Elevated Levels of IFN-γ in CSF and Serum of Patients with Amyotrophic Lateral Sclerosis
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{"title"=>"Elevated levels of IFN-γ in CSF and serum of patients with amyotrophic lateral sclerosis", "type"=>"journal", "authors"=>[{"first_name"=>"Juan", "last_name"=>"Liu", "scopus_author_id"=>"56966309900"}, {"first_name"=>"Lina", "last_name"=>"Gao", "scopus_author_id"=>"56346703800"}, {"first_name"=>"Dawei", "last_name"=>"Zang", "scopus_author_id"=>"7006160577"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"26332465", "sgr"=>"84947434719", "doi"=>"10.1371/journal.pone.0136937", "scopus"=>"2-s2.0-84947434719", "pui"=>"606945732", "issn"=>"19326203"}, "id"=>"6dd49c5b-ae02-3693-8f12-7d6ba557cb1c", "abstract"=>"OBJECTIVES To explore whether the levels of IFN-γ in cerebral spinal fluid (CSF) and serum are elevated in ALS patients and to analyze the correlations between the IFN-γ levels and disease progression. METHODS CSF and serum samples were obtained from 52 ALS patients and 31 non-ALS patients. The levels of IFN-γ in CSF and serum were assessed, and disease progression parameters, including the disease interval (months from onset, MFO), the revised ALS Functional Rating Scale (ALSFRS-r) score and the disease progression rate (DPR) were analyzed by registered neurologists. All samples were measured using a commercial enzyme-linked immunosorbent assay. Statistical analyses were performed using Prism software. RESULTS Compared to the non-ALS patients, the ALS patients displayed significantly increased levels of IFN-γ in both CSF and serum, and these values consistently correlated with disease progression. CONCLUSIONS These results demonstrated that IFN-γ in CSF may serve as a biomarker of ALS differentiation and progression. CSF IFN-γ was a more reliable biomarker of disease diagnosis and progression than serum IFN-γ.", "link"=>"http://www.mendeley.com/research/elevated-levels-ifn%CE%B3-csf-serum-patients-amyotrophic-lateral-sclerosis", "reader_count"=>14, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>3, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>3, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>5}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Korea (South)"=>1, "Belgium"=>1, "United States"=>1, "Australia"=>1, "Spain"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2250438"], "description"=>"<p>Fig 1A-C show the correlations between the CSF IFN-γ levels and the DPR, ALSFRS-r, and MFO in the ALS patients. The IFN-γ levels in CSF positively correlate with the DPR (A) and the MFO (C) but not the ALSFRS-r score (B). Fig 1D-F show the correlations between the serum IFN-γ levels and the DPR, the ALSFRS-r score, and the MFO in the ALS patients. The IFN-γ level in serum significantly correlate with the DPR (D) but not the ALSFRS-r score (E) or the MFO (F).</p>", "links"=>[], "tags"=>["52 ALS patients", "dpr", "ALS Functional Rating Scale", "disease progression.ConclusionsThese results", "serum", "mfo", "ALS patients", "csf", "disease progression rate", "ifn", "Amyotrophic Lateral Sclerosis ObjectivesTo", "disease progression parameters"], "article_id"=>1533475, "categories"=>["Uncategorised"], "users"=>["Juan Liu", "Lina Gao", "Dawei Zang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136937.g001", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlations_between_the_levels_of_IFN_947_and_disease_progression_/1533475", "title"=>"Correlations between the levels of IFN-γ and disease progression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-02 02:55:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/2250439"], "description"=>"<p>Fig 2A shows the levels of IFN-γ in CSF of ALS patients with bulbar or limb onset. There are significant differences in the CSF levels of IFN-γ in ALS patients (both bulbar and limb onset) compared with non-ALS patients (P<0.01), but no difference is observed between the bulbar and limb onset subgroups (P>0.05). Fig 2B-C show the correlations between the CSF IFN-γ levels and the DPR. The CSF IFN-γ levels do not correlate with the DPR in bulbar onset patients (B) but positively correlate with the DPR in limb onset patients (C). Fig 2D shows the levels of IFN-γ in serum of ALS patients with bulbar or limb onset. There are significant differences in the serum levels of IFN-γ in ALS patients (both bulbar and limb onset) compared with non-ALS patients (P<0.01), but no difference is observed between the bulbar and limb onset subgroups (P>0.05). Fig 2E-F show the correlations between the serum IFN-γ levels and the DPR. The serum IFN-γ levels do not correlate with the DPR in bulbar onset patients (E) but positively correlate with the DPR in limb onset patients (F). * indicates significant differences (p<0.01) in the CSF or serum IFN-γ levels between the ALS patients (both bulbar and limb onset) and the non-ALS patients.</p>", "links"=>[], "tags"=>["52 ALS patients", "dpr", "ALS Functional Rating Scale", "disease progression.ConclusionsThese results", "serum", "mfo", "ALS patients", "csf", "disease progression rate", "ifn", "Amyotrophic Lateral Sclerosis ObjectivesTo", "disease progression parameters"], "article_id"=>1533476, "categories"=>["Uncategorised"], "users"=>["Juan Liu", "Lina Gao", "Dawei Zang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136937.g002", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_levels_of_IFN_947_in_CSF_and_serum_of_ALS_patients_with_bulbar_or_limb_onset_and_their_correlations_with_disease_progression_/1533476", "title"=>"The levels of IFN-γ in CSF and serum of ALS patients with bulbar or limb onset and their correlations with disease progression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-02 02:55:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/2250440"], "description"=>"<p>Fig 3A shows the levels of IFN-γ in CSF of ALS patients stratified according to MFO. There are significant differences in both ALS subgroups (ALS<12 m and ALS≥12 m) compared with the non-ALS patients (P<0.01), and a difference is detected between the ALS<12 m and ALS≥12 m subgroups (P<0.01). Fig 3B-C show the correlations between the CSF IFN-γ levels and the DPR in the ALS<12 m and ALS≥12 m subgroups. The CSF IFN-γ levels positively correlate with the DPR in both subgroups. Fig 3D shows the levels of IFN-γ in serum of ALS patients stratified according to MFO. There are significant differences in both ALS subgroups (ALS<12 m and ALS≥12 m) compared with the non-ALS patients (P<0.01), but no difference is observed between the ALS<12 m and ALS≥12 m subgroups (P>0.05). Fig 3E-F show the correlations between the serum IFN-γ levels and the DPR in ALS<12 m and ALS≥12 m subgroups. The serum IFN-γ levels positively correlate with the DPR in the ALS<12 m subgroup but not in the ALS≥12 m subgroup. * indicates significant differences (p<0.01) in the CSF or serum IFN-γ levels between the ALS patients (both ALS<12 m and ALS≥12 m) and the non-ALS patients. # indicates a significant difference (p<0.01) in the CSF IFN-γ levels between the ALS≥12 m and ALS<12 m subgroups.</p>", "links"=>[], "tags"=>["52 ALS patients", "dpr", "ALS Functional Rating Scale", "disease progression.ConclusionsThese results", "serum", "mfo", "ALS patients", "csf", "disease progression rate", "ifn", "Amyotrophic Lateral Sclerosis ObjectivesTo", "disease progression parameters"], "article_id"=>1533477, "categories"=>["Uncategorised"], "users"=>["Juan Liu", "Lina Gao", "Dawei Zang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136937.g003", "stats"=>{"downloads"=>5, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_levels_of_IFN_947_in_CSF_and_serum_of_ALS_patients_stratified_according_to_MFO_and_their_correlations_with_disease_progression_/1533477", "title"=>"The levels of IFN-γ in CSF and serum of ALS patients stratified according to MFO and their correlations with disease progression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-02 02:55:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/2250441"], "description"=>"<p>M: male; F: Female. B: bulbar onset; L: limb onset; MFO: interval from the observation of initial symptoms to diagnosis; DPR: disease progression rate; ALSFRS-r: Amyotrophic Lateral Sclerosis Functional Rating Scale revised.</p><p>* indicates a significant difference (p<0.01) in the IFN-γ levels between ALS and Non-ALS.</p><p># indicates a significant difference (p<0.01) in the CSF IFN-γ levels compared with the serum IFN-γ levels; mean±se.</p><p>Summary of samples from ALS patients (ALS) and from non-ALS patients (Non-ALS).</p>", "links"=>[], "tags"=>["52 ALS patients", "dpr", "ALS Functional Rating Scale", "disease progression.ConclusionsThese results", "serum", "mfo", "ALS patients", "csf", "disease progression rate", "ifn", "Amyotrophic Lateral Sclerosis ObjectivesTo", "disease progression parameters"], "article_id"=>1533478, "categories"=>["Uncategorised"], "users"=>["Juan Liu", "Lina Gao", "Dawei Zang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136937.t001", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_samples_from_ALS_patients_ALS_and_from_non_ALS_patients_Non_ALS_/1533478", "title"=>"Summary of samples from ALS patients (ALS) and from non-ALS patients (Non-ALS).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-02 02:55:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/2250442"], "description"=>"<p>ALS<12 m: the time from ALS onset to diagnosis was less than 12 months; AL≥12 m: the time from ALS onset to diagnosis was equal to or more than 12 months</p><p>* indicates a significant difference (p<0.01) in the IFN-γ levels between ALS and Non-ALS.</p><p># indicates a significant difference (p<0.01) in the CSF IFN-γ levels between the ALS≥12 m and ALS<12 m subgroups.</p><p>+ indicates a significant difference (p<0.01) in the CSF IFN-γ levels in the ALS≥12 m subgroup compared with either the serum IFN-γ level in the ALS<12 m subgroup or the serum IFN-γ levels in the ALS≥12 m subgroup; mean±se.</p><p>Summary of samples from ALS patients (ALS) categorized according to MFO and from non-ALS patients (Non-ALS).</p>", "links"=>[], "tags"=>["52 ALS patients", "dpr", "ALS Functional Rating Scale", "disease progression.ConclusionsThese results", "serum", "mfo", "ALS patients", "csf", "disease progression rate", "ifn", "Amyotrophic Lateral Sclerosis ObjectivesTo", "disease progression parameters"], "article_id"=>1533479, "categories"=>["Uncategorised"], "users"=>["Juan Liu", "Lina Gao", "Dawei Zang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0136937.t002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_samples_from_ALS_patients_ALS_categorized_according_to_MFO_and_from_non_ALS_patients_Non_ALS_/1533479", "title"=>"Summary of samples from ALS patients (ALS) categorized according to MFO and from non-ALS patients (Non-ALS).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-02 02:55:38"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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