflexive-attention-task", "reader_count"=>10, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>7, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Psychology"=>{"Psychology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2133559"], "description"=>"<p>The cue duration plus the gap duration (inter-stimulus interval) makes the stimulus onset asynchrony (SOA) 150 msec. The inter-trial interval varied from 600–3000 msec.</p>", "links"=>[], "tags"=>["bdnf", "drd", "rt", "snap", "apoe", "Childhood Reflexive Attention Task Individuals", "igf", "maoa", "htr", "gene", "interindividual variability", "SLC 5A SLC 6A", "childhood reflexive attention task", "comt", "reflexive attention task", "Genetic association studies", "CHRNA"], "article_id"=>1460965, "categories"=>["Uncategorised"], "users"=>["Rebecca A. Lundwall", "Jeffrey K. Watkins"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130668.g002", "stats"=>{"downloads"=>3, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_of_the_child_spatial_cueing_SC_task_/1460965", "title"=>"Schematic of the child spatial cueing (SC) task.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-23 02:47:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/2133560"], "description"=>"<p>Primary measures.</p>", "links"=>[], "tags"=>["bdnf", "drd", "rt", "snap", "apoe", "Childhood Reflexive Attention Task Individuals", "igf", "maoa", "htr", "gene", "interindividual variability", "SLC 5A SLC 6A", "childhood reflexive attention task", "comt", "reflexive attention task", "Genetic association studies", "CHRNA"], "article_id"=>1460966, "categories"=>["Uncategorised"], "users"=>["Rebecca A. Lundwall", "Jeffrey K. Watkins"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130668.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primary_measures_/1460966", "title"=>"Primary measures.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-23 02:47:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/2133558"], "description"=>"<p><i>Top</i>. Moment-to-moment variability showing more variability for the GG genotype and less for the AA genotype. <i>Bottom</i>. Slope variability showing increase RT over the course of the task (GG genotype) and decreasing RT (AA genotype). It is possible for subjects to have both types of variability. In this paper we examine slope variability.</p>", "links"=>[], "tags"=>["bdnf", "drd", "rt", "snap", "apoe", "Childhood Reflexive Attention Task Individuals", "igf", "maoa", "htr", "gene", "interindividual variability", "SLC 5A SLC 6A", "childhood reflexive attention task", "comt", "reflexive attention task", "Genetic association studies", "CHRNA"], "article_id"=>1460964, "categories"=>["Uncategorised"], "users"=>["Rebecca A. Lundwall", "Jeffrey K. Watkins"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130668.g001", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hypothetical_illustration_of_the_two_types_of_variability_addressed_in_this_paper_/1460964", "title"=>"Hypothetical illustration of the two types of variability addressed in this paper.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-23 02:47:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/2133561"], "description"=>"<p>NB = Neutral Bright; SBI = Single Bright Invalid; SDI = Single Dim Invalid; SDV = Single Dim Valid</p><p>Analyses were conducted with the log transformed RT using covariates; however unadjusted, raw RTs are shown for interpretability.</p><p>Positive slopes indicate increasing RT across approx. 24 trials of a given type (only correct trials were used).</p><p>* = unknown risk allele</p><p>RT Slope Variability Means</p>", "links"=>[], "tags"=>["bdnf", "drd", "rt", "snap", "apoe", "Childhood Reflexive Attention Task Individuals", "igf", "maoa", "htr", "gene", "interindividual variability", "SLC 5A SLC 6A", "childhood reflexive attention task", "comt", "reflexive attention task", "Genetic association studies", "CHRNA"], "article_id"=>1460967, "categories"=>["Uncategorised"], "users"=>["Rebecca A. Lundwall", "Jeffrey K. Watkins"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130668.t002", "stats"=>{"downloads"=>23, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RT_Slope_Variability_Means_/1460967", "title"=>"RT Slope Variability Means", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-23 02:47:40"}

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  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
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  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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