Seasonal Variation in the Skin Transcriptome of Common Bottlenose Dolphins (Tursiops truncatus) from the Northern Gulf of Mexico
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{"title"=>"Seasonal variation in the skin transcriptome of common bottlenose dolphins (Tursiops truncatus) from the northern Gulf of Mexico", "type"=>"journal", "authors"=>[{"first_name"=>"Frances M.", "last_name"=>"Van Dolah", "scopus_author_id"=>"6701700273"}, {"first_name"=>"Marion G.", "last_name"=>"Neely", "scopus_author_id"=>"14820953000"}, {"first_name"=>"Lauren E.", "last_name"=>"McGeorge", "scopus_author_id"=>"56719690300"}, {"first_name"=>"Brian C.", "last_name"=>"Balmer", "scopus_author_id"=>"35775026100"}, {"first_name"=>"Gina M.", "last_name"=>"Ylitalo", "scopus_author_id"=>"6602749801"}, {"first_name"=>"Eric S.", "last_name"=>"Zolman", "scopus_author_id"=>"6508103721"}, {"first_name"=>"Todd", "last_name"=>"Speakman", "scopus_author_id"=>"24729567900"}, {"first_name"=>"Carrie", "last_name"=>"Sinclair", "scopus_author_id"=>"53064529500"}, {"first_name"=>"Nicholas M.", "last_name"=>"Kellar", "scopus_author_id"=>"12143859900"}, {"first_name"=>"Patricia E.", "last_name"=>"Rosel", "scopus_author_id"=>"35617560300"}, {"first_name"=>"Keith D.", "last_name"=>"Mullin", "scopus_author_id"=>"7004278422"}, {"first_name"=>"Lori H.", "last_name"=>"Schwacke", "scopus_author_id"=>"6506528517"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"26110790", "doi"=>"10.1371/journal.pone.0130934", "sgr"=>"84938630823", "scopus"=>"2-s2.0-84938630823", "issn"=>"19326203", "pui"=>"605398541"}, "id"=>"a2b8da0c-57ad-3415-9d79-60527169e79a", "abstract"=>"As long-lived predators that integrate exposures across multiple trophic levels, cetaceans are recognized as sentinels for the health of marine ecosystems. Their utility as sentinels requires the establishment of baseline health parameters. Because cetaceans are protected, measurements obtained with minimal disruption to free ranging animals are highly desirable. In this study we investigated the utility of skin gene expression profiling to monitor health and contaminant exposure in common bottlenose dolphins (Tursiops truncatus). Remote integument biopsies were collected in the northern Gulf of Mexico prior to the Deepwater Horizon oil spill (May 2010) and during summer and winter for two years following oil contamination (2010-2011). A bottlenose dolphin microarray was used to characterize the skin transcriptomes of 94 individuals from three populations: Barataria Bay, Louisiana, Chandeleur Sound, Louisiana, and Mississippi Sound, Mississippi/Alabama. Skin transcriptomes did not differ significantly between populations. In contrast, season had a profound effect on gene expression, with nearly one-third of all genes on the array differing in expression between winter and the warmer seasons (moderated T-test; p<0.01, fold-change≥1.5). Persistent organic pollutants (POPs) in blubber changed concurrently, reaching >two-fold higher concentrations in summer compared to winter, due to a seasonal decrease in blubber thickness and loss of stored lipid. However, global gene expression did not correlate strongly with seasonally changing contaminant concentrations, most likely because the refractory, lipid-stored metabolites are not substrates for phase I or II xenobiotic detoxification pathways. Rather, processes related to cell proliferation, motility, and differentiation dominated the differences in expression in winter and the warmer seasons. More subtle differences were seen between spring and summer (1.5% of genes differentially expressed). However, two presumed oil-exposed animals from spring presented gene expression profiles more similar to the summer animals (presumed exposed) than to other spring animals. Seasonal effects have not previously been considered in studies assessing gene expression in cetaceans, but clearly must be taken into account when applying transcriptomic analyses to investigate their contaminant exposure or health status.", "link"=>"http://www.mendeley.com/research/seasonal-variation-skin-transcriptome-common-bottlenose-dolphins-tursiops-truncatus-northern-gulf-me", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. 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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2149915"], "description"=>"<p>A. Principal component analysis on all 94 microarrays shows complete separation of winter samples from all others, with no apparent segregation according to location. B. Unsupervised hierarchical cluster analysis of the normalized array data similarly shows complete separation of winter samples from the warmer seasons.</p>", "links"=>[], "tags"=>["bottlenose dolphin microarray", "Tursiops truncatus", "Common Bottlenose Dolphins", "gene expression profiles", "gene expression", "baseline health parameters", "contaminant exposure", "Deepwater Horizon oil spill", "Remote integument biopsies", "skin gene expression", "cetacean", "II xenobiotic detoxification pathways"], "article_id"=>1464446, "categories"=>["Uncategorised"], "users"=>["Frances M. Van Dolah", "Marion G. Neely", "Lauren E. McGeorge", "Brian C. Balmer", "Gina M. Ylitalo", "Eric S. Zolman", "Todd Speakman", "Carrie Sinclair", "Nicholas M. Kellar", "Patricia E. Rosel", "Keith D. Mullin", "Lori H. Schwacke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130934.g002", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Seasonal_Variation_in_the_Skin_Transcriptome_of_Common_Bottlenose_Dolphins_Tursiops_truncatus_Fig_2_from_the_Northern_Gulf_of_Mexico_/1464446", "title"=>"Seasonal Variation in the Skin Transcriptome of Common Bottlenose Dolphins (<i>Tursiops truncatus - Fig 2 </i>) from the Northern Gulf of Mexico", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-25 04:02:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/2149924"], "description"=>"<p>Within a season, there is no significant correlation (Spearman rank) between ∑POPs in blubber (μg/g lipid) and the PC1 scores, which are responsible for 22.7% (winter, B) and 20.6% (summer, D) of the total variance in the gene expression profiles. Symbols: red—Barataria Bay, blue—Chandeleur Sound, brown—Mississippi Sound.</p>", "links"=>[], "tags"=>["bottlenose dolphin microarray", "Tursiops truncatus", "Common Bottlenose Dolphins", "gene expression profiles", "gene expression", "baseline health parameters", "contaminant exposure", "Deepwater Horizon oil spill", "Remote integument biopsies", "skin gene expression", "cetacean", "II xenobiotic detoxification pathways"], "article_id"=>1464454, "categories"=>["Uncategorised"], "users"=>["Frances M. Van Dolah", "Marion G. Neely", "Lauren E. McGeorge", "Brian C. Balmer", "Gina M. Ylitalo", "Eric S. Zolman", "Todd Speakman", "Carrie Sinclair", "Nicholas M. Kellar", "Patricia E. Rosel", "Keith D. Mullin", "Lori H. Schwacke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130934.g005", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_components_analyses_on_males_from_within_a_season_winter_A_summer_C_/1464454", "title"=>"Principal components analyses on males from within a season: winter (A), summer (C).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-25 04:02:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/2149919"], "description"=>"<p>Spring Chandeleur Sound (boxed) animals cluster with the summer expression profiles. Heat map color is relative to the median intensity for each probe: red is increased, blue is decreased, log<sub>2</sub> scale.</p>", "links"=>[], "tags"=>["bottlenose dolphin microarray", "Tursiops truncatus", "Common Bottlenose Dolphins", "gene expression profiles", "gene expression", "baseline health parameters", "contaminant exposure", "Deepwater Horizon oil spill", "Remote integument biopsies", "skin gene expression", "cetacean", "II xenobiotic detoxification pathways"], "article_id"=>1464450, "categories"=>["Uncategorised"], "users"=>["Frances M. Van Dolah", "Marion G. Neely", "Lauren E. McGeorge", "Brian C. Balmer", "Gina M. Ylitalo", "Eric S. Zolman", "Todd Speakman", "Carrie Sinclair", "Nicholas M. Kellar", "Patricia E. Rosel", "Keith D. Mullin", "Lori H. Schwacke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130934.g003", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_dimensional_hierarchical_cluster_analysis_of_391_probes_differentially_expressed_in_29_samples_collected_from_spring_and_summer_2010_pre_and_post_oiling_p_lt_0_01_fold_change_8805_1_5_/1464450", "title"=>"Two-dimensional hierarchical cluster analysis of 391 probes differentially expressed in 29 samples collected from spring and summer 2010 (pre- and post-oiling) (p<0.01, fold change ≥1.5).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-25 04:02:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/2149933", "https://ndownloader.figshare.com/files/2149934", "https://ndownloader.figshare.com/files/2149935", "https://ndownloader.figshare.com/files/2149936", "https://ndownloader.figshare.com/files/2149937", "https://ndownloader.figshare.com/files/2149938"], "description"=>"<div><p>As long-lived predators that integrate exposures across multiple trophic levels, cetaceans are recognized as sentinels for the health of marine ecosystems. Their utility as sentinels requires the establishment of baseline health parameters. Because cetaceans are protected, measurements obtained with minimal disruption to free ranging animals are highly desirable. In this study we investigated the utility of skin gene expression profiling to monitor health and contaminant exposure in common bottlenose dolphins (<i>Tursiops truncatus</i>). Remote integument biopsies were collected in the northern Gulf of Mexico prior to the <i>Deepwater Horizon</i> oil spill (May 2010) and during summer and winter for two years following oil contamination (2010-2011). A bottlenose dolphin microarray was used to characterize the skin transcriptomes of 94 individuals from three populations: Barataria Bay, Louisiana, Chandeleur Sound, Louisiana, and Mississippi Sound, Mississippi/Alabama. Skin transcriptomes did not differ significantly between populations. In contrast, season had a profound effect on gene expression, with nearly one-third of all genes on the array differing in expression between winter and the warmer seasons (moderated T-test; p<0.01, fold-change≥1.5). Persistent organic pollutants (POPs) in blubber changed concurrently, reaching >two-fold higher concentrations in summer compared to winter, due to a seasonal decrease in blubber thickness and loss of stored lipid. However, global gene expression did not correlate strongly with seasonally changing contaminant concentrations, most likely because the refractory, lipid-stored metabolites are not substrates for phase I or II xenobiotic detoxification pathways. Rather, processes related to cell proliferation, motility, and differentiation dominated the differences in expression in winter and the warmer seasons. More subtle differences were seen between spring and summer (1.5% of genes differentially expressed). However, two presumed oil-exposed animals from spring presented gene expression profiles more similar to the summer animals (presumed exposed) than to other spring animals. Seasonal effects have not previously been considered in studies assessing gene expression in cetaceans, but clearly must be taken into account when applying transcriptomic analyses to investigate their contaminant exposure or health status.</p></div>", "links"=>[], "tags"=>["bottlenose dolphin microarray", "Tursiops truncatus", "Common Bottlenose Dolphins", "gene expression profiles", "gene expression", "baseline health parameters", "contaminant exposure", "Deepwater Horizon oil spill", "Remote integument biopsies", "skin gene expression", "cetacean", "II xenobiotic detoxification pathways"], "article_id"=>1464463, "categories"=>["Uncategorised"], "users"=>["Frances M. Van Dolah", "Marion G. Neely", "Lauren E. McGeorge", "Brian C. Balmer", "Gina M. Ylitalo", "Eric S. Zolman", "Todd Speakman", "Carrie Sinclair", "Nicholas M. Kellar", "Patricia E. Rosel", "Keith D. Mullin", "Lori H. Schwacke"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0130934.s001", "https://dx.doi.org/10.1371/journal.pone.0130934.s002", "https://dx.doi.org/10.1371/journal.pone.0130934.s003", "https://dx.doi.org/10.1371/journal.pone.0130934.s004", "https://dx.doi.org/10.1371/journal.pone.0130934.s005", "https://dx.doi.org/10.1371/journal.pone.0130934.s006"], "stats"=>{"downloads"=>31, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Seasonal_Variation_in_the_Skin_Transcriptome_of_Common_Bottlenose_Dolphins_Tursiops_truncatus_from_the_Northern_Gulf_of_Mexico/1464463", "title"=>"Seasonal Variation in the Skin Transcriptome of Common Bottlenose Dolphins (<i>Tursiops truncatus</i>) from the Northern Gulf of Mexico", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-06-25 04:02:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/2149929"], "description"=>"<p>*pre oil-exposure</p><p>** possible exposure; all others post-exposure</p><p>Samples included in microarray analysis.</p>", "links"=>[], "tags"=>["bottlenose dolphin microarray", "Tursiops truncatus", "Common Bottlenose Dolphins", "gene expression profiles", "gene expression", "baseline health parameters", "contaminant exposure", "Deepwater Horizon oil spill", "Remote integument biopsies", "skin gene expression", "cetacean", "II xenobiotic detoxification pathways"], "article_id"=>1464459, "categories"=>["Uncategorised"], "users"=>["Frances M. Van Dolah", "Marion G. Neely", "Lauren E. McGeorge", "Brian C. Balmer", "Gina M. Ylitalo", "Eric S. Zolman", "Todd Speakman", "Carrie Sinclair", "Nicholas M. Kellar", "Patricia E. Rosel", "Keith D. Mullin", "Lori H. Schwacke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130934.t001", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Samples_included_in_microarray_analysis_/1464459", "title"=>"Samples included in microarray analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-25 04:02:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/2149910"], "description"=>"<p>Location of biopsy samples collected from Barataria Bay (BB), Chandeleur Sound (CS), and Mississippi Sound (MS), in the northern Gulf of Mexico.</p>", "links"=>[], "tags"=>["bottlenose dolphin microarray", "Tursiops truncatus", "Common Bottlenose Dolphins", "gene expression profiles", "gene expression", "baseline health parameters", "contaminant exposure", "Deepwater Horizon oil spill", "Remote integument biopsies", "skin gene expression", "cetacean", "II xenobiotic detoxification pathways"], "article_id"=>1464441, "categories"=>["Uncategorised"], "users"=>["Frances M. Van Dolah", "Marion G. Neely", "Lauren E. McGeorge", "Brian C. Balmer", "Gina M. Ylitalo", "Eric S. Zolman", "Todd Speakman", "Carrie Sinclair", "Nicholas M. Kellar", "Patricia E. Rosel", "Keith D. Mullin", "Lori H. Schwacke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130934.g001", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Location_of_biopsy_samples_collected_from_Barataria_Bay_BB_Chandeleur_Sound_CS_and_Mississippi_Sound_MS_in_the_northern_Gulf_of_Mexico_/1464441", "title"=>"Location of biopsy samples collected from Barataria Bay (BB), Chandeleur Sound (CS), and Mississippi Sound (MS), in the northern Gulf of Mexico.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-25 04:02:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/2149928"], "description"=>"<p>Heat map color is relative to the median intensity for each probe: red is increased, blue is decreased, log<sub>2</sub> scale.</p>", "links"=>[], "tags"=>["bottlenose dolphin microarray", "Tursiops truncatus", "Common Bottlenose Dolphins", "gene expression profiles", "gene expression", "baseline health parameters", "contaminant exposure", "Deepwater Horizon oil spill", "Remote integument biopsies", "skin gene expression", "cetacean", "II xenobiotic detoxification pathways"], "article_id"=>1464458, "categories"=>["Uncategorised"], "users"=>["Frances M. Van Dolah", "Marion G. Neely", "Lauren E. McGeorge", "Brian C. Balmer", "Gina M. Ylitalo", "Eric S. Zolman", "Todd Speakman", "Carrie Sinclair", "Nicholas M. Kellar", "Patricia E. Rosel", "Keith D. Mullin", "Lori H. Schwacke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130934.g006", "stats"=>{"downloads"=>0, "page_views"=>171, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hierarchical_cluster_of_probes_mapping_to_the_KEGG_pathway_8220_Metabolism_of_xenobiotics_by_cytochrome_p450_8221_/1464458", "title"=>"Hierarchical cluster of probes mapping to the KEGG pathway “Metabolism of xenobiotics by cytochrome p450”.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-25 04:02:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/2149921"], "description"=>"<p>A. Principal component analysis of 56 males shows complete separation between winter samples (circles) and those from spring (squares) or summer (triangles). B. A significant positive correlation (Spearman rank) exists between PC1 sample scores and ∑POPs in blubber. C. An equivalent negative correlation exists between blubber % lipid and PC1. D. ∑POPs reported on a blubber wet weight basis has the same correlation as lipid normalized ∑POPs.</p>", "links"=>[], "tags"=>["bottlenose dolphin microarray", "Tursiops truncatus", "Common Bottlenose Dolphins", "gene expression profiles", "gene expression", "baseline health parameters", "contaminant exposure", "Deepwater Horizon oil spill", "Remote integument biopsies", "skin gene expression", "cetacean", "II xenobiotic detoxification pathways"], "article_id"=>1464452, "categories"=>["Uncategorised"], "users"=>["Frances M. Van Dolah", "Marion G. Neely", "Lauren E. McGeorge", "Brian C. Balmer", "Gina M. Ylitalo", "Eric S. Zolman", "Todd Speakman", "Carrie Sinclair", "Nicholas M. Kellar", "Patricia E. Rosel", "Keith D. Mullin", "Lori H. Schwacke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0130934.g004", "stats"=>{"downloads"=>6, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Seasonal_Variation_in_the_Skin_Transcriptome_of_Common_Bottlenose_Dolphins_Tursiops_truncatus_Fig_4_from_the_Northern_Gulf_of_Mexico_/1464452", "title"=>"Seasonal Variation in the Skin Transcriptome of Common Bottlenose Dolphins (<i>Tursiops truncatus - Fig 4 </i>) from the Northern Gulf of Mexico", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-25 04:02:21"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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