Impacts of Co-Existing Chronic Rhinosinusitis on Disease Severity and Risks of Exacerbations in Chinese Adults with Bronchiectasis
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{"title"=>"Impacts of co-existing chronic rhinosinusitis on disease Severity and risks of exacerbations in Chinese adults with bronchiectasis", "type"=>"journal", "authors"=>[{"first_name"=>"Wei Jie", "last_name"=>"Guan", "scopus_author_id"=>"55220462400"}, {"first_name"=>"Yong Hua", "last_name"=>"Gao", "scopus_author_id"=>"55994052700"}, {"first_name"=>"Hui Min", "last_name"=>"Li", "scopus_author_id"=>"56278805100"}, {"first_name"=>"Jing Jing", "last_name"=>"Yuan", "scopus_author_id"=>"56903370300"}, {"first_name"=>"Rong Chang", "last_name"=>"Chen", "scopus_author_id"=>"14017626800"}, {"first_name"=>"Nan Shan", "last_name"=>"Zhong", "scopus_author_id"=>"7102137996"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84944345523", "sgr"=>"84944345523", "pui"=>"606423680", "pmid"=>"26340660", "doi"=>"10.1371/journal.pone.0137348"}, "id"=>"3ecef00c-3bc4-39d3-9701-cae3bf2af290", "abstract"=>"BACKGROUND: Mounting evidence supports the notion of \"one airway, one disease.\" OBJECTIVE: To determine whether chronic rhinosinusitis (CRS) poses adverse impacts on Chinese adults with bronchiectasis. METHODS: We enrolled 148 consecutive adults with clinically stable bronchiectasis. CRS diagnosed based on the 2012 EP3OS criteria. We systematically evaluated the bronchiectasis etiology, radiology, lung function, sputum bacteriology, airway inflammatory biomarkers, Bronchiectasis Severity Index, cough sensitivity and healthcare resource utilization. All patients were prospectively followed-up for 1 year to examine the frequency of bronchiectasis exacerbations (BEs). RESULTS: Forty-seven patients (31.8%) were diagnosed as having CRS. Bronchiectasis etiologies did not vary statistically between CRS and no-CRS group. There was a trend towards non-statistically higher Bronchiectasis Severity Index [6.4±3.4 vs. 5.0(6.0), P = 0.19], a higher proportion of patients with BEs needing hospitalization before enrollment (48.9% vs. 29.7%, P = 0.13), poorer FVC [78.2±19.8% vs. 82.2(16.8)%, P = 0.54] and FEV1 [68.2±24.8% vs. 74.8(21.2)%, P = 0.29], a higher prevalence of Pseudomonas aeruginosa isolated (36.2% vs. 26.7%, P = 0.27) or colonized in sputum (36.2% vs. 21.8%, P = 0.12) and greater capsaicin cough sensitivity [C2: 3.9(123.0) μmol/L vs. 11.7(123.0) μmol/L, P = 0.81; C5: 62.5(996.0) μmol/L vs. 250.0(973.0) μmol/L, P = 0.32]. Patients with CRS had significantly greater risks of experiencing BEs during follow-up (P = 0.02 for negative binominal regression test). CONCLUSION: Chinese adults with bronchiectasis appear to have a lower prevalence of CRS than that in western countries. There was a trend towards greater adverse impacts on bronchiectasis in patients with CRS. Studies with greater sample sizes might help to resolve this issue. In future clinical practice, physicians should be vigilant to the screening of concomitant CRS in bronchiectasis so as to better improve patient's healthcare. Our findings may be of clinical significance in that proper treatment of upper airway symptoms due to CRS will be the prevention of infection or re-infection of the tracheobronchial tree, which should be addressed for the future management of bronchiectasis.", "link"=>"http://www.mendeley.com/research/impacts-coexisting-chronic-rhinosinusitis-disease-severity-risks-exacerbations-chinese-adults-bronch", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Librarian"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Librarian"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>4, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Portugal"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2253170"], "description"=>"<p>OR: Odds ratio; 95%CI: 95% confidence interval; BSI: <i>Bronchiectasis Severity Index</i></p><p>Model 1: CRS diagnosis + adjustment with sex</p><p>Model 2: Model 1 + adjustment with smoking status</p><p>Model 3: Model 2 + adjustment with asthma or COPD diagnosis</p><p>Model 4: Model 3 + adjustment with the BSI</p><p>Association between CRS and the number of BEs within 2 years before enrollment in patients with bronchiectasis.</p>", "links"=>[], "tags"=>["be", "future management", "lung function", "sample sizes", "fvc", "mol", "Chinese adults", "crs", "healthcare resource utilization", "1 year", "Bronchiectasis BackgroundMounting evidence", "bronchiectasis exacerbations", "cough sensitivity", "Capsaicin Cough Sensitivity", "fev", "Bronchiectasis Severity Index", "2012 EP 3OS criteria", "disease severity", "vs", "Bronchiectasis etiologies", "Pseudomonas aeruginosa", "bronchiectasis etiology", "sputum bacteriology", "Airway Symptoms", "tracheobronchial tree"], "article_id"=>1535605, "categories"=>["Biological Sciences"], "users"=>["Wei-jie Guan", "Yong-hua Gao", "Hui-min Li", "Jing-jing Yuan", "Rong-chang Chen", "Nan-Shan Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137348.t004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_CRS_and_the_number_of_BEs_within_2_years_before_enrollment_in_patients_with_bronchiectasis_/1535605", "title"=>"Association between CRS and the number of BEs within 2 years before enrollment in patients with bronchiectasis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-04 02:52:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/2253169"], "description"=>"<p>Numerical data were presented as mean ± standard deviation for normal distribution or otherwise median (interquartile range). Categorical data were expressed as number (percentage).</p><p>Data in bold indicated the comparisons with statistical significance.</p><p>* Other potentially pathogenic microorganisms included <i>Haemophilus influenzae</i>, <i>Haemophilus parainfluenzae</i>, <i>Staphylococcus aureus</i>, <i>Stenotrophomonas maltophilia</i>, <i>Escherichia colitis</i>, <i>Sphingomonas paucimobilis</i>, <i>Alcaligenes faecalis subsp faecalis</i>, <i>Psedumonas pseudoalcaligenes</i> and <i>Serratia marcescens</i>.</p><p>** Data were presented as geometric means.</p><p>IL: interleukin; TNF: tumor necrosis factor</p><p>Chest imaging characteristics, lung function, sputum bacteriology, sputum inflammatory biomarkers and cough sensitivity.</p>", "links"=>[], "tags"=>["be", "future management", "lung function", "sample sizes", "fvc", "mol", "Chinese adults", "crs", "healthcare resource utilization", "1 year", "Bronchiectasis BackgroundMounting evidence", "bronchiectasis exacerbations", "cough sensitivity", "Capsaicin Cough Sensitivity", "fev", "Bronchiectasis Severity Index", "2012 EP 3OS criteria", "disease severity", "vs", "Bronchiectasis etiologies", "Pseudomonas aeruginosa", "bronchiectasis etiology", "sputum bacteriology", "Airway Symptoms", "tracheobronchial tree"], "article_id"=>1535604, "categories"=>["Biological Sciences"], "users"=>["Wei-jie Guan", "Yong-hua Gao", "Hui-min Li", "Jing-jing Yuan", "Rong-chang Chen", "Nan-Shan Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137348.t003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Chest_imaging_characteristics_lung_function_sputum_bacteriology_sputum_inflammatory_biomarkers_and_cough_sensitivity_/1535604", "title"=>"Chest imaging characteristics, lung function, sputum bacteriology, sputum inflammatory biomarkers and cough sensitivity.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-04 02:52:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/2253165"], "description"=>"<p>The BEs during follow-up were analyzed with Cox regression model, with sex, smoking status, the diagnosis of asthma or COPD, and the BSI as covariates. The grey dotted line indicated the bronchiectasis patients without CRS, whereas the dark dotted line indicated the bronchiectasis patients with CRS. Shown at the bottom of the figure were the number of bronchiectasis patients at risks of experiencing subsequent exacerbations at different time points.</p>", "links"=>[], "tags"=>["be", "future management", "lung function", "sample sizes", "fvc", "mol", "Chinese adults", "crs", "healthcare resource utilization", "1 year", "Bronchiectasis BackgroundMounting evidence", "bronchiectasis exacerbations", "cough sensitivity", "Capsaicin Cough Sensitivity", "fev", "Bronchiectasis Severity Index", "2012 EP 3OS criteria", "disease severity", "vs", "Bronchiectasis etiologies", "Pseudomonas aeruginosa", "bronchiectasis etiology", "sputum bacteriology", "Airway Symptoms", "tracheobronchial tree"], "article_id"=>1535600, "categories"=>["Biological Sciences"], "users"=>["Wei-jie Guan", "Yong-hua Gao", "Hui-min Li", "Jing-jing Yuan", "Rong-chang Chen", "Nan-Shan Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137348.g002", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cox_proportional_hazards_analysis_on_the_risks_of_having_bronchiectasis_exacerbations_during_follow_up_in_patients_with_and_without_CRS_/1535600", "title"=>"Cox proportional hazards analysis on the risks of having bronchiectasis exacerbations during follow-up in patients with and without CRS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-04 02:52:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/2253163"], "description"=>"<p>(A). Distribution of the number of BEs within 2 years before enrollment. Shown are the percentages of patients with different numbers of bronchiectasis exacerbations within the previous 2 years. Light dotted bars indicated the bronchiectasis patients without CRS, whereas the dark cross bars indicated the bronchiectasis patients with CRS. (B). Distribution of the number of BEs during follow-up. Shown are the percentages of patients with different numbers of bronchiectasis exacerbations during the 1-year’s follow-up since patients recruitment. Light dotted bars indicated the bronchiectasis patients without CRS, whereas the dark cross bars indicated the bronchiectasis patients with CRS. AEs: acute exacerbations of bronchiectasis.</p>", "links"=>[], "tags"=>["be", "future management", "lung function", "sample sizes", "fvc", "mol", "Chinese adults", "crs", "healthcare resource utilization", "1 year", "Bronchiectasis BackgroundMounting evidence", "bronchiectasis exacerbations", "cough sensitivity", "Capsaicin Cough Sensitivity", "fev", "Bronchiectasis Severity Index", "2012 EP 3OS criteria", "disease severity", "vs", "Bronchiectasis etiologies", "Pseudomonas aeruginosa", "bronchiectasis etiology", "sputum bacteriology", "Airway Symptoms", "tracheobronchial tree"], "article_id"=>1535598, "categories"=>["Biological Sciences"], "users"=>["Wei-jie Guan", "Yong-hua Gao", "Hui-min Li", "Jing-jing Yuan", "Rong-chang Chen", "Nan-Shan Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137348.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_the_number_of_BEs_within_2_years_before_enrollment_and_during_follow_up_/1535598", "title"=>"Distribution of the number of BEs within 2 years before enrollment and during follow-up.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-04 02:52:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/2253168"], "description"=>"<p>BEs: bronchiectasis exacerbations</p><p>* 2 patients without CRS had missing data.</p><p>Numerical data were presented as mean ± standard deviation for normal distribution or otherwise median (interquartile range). Categorical data were expressed as number (percentage).</p><p>Comparisons of medications used within 6 months, healthcare utilization and comorbidities between the two group.</p>", "links"=>[], "tags"=>["be", "future management", "lung function", "sample sizes", "fvc", "mol", "Chinese adults", "crs", "healthcare resource utilization", "1 year", "Bronchiectasis BackgroundMounting evidence", "bronchiectasis exacerbations", "cough sensitivity", "Capsaicin Cough Sensitivity", "fev", "Bronchiectasis Severity Index", "2012 EP 3OS criteria", "disease severity", "vs", "Bronchiectasis etiologies", "Pseudomonas aeruginosa", "bronchiectasis etiology", "sputum bacteriology", "Airway Symptoms", "tracheobronchial tree"], "article_id"=>1535603, "categories"=>["Biological Sciences"], "users"=>["Wei-jie Guan", "Yong-hua Gao", "Hui-min Li", "Jing-jing Yuan", "Rong-chang Chen", "Nan-Shan Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137348.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparisons_of_medications_used_within_6_months_healthcare_utilization_and_comorbidities_between_the_two_group_/1535603", "title"=>"Comparisons of medications used within 6 months, healthcare utilization and comorbidities between the two group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-04 02:52:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/2253167"], "description"=>"<p>Numerical data were presented as mean ± standard deviation for normal distribution or otherwise median (interquartile range). Categorical data were expressed as number (percentage).</p><p>Data in bold indicated the comparisons with statistical significance.</p><p>* Of all bronchiectasis patients, other known causes consisted of immunodeficiency (n = 13, 8.8%), asthma (n = 8, 5.4%), gastroesophageal reflux (n = 6, 4.1%), aspergillosis (n = 2, 1.4%), rheumatoid arthritis (n = 2, 1.4%), Kartagener syndrome (n = 2, 1.4%), lung maldevelopment (n = 2, 1.4%), Young’s syndrome (n = 1, 0.7%), COPD (n = 1, 0.7%), lung sequestration (n = 1, 0.7%), yellow nail syndrome (n = 1, 0.7%) and diffuse panbronchiolitis (n = 1, 0.7%).</p><p>None of the patients had ever used inhaled antibiotics in this study.</p><p>Clinical characteristics of patients with bronchiectasis.</p>", "links"=>[], "tags"=>["be", "future management", "lung function", "sample sizes", "fvc", "mol", "Chinese adults", "crs", "healthcare resource utilization", "1 year", "Bronchiectasis BackgroundMounting evidence", "bronchiectasis exacerbations", "cough sensitivity", "Capsaicin Cough Sensitivity", "fev", "Bronchiectasis Severity Index", "2012 EP 3OS criteria", "disease severity", "vs", "Bronchiectasis etiologies", "Pseudomonas aeruginosa", "bronchiectasis etiology", "sputum bacteriology", "Airway Symptoms", "tracheobronchial tree"], "article_id"=>1535602, "categories"=>["Biological Sciences"], "users"=>["Wei-jie Guan", "Yong-hua Gao", "Hui-min Li", "Jing-jing Yuan", "Rong-chang Chen", "Nan-Shan Zhong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137348.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_characteristics_of_patients_with_bronchiectasis_/1535602", "title"=>"Clinical characteristics of patients with bronchiectasis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-04 02:52:24"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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