Human Leukocyte Antigen DQB1 (HLA-DQB1) Polymorphisms and the Risk for Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis
- Publication Date
- July 23, 2015
- Journal
- PLOS ONE
- Authors
- Peng Peng Jin, Li Li Sun, Bo Jun Ding, Na Qin, et al
- Volume
- 10
- Issue
- 7
- Pages
- e0131374
- DOI
- https://dx.plos.org/10.1371/journal.pone.0131374
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0131374
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/26204120
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512729
- Europe PMC
- http://europepmc.org/abstract/MED/26204120
- Web of Science
- 000358621000002
- Scopus
- 84941767053
- Mendeley
- http://www.mendeley.com/research/human-leukocyte-antigen-dqb1-hladqb1-polymorphisms-risk-guillainbarr%C3%A9-syndrome-systematic-review-met
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Mendeley | Further Information
{"title"=>"Human Leukocyte Antigen DQB1 (HLA-DQB1) Polymorphisms and the Risk for Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Peng-Peng", "last_name"=>"Jin"}, {"first_name"=>"Li-Li", "last_name"=>"Sun"}, {"first_name"=>"Bo-Jun", "last_name"=>"Ding"}, {"first_name"=>"Na", "last_name"=>"Qin"}, {"first_name"=>"Bin", "last_name"=>"Zhou"}, {"first_name"=>"Feng", "last_name"=>"Xia"}, {"first_name"=>"Li", "last_name"=>"Li"}, {"first_name"=>"Li-Juan", "last_name"=>"Liu"}, {"first_name"=>"Xue-Dong", "last_name"=>"Liu"}, {"first_name"=>"Gang", "last_name"=>"Zhao"}, {"first_name"=>"Wen", "last_name"=>"Wang"}, {"first_name"=>"Yan-Chun", "last_name"=>"Deng"}, {"first_name"=>"Shuang-Xing", "last_name"=>"Hou"}], "year"=>2015, "source"=>"PLOS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0131374", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"26204120"}, "id"=>"db2d10e9-0b27-3de1-881d-1663fb0da7bc", "abstract"=>"Guillain-Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. There is no consensus regarding reported associations between human leukocyte antigen DQB1 (HLA-DQB1) polymorphisms and the risk for developing GBS. Here, we evaluated possible associations between HLA-DQB1 polymorphisms and the risk for GBS using a meta-analysis. We searched PubMed for case-control genetic association studies for HLA-DQB1 polymorphisms (*020x, *030x, *040x, *050x, and *060x) and the risk for GBS. Fixed-effect meta-analytical methods were used for the outcome measure and subgroup analyses. Estimated odds ratios (ORs) and 95% confidence intervals (CIs) were used to investigate the associations between HLA-DQB1 polymorphisms and the risk for GBS. Nine case-control studies involving 780 cases of GBS and 1353 controls were identified in the current study. The meta-analysis demonstrated no significant associations between HLA-DQB1 polymorphisms and the risk for GBS in Asian and Caucasian populations. There were two associations that approached significance: HLA-DQB1*030x in Asian patients (P = 0.07; OR: 0.76, 95% CI: 0.57-1.03) and HLA-DQB1*060x in all patients (P = 0.08; OR: 1.48, 95% CI: 0.96-2.29). Additional studies with larger sample sizes are required to establish a definitive assessment of the contribution of HLA-DQB1 polymorphisms to GBS risk.", "link"=>"http://www.mendeley.com/research/human-leukocyte-antigen-dqb1-hladqb1-polymorphisms-risk-guillainbarr%C3%A9-syndrome-systematic-review-met", "reader_count"=>12, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>4, "Student > Bachelor"=>3, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>4, "Student > Bachelor"=>3, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>3, "Economics, Econometrics and Finance"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}CrossRef
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- http://doi.org/10.1007/s12035-017-0635-y
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Scopus | Further Information
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Relative Metric
{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}Loading … 

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