Diaphragm Repair with a Novel Cross-Linked Collagen Biomaterial in a Growing Rabbit Model
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Mendeley | Further Information

{"title"=>"Diaphragm repair with a novel cross-linked collagen biomaterial in a growing rabbit model", "type"=>"journal", "authors"=>[{"first_name"=>"Steffi", "last_name"=>"Mayer", "scopus_author_id"=>"24491318600"}, {"first_name"=>"Herbert", "last_name"=>"Decaluwe", "scopus_author_id"=>"6505875791"}, {"first_name"=>"Michele", "last_name"=>"Ruol", "scopus_author_id"=>"57193820778"}, {"first_name"=>"Stefano", "last_name"=>"Manodoro", "scopus_author_id"=>"36451872300"}, {"first_name"=>"Manuel", "last_name"=>"Kramer", "scopus_author_id"=>"56799677600"}, {"first_name"=>"Holger", "last_name"=>"Till", "scopus_author_id"=>"55334722700"}, {"first_name"=>"Jan", "last_name"=>"Deprest", "scopus_author_id"=>"7006218373"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84940069428", "sgr"=>"84940069428", "pui"=>"605749893", "pmid"=>"26147985", "doi"=>"10.1371/journal.pone.0132021"}, "id"=>"4889318a-509d-3f63-bd19-e76a6c993661", "abstract"=>"BACKGROUND: Neonates with congenital diaphragmatic hernia and large defects often require patch closure. Acellular collagen matrices (ACM) have been suggested as an alternative to synthetic durable patches as they are remodeled by the host or could also be used for tissue engineering purposes.\\n\\nMATERIALS AND METHODS: 2.0x1.0 cm diaphragmatic defects were created in 6-weeks old New-Zealand white rabbits. We compared reconstruction with a purpose-designed cross-linked ACM (Matricel) to 4-layer non-cross-linked small intestinal submucosa (SIS) and a 1-layer synthetic Dual Mesh (Gore-Tex). Unoperated animals or animals undergoing primary closure (4/0 polyglecaprone) served as age-matched controls. 60 (n = 25) resp. 90 (n = 17) days later, animals underwent chest x-ray and obduction for gross examination of explants, scoring of adhesion and inflammatory response. Also, uniaxial tensiometry was done, comparing explants to contralateral native diaphragmatic tissue.\\n\\nRESULTS: Overall weight nearly doubled from 1,554±242 g at surgery to 2,837±265 g at obduction (+84%). X-rays did show rare elevation of the left diaphragm (SIS = 1, Gore-Tex = 1, unoperated control = 1), but no herniation of abdominal organs. 56% of SIS and 10% of Matricel patches degraded with visceral bulging in four (SIS = 3, Matricel = 1). Adhesion scores were limited: 0.5 (Matricel) to 1 (SIS, Gore-Tex) to the left lung (p = 0.008) and 2.5 (Gore-Tex), 3 (SIS) and 4 (Matricel) to the liver (p<0.0001). Tensiometry revealed a reduced bursting strength but normal compliance for SIS. Compliance was reduced in Matricel and Gore-Tex (p<0.01). Inflammatory response was characterized by a more polymorphonuclear cell (SIS) resp. macrophage (Matricel) type of infiltrate (p<0.05). Fibrosis was similar for all groups, except there was less mature collagen deposited to Gore-Tex implants (p<0.05).\\n\\nCONCLUSIONS: Matricel induced a macrophage-dominated inflammatory response, more adhesions, had appropriate strength but a lesser compliance compared to native tissue. The herein investigated ACM is not a viable option for CDH repair.", "link"=>"http://www.mendeley.com/research/diaphragm-repair-novel-crosslinked-collagen-biomaterial-growing-rabbit-model", "reader_count"=>14, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>6, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2164876"], "description"=>"<p>Unoperated control (d90; A), left-convex scoliosis, postoperative changes of the 9<sup>th</sup> and 10<sup>th</sup> left rib (SIS d90; B), discrete elevation of the left diaphragm (SIS d60; C), and discrete reduced left-thoracic volume with postoperative calcifications adjacent to the 8<sup>th</sup> left rib (Matricel d90; D).</p>", "links"=>[], "tags"=>["sis", "Dual Mesh", "Matricel patches", "Unoperated animals", "uniaxial tensiometry", "Rabbit Model BackgroundNeonates", "patch closure", "compliance", "CDH repair", "tissue engineering purposes.Materials", "acm", "Acellular collagen matrices", "diaphragmatic hernia", "Diaphragm Repair", "diaphragmatic tissue.ResultsOverall weight", "polymorphonuclear cell", "Methods 2.0x cm diaphragmatic defects", "response"], "article_id"=>1475440, "categories"=>["Biological Sciences"], "users"=>["Steffi Mayer", "Herbert Decaluwe", "Michele Ruol", "Stefano Manodoro", "Manuel Kramer", "Holger Till", "Jan Deprest"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132021.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Radiographic_evaluation_/1475440", "title"=>"Radiographic evaluation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-06 05:14:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164877"], "description"=>"<p>A. Primary repair (d60), polyglecaprone suture absorbed (<i>arrow</i>). B. Gore-Tex (d 60), encapsulated with perihepatic adhesions. Matricel patches were preserved in all (d60; C) but one animal (d90; D, <i>arrow =</i> patch remnant) with high-grade perihepatic adhesions (D). SIS patches were degraded in five animals with bulging of viscera in three (d60, E). Seroma was observed twice (d 60, F, <i>asterisk</i>).</p>", "links"=>[], "tags"=>["sis", "Dual Mesh", "Matricel patches", "Unoperated animals", "uniaxial tensiometry", "Rabbit Model BackgroundNeonates", "patch closure", "compliance", "CDH repair", "tissue engineering purposes.Materials", "acm", "Acellular collagen matrices", "diaphragmatic hernia", "Diaphragm Repair", "diaphragmatic tissue.ResultsOverall weight", "polymorphonuclear cell", "Methods 2.0x cm diaphragmatic defects", "response"], "article_id"=>1475441, "categories"=>["Biological Sciences"], "users"=>["Steffi Mayer", "Herbert Decaluwe", "Michele Ruol", "Stefano Manodoro", "Manuel Kramer", "Holger Till", "Jan Deprest"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132021.g003", "stats"=>{"downloads"=>4, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Macroscopic_findings_/1475441", "title"=>"Macroscopic findings.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-06 05:14:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164878"], "description"=>"<p>Maximal stress at the point of disruption (A, <i>p = 0</i>.<i>01</i><sup>$</sup>) and stiffness of the comfort zone (B, <i>p = 0</i>.<i>3</i>) for the mesh-tissue interface <i>(white)</i> compared to the right-sided unoperated diaphragm <i>(black)</i>. Inflammatory response (C): foreign body giant cells (FBGC; <i>p = 0</i>.<i>0008; white</i>), polymorphonuclear cells (PMN; <i>p<0</i>.<i>0001; black</i>) resp. macrophages (RAM 11; <i>p<0</i>.<i>0001; light grey</i>). Fibrotic process (D): collagen organization (<i>p = 0</i>.<i>2; dark grey</i>), composition (<i>p = 0</i>.<i>0005; black</i>) and amount (<i>p = 0</i>.<i>1</i><sup>$</sup>; <i>light grey</i>), neovascularization (<i>p = 0</i>.<i>2; white</i>). Mean+SD with overall p-value (Kruskal-Wallis test or ANOVA [<sup>$</sup>]). Multiple groups comparison (Wilcoxon each pair test or posthoc Tukey test): solid line = significant, dashed line = non-significant, * = significant difference between unoperated controls / primary repair and the three patch materials. Matched-pairs comparison (paired t-test or Wilcoxon signed rank test): [squared bracket = significance level].</p>", "links"=>[], "tags"=>["sis", "Dual Mesh", "Matricel patches", "Unoperated animals", "uniaxial tensiometry", "Rabbit Model BackgroundNeonates", "patch closure", "compliance", "CDH repair", "tissue engineering purposes.Materials", "acm", "Acellular collagen matrices", "diaphragmatic hernia", "Diaphragm Repair", "diaphragmatic tissue.ResultsOverall weight", "polymorphonuclear cell", "Methods 2.0x cm diaphragmatic defects", "response"], "article_id"=>1475442, "categories"=>["Biological Sciences"], "users"=>["Steffi Mayer", "Herbert Decaluwe", "Michele Ruol", "Stefano Manodoro", "Manuel Kramer", "Holger Till", "Jan Deprest"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132021.g004", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tensiometric_and_histological_results_/1475442", "title"=>"Tensiometric and histological results.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-06 05:14:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164879"], "description"=>"<p>Representative micrographs of all groups (columns) obtained at x400 magnification with identical settings for each stain from the mesh-tissue interface. Meshes are invisible form degradation or processing, respectively. Inflammation is represented by the number of macrophages (first row, black arrows), foreign body giant cells (second row, black arrows) and polymorphonuclear cells (second row, white arrows), fibrosis depicted by the amount of neovascularization (second row, v vessel) as well as the amount and composition of collagen (third row, * muscle, ⏏ mature collagen, ⌃ immature collagen, ★ patch). H&E: Hematoxylin-eosin.</p>", "links"=>[], "tags"=>["sis", "Dual Mesh", "Matricel patches", "Unoperated animals", "uniaxial tensiometry", "Rabbit Model BackgroundNeonates", "patch closure", "compliance", "CDH repair", "tissue engineering purposes.Materials", "acm", "Acellular collagen matrices", "diaphragmatic hernia", "Diaphragm Repair", "diaphragmatic tissue.ResultsOverall weight", "polymorphonuclear cell", "Methods 2.0x cm diaphragmatic defects", "response"], "article_id"=>1475443, "categories"=>["Biological Sciences"], "users"=>["Steffi Mayer", "Herbert Decaluwe", "Michele Ruol", "Stefano Manodoro", "Manuel Kramer", "Holger Till", "Jan Deprest"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132021.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histology_/1475443", "title"=>"Histology.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-06 05:14:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164880"], "description"=>"<p>Values presented as absolute numbers per group (n) or mean ± SD with overall p-value (ANOVA).</p><p>Studied animals and intervention groups.</p>", "links"=>[], "tags"=>["sis", "Dual Mesh", "Matricel patches", "Unoperated animals", "uniaxial tensiometry", "Rabbit Model BackgroundNeonates", "patch closure", "compliance", "CDH repair", "tissue engineering purposes.Materials", "acm", "Acellular collagen matrices", "diaphragmatic hernia", "Diaphragm Repair", "diaphragmatic tissue.ResultsOverall weight", "polymorphonuclear cell", "Methods 2.0x cm diaphragmatic defects", "response"], "article_id"=>1475444, "categories"=>["Biological Sciences"], "users"=>["Steffi Mayer", "Herbert Decaluwe", "Michele Ruol", "Stefano Manodoro", "Manuel Kramer", "Holger Till", "Jan Deprest"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132021.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Studied_animals_and_intervention_groups_/1475444", "title"=>"Studied animals and intervention groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-06 05:14:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164875"], "description"=>"<p>A left-dorsolateral thoracotomy was performed to expose the diaphragm. After placement of a traction suture (A, <i>arrow</i>) a 2.0 x 1.0 cm defect was cut in the tendomuscular part of the diaphragm and repaired by either placing a running suture (B) or inserting a cone-shaped patch (C, D) made from different materials.</p>", "links"=>[], "tags"=>["sis", "Dual Mesh", "Matricel patches", "Unoperated animals", "uniaxial tensiometry", "Rabbit Model BackgroundNeonates", "patch closure", "compliance", "CDH repair", "tissue engineering purposes.Materials", "acm", "Acellular collagen matrices", "diaphragmatic hernia", "Diaphragm Repair", "diaphragmatic tissue.ResultsOverall weight", "polymorphonuclear cell", "Methods 2.0x cm diaphragmatic defects", "response"], "article_id"=>1475439, "categories"=>["Biological Sciences"], "users"=>["Steffi Mayer", "Herbert Decaluwe", "Michele Ruol", "Stefano Manodoro", "Manuel Kramer", "Holger Till", "Jan Deprest"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132021.g001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Surgical_procedure_/1475439", "title"=>"Surgical procedure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-06 05:14:39"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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