Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120
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{"title"=>"Fish oil accelerates diet-induced entrainment of the mouse peripheral clock via GPR120", "type"=>"journal", "authors"=>[{"first_name"=>"Akiko", "last_name"=>"Furutani", "scopus_author_id"=>"56835368000"}, {"first_name"=>"Yuko", "last_name"=>"Ikeda", "scopus_author_id"=>"56086923000"}, {"first_name"=>"Misa", "last_name"=>"Itokawa", "scopus_author_id"=>"55561627900"}, {"first_name"=>"Hiroki", "last_name"=>"Nagahama", "scopus_author_id"=>"36622203200"}, {"first_name"=>"Teiji", "last_name"=>"Ohtsu", "scopus_author_id"=>"55561757900"}, {"first_name"=>"Naoki", "last_name"=>"Furutani", "scopus_author_id"=>"57191402255"}, {"first_name"=>"Mayo", "last_name"=>"Kamagata", "scopus_author_id"=>"56450922300"}, {"first_name"=>"Zhi Hong", "last_name"=>"Yang", "scopus_author_id"=>"55716656600"}, {"first_name"=>"Akira", "last_name"=>"Hirasawa", "scopus_author_id"=>"56502463200"}, {"first_name"=>"Yu", "last_name"=>"Tahara", "scopus_author_id"=>"14521428000"}, {"first_name"=>"Shigenobu", "last_name"=>"Shibata", "scopus_author_id"=>"7402120611"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"605952179", "sgr"=>"84941334292", "issn"=>"19326203", "pmid"=>"26161796", "scopus"=>"2-s2.0-84941334292", "doi"=>"10.1371/journal.pone.0132472", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"26be92cf-9c1b-345b-bae5-27648b8d2370", "abstract"=>"The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock.", "link"=>"http://www.mendeley.com/research/fish-oil-accelerates-dietinduced-entrainment-mouse-peripheral-clock-via-gpr120", "reader_count"=>29, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>3, "Student > Bachelor"=>5, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>3, "Student > Bachelor"=>5, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>4, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Sweden"=>2, "Brazil"=>2, "United Kingdom"=>2}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2171962"], "description"=>"<p>(A, C) mice were fed an AIN-93M diet tablet containing various substituted oils at ZT0 for 2 days or 7 days, and bioluminescence rhythm was recorded after sacrifice on Day 3 or Day 8. The horizontal axis indicates projected Zeitgeber time (pZT) at the peak of the bioluminescence rhythm. ZT0 is lights-on time and ZT12 is lights-off time in the housing room prior to sacrifice. (A) experimental protocol. RF was applied for 2 days at ZT0. (B) de-trended expression rhythms of the liver PER2::LUCIFERASE bioluminescence in mice under RF of an AIN-93M diet containing tuna oil (arrows) or soybean oil (arrow heads) for 2 days at ZT0. The horizontal line indicates time lapse. (C) magnitude of phase delay by fish oil-containing AIN-93M diet chow for 2 days at ZT0. A control experiment was prepared under free feeding conditions (closed triangle, FF). SB (7 days) shows the magnitude of the phase shifts by 7-day RF of soybean oil-containing AIM-93M at ZT0–ZT4 (Values are expressed as mean ± SEM. **<i>P</i> < 0.01, ***<i>P</i> < 0.001 (vs. SB, control chow, Dunn test). #<i>P</i> < 0.05, ###<i>P</i> < 0.001 [vs. SB, (FF), Dunn test]. (D) magnitude of phase-delay or phase-advance by DHA/EPA-containing AIN-93M diet chow. SB, soybean; FF, free-feeding. Numbers in parentheses indicate the number of tested mice. Values are expressed as mean ± SEM. *<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001 (vs. SB, control chow, Tukey-Kramer test).</p>", "links"=>[], "tags"=>["per", "epa", "Mouse Peripheral Clock", "rf", "dha", "Insulin secretion", "gpr", "Soybean oil", "soybean oil component", "fish oil"], "article_id"=>1480307, "categories"=>["Biological Sciences"], "users"=>["Akiko Furutani", "Yuko Ikeda", "Misa Itokawa", "Hiroki Nagahama", "Teiji Ohtsu", "Naoki Furutani", "Mayo Kamagata", "Zhi-Hong Yang", "Akira Hirasawa", "Yu Tahara", "Shigenobu Shibata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132472.g001", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AIN_93M_diet_chow_containing_various_fish_oils_or_DHA_EPA_dissolved_in_soybean_oil_and_RF_induced_phase_shifts_of_the_liver_and_SCN_circadian_clock_/1480307", "title"=>"AIN-93M diet chow containing various fish oils or DHA/EPA dissolved in soybean oil and RF-induced phase shifts of the liver and SCN circadian clock.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 05:25:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171963"], "description"=>"<p>Mice were fed an AIN-93M diet containing tuna oil at ZT0 for 2 days or 7 days, and bioluminescence rhythm was recorded after sacrifice on Day 3 or Day 8. The horizontal axis indicates projected Zeitgeber time (pZT) at the peak of the bioluminescence rhythm. (A, B) simultaneous recording of bioluminescence from SCN (A) and liver (B). SB, soybean; FF, free-feeding. Numbers in parentheses indicate the number of tested mice. Values are expressed as mean ± SEM. ***<i>P</i> < 0.001 [vs. SB (2 days), control chow, Tukey-Kramer test]. ###<i>P</i> < 0.001 [vs. Tuna (FF) or SB (FF), Tukey-Kramer test].</p>", "links"=>[], "tags"=>["per", "epa", "Mouse Peripheral Clock", "rf", "dha", "Insulin secretion", "gpr", "Soybean oil", "soybean oil component", "fish oil"], "article_id"=>1480308, "categories"=>["Biological Sciences"], "users"=>["Akiko Furutani", "Yuko Ikeda", "Misa Itokawa", "Hiroki Nagahama", "Teiji Ohtsu", "Naoki Furutani", "Mayo Kamagata", "Zhi-Hong Yang", "Akira Hirasawa", "Yu Tahara", "Shigenobu Shibata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132472.g002", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_AIN_93M_diet_chow_containing_tuna_oil_on_RF_induced_phase_shifts_of_the_liver_and_SCN_circadian_clock_/1480308", "title"=>"Effect of AIN-93M diet chow containing tuna oil on RF-induced phase shifts of the liver and SCN circadian clock.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 05:25:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171964"], "description"=>"<p>(A, B) on Day 2 under RF conditions, mice were fed an AIN-93M diet containing tuna, menhaden, soybean, DHA/EPA-containing soybean oil or without oil at ZT0; mice were sacrificed at 60 min, 120 min, or 240 min after feeding of fish oil (A) and 120 min after feeding of DHA/EPA (B). Serum insulin levels were measured. SB, soybean; w/o oil, without oil. Numbers in parentheses indicate the number of tested mice. Values are expressed as mean ± SEM. *<i>P</i> < 0.05 (vs. SB control chow, Tukey-Kramer test).</p>", "links"=>[], "tags"=>["per", "epa", "Mouse Peripheral Clock", "rf", "dha", "Insulin secretion", "gpr", "Soybean oil", "soybean oil component", "fish oil"], "article_id"=>1480309, "categories"=>["Biological Sciences"], "users"=>["Akiko Furutani", "Yuko Ikeda", "Misa Itokawa", "Hiroki Nagahama", "Teiji Ohtsu", "Naoki Furutani", "Mayo Kamagata", "Zhi-Hong Yang", "Akira Hirasawa", "Yu Tahara", "Shigenobu Shibata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132472.g003", "stats"=>{"downloads"=>4, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AIN_93M_diet_chow_containing_tuna_oil_and_DHA_EPA_and_RF_induced_insulin_secretion_/1480309", "title"=>"AIN-93M diet chow containing tuna oil and DHA/EPA and RF-induced insulin secretion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 05:25:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171965"], "description"=>"<p>(A, B) on Day 2 under RF conditions, mice were fed AIN-93M containing tuna, menhaden, soybean, DHA/EPA-containing soybean oil or without oil at ZT0; mice were sacrificed at 60 min, 120 min, and 240 min after feeding of fish oil (A) and 120 min after feeding of DHA/EPA (B). <i>Per2</i> gene expression was measured. The relative levels of expression were normalized to <i>GAPDH</i>. SB, soybean; w/o oil, without oil. Numbers in parentheses indicate the number of tested mice. Values are expressed as mean ± SEM. *<i>P</i> < 0.05 (vs. SB control chow, Tukey-Kramer test).</p>", "links"=>[], "tags"=>["per", "epa", "Mouse Peripheral Clock", "rf", "dha", "Insulin secretion", "gpr", "Soybean oil", "soybean oil component", "fish oil"], "article_id"=>1480310, "categories"=>["Biological Sciences"], "users"=>["Akiko Furutani", "Yuko Ikeda", "Misa Itokawa", "Hiroki Nagahama", "Teiji Ohtsu", "Naoki Furutani", "Mayo Kamagata", "Zhi-Hong Yang", "Akira Hirasawa", "Yu Tahara", "Shigenobu Shibata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132472.g004", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AIN_93M_diet_chow_containing_various_fish_oils_and_DHA_EPA_and_the_RF_induced_increase_of_Per2_gene_expression_in_the_liver_/1480310", "title"=>"AIN-93M diet chow containing various fish oils and DHA/EPA and the RF-induced increase of <i>Per2</i> gene expression in the liver.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 05:25:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171966"], "description"=>"<p>(A) magnitude of phase shifts induced by tuna oil or soybean oil containing DHA and/or EPA administration at ZT0 for 2 days under free-feeding conditions. Tuna oil, soybean oil, DHA- or EPA-containing oil was administered at 0.034 ml/10 g BW for 2 days, and mice were sacrificed to examine the phase of bioluminescence of liver on Day 3. (B) tuna oil, menhaden oil, or DHA-containing oil was administered at 0.034 ml/10 g BW at ZT0 under free-feeding conditions, and mice were sacrificed 2 h after injection to examine serum insulin level. *<i>P</i> < 0.05 (vs. SB group, Tukey-Kramer test). Numbers in parentheses indicate the number of tested mice.</p>", "links"=>[], "tags"=>["per", "epa", "Mouse Peripheral Clock", "rf", "dha", "Insulin secretion", "gpr", "Soybean oil", "soybean oil component", "fish oil"], "article_id"=>1480311, "categories"=>["Biological Sciences"], "users"=>["Akiko Furutani", "Yuko Ikeda", "Misa Itokawa", "Hiroki Nagahama", "Teiji Ohtsu", "Naoki Furutani", "Mayo Kamagata", "Zhi-Hong Yang", "Akira Hirasawa", "Yu Tahara", "Shigenobu Shibata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132472.g005", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_oral_administration_of_fish_oil_or_soybean_oil_containing_DHA_and_or_EPA_alone_at_daytime_under_free_feeding_conditions_on_phase_shifts_and_insulin_level_/1480311", "title"=>"Effect of oral administration of fish oil or soybean oil containing DHA and/or EPA alone at daytime under free-feeding conditions on phase shifts and insulin level.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 05:25:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171967"], "description"=>"<p>(A) bioluminescence rhythm recorded in the liver of STZ-treated mice fed AIN-93M diet chow containing tuna or soybean oil at ZT0 for 2 days. The horizontal axis indicates pZT at the peak of the bioluminescence rhythm. (B) on Day 2 under RF conditions, STZ-treated mice were fed AIN-93M containing tuna or soybean oil at ZT0 and sacrificed 120 min after feeding. Serum insulin levels were measured. Numbers in parentheses indicate the number of tested mice. Values are expressed as mean ± SEM. **<i>P</i> < 0.01 (vs. STZ-treated group, Tukey-Kramer test).</p>", "links"=>[], "tags"=>["per", "epa", "Mouse Peripheral Clock", "rf", "dha", "Insulin secretion", "gpr", "Soybean oil", "soybean oil component", "fish oil"], "article_id"=>1480312, "categories"=>["Biological Sciences"], "users"=>["Akiko Furutani", "Yuko Ikeda", "Misa Itokawa", "Hiroki Nagahama", "Teiji Ohtsu", "Naoki Furutani", "Mayo Kamagata", "Zhi-Hong Yang", "Akira Hirasawa", "Yu Tahara", "Shigenobu Shibata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132472.g006", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AIN_93M_diet_chow_containing_tuna_oil_and_RF_induced_phase_delay_of_the_liver_circadian_clock_and_serum_insulin_in_streptozotocin_pretreated_mice_/1480312", "title"=>"AIN-93M diet chow containing tuna oil and RF-induced phase-delay of the liver circadian clock and serum insulin in streptozotocin-pretreated mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 05:25:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171968"], "description"=>"<p>GPR120-deficient (KO) and wild-type (WT) mice were fed an AIN-93M diet tablet containing tuna oil at ZT0 for 2 days and bioluminescence rhythm was recorded after sacrifice on Day 3. The horizontal axis indicates projected Zeitgeber time (pZT) at the peak of the bioluminescence rhythm. ZT0 is lights-on time and ZT12 is lights-off time in the housing room prior to sacrifice. (A) de-trended data of expression rhythms of liver <i>PER2</i>::LUCIFERASE bioluminescence in mice under restricted-feeding (RF) of AIN-93M diet containing tuna or soybean oil. The horizontal line indicates time lapse. (B) magnitude of phase-delay by tuna or soybean oil in WT or KO mice. Values are expressed as mean ± SEM. **<i>P</i> < 0.01, (vs. WT SB group, Tukey-Kramer test). (C, D) on Day 2 under RF conditions, mice were fed AIN-93M containing tuna or soybean oil at ZT0, and sacrificed at 120 min to measure insulin and clock gene expression in the liver after feeding. (C) serum insulin levels. Values are expressed as mean ± SEM. *<i>P</i> < 0.05 *** <i>P</i> < 0.001 vs. WT SB group, ## <i>P</i> < 0.01 vs. WT SB (FF) group, Dunn test. (D) <i>Per2</i> gene expression. The relative levels of expression were normalized to <i>GAPDH</i>. *** <i>P</i> < 0.001 (vs. WT SB group), # <i>P</i> < 0.05 [vs. WT SB (FF) group Dunn test]. SB, soybean; FF, free feeding. Numbers in parentheses indicate the number of tested mice.</p>", "links"=>[], "tags"=>["per", "epa", "Mouse Peripheral Clock", "rf", "dha", "Insulin secretion", "gpr", "Soybean oil", "soybean oil component", "fish oil"], "article_id"=>1480313, "categories"=>["Biological Sciences"], "users"=>["Akiko Furutani", "Yuko Ikeda", "Misa Itokawa", "Hiroki Nagahama", "Teiji Ohtsu", "Naoki Furutani", "Mayo Kamagata", "Zhi-Hong Yang", "Akira Hirasawa", "Yu Tahara", "Shigenobu Shibata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132472.g007", "stats"=>{"downloads"=>2, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phase_shift_of_liver_clock_insulin_secretion_and_clock_gene_expression_in_GPR120_deficient_mice_with_tuna_oil_containing_diet_/1480313", "title"=>"Phase shift of liver clock, insulin secretion, and clock gene expression in GPR120-deficient mice with tuna oil-containing diet.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-10 05:25:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2171969", "https://ndownloader.figshare.com/files/2171970", "https://ndownloader.figshare.com/files/2171971", "https://ndownloader.figshare.com/files/2171972"], "description"=>"<div><p>The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock.</p></div>", "links"=>[], "tags"=>["per", "epa", "Mouse Peripheral Clock", "rf", "dha", "Insulin secretion", "gpr", "Soybean oil", "soybean oil component", "fish oil"], "article_id"=>1480314, "categories"=>["Biological Sciences"], "users"=>["Akiko Furutani", "Yuko Ikeda", "Misa Itokawa", "Hiroki Nagahama", "Teiji Ohtsu", "Naoki Furutani", "Mayo Kamagata", "Zhi-Hong Yang", "Akira Hirasawa", "Yu Tahara", "Shigenobu Shibata"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0132472.s001", "https://dx.doi.org/10.1371/journal.pone.0132472.s002", "https://dx.doi.org/10.1371/journal.pone.0132472.s003", "https://dx.doi.org/10.1371/journal.pone.0132472.s004"], "stats"=>{"downloads"=>8, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fish_Oil_Accelerates_Diet_Induced_Entrainment_of_the_Mouse_Peripheral_Clock_via_GPR120_/1480314", "title"=>"Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-07-10 05:25:58"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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