PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups
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{"title"=>"PD-1 and PD-L1 expression in NSCLC indicate a favorable prognosis in defined subgroups", "type"=>"journal", "authors"=>[{"first_name"=>"Lars Henning", "last_name"=>"Schmidt", "scopus_author_id"=>"7401563359"}, {"first_name"=>"Andreas", "last_name"=>"Kümmel", "scopus_author_id"=>"13406657700"}, {"first_name"=>"Dennis", "last_name"=>"Görlich", "scopus_author_id"=>"39261410500"}, {"first_name"=>"Michael", "last_name"=>"Mohr", "scopus_author_id"=>"57191854896"}, {"first_name"=>"Sebastian", "last_name"=>"Bröckling", "scopus_author_id"=>"56891688900"}, {"first_name"=>"Jan Henrik", "last_name"=>"Mikesch", "scopus_author_id"=>"14058611000"}, {"first_name"=>"Inga", "last_name"=>"Grünewald", "scopus_author_id"=>"56001549100"}, {"first_name"=>"Alessandro", "last_name"=>"Marra", "scopus_author_id"=>"7006030449"}, {"first_name"=>"Anne M.", "last_name"=>"Schultheis", "scopus_author_id"=>"14020583100"}, {"first_name"=>"Eva", "last_name"=>"Wardelmann", "scopus_author_id"=>"7003709018"}, {"first_name"=>"Carsten", "last_name"=>"Müller-Tidow", "scopus_author_id"=>"7004555214"}, {"first_name"=>"Tilmann", "last_name"=>"Spieker", "scopus_author_id"=>"6602949654"}, {"first_name"=>"Christoph", "last_name"=>"Schliemann", "scopus_author_id"=>"15045622300"}, {"first_name"=>"Wolfgang E.", "last_name"=>"Berdel", "scopus_author_id"=>"7103214720"}, {"first_name"=>"Rainer", "last_name"=>"Wiewrodt", "scopus_author_id"=>"55973825400"}, {"first_name"=>"Wolfgang", "last_name"=>"Hartmann", "scopus_author_id"=>"7201802085"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84943340055", "pui"=>"606225917", "doi"=>"10.1371/journal.pone.0136023", "isbn"=>"1932-6203", "sgr"=>"84943340055", "pmid"=>"26313362"}, "id"=>"a31fb346-7191-3744-b8d6-815e66fbaee0", "abstract"=>"BACKGROUND: Immunotherapy can become a crucial therapeutic option to improve prognosis for lung cancer patients. First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors. However, in lung cancer the diagnostic, prognostic and predictive value of these immunologic factors remains unclear. METHOD: The impact of both factors was evaluated in a study collective of 321 clinically well-annotated patients with non-small lung cancer (NSCLC) using immunohistochemistry. RESULTS: PD-1 expression by tumor infiltrating lymphocytes (TILs) was found in 22%, whereas tumor cell associated PD-L1 expression was observed in 24% of the NSCLC tumors. In Fisher's exact test a positive correlation was found for PD-L1 and Bcl-xl protein expression (p = 0.013). Interestingly, PD-L1 expression on tumor cells was associated with improved overall survival in pulmonary squamous cell carcinomas (SCC, p = 0.042, log rank test), with adjuvant therapy (p = 0.017), with increased tumor size (pT2-4, p = 0.039) and with positive lymph node status (pN1-3, p = 0.010). These observations were confirmed by multivariate cox regression models. CONCLUSION: One major finding of our study is the identification of a prognostic implication of PD-L1 in subsets of NSCLC patients with pulmonary SCC, with increased tumor size, with a positive lymph node status and NSCLC patients who received adjuvant therapies. This study provides first data for immune-context related risk stratification of NSCLC patients. Further studies are necessary both to confirm this observation and to evaluate the predictive value of PD-1 and PD-L1 in NSCLC in the context of PD-1 inhibition.", "link"=>"http://www.mendeley.com/research/pd1-pdl1-expression-nsclc-indicate-favorable-prognosis-defined-subgroups", "reader_count"=>58, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>17, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>8, "Other"=>5, "Student > Master"=>6, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>17, "Student > Doctoral Student"=>2, "Student > Ph. D. 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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2231243"], "description"=>"<p>Whereas for the full study collective (n = 321 patients), no prognostic effect was found, neither for PD-1 (A) nor for PD-L1 (B), patients who received adjuvant therapy (C), patients with pulmonary squamous cell carcinomas (D), patients with pT2-T4 tumors (E) and patients with a positive lymph node status (pN1-3, F) had an increased overall survival.</p>", "links"=>[], "tags"=>["cell death receptor PD", "NSCLC patients", "til", "tumor size", "lung cancer patients", "scc", "lymph node status", "expression", "multivariate cox regression models.ConclusionOne", "Defined Subgroups BackgroundImmunotherapy"], "article_id"=>1526024, "categories"=>["Uncategorised"], "users"=>["Lars Henning Schmidt", "Andreas Kümmel", "Dennis Görlich", "Michael Mohr", "Sebastian Bröckling", "Jan Henrik Mikesch", "Inga Grünewald", "Alessandro Marra", "Anne M. Schultheis", "Eva Wardelmann", "Carsten Müller-Tidow", "Tilmann Spieker", "Christoph Schliemann", "Wolfgang E. Berdel", "Rainer Wiewrodt", "Wolfgang Hartmann"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136023.g002", "stats"=>{"downloads"=>3, "page_views"=>46, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prognostic_impact_of_PD_L1_expression_by_tumor_cells_depends_on_tumor_histology_/1526024", "title"=>"Prognostic impact of PD-L1 expression by tumor cells depends on tumor histology.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-08-27 03:51:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/2231245", "https://ndownloader.figshare.com/files/2231246"], "description"=>"<div><p>Background</p><p>Immunotherapy can become a crucial therapeutic option to improve prognosis for lung cancer patients. First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors. However, in lung cancer the diagnostic, prognostic and predictive value of these immunologic factors remains unclear.</p><p>Method</p><p>The impact of both factors was evaluated in a study collective of 321 clinically well-annotated patients with non-small lung cancer (NSCLC) using immunohistochemistry.</p><p>Results</p><p>PD-1 expression by tumor infiltrating lymphocytes (TILs) was found in 22%, whereas tumor cell associated PD-L1 expression was observed in 24% of the NSCLC tumors. In Fisher’s exact test a positive correlation was found for PD-L1 and Bcl-xl protein expression (p = 0.013). Interestingly, PD-L1 expression on tumor cells was associated with improved overall survival in pulmonary squamous cell carcinomas (SCC, p = 0.042, log rank test), with adjuvant therapy (p = 0.017), with increased tumor size (pT2-4, p = 0.039) and with positive lymph node status (pN1-3, p = 0.010). These observations were confirmed by multivariate cox regression models.</p><p>Conclusion</p><p>One major finding of our study is the identification of a prognostic implication of PD-L1 in subsets of NSCLC patients with pulmonary SCC, with increased tumor size, with a positive lymph node status and NSCLC patients who received adjuvant therapies. This study provides first data for immune-context related risk stratification of NSCLC patients. Further studies are necessary both to confirm this observation and to evaluate the predictive value of PD-1 and PD-L1 in NSCLC in the context of PD-1 inhibition.</p></div>", "links"=>[], "tags"=>["cell death receptor PD", "NSCLC patients", "til", "tumor size", "lung cancer patients", "scc", "lymph node status", "expression", "multivariate cox regression models.ConclusionOne", "Defined Subgroups BackgroundImmunotherapy"], "article_id"=>1526026, "categories"=>["Uncategorised"], "users"=>["Lars Henning Schmidt", "Andreas Kümmel", "Dennis Görlich", "Michael Mohr", "Sebastian Bröckling", "Jan Henrik Mikesch", "Inga Grünewald", "Alessandro Marra", "Anne M. Schultheis", "Eva Wardelmann", "Carsten Müller-Tidow", "Tilmann Spieker", "Christoph Schliemann", "Wolfgang E. Berdel", "Rainer Wiewrodt", "Wolfgang Hartmann"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0136023.s001", "https://dx.doi.org/10.1371/journal.pone.0136023.s002"], "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PD_1_and_PD_L1_Expression_in_NSCLC_Indicate_a_Favorable_Prognosis_in_Defined_Subgroups_/1526026", "title"=>"PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-08-27 03:51:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/2231241"], "description"=>"<p>All images at x20, inlay x40.</p>", "links"=>[], "tags"=>["cell death receptor PD", "NSCLC patients", "til", "tumor size", "lung cancer patients", "scc", "lymph node status", "expression", "multivariate cox regression models.ConclusionOne", "Defined Subgroups BackgroundImmunotherapy"], "article_id"=>1526022, "categories"=>["Uncategorised"], "users"=>["Lars Henning Schmidt", "Andreas Kümmel", "Dennis Görlich", "Michael Mohr", "Sebastian Bröckling", "Jan Henrik Mikesch", "Inga Grünewald", "Alessandro Marra", "Anne M. Schultheis", "Eva Wardelmann", "Carsten Müller-Tidow", "Tilmann Spieker", "Christoph Schliemann", "Wolfgang E. Berdel", "Rainer Wiewrodt", "Wolfgang Hartmann"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136023.g001", "stats"=>{"downloads"=>8, "page_views"=>275, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_immunohistochemical_staining_results_for_PD_1_A_normal_lung_tissue_negative_control_B_tonsillar_tissue_positive_control_C_PD_1_negative_tumor_infiltrating_lymphocytes_D_PD_1_positive_tumor_infiltrating_lymphocytes_in_squamous_cell_carcinom/1526022", "title"=>"Representative immunohistochemical staining results for PD-1 (A: normal lung tissue, negative control; B: tonsillar tissue, positive control; C: PD-1-negative tumor infiltrating lymphocytes; D: PD-1-positive tumor infiltrating lymphocytes in squamous cell carcinomas) and for PD-L1 (E: normal lung tissue, negative control; F: tonsillar tissue, positive control; G: PD-L1 negative squamous cell carcinomas; H: PD-L1 positive squamous cell carcinomas).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-08-27 03:51:08"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

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