Clinical Parameters vs Cytokine Profiles as Predictive Markers of IgE-Mediated Allergy in Young Children
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{"title"=>"Clinical parameters vs cytokine profiles as predictive markers of IgE-mediated allergy in young children", "type"=>"journal", "authors"=>[{"first_name"=>"Catherine", "last_name"=>"Lombard", "scopus_author_id"=>"7102253983"}, {"first_name"=>"Floriane", "last_name"=>"André", "scopus_author_id"=>"55431679500"}, {"first_name"=>"Jérôme", "last_name"=>"Paul", "scopus_author_id"=>"56513133900"}, {"first_name"=>"Catherine", "last_name"=>"Wanty", "scopus_author_id"=>"16641109500"}, {"first_name"=>"Olivier", "last_name"=>"Vosters", "scopus_author_id"=>"6507692240"}, {"first_name"=>"Pierre", "last_name"=>"Bernard", "scopus_author_id"=>"35130569600"}, {"first_name"=>"Charles", "last_name"=>"Pilette", "scopus_author_id"=>"36818722500"}, {"first_name"=>"Pierre", "last_name"=>"Dupont", "scopus_author_id"=>"56850016200"}, {"first_name"=>"Etienne M.", "last_name"=>"Sokal", "scopus_author_id"=>"35380002300"}, {"first_name"=>"Françoise", "last_name"=>"Smets", "scopus_author_id"=>"55402809000"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"26214693", "sgr"=>"84941783536", "doi"=>"10.1371/journal.pone.0132753", "scopus"=>"2-s2.0-84941783536", "pui"=>"605996818", "isbn"=>"19326203 (ISSN)", "issn"=>"19326203"}, "id"=>"4b5fbd57-afb5-373e-b5c9-b99174772255", "abstract"=>"BACKGROUND: Allergy afflicts one third of children, negatively impacting their quality of life and generating a significant socio-economic burden. To this day, this disorder remains difficult to diagnose early in young patients, with no predictive test available.\\n\\nOBJECTIVE: This study was designed to correlate cytokine profiles with clinical phenotypes of allergy development.\\n\\nMETHODS: Three hundred patients were recruited and followed from birth to 18 months of age. They were given a clinical exam at birth and at 2, 6, 12, and 18 months of age, with skin prick tests at 6, and 18 months, in order to have a record of their medical history and determine their allergic status. In addition, mononuclear cells from 131 patients were isolated from cord blood and from peripheral blood samples at 2, 6 and 18 months of age, to analyse their cytokine and chemokine production.\\n\\nRESULTS: Cord blood mononuclear cells (CBMCs) from future Immunoglobulin (Ig) E-mediated allergic children produced significantly less Interleukin (IL)-12p70 and IL-15 than cells from the rest of the cohort. Multivariate analyses revealed that the best predictive model of allergy was built on cytokine data, whereas the best predictive model of IgE-mediated allergy was built on clinical parameters.\\n\\nCONCLUSIONS AND CLINICAL RELEVANCE: Although univariate analyses can yield interesting information regarding the immune responses of allergic children, finding predictive markers of the disorder will likely rely on monitoring multiple parameters. Nonetheless these analyses suggest a potential key role for IL-15 in the development of atopic disease. In addition, the study highlights the importance of clinical parameters in predicting the development of IgE-mediated allergy.", "link"=>"http://www.mendeley.com/research/clinical-parameters-vs-cytokine-profiles-predictive-markers-igemediated-allergy-young-children", "reader_count"=>14, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Belgium"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2190974"], "description"=>"<p>Types of allergies diagnosed in the cohort up to eighteen months and the corresponding percentages of patients affected.</p>", "links"=>[], "tags"=>["allergy", "disorder", "Young Children BackgroundAllergy", "il", "chemokine production.ResultsCord blood", "18 months", "cbmc", "Skin prick tests", "parameter", "cytokine", "relevanceAlthough univariate analyses", "test available.ObjectiveThis study", "Clinical Parameters vs Cytokine Profiles", "model"], "article_id"=>1494858, "categories"=>["Biological Sciences"], "users"=>["Catherine Lombard", "Floriane André", "Jérôme Paul", "Catherine Wanty", "Olivier Vosters", "Pierre Bernard", "Charles Pilette", "Pierre Dupont", "Etienne M. Sokal", "Françoise Smets"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132753.g001", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_information_on_the_cohort_/1494858", "title"=>"Demographic information on the cohort.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-27 02:47:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2190975"], "description"=>"<p>Plasma collected during the 18 month check-up visit was assayed for total IgE. The data are shown as box plots of the median, lower and upper quartile ± standard deviation from the median. Individual dots represent outliers.</p>", "links"=>[], "tags"=>["allergy", "disorder", "Young Children BackgroundAllergy", "il", "chemokine production.ResultsCord blood", "18 months", "cbmc", "Skin prick tests", "parameter", "cytokine", "relevanceAlthough univariate analyses", "test available.ObjectiveThis study", "Clinical Parameters vs Cytokine Profiles", "model"], "article_id"=>1494859, "categories"=>["Biological Sciences"], "users"=>["Catherine Lombard", "Floriane André", "Jérôme Paul", "Catherine Wanty", "Olivier Vosters", "Pierre Bernard", "Charles Pilette", "Pierre Dupont", "Etienne M. Sokal", "Françoise Smets"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132753.g002", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_IgE_concentration_in_the_plasma_of_18_month_old_allergic_and_non_allergic_children_/1494859", "title"=>"Total IgE concentration in the plasma of 18 month old allergic and non-allergic children.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-27 02:47:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2190976"], "description"=>"<p>Definitions of allergy used for the classification of children.</p>", "links"=>[], "tags"=>["allergy", "disorder", "Young Children BackgroundAllergy", "il", "chemokine production.ResultsCord blood", "18 months", "cbmc", "Skin prick tests", "parameter", "cytokine", "relevanceAlthough univariate analyses", "test available.ObjectiveThis study", "Clinical Parameters vs Cytokine Profiles", "model"], "article_id"=>1494860, "categories"=>["Biological Sciences"], "users"=>["Catherine Lombard", "Floriane André", "Jérôme Paul", "Catherine Wanty", "Olivier Vosters", "Pierre Bernard", "Charles Pilette", "Pierre Dupont", "Etienne M. Sokal", "Françoise Smets"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132753.t001", "stats"=>{"downloads"=>3, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Definitions_of_allergy_used_for_the_classification_of_children_/1494860", "title"=>"Definitions of allergy used for the classification of children.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-27 02:47:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2190977"], "description"=>"<p>Cytokines and chemokines analysed by Luminex and detection limits.</p>", "links"=>[], "tags"=>["allergy", "disorder", "Young Children BackgroundAllergy", "il", "chemokine production.ResultsCord blood", "18 months", "cbmc", "Skin prick tests", "parameter", "cytokine", "relevanceAlthough univariate analyses", "test available.ObjectiveThis study", "Clinical Parameters vs Cytokine Profiles", "model"], "article_id"=>1494861, "categories"=>["Biological Sciences"], "users"=>["Catherine Lombard", "Floriane André", "Jérôme Paul", "Catherine Wanty", "Olivier Vosters", "Pierre Bernard", "Charles Pilette", "Pierre Dupont", "Etienne M. Sokal", "Françoise Smets"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132753.t002", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokines_and_chemokines_analysed_by_Luminex_and_detection_limits_/1494861", "title"=>"Cytokines and chemokines analysed by Luminex and detection limits.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-27 02:47:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2190979"], "description"=>"<div><p>Background</p><p>Allergy afflicts one third of children, negatively impacting their quality of life and generating a significant socio-economic burden. To this day, this disorder remains difficult to diagnose early in young patients, with no predictive test available.</p><p>Objective</p><p>This study was designed to correlate cytokine profiles with clinical phenotypes of allergy development.</p><p>Methods</p><p>Three hundred patients were recruited and followed from birth to 18 months of age. They were given a clinical exam at birth and at 2, 6, 12, and 18 months of age, with skin prick tests at 6, and 18 months, in order to have a record of their medical history and determine their allergic status. In addition, mononuclear cells from 131 patients were isolated from cord blood and from peripheral blood samples at 2, 6 and 18 months of age, to analyse their cytokine and chemokine production.</p><p>Results</p><p>Cord blood mononuclear cells (CBMCs) from future Immunoglobulin (Ig) E-mediated allergic children produced significantly less Interleukin (IL)-12p70 and IL-15 than cells from the rest of the cohort. Multivariate analyses revealed that the best predictive model of allergy was built on cytokine data, whereas the best predictive model of IgE-mediated allergy was built on clinical parameters.</p><p>Conclusions and clinical relevance</p><p>Although univariate analyses can yield interesting information regarding the immune responses of allergic children, finding predictive markers of the disorder will likely rely on monitoring multiple parameters. Nonetheless these analyses suggest a potential key role for IL-15 in the development of atopic disease. In addition, the study highlights the importance of clinical parameters in predicting the development of IgE-mediated allergy.</p></div>", "links"=>[], "tags"=>["allergy", "disorder", "Young Children BackgroundAllergy", "il", "chemokine production.ResultsCord blood", "18 months", "cbmc", "Skin prick tests", "parameter", "cytokine", "relevanceAlthough univariate analyses", "test available.ObjectiveThis study", "Clinical Parameters vs Cytokine Profiles", "model"], "article_id"=>1494863, "categories"=>["Biological Sciences"], "users"=>["Catherine Lombard", "Floriane André", "Jérôme Paul", "Catherine Wanty", "Olivier Vosters", "Pierre Bernard", "Charles Pilette", "Pierre Dupont", "Etienne M. Sokal", "Françoise Smets"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132753", "stats"=>{"downloads"=>6, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_Parameters_vs_Cytokine_Profiles_as_Predictive_Markers_of_IgE_Mediated_Allergy_in_Young_Children_/1494863", "title"=>"Clinical Parameters vs Cytokine Profiles as Predictive Markers of IgE-Mediated Allergy in Young Children", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-27 02:47:06"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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