Characterisation of Brachycephalic Obstructive Airway Syndrome in French Bulldogs Using Whole-Body Barometric Plethysmography
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{"title"=>"Characterisation of brachycephalic obstructive airway syndrome in French bulldogs using whole-body barometric plethysmography", "type"=>"journal", "authors"=>[{"first_name"=>"Nai Chieh", "last_name"=>"Liu", "scopus_author_id"=>"56735069100"}, {"first_name"=>"David R.", "last_name"=>"Sargan", "scopus_author_id"=>"7004105709"}, {"first_name"=>"Vicki J.", "last_name"=>"Adams", "scopus_author_id"=>"7102033262"}, {"first_name"=>"Jane F.", "last_name"=>"Ladlow", "scopus_author_id"=>"6602304923"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0130741", "pui"=>"605265680", "scopus"=>"2-s2.0-84937951583", "issn"=>"19326203", "pmid"=>"26079684", "sgr"=>"84937951583", "isbn"=>"1932-6203"}, "id"=>"402132a8-b774-3499-964a-0508d59d02f3", "abstract"=>"Brachycephalic obstructive airway syndrome (BOAS) is an important health and welfare problem in several popular dog breeds. Whole-body barometric plethysmography (WBBP) is a non-invasive method that allows safe and repeated quantitative measurements of respiratory cycles on unsedated dogs. Here respiratory flow traces in French bulldogs from the pet population were characterised using WBBP, and a computational application was developed to recognise affected animals. Eighty-nine French bulldogs and twenty non-brachycephalic controls underwent WBBP testing. A respiratory functional grading system was used on each dog based on respiratory signs (i.e. respiratory noise, effort, etc.) before and after exercise. For development of an objective BOAS classifier, functional Grades 0 and I were considered to have insignificant clinical signs (termed here BOAS-) and Grades II and III to have significant signs (termed here BOAS+). A comparison between owner-perception of BOAS and functional grading revealed that 60 % of owners failed to recognise BOAS in dogs that graded BOAS+ in this study.WBBP flow traces were found to be significantly different between non-brachycephalic controls and Grade 0 French bulldogs; BOAS- and BOAS+ French bulldogs. A classifier was developed using quadratic discriminant analysis of the respiratory parameters to distinguish BOAS- and BOAS + French bulldogs, and a BOAS Index was calculated for each dog. A cut-off value of the BOAS Index was selected based on a receiver operating characteristic (ROC) curve. Sensitivity, specificity, positive predictive value, and negative predictive value of the classifier on the training group (n=69) were 0.97, 0.93, 0.95, and 0.97, respectively. The classifier was validated using a test group of French bulldogs (n=20) with an accuracy of 0.95. WBBP offers objective screening for the diagnosis of BOAS in French Bulldogs. The technique may be applied to other brachycephalic breeds affected by BOAS, and possibly to other respiratory disease in dogs.", "link"=>"http://www.mendeley.com/research/characterisation-brachycephalic-obstructive-airway-syndrome-french-bulldogs-using-wholebody-barometr", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>3, "Other"=>3, "Student > Master"=>10, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>3, "Other"=>3, "Student > Master"=>10, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>6, "Neuroscience"=>1, "Veterinary Science and Veterinary Medicine"=>11, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Unspecified"=>{"Unspecified"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>11}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>4}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2116004"], "description"=>"<p>FB = French bulldogs; PEF/PIF = peak expiratory flow rate/ peak inspiratory flow rate; MV/BW = minute ventilation/ body weight, ml/kg; Te/Ti = expiratory time/ inspiratory time. 20 representative breaths per dog.</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451168, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.g005", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Breaths_plotted_against_three_selected_respiratory_parameters_/1451168", "title"=>"Breaths plotted against three selected respiratory parameters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116005"], "description"=>"<p>(A) Distribution of the BOAS Index for the French bulldog training dataset; (B) Box plots of the BOAS Index for the French bulldog training dataset according to functional grade. Boxes present lines at median, upper and lower quartiles; between whiskers = 95% confidence interval; circles = outliers within the inner fence; stars = outliers within the outer fence.</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451169, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.g006", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Classification_performance_of_the_BOAS_Index_/1451169", "title"=>"Classification performance of the BOAS Index.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116006"], "description"=>"<p>Bootstrapping was used to generate the associated 95% confidence intervals (area in blue) to delineate the expected range of screening performance. The black dot with whiskers (95% confidence interval) shows the position of the BOAS Index of 0.46 suggested as a cut off point for distinguishing functionally BOAS- and BOAS+ French bulldogs.</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451170, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.g007", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Receiver_operating_characteristic_ROC_curve_of_the_BOAS_Index_for_diagnosis_of_functional_BOAS_French_bulldogs_/1451170", "title"=>"Receiver operating characteristic (ROC) curve of the BOAS Index for diagnosis of functional BOAS+ French bulldogs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116007"], "description"=>"<p>Data are presented as median (minimum-maximum). BOAS refers to Brachycephalic Obstructive Airway Syndrome; BCS, body condition score.</p><p><sup><b>a</b></sup> Functional grades, refer to <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130741#pone.0130741.t001\" target=\"_blank\">Table 1</a>.</p><p><sup><b>b</b></sup> Breeds: English springer spaniel (n = 2), Border collie (n = 1), Jack Russell terrier (n = 1), Labrador retriever (n = 3), American bullterrier (n = 1), Beagles (n = 6), Dachshund (n = 1), Cairn terrier (n = 1), West Highland white terrier (n = 1), cross breeds (n = 3).</p><p>Signalment (median [minimum-maximum]) and details of French bulldogs and non-brachycephalic controls.</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451171, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.t002", "stats"=>{"downloads"=>5, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Signalment_median_minimum_maximum_and_details_of_French_bulldogs_and_non_brachycephalic_controls_/1451171", "title"=>"Signalment (median [minimum-maximum]) and details of French bulldogs and non-brachycephalic controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116008"], "description"=>"<p>Means (m) and standard deviations of the means (sd) of RR, Te/Ti, PEF/PIF, and MV/BW were calculated for 20 breaths collected from each dog.</p><p>RR = respiratory rate (breath per minute); Te/Ti = expiratory time (s) /inspiratory time(s); PEF/PIF = peak expiratory flow rate (ml/s)/ peak inspiratory flow rate (ml/s); MV/BW = minute volume (ml)/ body weight(kg); m = mean of the parameter calculated from the 20 breaths of each dog; sd = standard deviation of the parameter calculated from the 20 breaths of each dog.</p><p><sup>a</sup> Breeds: English springer spaniel (n = 2), Border collie (n = 1), Jack Russell terrier (n = 1), Labrador retriever (n = 3), American bullterrier (n = 1), Beagles (n = 6), Dachshund (n = 1), Cairn terrier (n = 1), West Highland white terrier (n = 1), cross breeds (n = 3).</p><p><sup>b</sup> BOAS- FB = Grade 0/I FB; BOAS+ FB = Grade II/III FB. Functional grades, refer to <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0130741#pone.0130741.t001\" target=\"_blank\">Table 1</a>.</p><p><sup>π</sup> The Kolmogorov-Smironov test was significant (i.e. data were not normal distributed); p<0.05.</p><p>* Significantly different from the non-brachycephalic control group, *p<0.05; **p<0.01; ***p<0.001.</p><p><sup>τ</sup> Significantly different from the BOAS- French bulldogs; <sup>τ</sup> p<0.05; <sup>τ τ</sup> p<0.01; <sup>τ τ τ</sup> p<0.001.</p><p>Respiratory parameters measured by whole-body barometric plethysmography (WBBP).</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451172, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.t003", "stats"=>{"downloads"=>7, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Respiratory_parameters_measured_by_whole_body_barometric_plethysmography_WBBP_/1451172", "title"=>"Respiratory parameters measured by whole-body barometric plethysmography (WBBP).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116009", "https://ndownloader.figshare.com/files/2116010"], "description"=>"<div><p>Brachycephalic obstructive airway syndrome (BOAS) is an important health and welfare problem in several popular dog breeds. Whole-body barometric plethysmography (WBBP) is a non-invasive method that allows safe and repeated quantitative measurements of respiratory cycles on unsedated dogs. Here respiratory flow traces in French bulldogs from the pet population were characterised using WBBP, and a computational application was developed to recognise affected animals. Eighty-nine French bulldogs and twenty non-brachycephalic controls underwent WBBP testing. A respiratory functional grading system was used on each dog based on respiratory signs (i.e. respiratory noise, effort, etc.) before and after exercise. For development of an objective BOAS classifier, functional Grades 0 and I were considered to have insignificant clinical signs (termed here BOAS-) and Grades II and III to have significant signs (termed here BOAS+). A comparison between owner-perception of BOAS and functional grading revealed that 60 % of owners failed to recognise BOAS in dogs that graded BOAS+ in this study.WBBP flow traces were found to be significantly different between non-brachycephalic controls and Grade 0 French bulldogs; BOAS- and BOAS+ French bulldogs. A classifier was developed using quadratic discriminant analysis of the respiratory parameters to distinguish BOAS- and BOAS + French bulldogs, and a BOAS Index was calculated for each dog. A cut-off value of the BOAS Index was selected based on a receiver operating characteristic (ROC) curve. Sensitivity, specificity, positive predictive value, and negative predictive value of the classifier on the training group (n=69) were 0.97, 0.93, 0.95, and 0.97, respectively. The classifier was validated using a test group of French bulldogs (n=20) with an accuracy of 0.95. WBBP offers objective screening for the diagnosis of BOAS in French Bulldogs. The technique may be applied to other brachycephalic breeds affected by BOAS, and possibly to other respiratory disease in dogs.</p></div>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451173, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0130741.s001", "https://dx.doi.org/10.1371/journal.pone.0130741.s002"], "stats"=>{"downloads"=>3, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterisation_of_Brachycephalic_Obstructive_Airway_Syndrome_in_French_Bulldogs_Using_Whole_Body_Barometric_Plethysmography_/1451173", "title"=>"Characterisation of Brachycephalic Obstructive Airway Syndrome in French Bulldogs Using Whole-Body Barometric Plethysmography", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116000"], "description"=>"<p>A pole of the chamber pressure differential transducer is opened to the top of the chamber (C); two inlets (A and B) are connected to the front and back of the chamber in order to ventilate with a bias flow of room air (20 L/minute); an audio sensor is located on the top of the chamber (D); together with pneumotachograph screens (E).</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451164, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.g001", "stats"=>{"downloads"=>2, "page_views"=>29, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_chamber_used_for_whole_body_barometric_plethysmography_WBBP_with_a_French_bulldog_undergoing_the_test_/1451164", "title"=>"The chamber used for whole-body barometric plethysmography (WBBP) with a French bulldog undergoing the test.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116001"], "description"=>"<p><b>The</b> flow cycle starts from inspiration (below the zero line of flow rate) then expiration (above the zero line of the flow rate).</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451165, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.g002", "stats"=>{"downloads"=>5, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WBBP_flow_waveform_illustration_for_a_single_respiratory_cycle_/1451165", "title"=>"WBBP flow waveform illustration for a single respiratory cycle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116002"], "description"=>"<p>WBBP = whole body barometric plethysmography; BOAS = brachycephalic obstructive airway syndrome; QDA = quadratic discriminant analysis; SD = standard deviation; Te/Ti = expiratory time/ inspiratory time; PEF/PIF = ratio of peak expiratory flow to peak inspiratory flow; MV/BW = minute volume / body weight.</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451166, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.g003", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_flowchart_of_the_study_design_/1451166", "title"=>"A flowchart of the study design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-16 03:10:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/2116003"], "description"=>"<p>(A) non-brachycephalic control dog; (B) BOAS- French bulldog; (C) BOAS+ French bulldog, respiratory cycle Type 1; (D) BOAS+ French bulldog, Type 2; (E) BOAS+ French bulldog, Type 3.</p>", "links"=>[], "tags"=>["study.WBBP flow traces", "roc", "French Bulldogs", "ii", "objective BOAS classifier", "Brachycephalic Obstructive Airway Syndrome", "iii", "BOAS Index"], "article_id"=>1451167, "categories"=>["Biological Sciences"], "users"=>["Nai-Chieh Liu", "David R. Sargan", "Vicki J. Adams", "Jane F. Ladlow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130741.g004", "stats"=>{"downloads"=>3, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_WBBP_flow_waveforms_for_several_study_dogs_/1451167", "title"=>"Representative WBBP flow waveforms for several study dogs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-16 03:10:11"}

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  • {"unique-ip"=>"57", "full-text"=>"64", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"83", "full-text"=>"110", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"28", "full-text"=>"31", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"37", "full-text"=>"38", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"53", "full-text"=>"67", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"34", "full-text"=>"38", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"78", "full-text"=>"96", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"83", "full-text"=>"105", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"68", "full-text"=>"85", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"87", "full-text"=>"106", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"1", "cited-by"=>"2", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"48", "full-text"=>"53", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"33", "full-text"=>"37", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"31", "full-text"=>"33", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"54", "full-text"=>"60", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"45", "full-text"=>"50", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"43", "full-text"=>"46", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
  • {"unique-ip"=>"39", "full-text"=>"42", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}
  • {"unique-ip"=>"55", "full-text"=>"59", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"2"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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