γδ T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice
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{"title"=>"γδ T cells are required for M2 macrophage polarization and resolution of ozone-induced pulmonary inflammation in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Joel A.", "last_name"=>"Mathews", "scopus_author_id"=>"36680158100"}, {"first_name"=>"David I.", "last_name"=>"Kasahara", "scopus_author_id"=>"6602532998"}, {"first_name"=>"Luiza", "last_name"=>"Ribeiro", "scopus_author_id"=>"56670336200"}, {"first_name"=>"Allison P.", "last_name"=>"Wurmbrand", "scopus_author_id"=>"55200338600"}, {"first_name"=>"Fernanda M.C.", "last_name"=>"Ninin", "scopus_author_id"=>"56153194200"}, {"first_name"=>"Stephanie A.", "last_name"=>"Shore", "scopus_author_id"=>"7101884379"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84940069348", "sgr"=>"84940069348", "doi"=>"10.1371/journal.pone.0131236", "pui"=>"605761497"}, "id"=>"6d29fdd3-3156-376e-a1ce-a64c44966cf7", "link"=>"http://www.mendeley.com/research/%CE%B3%CE%B4-t-cells-required-m2-macrophage-polarization-resolution-ozoneinduced-pulmonary-inflammation-mice", "reader_count"=>6, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Ph. D. Student"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Ph. D. Student"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2160739"], "description"=>"<p>Pulmonary (A) <i>Clec10a</i>, (B) <i>Arg1</i>, (C) <i>Retnla</i>, (D) <i>Il13</i>, <i>and (E) Il17a</i> mRNA abundance in WT and TCRδ<sup>-/-</sup> mice exposed to room air or to ozone (O<sub>3</sub>, 0.3 ppm for 72 h) and then euthanized either immediately or 1 or 3 days after cessation of O<sub>3</sub> exposure. (F) IL-17A<sup>+</sup>γδ were determined by flow cytometry. Note that data from the air and immediately post mice have been previously published [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131236#pone.0131236.ref028\" target=\"_blank\">28</a>] Results are mean ± SE of 4–8 air exposed mice and 6–14 O<sub>3</sub> exposed mice in each group. * p<0.05 versus air; # p<0.05 versus 72 hour O<sub>3</sub>; $ p<0.05 versus WT mice.</p>", "links"=>[], "tags"=>["WT mice", "M 2 genes", "tcr", "bronchoalveolar lavage neutrophils", "il", "Pulmonary mRNA abundance", "ozone exposure", "M 2 macrophage polarization", "γδ T cells", "M 2 polarization", "m 2 macrophages"], "article_id"=>1472301, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Joel A. Mathews", "David I. Kasahara", "Luiza Ribeiro", "Allison P. Wurmbrand", "Fernanda M. C. Ninin", "Stephanie A. Shore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131236.g002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pulmonary_M2_gene_expression_after_cessation_of_O_3_exposure_/1472301", "title"=>"Pulmonary M2 gene expression after cessation of O<sub>3</sub> exposure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-02 03:38:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/2160753"], "description"=>"<p>(A) Total interstitial macrophages, (B) alive macrophages, (C) early apoptotic interstitial macrophages, and (D) late apoptotic interstitial macrophages in lungs of WT and TCRδ<sup>-/-</sup> mice exposed to O<sub>3</sub> for 72 h, and then transferred to room air and studied 3 days later. Results are mean ± SEM for 4–6 mice per group. $ p<0.05 versus WT mice.</p>", "links"=>[], "tags"=>["WT mice", "M 2 genes", "tcr", "bronchoalveolar lavage neutrophils", "il", "Pulmonary mRNA abundance", "ozone exposure", "M 2 macrophage polarization", "γδ T cells", "M 2 polarization", "m 2 macrophages"], "article_id"=>1472315, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Joel A. Mathews", "David I. Kasahara", "Luiza Ribeiro", "Allison P. Wurmbrand", "Fernanda M. C. Ninin", "Stephanie A. Shore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131236.g006", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Macrophages_accumulate_in_the_lungs_of_TCR_mice_/1472315", "title"=>"Macrophages accumulate in the lungs of TCRδ<sup>-/-</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-02 03:38:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/2160746"], "description"=>"<p>WT mice were exposed to either air or O<sub>3</sub> (0.3 ppm for 72 h) and lungs were harvested either immediately or 1 or 3 days after cessation of O<sub>3</sub> exposure. (A) Total macrophages, (B) Alveolar Macrophages, and (C) Interstitial macrophages assessed by flow cytometry. (D) Representative gating for apoptotic macrophages in a WT mouse studied 1 day after cessation of O<sub>3</sub> exposure. (E) Early apoptotic interstitial macrophages and (F) late apoptotic interstitial macrophages in WT mice at various times after cessation of O<sub>3</sub> exposure. Results are mean ± SEM for 4–6 mice per group. * p<0.05 versus air; # p<0.05 versus immediate post.</p>", "links"=>[], "tags"=>["WT mice", "M 2 genes", "tcr", "bronchoalveolar lavage neutrophils", "il", "Pulmonary mRNA abundance", "ozone exposure", "M 2 macrophage polarization", "γδ T cells", "M 2 polarization", "m 2 macrophages"], "article_id"=>1472308, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Joel A. Mathews", "David I. Kasahara", "Luiza Ribeiro", "Allison P. Wurmbrand", "Fernanda M. C. Ninin", "Stephanie A. Shore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131236.g005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lung_apoptotic_macrophages_are_elevated_after_O_3_exposure_/1472308", "title"=>"Lung apoptotic macrophages are elevated after O<sub>3</sub> exposure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-02 03:38:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/2160743"], "description"=>"<p>Bronchoalveolar lavage (BAL) neutrophils (A), macrophages (B), G-CSF (C), MCP-1 in wildtype (WT) and γδ T cell deficient (TCRδ<sup>-/-</sup>) mice exposed to room air or to ozone (O<sub>3</sub>, 0.3 ppm for 72 h) and then euthanized either immediately or 1, 3, or 5 days after cessation of O<sub>3</sub> exposure. Data for the air and immediately post O<sub>3</sub> time points have been previously published [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131236#pone.0131236.ref028\" target=\"_blank\">28</a>]. Results are mean ± SE of 4–8 air exposed mice and 6–14 O<sub>3</sub> exposed mice in each group. * p<0.05 versus air; # p<0.05 versus immediately post O<sub>3</sub>; $ p<0.05 versus WT mice.</p>", "links"=>[], "tags"=>["WT mice", "M 2 genes", "tcr", "bronchoalveolar lavage neutrophils", "il", "Pulmonary mRNA abundance", "ozone exposure", "M 2 macrophage polarization", "γδ T cells", "M 2 polarization", "m 2 macrophages"], "article_id"=>1472305, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Joel A. Mathews", "David I. Kasahara", "Luiza Ribeiro", "Allison P. Wurmbrand", "Fernanda M. C. Ninin", "Stephanie A. Shore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131236.g004", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_O_3_induced_inflammation_in_WT_and_947_948_T_cell_deficient_mice_after_cessation_of_O_3_exposure_/1472305", "title"=>"O<sub>3</sub>-induced inflammation in WT and γδ T cell deficient mice after cessation of O<sub>3</sub> exposure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-02 03:38:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/2160740"], "description"=>"<p>Pulmonary mRNA abundance of (A) <i>Clec10a</i> and (B) <i>Arg1</i> measured as changes in Ct values in lungs from mice treated with IL-17A neutralizing versus isotype control antibody injected i.p. prior to O<sub>3</sub> exposure. Note that an increase in Ct indicates a decrease in expression. Mice were exposed to O<sub>3</sub> for either 48 or 72 h and euthanized immediately after cessation of exposure. Other data from these mice has been previously published [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131236#pone.0131236.ref027\" target=\"_blank\">27</a>,<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131236#pone.0131236.ref028\" target=\"_blank\">28</a>]. (C) As a marker of M1 activation, TNFα was measured in the BAL by ELISA. Results are mean ± SE 5–7 mice in each group. % p<0.05 versus isotype control, as assessed by factorial ANOVA.</p>", "links"=>[], "tags"=>["WT mice", "M 2 genes", "tcr", "bronchoalveolar lavage neutrophils", "il", "Pulmonary mRNA abundance", "ozone exposure", "M 2 macrophage polarization", "γδ T cells", "M 2 polarization", "m 2 macrophages"], "article_id"=>1472302, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Joel A. Mathews", "David I. Kasahara", "Luiza Ribeiro", "Allison P. Wurmbrand", "Fernanda M. C. Ninin", "Stephanie A. Shore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131236.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Blocking_IL_17A_reduces_pulmonary_expression_of_Arg1_and_Clec10a_/1472302", "title"=>"Blocking IL-17A reduces pulmonary expression of <i>Arg1 and Clec10a</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-02 03:38:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/2160737"], "description"=>"<p>WT mice were exposed to either air or O<sub>3</sub> (0.3 ppm) for 24, 48 or 72 hours and euthanized immediately after exposure. (A) Total lung macrophages (F4/80<sup>+</sup> cells) and (B) total lung M2 macrophages (F4/80<sup>+</sup>CD80<sup>-</sup>CD206<sup>+</sup> cells) were measured by flow cytometry. The pulmonary mRNA abundance of M2 markers (C) <i>Arg1</i> (D) <i>Clec10a</i> and (E) <i>Retnla</i> were also assessed by RT-qPCR in WT and TCRδ<sup>-/-</sup> mice exposed to room air or O<sub>3</sub>. Total macrophages (F), M1 macrophages (G) and M2 macrophages (H) were also assessed in WT and TCRδ<sup>-/-</sup> mice exposed to air or O<sub>3</sub> (0.3 ppm for 72 h). (I) BAL TNFα was measured in the BAL by ELISA. Results are mean ± SE of 4–8 air exposed mice and 6–14 O<sub>3</sub> exposed mice in each group. * p<0.05 versus air; # p<0.05 versus WT mice.</p>", "links"=>[], "tags"=>["WT mice", "M 2 genes", "tcr", "bronchoalveolar lavage neutrophils", "il", "Pulmonary mRNA abundance", "ozone exposure", "M 2 macrophage polarization", "γδ T cells", "M 2 polarization", "m 2 macrophages"], "article_id"=>1472299, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Joel A. Mathews", "David I. Kasahara", "Luiza Ribeiro", "Allison P. Wurmbrand", "Fernanda M. C. Ninin", "Stephanie A. Shore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131236.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Induction_of_M2_macrophage_by_subacute_O_3_exposure_is_reduced_in_TCR_948_mice_/1472299", "title"=>"Induction of M2 macrophage by subacute O<sub>3</sub> exposure is reduced in TCRδ<sup>-/-</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-02 03:38:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/2160754"], "description"=>"<p>(A) pulmonary <i>Cldn4</i> mRNA abundance, (B) BAL protein, and (C) terminal bronchiolar lesions, scored as explained in the methods. Results are mean ± SE of 4–8 air exposed mice and 6–14 O<sub>3</sub> exposed mice in each group. * p<0.05 versus air; # p<0.05 versus immediate post O<sub>3</sub>; $ p<0.05 versus WT mice.</p>", "links"=>[], "tags"=>["WT mice", "M 2 genes", "tcr", "bronchoalveolar lavage neutrophils", "il", "Pulmonary mRNA abundance", "ozone exposure", "M 2 macrophage polarization", "γδ T cells", "M 2 polarization", "m 2 macrophages"], "article_id"=>1472316, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Joel A. Mathews", "David I. Kasahara", "Luiza Ribeiro", "Allison P. Wurmbrand", "Fernanda M. C. Ninin", "Stephanie A. Shore"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131236.g007", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_O_3_induced_injury_/1472316", "title"=>"O<sub>3</sub> induced injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-02 03:38:17"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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