Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice
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{"title"=>"Analgesic and anti-inflammatory properties of gelsolin in acetic acid induced writhing, tail immersion and carrageenan induced paw edema in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Ashok Kumar", "last_name"=>"Gupta", "scopus_author_id"=>"56883428000"}, {"first_name"=>"Devraj", "last_name"=>"Parasar", "scopus_author_id"=>"56884710300"}, {"first_name"=>"Amin", "last_name"=>"Sagar", "scopus_author_id"=>"54380569300"}, {"first_name"=>"Vikas", "last_name"=>"Choudhary", "scopus_author_id"=>"55764898600"}, {"first_name"=>"Bhupinder Singh", "last_name"=>"Chopra", "scopus_author_id"=>"56429025800"}, {"first_name"=>"Renu", "last_name"=>"Garg", "scopus_author_id"=>"56883828200"}, {"last_name"=>"Ashish", "scopus_author_id"=>"24774275700"}, {"first_name"=>"Neeraj", "last_name"=>"Khatri", "scopus_author_id"=>"56247231100"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84942848030", "pmid"=>"26426535", "sgr"=>"84942848030", "issn"=>"19326203", "pui"=>"606195703", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0135558"}, "id"=>"4f5cf468-c2f1-3507-995e-58fd02fc6863", "abstract"=>"Plasma gelsolin levels significantly decline in several disease conditions, since gelsolin gets scavenged when it depolymerizes and caps filamentous actin released in the circulation following tissue injury. It is well established that our body require/implement inflammatory and analgesic responses to protect against cell damage and injury to the tissue. This study was envisaged to examine analgesic and anti-inflammatory activity of exogenous gelsolin (8 mg/mouse) in mice models of pain and acute inflammation. Administration of gelsolin in acetic acid-induced writhing and tail immersion tests not only demonstrated a significant reduction in the number of acetic acid-induced writhing effects, but also exhibited an analgesic activity in tail immersion test in mice as compared to placebo treated mice. Additionally, anti-inflammatory function of gelsolin (8 mg/mouse) compared with anti-inflammatory drug diclofenac sodium (10 mg/kg)] was confirmed in the carrageenan injection induced paw edema where latter was measured by vernier caliper and fluorescent tomography imaging. Interestingly, results showed that plasma gelsolin was capable of reducing severity of inflammation in mice comparable to diclofenac sodium. Analysis of cytokines and histopathological examinations of tissue revealed administration of gelsolin and diclofenac sodium significantly reduced production of pro-inflammatory cytokines, TNF-α and IL-6. Additionally, carrageenan groups pretreated with diclofenac sodium or gelsolin showed a marked decrease in edema and infiltration of inflammatory cells in paw tissue. Our study provides evidence that administration of gelsolin can effectively reduce the pain and inflammation in mice model.", "link"=>"http://www.mendeley.com/research/analgesic-antiinflammatory-properties-gelsolin-acetic-acid-induced-writhing-tail-immersion-carrageen", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>1, "Other"=>1, "Student > Master"=>8, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>1, "Other"=>1, "Student > Master"=>8, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "group_count"=>2}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/2212729"], "description"=>"<p>Comparison curve of diclofenac sodium and rhuGSN have been plotted.</p>", "links"=>[], "tags"=>["diclofenac sodium", "tail immersion test", "tail immersion tests", "Carrageenan Induced Paw Edema", "caps filamentous actin", "Mice Plasma gelsolin levels", "carrageenan groups pretreated", "tissue", "tnf", "il"], "article_id"=>1511178, "categories"=>["Biological Sciences"], "users"=>["Ashok Kumar Gupta", "Devraj Parasar", "Amin Sagar", "Vikas Choudhary", "Bhupinder Singh Chopra", "Renu Garg", "Ashish", "Neeraj Khatri"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135558.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_rhuGSN_and_diclofenac_sodium_on_protein_denaturation_/1511178", "title"=>"Effect of rhuGSN and diclofenac sodium on protein denaturation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-08-14 02:57:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2212730"], "description"=>"<p>Measurement of edema of paw in mice (N = 6) of different treatment groups.</p>", "links"=>[], "tags"=>["diclofenac sodium", "tail immersion test", "tail immersion tests", "Carrageenan Induced Paw Edema", "caps filamentous actin", "Mice Plasma gelsolin levels", "carrageenan groups pretreated", "tissue", "tnf", "il"], "article_id"=>1511179, "categories"=>["Biological Sciences"], "users"=>["Ashok Kumar Gupta", "Devraj Parasar", "Amin Sagar", "Vikas Choudhary", "Bhupinder Singh Chopra", "Renu Garg", "Ashish", "Neeraj Khatri"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135558.g004", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_rhuGSN_ameliorated_the_symptoms_of_acute_inflammation_induced_by_carrageenan_/1511179", "title"=>"rhuGSN ameliorated the symptoms of acute inflammation induced by carrageenan.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-08-14 02:57:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/2212735"], "description"=>"<p>Photos of the hind paws of normal, carrageenan treated (Control), diclofenac sod. (carrageenan + diclofenac sodium) and rhuGSN (carrageenan + rhuGSN mice) (A), histopathology data representing H&E-stained sections of paws of normal, control, diclofenac sodium and rhuGSN treated mice (B), fluorescent tomographic imaging of paws (N = 3) probed with MMPSense 750, signifying a decrease in disease severity by rhuGSN treatment (C), Photos of the hind paws of normal, carrageenan treated (Control), diclofenac sod. (carrageenan + diclofenac sodium) and rhuGSN (carrageenan + rhuGSN mice) showing leakage of Evans Blue dye (D)</p>", "links"=>[], "tags"=>["diclofenac sodium", "tail immersion test", "tail immersion tests", "Carrageenan Induced Paw Edema", "caps filamentous actin", "Mice Plasma gelsolin levels", "carrageenan groups pretreated", "tissue", "tnf", "il"], "article_id"=>1511184, "categories"=>["Biological Sciences"], "users"=>["Ashok Kumar Gupta", "Devraj Parasar", "Amin Sagar", "Vikas Choudhary", "Bhupinder Singh Chopra", "Renu Garg", "Ashish", "Neeraj Khatri"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135558.g005", "stats"=>{"downloads"=>2, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analgesic_and_Anti_Inflammatory_Properties_of_Gelsolin_in_Acetic_Acid_Induced_Writhing_Tail_Immersion_and_Carrageenan_Induced_Paw_Edema_in_Mice_Fig_5_/1511184", "title"=>"Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice - Fig 5", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-08-14 02:57:15"}
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Relative Metric

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