Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice
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{"title"=>"Alterations in hippocampal oxidative stress, expression of AMPA receptor GluR2 subunit and associated spatial memory loss by Bacopa monnieri extract (CDRI-08) in streptozotocin-induced diabetes mellitus type 2 mice", "type"=>"journal", "authors"=>[{"first_name"=>"Surya P.", "last_name"=>"Pandey", "scopus_author_id"=>"57199920036"}, {"first_name"=>"Hemant K.", "last_name"=>"Singh", "scopus_author_id"=>"35450235300"}, {"first_name"=>"S.", "last_name"=>"Prasad", "scopus_author_id"=>"16213084600"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84941286838", "pmid"=>"26161865", "doi"=>"10.1371/journal.pone.0131862", "pui"=>"605952217", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84941286838"}, "id"=>"b2c35fdd-d149-329f-b0a3-71203001f508", "abstract"=>"Bacopa monnieri extract has been implicated in the recovery of memory impairments due to various neurological disorders in animal models and humans. However, the precise molecular mechanism of the role of CDRI-08, a well characterized fraction of Bacopa monnieri extract, in recovery of the diabetes mellitus-induced memory impairments is not known. Here, we demonstrate that DM2 mice treated orally with lower dose of CDRI-08 (50- or 100 mg/kg BW) is able to significantly enhance spatial memory in STZ-DM2 mice and this is correlated with a significant decline in oxidative stress and up regulation of the AMPA receptor GluR2 subunit gene expression in the hippocampus. Treatment of DM2 mice with its higher dose (150 mg/kg BW or above) shows anti-diabetic effect in addition to its ability to recover the spatial memory impairment by reversing the DM2-induced elevated oxidative stress and decreased GluR2 subunit expression near to their values in normal and CDRI-08 treated control mice. Our results provide evidences towards molecular basis of the memory enhancing and anti diabetic role of the Bacopa monnieri extract in STZ-induced DM2 mice, which may have therapeutic implications.", "link"=>"http://www.mendeley.com/research/alterations-hippocampal-oxidative-stress-expression-ampa-receptor-glur2-subunit-associated-spatial-m", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>2, "Design"=>1, "Neuroscience"=>4, "Arts and Humanities"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Psychology"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>4}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2171390"], "description"=>"<p>Association analysis related values are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131862#pone.0131862.s003\" target=\"_blank\">S2 Table</a>.</p>", "links"=>[], "tags"=>["AMPA receptor GluR 2 subunit gene expression", "dose", "bw", "GluR 2 subunit expression", "Bacopa monnieri Extract", "Hippocampal Oxidative Stress", "mg", "oxidative stress", "DM 2 mice", "recovery", "role", "impairment", "Bacopa monnieri", "cdri", "AMPA Receptor GluR 2 Subunit"], "article_id"=>1479885, "categories"=>["Biological Sciences"], "users"=>["Surya P. Pandey", "Hemant K. Singh", "S. Prasad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131862.g007", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_association_analysis_between_CDRI_08_dose_dependent_alterations_in_spatial_memory_performance_escape_latency_and_oxidative_stress_MDA_level_in_normal_control_and_in_DM2_mice_A_and_GluR2_subunit_protein_and_transcript_levels_in_normal_control_/1479885", "title"=>"Correlation/association analysis between CDRI-08 dose-dependent alterations in spatial memory performance (escape latency) and oxidative stress (MDA level) in normal control and in DM2 mice (A) and GluR2 subunit protein and transcript levels in normal control and DM2 mice (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 04:28:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171386"], "description"=>"<p>Bar values represent mean RDV ± SEM. Cont, Control; STZ, Streptozotocin treated; BR, CDRI-08 treated (figures indicate CDRI-08 dose in mg/kg BW of mice; * denotes comparison between experimental groups and control; ¥ denotes comparison between STZ- treated (diabetic) mice. *, # & ¥ denote <i>P</i><0.05).</p>", "links"=>[], "tags"=>["AMPA receptor GluR 2 subunit gene expression", "dose", "bw", "GluR 2 subunit expression", "Bacopa monnieri Extract", "Hippocampal Oxidative Stress", "mg", "oxidative stress", "DM 2 mice", "recovery", "role", "impairment", "Bacopa monnieri", "cdri", "AMPA Receptor GluR 2 Subunit"], "article_id"=>1479881, "categories"=>["Biological Sciences"], "users"=>["Surya P. Pandey", "Hemant K. Singh", "S. Prasad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131862.g004", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blot_analysis_of_CDRI_08_effects_on_the_expression_of_GluR2_subunit_protein_in_the_hippocampus_of_normal_control_and_DM2_mice_/1479881", "title"=>"Western blot analysis of CDRI-08 effects on the expression of GluR2 subunit protein in the hippocampus of normal control and DM2 mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 04:28:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171384"], "description"=>"<p>Bar values represent mean ± SEM. Cont., Control; STZ, Streptozotocin treated; BR, CDRI-08 treated (figures indicate CDRI-08 dose in mg/kg BW of mice; Cont, Control; STZ, Streptozotocin treated; BE, CDRI-08 treated (figures indicate dose in mg/kg BW of mice; * denotes comparison within groups of control and different dose of CDRI-08 alone; ¥ denotes comparison within groups of DM2 and CDRI-08 treated DM2 mice; # denotes comparison between same dose of CDRI-08 in normal and DM2. *, # & ¥ denote <i>P</i><0.05).</p>", "links"=>[], "tags"=>["AMPA receptor GluR 2 subunit gene expression", "dose", "bw", "GluR 2 subunit expression", "Bacopa monnieri Extract", "Hippocampal Oxidative Stress", "mg", "oxidative stress", "DM 2 mice", "recovery", "role", "impairment", "Bacopa monnieri", "cdri", "AMPA Receptor GluR 2 Subunit"], "article_id"=>1479879, "categories"=>["Biological Sciences"], "users"=>["Surya P. Pandey", "Hemant K. Singh", "S. Prasad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131862.g003", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CDRI_08_on_the_level_of_MDA_in_hippocampus_of_normal_and_CDRI_08control_and_DM2_mice_/1479879", "title"=>"Effects of CDRI-08 on the level of MDA in hippocampus of normal and CDRI-08control and DM2 mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 04:28:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171383"], "description"=>"<p>A) Track path of mice in Morris-water- maze pool; B) Escape latency (Sec). Bar values represent mean ± SEM. Cont, Control; STZ, Streptozotocin-treated; BR, CDRI-08 treated (figures indicate CDRI-08 dose in mg/kg BW of mice; * denotes comparison within groups of control and different dose of CDRI-08 alone. ¥ denotes comparison within groups of DM2 and CDRI-08 treated DM2 mice; # denotes comparison between same dose of CDRI-08 in normal and DM2. *, # & ¥ denote <i>P</i><0.05).</p>", "links"=>[], "tags"=>["AMPA receptor GluR 2 subunit gene expression", "dose", "bw", "GluR 2 subunit expression", "Bacopa monnieri Extract", "Hippocampal Oxidative Stress", "mg", "oxidative stress", "DM 2 mice", "recovery", "role", "impairment", "Bacopa monnieri", "cdri", "AMPA Receptor GluR 2 Subunit"], "article_id"=>1479878, "categories"=>["Biological Sciences"], "users"=>["Surya P. Pandey", "Hemant K. Singh", "S. Prasad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131862.g002", "stats"=>{"downloads"=>3, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CDRI_08_on_the_spatial_memory_in_normal_and_CDRI_08_control_and_DM2_mice_/1479878", "title"=>"Effects of CDRI-08 on the spatial memory in normal and CDRI-08 control and DM2 mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 04:28:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171391", "https://ndownloader.figshare.com/files/2171392", "https://ndownloader.figshare.com/files/2171393"], "description"=>"<div><p><i>Bacopa monnieri</i> extract has been implicated in the recovery of memory impairments due to various neurological disorders in animal models and humans. However, the precise molecular mechanism of the role of CDRI-08, a well characterized fraction of <i>Bacopa monnieri</i> extract, in recovery of the diabetes mellitus-induced memory impairments is not known. Here, we demonstrate that DM2 mice treated orally with lower dose of CDRI-08 (50- or 100 mg/kg BW) is able to significantly enhance spatial memory in STZ-DM2 mice and this is correlated with a significant decline in oxidative stress and up regulation of the AMPA receptor GluR2 subunit gene expression in the hippocampus. Treatment of DM2 mice with its higher dose (150 mg/kg BW or above) shows anti-diabetic effect in addition to its ability to recover the spatial memory impairment by reversing the DM2-induced elevated oxidative stress and decreased GluR2 subunit expression near to their values in normal and CDRI-08 treated control mice. Our results provide evidences towards molecular basis of the memory enhancing and anti diabetic role of the <i>Bacopa monnieri</i> extract in STZ-induced DM2 mice, which may have therapeutic implications.</p></div>", "links"=>[], "tags"=>["AMPA receptor GluR 2 subunit gene expression", "dose", "bw", "GluR 2 subunit expression", "Bacopa monnieri Extract", "Hippocampal Oxidative Stress", "mg", "oxidative stress", "DM 2 mice", "recovery", "role", "impairment", "Bacopa monnieri", "cdri", "AMPA Receptor GluR 2 Subunit"], "article_id"=>1479886, "categories"=>["Biological Sciences"], "users"=>["Surya P. Pandey", "Hemant K. Singh", "S. Prasad"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0131862.s001", "https://dx.doi.org/10.1371/journal.pone.0131862.s002", "https://dx.doi.org/10.1371/journal.pone.0131862.s003"], "stats"=>{"downloads"=>9, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Alterations_in_Hippocampal_Oxidative_Stress_Expression_of_AMPA_Receptor_GluR2_Subunit_and_Associated_Spatial_Memory_Loss_by_Bacopa_monnieri_Extract_CDRI_08_in_Streptozotocin_Induced_Diabetes_Mellitus_Type_2_Mice/1479886", "title"=>"Alterations in Hippocampal Oxidative Stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by <i>Bacopa monnieri</i> Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-07-10 04:28:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171388"], "description"=>"<p>A) Photomicrograph showing immunoflorescence signal of GluR2 subunit in CA1 and CA3 regions of hippocampus, Bar diagram showing FITC signal intensity in B) CA1 and C) CA3 hippocampal regions, separately. Bar values represent mean ± SEM. Cont., Control; STZ, STZ-treated; BR, CDRI-08 treated (figures indicate CDRI-08 dose in mg/kg BW of mice; Cont, Control; STZ, STZ-treated; BR, CDRI-08 treated (figures indicate CDRI-08 dose in mg/kg BW of mice; * denotes comparison within groups of control and different dose of CDRI-08 alone; ¥ denotes comparison within groups of DM2 and CDRI-08 treated DM2 mice; # denotes comparison between same dose of CDRI-08 in normal and DM2*, # & ¥ denote <i>P</i><0.05), Scale bar = 100μ.</p>", "links"=>[], "tags"=>["AMPA receptor GluR 2 subunit gene expression", "dose", "bw", "GluR 2 subunit expression", "Bacopa monnieri Extract", "Hippocampal Oxidative Stress", "mg", "oxidative stress", "DM 2 mice", "recovery", "role", "impairment", "Bacopa monnieri", "cdri", "AMPA Receptor GluR 2 Subunit"], "article_id"=>1479883, "categories"=>["Biological Sciences"], "users"=>["Surya P. Pandey", "Hemant K. Singh", "S. Prasad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131862.g006", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunofluorescence_analysis_of_the_effects_of_CDRI_08_on_expression_of_the_GluR2_subunit_protein_in_hippocampus_area_CA1_and_CA3_of_normal_and_DM2_mice_/1479883", "title"=>"Immunofluorescence analysis of the effects of CDRI-08 on expression of the GluR2 subunit protein in hippocampus area CA1 and CA3 of normal and DM2 mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 04:28:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171387"], "description"=>"<p>Bar values represent mean RDV ± SEM. Cont, Control; STZ, Streptozotocin treated; BR, CDRI-08 treated (figures indicate CDRI-08 dose in mg/kg BW of mice; * denotes comparison between experimental groups and control; ¥ denotes comparison between STZ- treated (diabetic) mice. *, # & ¥ denote <i>P</i><0.05).</p>", "links"=>[], "tags"=>["AMPA receptor GluR 2 subunit gene expression", "dose", "bw", "GluR 2 subunit expression", "Bacopa monnieri Extract", "Hippocampal Oxidative Stress", "mg", "oxidative stress", "DM 2 mice", "recovery", "role", "impairment", "Bacopa monnieri", "cdri", "AMPA Receptor GluR 2 Subunit"], "article_id"=>1479882, "categories"=>["Biological Sciences"], "users"=>["Surya P. Pandey", "Hemant K. Singh", "S. Prasad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131862.g005", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Semi_quantitative_RT_PCR_analysis_of_effects_of_CDRI_08_on_expression_of_GluR2_subunit_transcript_in_hippocampus_of_the_normal_control_and_DM2_mice_/1479882", "title"=>"Semi quantitative RT-PCR analysis of effects of CDRI-08 on expression of GluR2 subunit transcript in hippocampus of the normal control and DM2 mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 04:28:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171382"], "description"=>"<p>A) Body weight (g/mouse); B) Serum insulin (μIU/ml); C) Insulin resistance (HOMA-IR); D) Blood glucose content (mg/1dL);E) Water consumption (ml/mouse/day) and F) Urine discharge (ml/mouse/day). Bar values represent mean ± SEM. Cont, Control; STZ, Streptozotocin treated; BR, CDRI-08 treated (figures on the x axis indicate CDRI-08 dose in mg/kg BW of mice; * denotes comparison within groups of control and different dose of CDRI-08 alone; ¥ denotes comparison within groups of DM2 and CDRI-08 treated DM2 mice; # denotes comparison between same dose of CDRI-08 in normal and DM2. *, # & ¥ denote <i>P</i><0.05).Details of fasting serum insulin and glucose content and the corresponding HOMA-IR data are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131862#pone.0131862.s002\" target=\"_blank\">S1 Table</a>.</p>", "links"=>[], "tags"=>["AMPA receptor GluR 2 subunit gene expression", "dose", "bw", "GluR 2 subunit expression", "Bacopa monnieri Extract", "Hippocampal Oxidative Stress", "mg", "oxidative stress", "DM 2 mice", "recovery", "role", "impairment", "Bacopa monnieri", "cdri", "AMPA Receptor GluR 2 Subunit"], "article_id"=>1479877, "categories"=>["Biological Sciences"], "users"=>["Surya P. Pandey", "Hemant K. Singh", "S. Prasad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0131862.g001", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CDRI_08_on_diabetic_parameters_in_normal_and_CDRI_08_control_and_DM2_mice_/1479877", "title"=>"Effects of CDRI-08 on diabetic parameters in normal and CDRI-08 control and DM2 mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 04:28:15"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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