The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The use of non-variant sites to improve the clinical assessment of whole-genome sequence data", "type"=>"journal", "authors"=>[{"first_name"=>"Alberto", "last_name"=>"Ferrarini", "scopus_author_id"=>"35302425700"}, {"first_name"=>"Luciano", "last_name"=>"Xumerle", "scopus_author_id"=>"23092645500"}, {"first_name"=>"Francesca", "last_name"=>"Griggio", "scopus_author_id"=>"23484765600"}, {"first_name"=>"Marianna", "last_name"=>"Garonzi", "scopus_author_id"=>"55832128900"}, {"first_name"=>"Chiara", "last_name"=>"Cantaloni", "scopus_author_id"=>"36553957200"}, {"first_name"=>"Cesare", "last_name"=>"Centomo", "scopus_author_id"=>"56463025000"}, {"first_name"=>"Sergio Marin", "last_name"=>"Vargas", "scopus_author_id"=>"56803431000"}, {"first_name"=>"Patrick", "last_name"=>"Descombes", "scopus_author_id"=>"7003741476"}, {"first_name"=>"Julien", "last_name"=>"Marquis", "scopus_author_id"=>"15123239900"}, {"first_name"=>"Sebastiano", "last_name"=>"Collino", "scopus_author_id"=>"54955406900"}, {"first_name"=>"Claudio", "last_name"=>"Franceschi", "scopus_author_id"=>"56236886700"}, {"first_name"=>"Paolo", "last_name"=>"Garagnani", "scopus_author_id"=>"16052588800"}, {"first_name"=>"Benjamin A.", "last_name"=>"Salisbury", "scopus_author_id"=>"6603811450"}, {"first_name"=>"John Max", "last_name"=>"Harvey", "scopus_author_id"=>"56803125800"}, {"first_name"=>"Massimo", "last_name"=>"Delledonne", "scopus_author_id"=>"6602083954"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84940173158", "pmid"=>"26147798", "pui"=>"605749680", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84940173158", "doi"=>"10.1371/journal.pone.0132180", "issn"=>"19326203"}, "id"=>"a42047af-7871-321d-b3e8-f637162558d7", "abstract"=>"Genetic testing, which is now a routine part of clinical practice and disease management protocols, is often based on the assessment of small panels of variants or genes. On the other hand, continuous improvements in the speed and per-base costs of sequencing have now made whole exome sequencing (WES) and whole genome sequencing (WGS) viable strategies for targeted or complete genetic analysis, respectively. Standard WGS/WES data analytical workflows generally rely on calling of sequence variants respect to the reference genome sequence. However, the reference genome sequence contains a large number of sites represented by rare alleles, by known pathogenic alleles and by alleles strongly associated to disease by GWAS. It's thus critical, for clinical applications of WGS and WES, to interpret whether non-variant sites are homozygous for the reference allele or if the corresponding genotype cannot be reliably called. Here we show that an alternative analytical approach based on the analysis of both variant and non-variant sites from WGS data allows to genotype more than 92% of sites corresponding to known SNPs compared to 6% genotyped by standard variant analysis. These include homozygous reference sites of clinical interest, thus leading to a broad and comprehensive characterization of variation necessary to an accurate evaluation of disease risk. Altogether, our findings indicate that characterization of both variant and non-variant clinically informative sites in the genome is necessary to allow an accurate clinical assessment of a personal genome. Finally, we propose a highly efficient extended VCF (eVCF) file format which allows to store genotype calls for sites of clinical interest while remaining compatible with current variant interpretation software.", "link"=>"http://www.mendeley.com/research/nonvariant-sites-improve-clinical-assessment-wholegenome-sequence-data", "reader_count"=>22, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>4, "Student > Bachelor"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>4, "Student > Bachelor"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Belgium"=>1, "China"=>1, "Italy"=>2}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84940173158"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84940173158?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940173158&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84940173158&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84940173158", "dc:identifier"=>"SCOPUS_ID:84940173158", "eid"=>"2-s2.0-84940173158", "dc:title"=>"The use of non-variant sites to improve the clinical assessment of whole-genome sequence data", "dc:creator"=>"Ferrarini A.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"10", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-07-06", "prism:coverDisplayDate"=>"6 July 2015", "prism:doi"=>"10.1371/journal.pone.0132180", "citedby-count"=>"6", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Università degli Studi di Verona", "affiliation-city"=>"Verona", "affiliation-country"=>"Italy"}], "pubmed-id"=>"26147798", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0132180", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0132180", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"78", "xml_views"=>"6", "html_views"=>"278"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"4", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"12"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2164569", "https://ndownloader.figshare.com/files/2164570", "https://ndownloader.figshare.com/files/2164571", "https://ndownloader.figshare.com/files/2164572", "https://ndownloader.figshare.com/files/2164573", "https://ndownloader.figshare.com/files/2164574", "https://ndownloader.figshare.com/files/2164575", "https://ndownloader.figshare.com/files/2164576", "https://ndownloader.figshare.com/files/2164577", "https://ndownloader.figshare.com/files/2164578", "https://ndownloader.figshare.com/files/2164579"], "description"=>"<div><p>Genetic testing, which is now a routine part of clinical practice and disease management protocols, is often based on the assessment of small panels of variants or genes. On the other hand, continuous improvements in the speed and per-base costs of sequencing have now made whole exome sequencing (WES) and whole genome sequencing (WGS) viable strategies for targeted or complete genetic analysis, respectively. Standard WGS/WES data analytical workflows generally rely on calling of sequence variants respect to the reference genome sequence. However, the reference genome sequence contains a large number of sites represented by rare alleles, by known pathogenic alleles and by alleles strongly associated to disease by GWAS. It’s thus critical, for clinical applications of WGS and WES, to interpret whether non-variant sites are homozygous for the reference allele or if the corresponding genotype cannot be reliably called. Here we show that an alternative analytical approach based on the analysis of both variant and non-variant sites from WGS data allows to genotype more than 92% of sites corresponding to known SNPs compared to 6% genotyped by standard variant analysis. These include homozygous reference sites of clinical interest, thus leading to a broad and comprehensive characterization of variation necessary to an accurate evaluation of disease risk. Altogether, our findings indicate that characterization of both variant and non-variant clinically informative sites in the genome is necessary to allow an accurate clinical assessment of a personal genome. Finally, we propose a highly efficient extended VCF (eVCF) file format which allows to store genotype calls for sites of clinical interest while remaining compatible with current variant interpretation software.</p></div>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475234, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0132180.s001", "https://dx.doi.org/10.1371/journal.pone.0132180.s002", "https://dx.doi.org/10.1371/journal.pone.0132180.s003", "https://dx.doi.org/10.1371/journal.pone.0132180.s004", "https://dx.doi.org/10.1371/journal.pone.0132180.s005", "https://dx.doi.org/10.1371/journal.pone.0132180.s006", "https://dx.doi.org/10.1371/journal.pone.0132180.s007", "https://dx.doi.org/10.1371/journal.pone.0132180.s008", "https://dx.doi.org/10.1371/journal.pone.0132180.s009", "https://dx.doi.org/10.1371/journal.pone.0132180.s010", "https://dx.doi.org/10.1371/journal.pone.0132180.s011"], "stats"=>{"downloads"=>65, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Use_of_Non_Variant_Sites_to_Improve_the_Clinical_Assessment_of_Whole_Genome_Sequence_Data_/1475234", "title"=>"The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-07-06 04:45:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164540"], "description"=>"<p>Percentage of exonic regions covered at a read depth ≥ 5, an alignment score ≥ 10, a basecall quality ≥ 10 from WGS subsets of the original full set with different average X-fold coverage values.</p>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475223, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132180.g001", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Exonic_regions_coverage_/1475223", "title"=>"Exonic regions coverage.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-06 04:45:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164541"], "description"=>"<p>Concordance of genotypes represented in VCF and gVCF files with those detected by the MI RISK Plus kit.</p>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475224, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132180.t001", "stats"=>{"downloads"=>6, "page_views"=>97, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Concordance_of_genotypes_represented_in_VCF_and_gVCF_files_with_those_detected_by_the_MI_RISK_Plus_kit_/1475224", "title"=>"Concordance of genotypes represented in VCF and gVCF files with those detected by the MI RISK Plus kit.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-06 04:45:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164542"], "description"=>"<p>Genotyping of GWAS catalog sites using the VCF and gVCF file formats and the number of homozygous reference sites and no-calls based on WGS data.</p>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475225, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132180.t002", "stats"=>{"downloads"=>4, "page_views"=>69, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotyping_of_GWAS_catalog_sites_using_the_VCF_and_gVCF_file_formats_and_the_number_of_homozygous_reference_sites_and_no_calls_based_on_WGS_data_/1475225", "title"=>"Genotyping of GWAS catalog sites using the VCF and gVCF file formats and the number of homozygous reference sites and no-calls based on WGS data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-06 04:45:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164543"], "description"=>"<p>Genotyping of known SNPs from dbSNP 141 using the VCF and gVCF file formats and the number of homozygous reference sites and no-calls based on WGS data.</p>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475226, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132180.t003", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotyping_of_known_SNPs_from_dbSNP_141_using_the_VCF_and_gVCF_file_formats_and_the_number_of_homozygous_reference_sites_and_no_calls_based_on_WGS_data_/1475226", "title"=>"Genotyping of known SNPs from dbSNP 141 using the VCF and gVCF file formats and the number of homozygous reference sites and no-calls based on WGS data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-06 04:45:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164544"], "description"=>"<p>Genotyping of known SNPs from ClinVar using the VCF and gVCF file formats and the number of homozygous reference sites and no-calls based on WGS data.</p>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475227, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132180.t004", "stats"=>{"downloads"=>11, "page_views"=>57, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotyping_of_known_SNPs_from_ClinVar_using_the_VCF_and_gVCF_file_formats_and_the_number_of_homozygous_reference_sites_and_no_calls_based_on_WGS_data_/1475227", "title"=>"Genotyping of known SNPs from ClinVar using the VCF and gVCF file formats and the number of homozygous reference sites and no-calls based on WGS data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-06 04:45:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164545"], "description"=>"<p>Comparison of the content and size of different standard file formats for the storage of genomic data.</p>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475228, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132180.t005", "stats"=>{"downloads"=>11, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_content_and_size_of_different_standard_file_formats_for_the_storage_of_genomic_data_/1475228", "title"=>"Comparison of the content and size of different standard file formats for the storage of genomic data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-06 04:45:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164546"], "description"=>"<p>Compatibility of the eVCF file format with different variation analysis suites.</p>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475229, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132180.t006", "stats"=>{"downloads"=>8, "page_views"=>38, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Compatibility_of_the_eVCF_file_format_with_different_variation_analysis_suites_/1475229", "title"=>"Compatibility of the eVCF file format with different variation analysis suites.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-06 04:45:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2164547"], "description"=>"<p>Comparison of the number of dbSNP, ClinVar and GWAScat sites represented using VCF, gVCF and eVCF files.</p>", "links"=>[], "tags"=>["GWAS", "sequence variants respect", "store genotype", "variant interpretation software", "exome sequencing", "WGS data", "Genome sequencing", "Clinical Assessment", "variant analysis", "VCF", "disease management protocols", "reference genome sequence", "wes", "disease risk", "reference sites", "snp", "reference allele"], "article_id"=>1475230, "categories"=>["Biological Sciences"], "users"=>["Alberto Ferrarini", "Luciano Xumerle", "Francesca Griggio", "Marianna Garonzi", "Chiara Cantaloni", "Cesare Centomo", "Sergio Marin Vargas", "Patrick Descombes", "Julien Marquis", "Sebastiano Collino", "Claudio Franceschi", "Paolo Garagnani", "Benjamin A. Salisbury", "John Max Harvey", "Massimo Delledonne"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132180.t007", "stats"=>{"downloads"=>6, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_number_of_dbSNP_ClinVar_and_GWAScat_sites_represented_using_VCF_gVCF_and_eVCF_files_/1475230", "title"=>"Comparison of the number of dbSNP, ClinVar and GWAScat sites represented using VCF, gVCF and eVCF files.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-06 04:45:54"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"3", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"26", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"20", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"22", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"28", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"40", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
Loading … Spinner
There are currently no alerts