Prospectively ECG-Triggered Sequential Dual-Source Coronary CT Angiography in Patients with Atrial Fibrillation: Influence of Heart Rate on Image Quality and Evaluation of Diagnostic Accuracy
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{"title"=>"Prospectively ECG-triggered sequential dual-source coronary CT angiography in patients with atrial fibrillation: Influence of heart rate on image quality and evaluation of diagnostic accuracy", "type"=>"journal", "authors"=>[{"first_name"=>"Lin", "last_name"=>"Yang", "scopus_author_id"=>"56382640600"}, {"first_name"=>"Lei", "last_name"=>"Xu", "scopus_author_id"=>"35270676000"}, {"first_name"=>"U. Joseph", "last_name"=>"Schoepf", "scopus_author_id"=>"7003500498"}, {"first_name"=>"Julian L.", "last_name"=>"Wichmann", "scopus_author_id"=>"55175155700"}, {"first_name"=>"Mary A.", "last_name"=>"Fox", "scopus_author_id"=>"56585276100"}, {"first_name"=>"Jing", "last_name"=>"Yan", "scopus_author_id"=>"56849737600"}, {"first_name"=>"Zhanming", "last_name"=>"Fan", "scopus_author_id"=>"12809202200"}, {"first_name"=>"Zhaoqi", "last_name"=>"Zhang", "scopus_author_id"=>"12802607200"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"605997120", "sgr"=>"84941760424", "doi"=>"10.1371/journal.pone.0134194", "scopus"=>"2-s2.0-84941760424", "isbn"=>"1932-6203", "pmid"=>"26221952"}, "id"=>"d7777819-e236-3396-9ad7-960ca2192604", "abstract"=>"Objectives To evaluate the effects of mean heart rate (HR) and heart rate variation (HRV) on image quality and diagnostic accuracy of prospectively ECG-triggered sequential dual-source coronary CT angiography (CCTA) in patients with atrial fibrillation (AF). Methods Eighty-five patients (49 women, 36 men; mean age 62.1±9.5 years) with persistent AF underwent prospectively ECG-triggered sequential second-generation dual-source CCTA. Tube current and voltage were adjusted according to body mass index (BMI) and iterative reconstruction was used. Image quality of coronary segments (four-point scale) and presence of significant stenosis (>50%) were evaluated. Diagnostic accuracy was analyzed in 30 of the 85 patients who underwent additional invasive coronary angiography (ICA). Results Only 8 of 1102 (0.7%) segments demonstrated poor image quality. No significant impact on image quality was found for mean HR (94.9±21.8 bpm; r=0.034, p=0.758; F=0.413, p=0.663) or HRV (67.5±22.8 bpm; r=0.097, p=0.377; F=0.111, p=0.895). On per-segment analysis, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 89.7% (26/29), 99.4% (355/357), 92.9% (26/28), and 99.2% (355/358), respectively, with excellent correlation (kappa=0.91) with ICA. Mean effective dose was 3.3±1.0 mSv. Conclusions Prospectively ECG-triggered sequential dual-source CCTA provides diagnostic image quality and good diagnostic accuracy for detection of coronary stenosis in AF patients without significant influence by HR or HRV.", "link"=>"http://www.mendeley.com/research/prospectively-ecgtriggered-sequential-dualsource-coronary-ct-angiography-patients-atrial-fibrillatio-2", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Postgraduate"=>1, "Other"=>4, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Postgraduate"=>1, "Other"=>4, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>9, "Business, Management and Accounting"=>1, "Physics and Astronomy"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2194434"], "description"=>"<p>Mean HR was 100 bpm (range, 68–137 bpm). Images reconstructed at 270 msec after R wave. Volume-rendered (A) and curved multiplanar reformation (B) images of RCA (white arrow) show atherosclerosis lesion (stenosis>50%) in distal segment. Conventional coronary angiogram (C) shows significant stenosis (>50%) in distal segment of RCA (black arrow). The ECG information (D) was recorded during data acquisition.</p>", "links"=>[], "tags"=>["ct", "hrv", "body mass index", "npv", "hr", "bpm", "bmi", "sequential", "image quality", "angiography", "ccta", "image", "ppv", "Diagnostic Accuracy ObjectivesTo", "stenosi", "heart rate variation", "accuracy", "af", "ica"], "article_id"=>1497624, "categories"=>["Biological Sciences"], "users"=>["Lin Yang", "Lei Xu", "U. Joseph Schoepf", "Julian L. Wichmann", "Mary A. Fox", "Jing Yan", "Zhanming Fan", "Zhaoqi Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0134194.g004", "stats"=>{"downloads"=>5, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prospectively_ECG_triggered_dual_source_CCTA_of_a_57_year_old_woman_with_AF_/1497624", "title"=>"Prospectively ECG-triggered dual-source CCTA of a 57-year-old woman with AF.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-29 04:21:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2194435"], "description"=>"<p>Data are means± standard deviations.</p><p>* Data is numbers of patients.</p><p><sup><b>Δ</b></sup> Data are median± interquartile range.</p><p>Patient characteristics.</p>", "links"=>[], "tags"=>["ct", "hrv", "body mass index", "npv", "hr", "bpm", "bmi", "sequential", "image quality", "angiography", "ccta", "image", "ppv", "Diagnostic Accuracy ObjectivesTo", "stenosi", "heart rate variation", "accuracy", "af", "ica"], "article_id"=>1497625, "categories"=>["Biological Sciences"], "users"=>["Lin Yang", "Lei Xu", "U. Joseph Schoepf", "Julian L. Wichmann", "Mary A. Fox", "Jing Yan", "Zhanming Fan", "Zhaoqi Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0134194.t001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_characteristics_/1497625", "title"=>"Patient characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-07-29 04:21:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2194431"], "description"=>"<p>No significant linear correlation between image quality and mean HR in AF patients by using prospectively ECG-triggered dual-source CT (Pearson correlation, r = 0.034, P = 0.758).</p>", "links"=>[], "tags"=>["ct", "hrv", "body mass index", "npv", "hr", "bpm", "bmi", "sequential", "image quality", "angiography", "ccta", "image", "ppv", "Diagnostic Accuracy ObjectivesTo", "stenosi", "heart rate variation", "accuracy", "af", "ica"], "article_id"=>1497621, "categories"=>["Biological Sciences"], "users"=>["Lin Yang", "Lei Xu", "U. Joseph Schoepf", "Julian L. Wichmann", "Mary A. Fox", "Jing Yan", "Zhanming Fan", "Zhaoqi Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0134194.g001", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Linear_regression_analysis_of_image_quality_versus_HR_/1497621", "title"=>"The Linear regression analysis of image quality versus HR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-29 04:21:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2194432"], "description"=>"<p>No significant linear correlation between image quality and HRV in AF patients using prospectively ECG-triggered dual-source CT. (Pearson correlation, r = 0.097, P = 0.377).</p>", "links"=>[], "tags"=>["ct", "hrv", "body mass index", "npv", "hr", "bpm", "bmi", "sequential", "image quality", "angiography", "ccta", "image", "ppv", "Diagnostic Accuracy ObjectivesTo", "stenosi", "heart rate variation", "accuracy", "af", "ica"], "article_id"=>1497622, "categories"=>["Biological Sciences"], "users"=>["Lin Yang", "Lei Xu", "U. Joseph Schoepf", "Julian L. Wichmann", "Mary A. Fox", "Jing Yan", "Zhanming Fan", "Zhaoqi Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0134194.g002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Linear_regression_analysis_of_image_quality_versus_HRV_/1497622", "title"=>"The Linear regression analysis of image quality versus HRV.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-29 04:21:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/2194433"], "description"=>"<p>Mean HR was 86 bpm (range, 60–107 bpm). Images reconstructed at 240 ms after R wave. Volume-rendered (A), maximum intensity projection (B) and curved multiplanar reformation (C) image of LCX (black arrow) show the vessel lumen was overlapped by calcified plaque in the distal segment. Conventional coronary angiogram (D) shows significant stenosis (>50%) in distal segment of LCX (black arrow). The ECG information was recorded during data acquisition.</p>", "links"=>[], "tags"=>["ct", "hrv", "body mass index", "npv", "hr", "bpm", "bmi", "sequential", "image quality", "angiography", "ccta", "image", "ppv", "Diagnostic Accuracy ObjectivesTo", "stenosi", "heart rate variation", "accuracy", "af", "ica"], "article_id"=>1497623, "categories"=>["Biological Sciences"], "users"=>["Lin Yang", "Lei Xu", "U. Joseph Schoepf", "Julian L. Wichmann", "Mary A. Fox", "Jing Yan", "Zhanming Fan", "Zhaoqi Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0134194.g003", "stats"=>{"downloads"=>7, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prospectively_ECG_triggered_dual_source_CCTA_of_a_60_year_old_man_with_AF_/1497623", "title"=>"Prospectively ECG-triggered dual-source CCTA of a 60-year-old man with AF.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-07-29 04:21:54"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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