Patterns of Adverse Drug Reactions in Different Age Groups: Analysis of Spontaneous Reports by Community Pharmacists
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{"title"=>"Patterns of Adverse Drug Reactions in Different Age Groups: Analysis of Spontaneous Reports by Community Pharmacists", "type"=>"journal", "authors"=>[{"first_name"=>"Yun Mi", "last_name"=>"Yu"}, {"first_name"=>"Wan Gyoon", "last_name"=>"Shin"}, {"first_name"=>"Ju-Yeun", "last_name"=>"Lee"}, {"first_name"=>"Soo An", "last_name"=>"Choi"}, {"first_name"=>"Yun Hee", "last_name"=>"Jo"}, {"first_name"=>"So Jung", "last_name"=>"Youn"}, {"first_name"=>"Mo Se", "last_name"=>"Lee"}, {"first_name"=>"Kwang Hoon", "last_name"=>"Choi"}], "year"=>2015, "source"=>"PLOS ONE", "identifiers"=>{"pmid"=>"26172050", "issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0132916"}, "id"=>"4191a7b4-b478-39b4-841b-d37a8ab9d515", "abstract"=>"PURPOSE: To evaluate the clinical manifestations and causative drugs associated with adverse drug reactions (ADRs) spontaneously reported by community pharmacists and to compare the ADRs by age.\\n\\nMETHODS: ADRs reported to the Regional Pharmacovigilance Center of the Korean Pharmaceutical Association by community pharmacists from January 2013 to June 2014 were included. Causality was assessed using the WHO-Uppsala Monitoring Centre system. The patient population was classified into three age groups. We analyzed 31,398 (74.9%) ADRs from 9,705 patients, identified as having a causal relationship, from a total pool of 41,930 ADRs from 9,873 patients. Median patient age was 58.0 years; 66.9% were female.\\n\\nRESULTS: Gastrointestinal system (34.4%), nervous system (14.4%), and psychiatric (12.1%) disorders were the most frequent symptoms. Prevalent causative drugs were those for acid-related disorders (11.4%), anti-inflammatory products (10.5%), analgesics (7.2%), and antibacterials (7.1%). Comparisons by age revealed diarrhea and antibacterials to be most commonly associated with ADRs in children (p < 0.001), whereas dizziness was prevalent in the elderly (p < 0.001). Anaphylactic reaction was the most frequent serious event (19.7%), mainly associated with cephalosporins and non-steroidal anti-inflammatory drugs. Among 612 ADRs caused by nonprescription drugs, the leading symptoms and causative drugs were skin disorders (29.6%) and non-steroidal anti-inflammatory drugs (16.2%), respectively.\\n\\nCONCLUSIONS: According to the community pharmacist reports, the leading clinical manifestations and causative drugs associated with ADRs in outpatients differed among age groups.", "link"=>"http://www.mendeley.com/research/patterns-adverse-drug-reactions-different-age-groups-analysis-spontaneous-reports-community-pharmaci-2", "reader_count"=>28, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>15, "Business, Management and Accounting"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>15}}, "reader_count_by_country"=>{"Korea (South)"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2174999"], "description"=>"<p>GI, gastrointestinal; RAS, renin-angiotensin system; OA, obstructive airway. Black bars: female; white bars: male.</p>", "links"=>[], "tags"=>["Korean Pharmaceutical Association", "disorder", "Different Age Groups", "Regional Pharmacovigilance Center", "community pharmacists", "Community Pharmacists PurposeTo", "adverse drug reactions", "Median patient age", "community pharmacist reports", "age groups", "adr"], "article_id"=>1482664, "categories"=>["Biological Sciences"], "users"=>["Yun Mi Yu", "Wan Gyoon Shin", "Ju-Yeun Lee", "Soo An Choi", "Yun Hee Jo", "So Jung Youn", "Mo Se Lee", "Kwang Hoon Choi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132916.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_of_adverse_drug_reactions_and_causative_drugs_according_to_sex_/1482664", "title"=>"Frequency of adverse drug reactions and causative drugs according to sex.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-14 03:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2175002"], "description"=>"<p>ADRs, adverse drug reactions; GU, genito-urinary.</p><p><sup>a</sup>680 adverse drug reactions from 394 patients.</p><p><sup>b</sup>Clinical manifestations reported for more than one adverse drug reaction and the number of adverse drug reactions.</p><p><sup>c</sup>Combinations of aluminum magnesium silicate/ranitidine/magnesium oxide/aluminum magnesium hydroxide.</p><p>Causative drugs and clinical manifestation among the nonprescription drugs.<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132916#t003fn002\" target=\"_blank\"><sup>a</sup></a></p>", "links"=>[], "tags"=>["Korean Pharmaceutical Association", "disorder", "Different Age Groups", "Regional Pharmacovigilance Center", "community pharmacists", "Community Pharmacists PurposeTo", "adverse drug reactions", "Median patient age", "community pharmacist reports", "age groups", "adr"], "article_id"=>1482667, "categories"=>["Biological Sciences"], "users"=>["Yun Mi Yu", "Wan Gyoon Shin", "Ju-Yeun Lee", "Soo An Choi", "Yun Hee Jo", "So Jung Youn", "Mo Se Lee", "Kwang Hoon Choi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132916.t003", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Causative_drugs_and_clinical_manifestation_among_the_nonprescription_drugs_a_/1482667", "title"=>"Causative drugs and clinical manifestation among the nonprescription drugs.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-14 03:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2175003", "https://ndownloader.figshare.com/files/2175004"], "description"=>"<div><p>Purpose</p><p>To evaluate the clinical manifestations and causative drugs associated with adverse drug reactions (ADRs) spontaneously reported by community pharmacists and to compare the ADRs by age.</p><p>Methods</p><p>ADRs reported to the Regional Pharmacovigilance Center of the Korean Pharmaceutical Association by community pharmacists from January 2013 to June 2014 were included. Causality was assessed using the WHO-Uppsala Monitoring Centre system. The patient population was classified into three age groups. We analyzed 31,398 (74.9%) ADRs from 9,705 patients, identified as having a causal relationship, from a total pool of 41,930 ADRs from 9,873 patients. Median patient age was 58.0 years; 66.9% were female.</p><p>Results</p><p>Gastrointestinal system (34.4%), nervous system (14.4%), and psychiatric (12.1%) disorders were the most frequent symptoms. Prevalent causative drugs were those for acid-related disorders (11.4%), anti-inflammatory products (10.5%), analgesics (7.2%), and antibacterials (7.1%). Comparisons by age revealed diarrhea and antibacterials to be most commonly associated with ADRs in children (p < 0.001), whereas dizziness was prevalent in the elderly (p < 0.001). Anaphylactic reaction was the most frequent serious event (19.7%), mainly associated with cephalosporins and non-steroidal anti-inflammatory drugs. Among 612 ADRs caused by nonprescription drugs, the leading symptoms and causative drugs were skin disorders (29.6%) and non-steroidal anti-inflammatory drugs (16.2%), respectively.</p><p>Conclusions</p><p>According to the community pharmacist reports, the leading clinical manifestations and causative drugs associated with ADRs in outpatients differed among age groups.</p></div>", "links"=>[], "tags"=>["Korean Pharmaceutical Association", "disorder", "Different Age Groups", "Regional Pharmacovigilance Center", "community pharmacists", "Community Pharmacists PurposeTo", "adverse drug reactions", "Median patient age", "community pharmacist reports", "age groups", "adr"], "article_id"=>1482668, "categories"=>["Biological Sciences"], "users"=>["Yun Mi Yu", "Wan Gyoon Shin", "Ju-Yeun Lee", "Soo An Choi", "Yun Hee Jo", "So Jung Youn", "Mo Se Lee", "Kwang Hoon Choi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0132916.s001", "https://dx.doi.org/10.1371/journal.pone.0132916.s002"], "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patterns_of_Adverse_Drug_Reactions_in_Different_Age_Groups_Analysis_of_Spontaneous_Reports_by_Community_Pharmacists_/1482668", "title"=>"Patterns of Adverse Drug Reactions in Different Age Groups: Analysis of Spontaneous Reports by Community Pharmacists", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-07-14 03:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2175000"], "description"=>"<p>Patient demographics.</p>", "links"=>[], "tags"=>["Korean Pharmaceutical Association", "disorder", "Different Age Groups", "Regional Pharmacovigilance Center", "community pharmacists", "Community Pharmacists PurposeTo", "adverse drug reactions", "Median patient age", "community pharmacist reports", "age groups", "adr"], "article_id"=>1482665, "categories"=>["Biological Sciences"], "users"=>["Yun Mi Yu", "Wan Gyoon Shin", "Ju-Yeun Lee", "Soo An Choi", "Yun Hee Jo", "So Jung Youn", "Mo Se Lee", "Kwang Hoon Choi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132916.t001", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_demographics_/1482665", "title"=>"Patient demographics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-14 03:23:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2175001"], "description"=>"<p>ADRs, adverse drug reactions; GI, gastrointestinal; OA, obstructive airway diseases; RAS, renin-angiotensin system; AR, anaphylactic reaction; AP, abdominal pain; HE, hepatic enzyme; CF, circulatory failure.</p><p><sup>a</sup>Numbers in parentheses indicate the number of adverse drug reactions.</p><p><sup>b</sup>Dexibuprofen, loxoprofen, and celecoxib, etc.</p><p><sup>c</sup>Combination of acetaminophen and tramadol, buprenorphine, and sumatriptan, etc.</p><p><sup>d</sup>Cefaclor, cefadroxil, and amoxicillin, etc.</p><p>Causative drugs and clinical manifestation in serious events.</p>", "links"=>[], "tags"=>["Korean Pharmaceutical Association", "disorder", "Different Age Groups", "Regional Pharmacovigilance Center", "community pharmacists", "Community Pharmacists PurposeTo", "adverse drug reactions", "Median patient age", "community pharmacist reports", "age groups", "adr"], "article_id"=>1482666, "categories"=>["Biological Sciences"], "users"=>["Yun Mi Yu", "Wan Gyoon Shin", "Ju-Yeun Lee", "Soo An Choi", "Yun Hee Jo", "So Jung Youn", "Mo Se Lee", "Kwang Hoon Choi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0132916.t002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Causative_drugs_and_clinical_manifestation_in_serious_events_/1482666", "title"=>"Causative drugs and clinical manifestation in serious events.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-14 03:23:44"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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