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{"title"=>"The association of LINE-1 hypomethylation with age and centromere positive micronuclei in human lymphocytes", "type"=>"journal", "authors"=>[{"first_name"=>"Yoon Hee", "last_name"=>"Cho", "scopus_author_id"=>"55472222600"}, {"first_name"=>"Hae Dong", "last_name"=>"Woo", "scopus_author_id"=>"54940560500"}, {"first_name"=>"Yoonhee", "last_name"=>"Jang", "scopus_author_id"=>"23479903000"}, {"first_name"=>"Virginia", "last_name"=>"Porter", "scopus_author_id"=>"56830281100"}, {"first_name"=>"Sonja", "last_name"=>"Christensen", "scopus_author_id"=>"56830071800"}, {"first_name"=>"Raymond F.", "last_name"=>"Hamilton", "scopus_author_id"=>"7402615277"}, {"first_name"=>"Hai Won", "last_name"=>"Chung", "scopus_author_id"=>"57198246258"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"26196382", "scopus"=>"2-s2.0-84941287148", "doi"=>"10.1371/journal.pone.0133909", "pui"=>"605939288", "issn"=>"19326203", "sgr"=>"84941287148"}, "id"=>"f9aa2c7c-c00b-3b07-906b-7bb03de3ae8f", "abstract"=>"Global hypomethylation in white blood cell (WBC) DNA has recently been proposed as a potential biomarker for determining cancer risk through genomic instability. However, the amplitude of the changes associated with age and the impacts of environmental factors on DNA methylation are unclear. In this study, we investigated the association of genomic hypomethylation with age, cigarette use, drinking status and the presence of centromere positive micronuclei (MNC+)-a biomarker for age-dependent genomic instability. Genomic hypomethylation of the repetitive element LINE-1 was measured in WBC DNA from 32 healthy male volunteers using the pyrosequencing assay. We also measured MNC+ with the micronucleus-centromere assay using a pan-centromeric probe. Possibly due to the small sample size and resulting low statistical power, smoking and drinking status had no significant effect on LINE-1 hypomethylation or the occurrence of MNC+. Consequently, we did not include them in further analyses. In contrast, LINE-1 hypomethylation and age significantly predicted MNC+; therefore, we examined whether LINE-1 hypomethylation plays a role in MNC+ formation by age, since genomic hypomethylation is associated with genomic instability. However, LINE-1 hypomethylation did not significantly mediate the effect of age on MNC+. Our data indicate that the repetitive element LINE-1 is demethylated with age and increasing MNC+ frequency, but additional studies are needed to fully understand the relation between genomic DNA hypomethylation, age and genomic instability.", "link"=>"http://www.mendeley.com/research/association-line1-hypomethylation-age-centromere-positive-micronuclei-human-lymphocytes", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>4, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>1}

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• http://doi.org/10.1038/s41598-020-79126-z
• http://doi.org/10.1134/S0006297917080120
• http://doi.org/10.1007/s12035-018-1371-7
• http://doi.org/10.3389/fgene.2019.00580
• http://doi.org/10.3389/fgene.2019.01001
• http://doi.org/10.1152/japplphysiol.00352.2019
• http://doi.org/10.1016/j.toxlet.2017.05.016
• http://doi.org/10.1016/j.mad.2018.02.002
• http://doi.org/10.1080/15384101.2018.1502576
• http://doi.org/10.1002/ajmg.b.32833
• http://doi.org/10.3389/fgene.2018.00514

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/2185078"], "description"=>"<p>^a The frequency of MNC+ per 1000 BN cells</p><p>^b Drinking status was classified as either a current alcohol drinker (yes) or not (no).</p><p>Mean values of MNC+ and LINE-1 hypomethylation stratified by smoking and drinking status.</p>", "links"=>[], "tags"=>["wbc", "mnc", "Human Lymphocytes Global hypomethylation", "drinking status", "element LINE", "genomic hypomethylation", "genomic instability", "Genomic DNA Hypomethylation"], "article_id"=>1490651, "categories"=>["Biological Sciences"], "users"=>["Yoon Hee Cho", "Hae Dong Woo", "Yoonhee Jang", "Virginia Porter", "Sonja Christensen", "Raymond F. Hamilton Jr.", "Hai Won Chung"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0133909.t002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_values_of_MNC_and_LINE_1_hypomethylation_stratified_by_smoking_and_drinking_status_/1490651", "title"=>"Mean values of MNC+ and LINE-1 hypomethylation stratified by smoking and drinking status.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-21 03:41:08"}
• {"files"=>["https://ndownloader.figshare.com/files/2185079"], "description"=>"<div><p>Global hypomethylation in white blood cell (WBC) DNA has recently been proposed as a potential biomarker for determining cancer risk through genomic instability. However, the amplitude of the changes associated with age and the impacts of environmental factors on DNA methylation are unclear. In this study, we investigated the association of genomic hypomethylation with age, cigarette use, drinking status and the presence of centromere positive micronuclei (MNC+)—a biomarker for age-dependent genomic instability. Genomic hypomethylation of the repetitive element LINE-1 was measured in WBC DNA from 32 healthy male volunteers using the pyrosequencing assay. We also measured MNC+ with the micronucleus-centromere assay using a pan-centromeric probe. Possibly due to the small sample size and resulting low statistical power, smoking and drinking status had no significant effect on LINE-1 hypomethylation or the occurrence of MNC+. Consequently, we did not include them in further analyses. In contrast, LINE-1 hypomethylation and age significantly predicted MNC+; therefore, we examined whether LINE-1 hypomethylation plays a role in MNC+ formation by age, since genomic hypomethylation is associated with genomic instability. However, LINE-1 hypomethylation did not significantly mediate the effect of age on MNC+. Our data indicate that the repetitive element LINE-1 is demethylated with age and increasing MNC+ frequency, but additional studies are needed to fully understand the relation between genomic DNA hypomethylation, age and genomic instability.</p></div>", "links"=>[], "tags"=>["wbc", "mnc", "Human Lymphocytes Global hypomethylation", "drinking status", "element LINE", "genomic hypomethylation", "genomic instability", "Genomic DNA Hypomethylation"], "article_id"=>1490652, "categories"=>["Biological Sciences"], "users"=>["Yoon Hee Cho", "Hae Dong Woo", "Yoonhee Jang", "Virginia Porter", "Sonja Christensen", "Raymond F. Hamilton Jr.", "Hai Won Chung"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0133909", "stats"=>{"downloads"=>5, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Association_of_LINE_1_Hypomethylation_with_Age_and_Centromere_Positive_Micronuclei_in_Human_Lymphocytes_/1490652", "title"=>"The Association of LINE-1 Hypomethylation with Age and Centromere Positive Micronuclei in Human Lymphocytes", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-21 03:41:08"}
• {"files"=>["https://ndownloader.figshare.com/files/2185076"], "description"=>"<p>(Top) the path from age to MNC+. (Bottom) another path from age through LINE-1 hypomethylation to MNC+. Arrows connecting one variable to another represent unstandardized regression coefficients of the path. Solid lines are significant whereas dashed lines are not.</p>", "links"=>[], "tags"=>["wbc", "mnc", "Human Lymphocytes Global hypomethylation", "drinking status", "element LINE", "genomic hypomethylation", "genomic instability", "Genomic DNA Hypomethylation"], "article_id"=>1490649, "categories"=>["Biological Sciences"], "users"=>["Yoon Hee Cho", "Hae Dong Woo", "Yoonhee Jang", "Virginia Porter", "Sonja Christensen", "Raymond F. Hamilton Jr.", "Hai Won Chung"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0133909.g001", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Causal_model_for_age_and_LINE_1_hypomethylation_prediction_of_MNC_/1490649", "title"=>"Causal model for age and LINE-1 hypomethylation prediction of MNC+.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-21 03:41:08"}
• {"files"=>["https://ndownloader.figshare.com/files/2185077"], "description"=>"<p>^a The frequency of MNC+ per 1000 BN cells</p><p>^b There was one missing value, and the total number of participants was 31.</p><p>^c Drinking status was classified as either a current alcohol drinker (yes) or not (no).</p><p>Characteristics of the participants.</p>", "links"=>[], "tags"=>["wbc", "mnc", "Human Lymphocytes Global hypomethylation", "drinking status", "element LINE", "genomic hypomethylation", "genomic instability", "Genomic DNA Hypomethylation"], "article_id"=>1490650, "categories"=>["Biological Sciences"], "users"=>["Yoon Hee Cho", "Hae Dong Woo", "Yoonhee Jang", "Virginia Porter", "Sonja Christensen", "Raymond F. Hamilton Jr.", "Hai Won Chung"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0133909.t001", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_participants_/1490650", "title"=>"Characteristics of the participants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-21 03:41:08"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime