Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects
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{"title"=>"Influence of the PNPLA3 rs738409 polymorphism on non-alcoholic fatty liver disease and renal function among normal weight subjects", "type"=>"journal", "authors"=>[{"first_name"=>"Kentaro", "last_name"=>"Oniki", "scopus_author_id"=>"15070790900"}, {"first_name"=>"Junji", "last_name"=>"Saruwatari", "scopus_author_id"=>"6507342556"}, {"first_name"=>"Tomoko", "last_name"=>"Izuka", "scopus_author_id"=>"56830510200"}, {"first_name"=>"Ayami", "last_name"=>"Kajiwara", "scopus_author_id"=>"55437742400"}, {"first_name"=>"Kazunori", "last_name"=>"Morita", "scopus_author_id"=>"42462045100"}, {"first_name"=>"Misaki", "last_name"=>"Sakata", "scopus_author_id"=>"55848708700"}, {"first_name"=>"Koji", "last_name"=>"Otake", "scopus_author_id"=>"56179259800"}, {"first_name"=>"Yasuhiro", "last_name"=>"Ogata", "scopus_author_id"=>"7201752456"}, {"first_name"=>"Kazuko", "last_name"=>"Nakagawa", "scopus_author_id"=>"56502870100"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"605939256", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0132640", "scopus"=>"2-s2.0-84941313453", "pmid"=>"26200108", "sgr"=>"84941313453"}, "id"=>"2b4d5df8-df52-3452-9f6d-f7341bacd38b", "abstract"=>"In normal weight subjects (body mass index < 25 kg/m2), non-alcoholic fatty liver disease (NAFLD) is likely to coexist with metabolic diseases. The patatin-like phospholipase 3 (PNPLA3) polymorphism rs738409 (c.444C>G) is associated with the risk of NAFLD and/or renal dysfunction; however, the influence of the weight status on the associations remains unknown. We aimed to clarify the associations of the PNPLA3 polymorphism with the risk of NAFLD and/or renal dysfunction, while also paying careful attention to the weight status of the subjects. Cross-sectional and retrospective longitudinal studies with 5.5 ± 1.1 years of follow-up were conducted in 740 and 393 Japanese participants (61.2 ± 10.5 and 67.5 ± 6.0 years), respectively, during a health screening program. Among 591 subjects who did not have a habitual alcohol intake and/or hepatitis B or C virus infections, the PNPLA3 G/G genotype was associated with the risk for NAFLD in normal weight subjects [odds ratio (95% CI): 3.06 (1.11-8.43), P < 0.05]. Among all subjects, carriers of the PNPLA3 G/G genotype with a normal weight had a lower eGFR than those of the C/C genotype [partial regression coefficient (SE): -3.26 (1.48), P < 0.05]. These associations were replicated in the longitudinal analyses. Among the overweight subjects, none of the genotypes were significantly associated in the cross-sectional and longitudinal analyses; however, the power of the analyses was small, especially in the analyses among overweight subjects. The findings of this study suggest that carriers of the PNPLA3 G/G genotype with a normal weight status should nevertheless be carefully monitored for the presence of NAFLD and/or renal dysfunction.", "link"=>"http://www.mendeley.com/research/influence-pnpla3-rs738409-polymorphism-nonalcoholic-fatty-liver-disease-renal-function-among-normal", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>1, "Sports and Recreations"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>0}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/2186882", "https://ndownloader.figshare.com/files/2186883", "https://ndownloader.figshare.com/files/2186884", "https://ndownloader.figshare.com/files/2186885", "https://ndownloader.figshare.com/files/2186886"], "description"=>"<div><p>In normal weight subjects (body mass index < 25 kg/m<sup>2</sup>), non-alcoholic fatty liver disease (NAFLD) is likely to coexist with metabolic diseases. The <i>patatin-like phospholipase 3 (PNPLA3)</i> polymorphism rs738409 (c.444C>G) is associated with the risk of NAFLD and/or renal dysfunction; however, the influence of the weight status on the associations remains unknown. We aimed to clarify the associations of the <i>PNPLA3</i> polymorphism with the risk of NAFLD and/or renal dysfunction, while also paying careful attention to the weight status of the subjects. Cross-sectional and retrospective longitudinal studies with 5.5 ± 1.1 years of follow-up were conducted in 740 and 393 Japanese participants (61.2 ± 10.5 and 67.5 ± 6.0 years), respectively, during a health screening program. Among 591 subjects who did not have a habitual alcohol intake and/or hepatitis B or C virus infections, the <i>PNPLA3</i> G/G genotype was associated with the risk for NAFLD in normal weight subjects [odds ratio (95% CI): 3.06 (1.11–8.43), <i>P</i> < 0.05]. Among all subjects, carriers of the <i>PNPLA3</i> G/G genotype with a normal weight had a lower eGFR than those of the C/C genotype [partial regression coefficient (SE): -3.26 (1.48), <i>P</i> < 0.05]. These associations were replicated in the longitudinal analyses. Among the overweight subjects, none of the genotypes were significantly associated in the cross-sectional and longitudinal analyses; however, the power of the analyses was small, especially in the analyses among overweight subjects. The findings of this study suggest that carriers of the <i>PNPLA3</i> G/G genotype with a normal weight status should nevertheless be carefully monitored for the presence of NAFLD and/or renal dysfunction.</p></div>", "links"=>[], "tags"=>["PNPLA 3 rs 738409 Polymorphism", "PNPLA 3 polymorphism", "association", "body mass index", "analyses", "C virus infections", "weight status", ".444C", "dysfunction", "Normal Weight Subjects", "genotype", "ci", "nafld", "se", "weight subjects", "health screening program"], "article_id"=>1491988, "categories"=>["Biological Sciences"], "users"=>["Kentaro Oniki", "Junji Saruwatari", "Tomoko Izuka", "Ayami Kajiwara", "Kazunori Morita", "Misaki Sakata", "Koji Otake", "Yasuhiro Ogata", "Kazuko Nakagawa"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0132640.s001", "https://dx.doi.org/10.1371/journal.pone.0132640.s002", "https://dx.doi.org/10.1371/journal.pone.0132640.s003", "https://dx.doi.org/10.1371/journal.pone.0132640.s004", "https://dx.doi.org/10.1371/journal.pone.0132640.s005"], "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Influence_of_the_PNPLA3_rs738409_Polymorphism_on_Non_Alcoholic_Fatty_Liver_Disease_and_Renal_Function_among_Normal_Weight_Subjects/1491988", "title"=>"Influence of the <i>PNPLA3</i> rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-07-22 03:27:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/2186879"], "description"=>"<p>The mean values of eGFR are shown as solid, dashed-dotted and dotted lines in the subjects with the <i>PNPLA3</i> C/C, C/G and G/G genotypes, respectively, and the SEs are shown as antennae. eGFR, estimated glomerular filtration rate; PNPLA3, patatin-like phospholipase 3; SE, standard error.</p>", "links"=>[], "tags"=>["PNPLA 3 rs 738409 Polymorphism", "PNPLA 3 polymorphism", "association", "body mass index", "analyses", "C virus infections", "weight status", ".444C", "dysfunction", "Normal Weight Subjects", "genotype", "ci", "nafld", "se", "weight subjects", "health screening program"], "article_id"=>1491985, "categories"=>["Biological Sciences"], "users"=>["Kentaro Oniki", "Junji Saruwatari", "Tomoko Izuka", "Ayami Kajiwara", "Kazunori Morita", "Misaki Sakata", "Koji Otake", "Yasuhiro Ogata", "Kazuko Nakagawa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132640.g002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_longitudinal_changes_in_eGFR_stratified_by_the_PNPLA3_genotype_among_normal_weight_subjects_/1491985", "title"=>"The longitudinal changes in eGFR stratified by the <i>PNPLA3</i> genotype among normal weight subjects.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-22 03:27:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/2186880"], "description"=>"<p>The data are the means ± standard deviation, median (range) for skewed variables, or the numbers of subjects (%) for categorical variables.</p><p><sup>a</sup> Fisher’s exact test.</p><p><sup>b</sup> Mann–Whitney U test (otherwise, Student’s t-test was used).</p><p>NAFLD, non-alcoholic fatty liver disease; BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglyceride; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; PNPLA3, patatin-like phospholipase 3.</p><p>Clinical characteristics of the subjects for the analyses regarding the risk of NAFLD.</p>", "links"=>[], "tags"=>["PNPLA 3 rs 738409 Polymorphism", "PNPLA 3 polymorphism", "association", "body mass index", "analyses", "C virus infections", "weight status", ".444C", "dysfunction", "Normal Weight Subjects", "genotype", "ci", "nafld", "se", "weight subjects", "health screening program"], "article_id"=>1491986, "categories"=>["Biological Sciences"], "users"=>["Kentaro Oniki", "Junji Saruwatari", "Tomoko Izuka", "Ayami Kajiwara", "Kazunori Morita", "Misaki Sakata", "Koji Otake", "Yasuhiro Ogata", "Kazuko Nakagawa"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132640.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_characteristics_of_the_subjects_for_the_analyses_regarding_the_risk_of_NAFLD_/1491986", "title"=>"Clinical characteristics of the subjects for the analyses regarding the risk of NAFLD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-22 03:27:50"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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