Constitutive STAT3 Phosphorylation in Circulating CD4+ T Lymphocytes Associates with Disease Activity and Treatment Response in Recent-Onset Rheumatoid Arthritis
Publication Date
September 09, 2015
Journal
PLOS ONE
Authors
Krista Kuuliala, Antti Kuuliala, Riitta Koivuniemi, Suvi Oksanen, et al
Volume
10
Issue
9
Pages
e0137385
DOI
https://dx.plos.org/10.1371/journal.pone.0137385
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0137385
Web of Science
000360932800079
Scopus
84944790482
Mendeley
http://www.mendeley.com/research/constitutive-stat3-phosphorylation-circulating-cd4-t-lymphocytes-associates-disease-activity-treatme
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Mendeley | Further Information

{"title"=>"Constitutive STAT3 phosphorylation in circulating CD4+ T lymphocytes associates with disease activity and treatment response in recent-onset rheumatoid arthritis", "type"=>"journal", "authors"=>[{"first_name"=>"Krista", "last_name"=>"Kuuliala", "scopus_author_id"=>"14123426500"}, {"first_name"=>"Antti", "last_name"=>"Kuuliala", "scopus_author_id"=>"6506875739"}, {"first_name"=>"Riitta", "last_name"=>"Koivuniemi", "scopus_author_id"=>"6507067814"}, {"first_name"=>"Suvi", "last_name"=>"Oksanen", "scopus_author_id"=>"57194645024"}, {"first_name"=>"Mari", "last_name"=>"Hämäläinen", "scopus_author_id"=>"7102722254"}, {"first_name"=>"Eeva", "last_name"=>"Moilanen", "scopus_author_id"=>"7005248041"}, {"first_name"=>"Hannu", "last_name"=>"Kautiainen", "scopus_author_id"=>"7006219084"}, {"first_name"=>"Marjatta", "last_name"=>"Leirisalo-Repo", "scopus_author_id"=>"7005159633"}, {"first_name"=>"Heikki", "last_name"=>"Repo", "scopus_author_id"=>"56212156000"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"606519534", "doi"=>"10.1371/journal.pone.0137385", "sgr"=>"84944790482", "isbn"=>"10.1371/journal.pone.0137385", "pmid"=>"26353115", "scopus"=>"2-s2.0-84944790482"}, "id"=>"5432f5d9-750e-3250-8357-0f23f1e6f31c", "abstract"=>"The aim of the present study was to examine constitutive signal transducer and activator of transcription 3 (STAT3) phosphorylation in circulating leukocytes as a candidate biomarker in rheumatoid arthritis (RA). 25 patients with recent-onset, untreated RA provided samples for whole blood flow cytometric determination of intracellular STAT3 phosphorylation, expressed as relative fluorescence units. The occurrence of constitutive STAT3 phosphorylation was evaluated by determining proportion of STAT3-phosphorylated cells among different leukocyte subtypes. Plasma levels of interleukin (IL)-6, IL-17 and IL-21 were measured by immunoassay, radiographs of hands and feet were examined and disease activity score (DAS28) was determined. Biomarkers were restudied and treatment response (according to European League Against Rheumatism) was determined after 12 months of treatment with disease-modifying antirheumatic drugs. At baseline, constitutive phosphorylation of STAT3 occurred in CD4+ T cells of 14 (56%) patients, CD8+ T cells of 13 (52%) patients, in CD19+ B cells of 7 (28%) patients, and in CD14+ monocytes of 12 (48%) patients. STAT3 phosphorylation levels of CD4+ T cells associated with DAS28, and those of all leukocyte subtypes studied associated with erosive disease. The presence of constitutive STAT3 phosphorylation in CD4+ T lymphocytes, pSTAT3 fluorescence intensity of CD4+ and CD8+ T cells and C-reactive protein (CRP) levels at baseline associated with good treatment response. In conclusion, constitutive STAT3 phosphorylation in circulating CD4+ T cells is common in recent-onset untreated RA and associates with good treatment response in patients characterized by high disease activity and the presence of systemic inflammation.", "link"=>"http://www.mendeley.com/research/constitutive-stat3-phosphorylation-circulating-cd4-t-lymphocytes-associates-disease-activity-treatme", "reader_count"=>10, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Librarian"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Librarian"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>3, "Psychology"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Finland"=>1, "United Kingdom"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2256370"], "description"=>"<p>Erythrocyte sedimentation rate and levels of C-reactive protein and cytokines at follow-up according to EULAR response.</p>", "links"=>[], "tags"=>["leukocyte subtypes", "intracellular STAT 3 phosphorylation", "Constitutive STAT 3 Phosphorylation", "ra", "constitutive signal transducer", "blood flow cytometric determination", "treatment response", "il", "disease activity score", "crp", "pSTAT 3 fluorescence intensity", "STAT 3 phosphorylation levels", "das"], "article_id"=>1538203, "categories"=>["Uncategorised"], "users"=>["Krista Kuuliala", "Antti Kuuliala", "Riitta Koivuniemi", "Suvi Oksanen", "Mari Hämäläinen", "Eeva Moilanen", "Hannu Kautiainen", "Marjatta Leirisalo-Repo", "Heikki Repo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137385.t003", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Erythrocyte_sedimentation_rate_and_levels_of_C_reactive_protein_and_cytokines_at_follow_up_according_to_EULAR_response_/1538203", "title"=>"Erythrocyte sedimentation rate and levels of C-reactive protein and cytokines at follow-up according to EULAR response.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-09 04:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256369"], "description"=>"<p>Abbreviations: CI = confidence interval, r = Spearman correlation coefficient, for other abbreviations see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137385#pone.0137385.t001\" target=\"_blank\">Table 1</a>.</p><p><sup>†</sup>Number of eroded joints in radiographs of hands and feet.</p><p>*p<0.05</p><p>**p<0.01</p><p>***p<0.001.</p><p>Correlations between baseline characteristics and pSTAT3 fluorescence intensity of lymphocyte subsets and monocytes at baseline.</p>", "links"=>[], "tags"=>["leukocyte subtypes", "intracellular STAT 3 phosphorylation", "Constitutive STAT 3 Phosphorylation", "ra", "constitutive signal transducer", "blood flow cytometric determination", "treatment response", "il", "disease activity score", "crp", "pSTAT 3 fluorescence intensity", "STAT 3 phosphorylation levels", "das"], "article_id"=>1538202, "categories"=>["Uncategorised"], "users"=>["Krista Kuuliala", "Antti Kuuliala", "Riitta Koivuniemi", "Suvi Oksanen", "Mari Hämäläinen", "Eeva Moilanen", "Hannu Kautiainen", "Marjatta Leirisalo-Repo", "Heikki Repo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137385.t002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlations_between_baseline_characteristics_and_pSTAT3_fluorescence_intensity_of_lymphocyte_subsets_and_monocytes_at_baseline_/1538202", "title"=>"Correlations between baseline characteristics and pSTAT3 fluorescence intensity of lymphocyte subsets and monocytes at baseline.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-09 04:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256368"], "description"=>"<p>Abbreviations: ACPA = anti-citrullinated protein antibody, DAS28 = 28 joint Disease Activity Score, RF = rheumatoid factor, RFU = relative fluorescence unit, VAS = visual analogue scale.</p><p>*Median (min-max) values for healthy reference subjects (n = 17); IL-6: 1.2 (0.8–2.9) pg/ml, IL-21: 151 (39–467) pg/ml, IL-17: 4.5 (1.0–19.2) pg/ml.</p><p><sup>†</sup>Mean (SD) values for healthy reference subjects (n = 17); CD4<sup>+</sup> T cells: 638 (122) RFU, CD8<sup>+</sup> T cells: 596 (114) RFU, CD19<sup>+</sup> B cells: 463 (89) RFU, CD14<sup>+</sup> monocytes: 829 (443) RFU.</p><p>Baseline characteristics according to EULAR response at follow-up.</p>", "links"=>[], "tags"=>["leukocyte subtypes", "intracellular STAT 3 phosphorylation", "Constitutive STAT 3 Phosphorylation", "ra", "constitutive signal transducer", "blood flow cytometric determination", "treatment response", "il", "disease activity score", "crp", "pSTAT 3 fluorescence intensity", "STAT 3 phosphorylation levels", "das"], "article_id"=>1538201, "categories"=>["Uncategorised"], "users"=>["Krista Kuuliala", "Antti Kuuliala", "Riitta Koivuniemi", "Suvi Oksanen", "Mari Hämäläinen", "Eeva Moilanen", "Hannu Kautiainen", "Marjatta Leirisalo-Repo", "Heikki Repo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137385.t001", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_according_to_EULAR_response_at_follow_up_/1538201", "title"=>"Baseline characteristics according to EULAR response at follow-up.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-09 04:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256366"], "description"=>"<p>Yes denotes good response, No denotes no or moderate response, and p values indicate significance between the two groups. Closed symbols denote pSTAT3<sup>+</sup> patients and open symbols pSTAT3<sup>-</sup> patients.</p>", "links"=>[], "tags"=>["leukocyte subtypes", "intracellular STAT 3 phosphorylation", "Constitutive STAT 3 Phosphorylation", "ra", "constitutive signal transducer", "blood flow cytometric determination", "treatment response", "il", "disease activity score", "crp", "pSTAT 3 fluorescence intensity", "STAT 3 phosphorylation levels", "das"], "article_id"=>1538199, "categories"=>["Uncategorised"], "users"=>["Krista Kuuliala", "Antti Kuuliala", "Riitta Koivuniemi", "Suvi Oksanen", "Mari Hämäläinen", "Eeva Moilanen", "Hannu Kautiainen", "Marjatta Leirisalo-Repo", "Heikki Repo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137385.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_pSTAT3_fluorescence_intensity_of_lymphocyte_subsets_and_monocytes_at_baseline_and_at_follow_up_according_to_EULAR_treatment_response_/1538199", "title"=>"The pSTAT3 fluorescence intensity of lymphocyte subsets and monocytes at baseline and at follow-up according to EULAR treatment response.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:03:41"}
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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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