High Intensity Interval Training (HIIT) Induces Specific Changes in Respiration and Electron Leakage in the Mitochondria of Different Rat Skeletal Muscles
Publication Date
June 29, 2015
Journal
PLOS ONE
Authors
Dionizio Ramos Filho, Gustavo Chicaybam, Eduardo De Souza Ferreira, Camila Guerra Martinez, et al
Volume
10
Issue
6
Pages
e0131766
DOI
https://dx.plos.org/10.1371/journal.pone.0131766
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0131766
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26121248
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488295
Europe PMC
http://europepmc.org/abstract/MED/26121248
Web of Science
000358150400155
Scopus
84938687110
Mendeley
http://www.mendeley.com/research/high-intensity-interval-training-hiit-induces-specific-changes-respiration-electron-leakage-mitochon
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Mendeley | Further Information

{"title"=>"High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles", "type"=>"journal", "authors"=>[{"first_name"=>"Dionizio", "last_name"=>"Ramos-Filho", "scopus_author_id"=>"56766243200"}, {"first_name"=>"Gustavo", "last_name"=>"Chicaybam", "scopus_author_id"=>"37009531600"}, {"first_name"=>"Eduardo", "last_name"=>"De-Souza-Ferreira", "scopus_author_id"=>"56685576200"}, {"first_name"=>"Camila Guerra", "last_name"=>"Martinez", "scopus_author_id"=>"51764154300"}, {"first_name"=>"Eleonora", "last_name"=>"Kurtenbach", "scopus_author_id"=>"6602706141"}, {"first_name"=>"Gustavo", "last_name"=>"Casimiro-Lopes", "scopus_author_id"=>"25521361700"}, {"first_name"=>"Antonio", "last_name"=>"Galina", "scopus_author_id"=>"6701330098"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84938687110", "sgr"=>"84938687110", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0131766", "pmid"=>"26121248", "pui"=>"605481273"}, "id"=>"b8158aa4-31e4-3826-bb3a-c071a1b35506", "abstract"=>"High intensity interval training (HIIT) is characterized by vigorous exercise with short rest intervals. Hydrogen peroxide (H2O2) plays a key role in muscle adaptation. This study aimed to evaluate whether HIIT promotes similar H2O2 formation via O2 consumption (electron leakage) in three skeletal muscles with different twitch characteristics. Rats were assigned to two groups: sedentary (n=10) and HIIT (n=10, swimming training). We collected the tibialis anterior (TA-fast), gastrocnemius (GAST-fast/slow) and soleus (SOL-slow) muscles. The fibers were analyzed for mitochondrial respiration, H2O2 production and citrate synthase (CS) activity. A multi-substrate (glycerol phosphate (G3P), pyruvate, malate, glutamate and succinate) approach was used to analyze the mitochondria in permeabilized fibers. Compared to the control group, oxygen flow coupled to ATP synthesis, complex I and complex II was higher in the TA of the HIIT group by 1.5-, 3.0- and 2.7-fold, respectively. In contrast, oxygen consumed by mitochondrial glycerol phosphate dehydrogenase (mGPdH) was 30% lower. Surprisingly, the oxygen flow coupled to ATP synthesis was 42% lower after HIIT in the SOL. Moreover, oxygen flow coupled to ATP synthesis and complex II was higher by 1.4- and 2.7-fold in the GAST of the HIIT group. After HIIT, CS activity increased 1.3-fold in the TA, and H2O2 production was 1.3-fold higher in the TA at sites containing mGPdH. No significant differences in H2O2 production were detected in the SOL. Surprisingly, HIIT increased H2O2 production in the GAST via complex II, phosphorylation, oligomycin and antimycin by 1.6-, 1.8-, 2.2-, and 2.2-fold, respectively. Electron leakage was 3.3-fold higher in the TA with G3P and 1.8-fold higher in the GAST with multiple substrates. Unexpectedly, the HIIT protocol induced different respiration and electron leakage responses in different types of muscle.", "link"=>"http://www.mendeley.com/research/high-intensity-interval-training-hiit-induces-specific-changes-respiration-electron-leakage-mitochon", "reader_count"=>45, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>11, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>11, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>7, "Sports and Recreations"=>17, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Sports and Recreations"=>{"Sports and Recreations"=>17}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Brazil"=>1, "United Kingdom"=>2}, "group_count"=>5}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2155587"], "description"=>"<p>(A and B) Tibialis anterior. (C and D) Gastrocnemius. (E and F) Soleus. 1, G3P (10 mM); 2, PMG (5:5:10 mM); 3, Succ (10 mM); 4, ADP (2.5 mM); 5, Oligo (2 μg/ml); 6, FCCP (1 μM); 7, ROT (1.0 μM); 8, MALO (10 mM); 9, KCN (5 mM). Black (HIIT); gray (SED).</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468238, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.g001", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Oxygen_depletion_by_different_skeletal_muscles_using_multiple_substrates_A_C_and_E_or_glycerol_phosphate_only_B_D_and_F_/1468238", "title"=>"Oxygen depletion by different skeletal muscles using multiple substrates (A, C and E) or glycerol phosphate only (B, D and F).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155588"], "description"=>"<p>(A and B) Tibialis Anterior. (C and D) Gastrocnemius. (E and F) Soleus. 1, G3P (10 mM); 2, PMG (5:5:10 mM); 3, Succ (10 mM); 4, ADP (2.5 mM); 5, CYT C (10 μM); 6, Oligo (2 μg/ml); 7, FCCP (1 μM); 8, ROT (1.0 μM); 9, MALO (10 mM); 10, KCN (5 mM). Black (HIIT); grey (SED). The data are expressed as the mean ± standard error. *p<0.05, HIIT vs SED. The number of individual experiments is in parentheses.</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468239, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.g002", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Oxygen_flux_in_high_resolution_respirometry_experiments_per_fiber_mass_/1468239", "title"=>"Oxygen flux in high-resolution respirometry experiments per fiber mass.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155589"], "description"=>"<p>(A and B) Tibialis anterior. (C and D) Gastrocnemius. (E and F) Soleus. 1, G3P (10 mM); 2, PMG (5;5;10 mM); 3, Succ (10 mM); 4 ADP (2.5 mM); 5, CYT C (10 μM); 6, Oligo (2 μg/ml); 7, FCCP (1 μM); 8, ROT (1.0 μM); 9, MALO (10 mM); 10, KCN (5 mM). Black (HIIT); gray (SED). The data are expressed as the mean ± standard error. *p<0.05, HIIT vs SED. The number of individual experiments is shown in parentheses.</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468240, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.g003", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Citrate_synthase_CS_activity_and_oxygen_flux_in_respirometry_experiments_normalized_to_CS_activity_/1468240", "title"=>"Citrate synthase (CS) activity and oxygen flux in respirometry experiments normalized to CS activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155590"], "description"=>"<p>Western Blots (A, B and C) for the tibialis anterior, (D, E and F) gastrocnemius, and (G, H and I) soleus. GAPDH was used as the loading control. The data are expressed as the mean ± standard error. *p<0.05, SED vs HIIT. n = 3 for the blot quantification for both the SED and HIIT groups.</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468241, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.g004", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_complex_V_content_Western_blot_and_ATP_synthesis_capacity_oligomycin_sensitive_O_2_consumption_among_the_three_muscles_/1468241", "title"=>"Comparison of complex V content (Western blot) and ATP synthesis capacity (oligomycin-sensitive O<sub>2</sub> consumption) among the three muscles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155591"], "description"=>"<p>Oxygen flux in mitochondria oxidizing glycerol phosphate (A) in the non-phosphorylated state (non-p-state) and phosphorylated state (p-state) in the tibialis anterior and gastrocnemius, normalized to CS activity. The same experimental protocol was performed using palmitoyl carnitine (B) as a substrate in the tibialis anterior and gastrocnemius with normalization to CS activity. Tibialis Anterior: white (SED) and black (HIIT). Gastrocnemius: light gray (SED) and dark gray (HIIT). The data are expressed as the mean ± standard error. *p<0.05, HIIT vs SED. The number of individual experiments (n) is shown based on 5 rats per group.</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468242, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.g005", "stats"=>{"downloads"=>0, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_High_Intensity_Interval_Training_HIIT_Induces_Specific_Changes_in_Respiration_and_Electron_Leakage_in_the_Mitochondria_of_Different_Rat_Skeletal_Muscles_Fig_5_/1468242", "title"=>"High Intensity Interval Training (HIIT) Induces Specific Changes in Respiration and Electron Leakage in the Mitochondria of Different Rat Skeletal Muscles - Fig 5", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155592"], "description"=>"<p>Tibialis anterior (F) (A and B), gastrocnemius (F/S) (C and D) and soleus (S) (E and F) normalized to wet weight (mg) or citrate synthase. 1, Basal; 2, G3P (10 mM); 3, PMG (5:5:10 mM); 4, Succ (10 mM); 5, ADP (2.5 mM); 6, Oligo (2 μg/ml); 7, FCCP (1 μM); 8, Ant A (5 μM). Black (HIIT); grey (SED). The data are presented as the mean ± standard error. *p<0.05, HIIT vs SED. The number of individual experiments (n) is shown; 5 rats were included in each group.</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468243, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.g006", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hydrogen_peroxide_production_using_multiple_titrations_/1468243", "title"=>"Hydrogen peroxide production using multiple titrations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155593"], "description"=>"<p>Tibialis anterior: white, SED; black, HIIT. Gastrocnemius: light gray, SED; dark gray, HIIT. The data are expressed as the mean ± standard error. *p<0.05, HIIT vs SED. The number of individual experiments (n) is shown; 5 rats were included in each group.</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468244, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.g007", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hydrogen_peroxide_production_by_oxidizing_glycerol_phosphate_A_or_palmitoylcarnitine_B_as_unique_substrates_in_the_tibialis_anterior_and_gastrocnemius_after_normalization_to_CS_/1468244", "title"=>"Hydrogen peroxide production by oxidizing glycerol phosphate (A) or palmitoylcarnitine (B) as unique substrates in the tibialis anterior and gastrocnemius after normalization to CS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155594"], "description"=>"<p>(A) O<sub>2</sub> flux. (B) H<sub>2</sub>O<sub>2</sub> production. (C) Electron leakage from oxidizing G3P. (D) O<sub>2</sub> flux. (E) H<sub>2</sub>O<sub>2</sub> production. (F) Electron leakage from oxidizing multiple substrates (G3P/PMG/Succ). The data are expressed as the mean ± standard error. *p<0.05, HIIT vs controls. The number of individual experiments (n) is shown based on 5 rats per group. Black (HIIT); white (SED).</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468245, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.g008", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_O_2_flux_normalized_to_CS_H_2_O_2_production_normalized_to_CS_and_electron_leakage_in_the_presence_of_G3P_or_multiple_substrates_G3P_PMG_Succ_for_the_three_muscles_/1468245", "title"=>"O<sub>2</sub> flux normalized to CS, H<sub>2</sub>O<sub>2</sub> production normalized to CS, and electron leakage in the presence of G3P or multiple substrates (G3P/PMG/Succ) for the three muscles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155595"], "description"=>"<p>The number of animals is shown in parentheses. The data are expressed as the mean ± standard error. NS: not statistically significant.</p><p>* p<0.05 vs controls.</p><p>Maximal Endurance Test (s), body weight, visceral fat, visceral fat percentage, and muscle weight in rats subjected to chronic high-intensity training (HIIT) over 6 weeks.</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468246, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Maximal_Endurance_Test_s_body_weight_visceral_fat_visceral_fat_percentage_and_muscle_weight_in_rats_subjected_to_chronic_high_intensity_training_HIIT_over_6_weeks_/1468246", "title"=>"Maximal Endurance Test (s), body weight, visceral fat, visceral fat percentage, and muscle weight in rats subjected to chronic high-intensity training (HIIT) over 6 weeks.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-29 04:30:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/2155596"], "description"=>"<p>The number of individual experiments is shown in parentheses. The data are expressed as the mean ± standard error.</p><p>* p<0.05 vs control.</p><p>Mitochondrial adaptations evaluated via O<sub>2</sub> consumption induced by G3P/P/MG/Succ in tibialis anterior (F), gastrocnemius (F/S) and soleus (S) skeletal muscle fibers (pmol O<sub>2</sub>/s<sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131766#t002fn002\" target=\"_blank\">*</a></sup>mg wet weight).</p>", "links"=>[], "tags"=>["electron leakage responses", "Muscles High intensity interval training", "gast", "HIIT group", "G 3P pyruvate", "High Intensity Interval Training", "cs", "O 2 consumption", "H 2O production", "sol", "mitochondrial glycerol phosphate dehydrogenase", "ta", "electron leakage", "ATP synthesis", "oxygen flow", "H 2O formation"], "article_id"=>1468247, "categories"=>["Uncategorised"], "users"=>["Dionizio Ramos-Filho", "Gustavo Chicaybam", "Eduardo de-Souza-Ferreira", "Camila Guerra Martinez", "Eleonora Kurtenbach", "Gustavo Casimiro-Lopes", "Antonio Galina"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131766.t002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mitochondrial_adaptations_evaluated_via_O_2_consumption_induced_by_G3P_P_MG_Succ_in_tibialis_anterior_F_gastrocnemius_F_S_and_soleus_S_skeletal_muscle_fibers_pmol_O_2_s_mg_wet_weight_/1468247", "title"=>"Mitochondrial adaptations evaluated via O<sub>2</sub> consumption induced by G3P/P/MG/Succ in tibialis anterior (F), gastrocnemius (F/S) and soleus (S) skeletal muscle fibers (pmol O<sub>2</sub>/s<sup>*</sup>mg wet weight).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-06-29 04:30:59"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"69", "full-text"=>"77", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"65", "full-text"=>"71", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"31", "full-text"=>"33", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"58", "full-text"=>"59", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"54", "full-text"=>"52", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"48", "full-text"=>"49", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"27", "full-text"=>"32", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"43", "full-text"=>"40", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"37", "full-text"=>"44", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"38", "full-text"=>"50", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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