Bocavirus Infection in Otherwise Healthy Children with Respiratory Disease
Publication Date
August 12, 2015
Journal
PLOS ONE
Authors
Nicola Principi, Antonio Piralla, Alberto Zampiero, Sonia Bianchini, et al
Volume
10
Issue
8
Pages
e0135640
DOI
https://dx.plos.org/10.1371/journal.pone.0135640
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0135640
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26267139
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534143
Europe PMC
http://europepmc.org/abstract/MED/26267139
Web of Science
000359492300146
Scopus
84942920069
Mendeley
http://www.mendeley.com/research/bocavirus-infection-otherwise-healthy-children-respiratory-disease-1
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Mendeley | Further Information

{"title"=>"Bocavirus infection in otherwise healthy children with respiratory disease", "type"=>"journal", "authors"=>[{"first_name"=>"Nicola", "last_name"=>"Principi", "scopus_author_id"=>"55336040900"}, {"first_name"=>"Antonio", "last_name"=>"Piralla", "scopus_author_id"=>"15848683600"}, {"first_name"=>"Alberto", "last_name"=>"Zampiero", "scopus_author_id"=>"55246295900"}, {"first_name"=>"Sonia", "last_name"=>"Bianchini", "scopus_author_id"=>"26634751900"}, {"first_name"=>"Giulia", "last_name"=>"Umbrello", "scopus_author_id"=>"56656569200"}, {"first_name"=>"Alessia", "last_name"=>"Scala", "scopus_author_id"=>"35937470100"}, {"first_name"=>"Samantha", "last_name"=>"Bosis", "scopus_author_id"=>"6602889090"}, {"first_name"=>"Emilio", "last_name"=>"Fossali", "scopus_author_id"=>"6603857998"}, {"first_name"=>"Fausto", "last_name"=>"Baldanti", "scopus_author_id"=>"7005590779"}, {"first_name"=>"Susanna", "last_name"=>"Esposito", "scopus_author_id"=>"7202860189"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84942920069", "doi"=>"10.1371/journal.pone.0135640", "pui"=>"606195466", "pmid"=>"26267139", "scopus"=>"2-s2.0-84942920069", "issn"=>"19326203"}, "id"=>"e15c25a6-72a5-3132-bf15-03710142c322", "abstract"=>"To evaluate the role of human bocavirus (hBoV) as a causative agent of respiratory disease, the importance of the viral load in respiratory disease type and severity and the pathogenicity of the different hBoV species, we studied all hBoV-positive nasopharyngeal samples collected from children who attended an emergency room for a respiratory tract infection during three winters (2009-2010, 2011-2012, and 2013-2014). Human bocavirus was detected using the respiratory virus panel fast assay and real-time PCR. Of the 1,823 nasopharyngeal samples, 104 (5.7%) were positive for hBoV; a similar prevalence was observed in all three periods studied. Among hBoV-infected children, 53.8% were between 1-2 years old, and hBoV was detected alone in 57/104 (54.8%) cases. All of the detected hBoV strains belonged to genotype 1. The median hBoV load was significantly higher in samples containing strains with both the N546H and T590S mutations compared to other samples (p<0.05). Children with a single hBoV-1 infection more frequently had upper respiratory tract infections (URTIs) than those who were co-infected (37.0% vs 17.8%, respectively, p = 0.04). The duration of hospitalization was longer among children with high viral loads than that observed among children with low viral loads (8.0 ±2.2 days vs 5.0 ±1.5 days, respectively, p = 0.03), and the use of aerosol therapy was more frequent among children with high viral loads than among those with low viral loads (77.1% vs 55.7%, respectively, p = 0.04). This study shows that hBoV is a relatively uncommon but stable infectious agent in children and that hBoV1 seems to be the only strain detected in Italy in respiratory samples. From a clinical point of view, hBoV1 seems to have in the majority of healthy children relatively low clinical relevance. Moreover, the viral load influences only the duration of hospitalization and the use of aerosol therapy without any association with the site of the respiratory disease.", "link"=>"http://www.mendeley.com/research/bocavirus-infection-otherwise-healthy-children-respiratory-disease-1", "reader_count"=>16, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>5, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>5, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>1, "Psychology"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1, "Mexico"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2209842"], "description"=>"<p>CRP: C reactive protein; SD: standard deviation; SpO<sub>2</sub>: peripheral oxygen saturation.”38.0°C or more any time during the illness (before or at enrolment, or during follow-up); <b>°</b>39.0°C or more any time during the illness (before or at enrolment, or during follow-up).</p><p><sup>a</sup>Data were extracted from datasets of different studies that collected different information, therefore the denominators vary across characteristics</p><p><sup>b</sup>Information available for 9 subjects only (6 with low and 3 with high viral load).</p><p>Comparison between subjects with low and high viral human bocavirus loads, according to demographic, clinical and laboratory variables.<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135640#t005fn002\" target=\"_blank\"><sup>a</sup></a></p>", "links"=>[], "tags"=>["546H", "pcr", "aerosol therapy", "T 590S mutations", "load", "HBoV 1", "sample", "urti"], "article_id"=>1509069, "categories"=>["Biological Sciences"], "users"=>["Nicola Principi", "Antonio Piralla", "Alberto Zampiero", "Sonia Bianchini", "Giulia Umbrello", "Alessia Scala", "Samantha Bosis", "Emilio Fossali", "Fausto Baldanti", "Susanna Esposito"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135640.t005", "stats"=>{"downloads"=>8, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_subjects_with_low_and_high_viral_human_bocavirus_loads_according_to_demographic_clinical_and_laboratory_variables_a_/1509069", "title"=>"Comparison between subjects with low and high viral human bocavirus loads, according to demographic, clinical and laboratory variables.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-12 03:20:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/2209838"], "description"=>"<p>FEL: fixed-effects likelihood; FUBAR: fast unconstrained Bayesian approximation methods; IFEL: internal branch fixed-effects likelihood; MEME: mixed effects model of evolution; SLAC: single-likelihood ancestor.</p><p>Positively and negatively selected sites for human bocavirus strains originating from this study.</p>", "links"=>[], "tags"=>["546H", "pcr", "aerosol therapy", "T 590S mutations", "load", "HBoV 1", "sample", "urti"], "article_id"=>1509065, "categories"=>["Biological Sciences"], "users"=>["Nicola Principi", "Antonio Piralla", "Alberto Zampiero", "Sonia Bianchini", "Giulia Umbrello", "Alessia Scala", "Samantha Bosis", "Emilio Fossali", "Fausto Baldanti", "Susanna Esposito"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135640.t002", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Positively_and_negatively_selected_sites_for_human_bocavirus_strains_originating_from_this_study_/1509065", "title"=>"Positively and negatively selected sites for human bocavirus strains originating from this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-12 03:20:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/2209836"], "description"=>"<p>Dots indicate identity. Amino acids highlighted in bold are under positive selective pressure. The bar length corresponds to the viral load levels. The viral load levels of strains with the T590S change and an additional change in a codon under positive selection are marked with an asterisk.</p>", "links"=>[], "tags"=>["546H", "pcr", "aerosol therapy", "T 590S mutations", "load", "HBoV 1", "sample", "urti"], "article_id"=>1509063, "categories"=>["Biological Sciences"], "users"=>["Nicola Principi", "Antonio Piralla", "Alberto Zampiero", "Sonia Bianchini", "Giulia Umbrello", "Alessia Scala", "Samantha Bosis", "Emilio Fossali", "Fausto Baldanti", "Susanna Esposito"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135640.g002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alignment_of_VP1_VP2_amino_acid_changes_with_respect_to_the_prototype_strain_human_bocavirus_hBoV_st1_DQ000495_in_105_Italian_hBoV_strains_/1509063", "title"=>"Alignment of VP1/VP2 amino acid changes with respect to the prototype strain (human bocavirus [hBoV] st1; DQ000495) in 105 Italian hBoV strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-08-12 03:20:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/2209837"], "description"=>"<p>One missing value for age.</p><p>Viral load was categorized in two groups, and was considered “low” for values ≤6 log (copies/mL) and “high” for values >6 log (copies/mL).</p><p>p-value = 0.03 for comparison between subgroups of presence of co-infection(s), according to age group (Cochran-Armitage trend test).</p><p>p-value = 0.67 for comparison between subgroups of viral load, according to age group (Cochran-Armitage trend test).</p><p>Positivity for bocavirus in children with respiratory tract infections, according to age group and presence of co-infection(s).</p>", "links"=>[], "tags"=>["546H", "pcr", "aerosol therapy", "T 590S mutations", "load", "HBoV 1", "sample", "urti"], "article_id"=>1509064, "categories"=>["Biological Sciences"], "users"=>["Nicola Principi", "Antonio Piralla", "Alberto Zampiero", "Sonia Bianchini", "Giulia Umbrello", "Alessia Scala", "Samantha Bosis", "Emilio Fossali", "Fausto Baldanti", "Susanna Esposito"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135640.t001", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Positivity_for_bocavirus_in_children_with_respiratory_tract_infections_according_to_age_group_and_presence_of_co_infection_s_/1509064", "title"=>"Positivity for bocavirus in children with respiratory tract infections, according to age group and presence of co-infection(s).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-12 03:20:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/2209831"], "description"=>"<p>Sequences originating from this study are indicated with black and red circles. HBoV reference stains are in bold. The percentage of replicate trees in which the associated taxa clustered together in the bootstrap test (1,000 replicates) are shown next to the branches.</p>", "links"=>[], "tags"=>["546H", "pcr", "aerosol therapy", "T 590S mutations", "load", "HBoV 1", "sample", "urti"], "article_id"=>1509059, "categories"=>["Biological Sciences"], "users"=>["Nicola Principi", "Antonio Piralla", "Alberto Zampiero", "Sonia Bianchini", "Giulia Umbrello", "Alessia Scala", "Samantha Bosis", "Emilio Fossali", "Fausto Baldanti", "Susanna Esposito"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135640.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogenetic_tree_based_on_complete_VP1_VP2_gene_sequences_of_human_bocavirus_hBoV_strains_/1509059", "title"=>"Phylogenetic tree based on complete VP1/VP2 gene sequences of human bocavirus (hBoV) strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-08-12 03:20:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/2209840"], "description"=>"<p>CRP: C reactive protein; SD: standard deviation; SpO<sub>2</sub>: peripheral oxygen saturation.”38.0°C or more any time during the illness (before or at enrolment, or during follow-up); <b>°</b>39.0°C or more any time during the illness (before or at enrolment, or during follow-up).</p><p><sup>a</sup>Data were extracted from datasets of different studies that collected different information, therefore the denominators vary across characteristics.</p><p><sup>b</sup>Information available for 9 subjects only (7 without co-infection and 2 with co-infection).</p><p>Comparisons between subjects positive for human bocavirus with or without co-infection(s), according to demographic, clinical and laboratory variables.<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135640#t004fn002\" target=\"_blank\"><sup>a</sup></a></p>", "links"=>[], "tags"=>["546H", "pcr", "aerosol therapy", "T 590S mutations", "load", "HBoV 1", "sample", "urti"], "article_id"=>1509067, "categories"=>["Biological Sciences"], "users"=>["Nicola Principi", "Antonio Piralla", "Alberto Zampiero", "Sonia Bianchini", "Giulia Umbrello", "Alessia Scala", "Samantha Bosis", "Emilio Fossali", "Fausto Baldanti", "Susanna Esposito"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135640.t004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparisons_between_subjects_positive_for_human_bocavirus_with_or_without_co_infection_s_according_to_demographic_clinical_and_laboratory_variables_a_/1509067", "title"=>"Comparisons between subjects positive for human bocavirus with or without co-infection(s), according to demographic, clinical and laboratory variables.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-12 03:20:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/2209839"], "description"=>"<p>Presence of mutations in human bocavirus strains and relation of mutations with viral load.</p>", "links"=>[], "tags"=>["546H", "pcr", "aerosol therapy", "T 590S mutations", "load", "HBoV 1", "sample", "urti"], "article_id"=>1509066, "categories"=>["Biological Sciences"], "users"=>["Nicola Principi", "Antonio Piralla", "Alberto Zampiero", "Sonia Bianchini", "Giulia Umbrello", "Alessia Scala", "Samantha Bosis", "Emilio Fossali", "Fausto Baldanti", "Susanna Esposito"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0135640.t003", "stats"=>{"downloads"=>4, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Presence_of_mutations_in_human_bocavirus_strains_and_relation_of_mutations_with_viral_load_/1509066", "title"=>"Presence of mutations in human bocavirus strains and relation of mutations with viral load.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-08-12 03:20:36"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"26", "full-text"=>"31", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
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  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"32", "full-text"=>"23", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
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  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
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  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
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  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
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  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"21", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"26", "full-text"=>"32", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2020", "month"=>"4"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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