Dietary Fish Oil Inhibits Pro-Inflammatory and ER Stress Signalling Pathways in the Liver of Sows during Lactation
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Mendeley | Further Information

{"title"=>"Dietary fish oil inhibits pro-inflammatory and ER stress signalling pathways in the liver of sows during lactation", "type"=>"journal", "authors"=>[{"first_name"=>"Denise K.", "last_name"=>"Gessner", "scopus_author_id"=>"49861227700"}, {"first_name"=>"Birthe", "last_name"=>"Gröne", "scopus_author_id"=>"56554053100"}, {"first_name"=>"Aline", "last_name"=>"Couturier", "scopus_author_id"=>"51664678500"}, {"first_name"=>"Susann", "last_name"=>"Rosenbaum", "scopus_author_id"=>"35226651700"}, {"first_name"=>"Sonja", "last_name"=>"Hillen", "scopus_author_id"=>"35789070100"}, {"first_name"=>"Sabrina", "last_name"=>"Becker", "scopus_author_id"=>"55366891600"}, {"first_name"=>"Georg", "last_name"=>"Erhardt", "scopus_author_id"=>"7006798489"}, {"first_name"=>"Gerald", "last_name"=>"Reiner", "scopus_author_id"=>"7005469960"}, {"first_name"=>"Robert", "last_name"=>"Ringseis", "scopus_author_id"=>"6506717271"}, {"first_name"=>"Klaus", "last_name"=>"Eder", "scopus_author_id"=>"7103034810"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"606519506", "sgr"=>"84944748501", "issn"=>"19326203", "pmid"=>"26351857", "scopus"=>"2-s2.0-84944748501", "doi"=>"10.1371/journal.pone.0137684"}, "id"=>"4e39aaec-899e-3819-987b-149fa6412f4a", "abstract"=>"Lactating sows have been shown to develop typical signs of an inflammatory condition in the liver during the transition from pregnancy to lactation. Hepatic inflammation is considered critical due to the induction of an acute phase response and the activation of stress signaling pathways like the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR), both of which impair animal´s health and performance. Whether ER stress-induced UPR is also activated in the liver of lactating sows and whether dietary fish oil as a source of anti-inflammatory effects n-3 PUFA is able to attenuate hepatic inflammation and ER stress-induced UPR in the liver of sows is currently unknown. Based on this, two experiments with lactating sows were performed. The first experiment revealed that ER stress-induced UPR occurs also in the liver of sows during lactation. This was evident from the up-regulation of a set of genes regulated by the UPR and numerically increased phosphorylation of the ER stress-transducer PERK and PERK-mediated phosphorylation of eIF2α and IκB. The second experiment showed that fish oil inhibits ER stress-induced UPR in the liver of lactating sows. This was demonstrated by decreased mRNA levels of a number of UPR-regulated genes and reduced phosphorylation of PERK and PERK-mediated phosphorylation of eIF2α and IκB in the liver of the fish oil group. The mRNA levels of various nuclear factor-κB-regulated genes encoding inflammatory mediators and acute phase proteins in the liver of lactating sows were also reduced in the fish oil group. In line with this, the plasma levels of acute phase proteins were reduced in the fish oil group, although differences to the control group were not significant. In conclusion, ER stress-induced UPR is present in the liver of lactating sows and fish oil is able to inhibit inflammatory signaling pathways and ER stress-induced UPR in the liver.", "link"=>"http://www.mendeley.com/research/dietary-fish-oil-inhibits-proinflammatory-er-stress-signalling-pathways-liver-sows-during-lactation", "reader_count"=>10, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>5, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2256678"], "description"=>"<p>Relative mRNA concentrations of nuclear factor E2-related factor 2 (Nrf2) target genes in the liver (A) and the skeletal muscle (B) of lactating sows with or without fish oil supplementation on day 20 of lactation. Filled circles (grey = control group, black = fish oil group) represent individual data for each animal. Black lines represent means of individual data for each group (n = 6–10 sows per group). The mean of the control group is set to 1. The mean of the fish oil group is expressed as fold of the control group and numerically indicated next to the black line. Superscript symbol indicates difference from control group (*p<0.05, <sup>#</sup>p<0.1). Abbreviations: CYP1A1, cytochrome P450, family 1, subfamily A, polypeptide 1; GPX1, glutathione peroxidase 1; HMOX1, heme oxygenase 1; NQO1, NAD(P)H dehydrogenase, quinone 1; PRDX6, peroxiredoxin 6; SOD1, superoxide dismutase 1, soluble; TXNRD1, thioredoxin reductase 1.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538400, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g008", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_fish_oil_on_mRNA_concentrations_of_Nrf2_target_genes_in_the_liver_and_skeletal_muscle_of_lactating_sows_/1538400", "title"=>"Effect of fish oil on mRNA concentrations of Nrf2 target genes in the liver and skeletal muscle of lactating sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256680"], "description"=>"<p>Relative mRNA concentrations genes involved in the NOD-like receptor P3 (NLRP3) inflammasome in the liver (A) and the skeletal muscle (B) of lactating sows with or without fish oil supplementation on day 20 of lactation. Filled circles (grey = control group, black = fish oil group) represent individual data for each animal. Black lines represent means of individual data for each group (n = 6–10 sows per group). The mean of the control group is set to 1. The mean of the fish oil group is expressed as fold of the control group and numerically indicated next to the black line. Superscript symbol indicates difference from control group (*p<0.05). Abbreviations: CASP1, caspase 1, apoptosis-related cysteine peptidase; IL1B, interleukin 1, beta; NLRP3, NLR family, pyrin domain containing 3; PYCARD, PYD and CARD domain containing.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538402, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g009", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_fish_oil_on_mRNA_concentrations_of_genes_involved_in_the_NLRP3_inflammasome_in_the_liver_and_skeletal_muscle_of_lactating_sows_/1538402", "title"=>"Effect of fish oil on mRNA concentrations of genes involved in the NLRP3 inflammasome in the liver and skeletal muscle of lactating sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256682"], "description"=>"<p>Relative protein concentrations of phosphorylated and total (PERK), eukaryotic translation initiation factor 2α (eIF2α) and inhibitor of κB (IκB) in the liver of lactating sows with or without fish oil supplementation on day 20 of lactation. Representative immunoblots specific to phosphorylated and total PERK, eIF2α and IκB and α-Tubulin as internal control are shown for one animal per group; immunoblots for the other animals revealed similar results. Filled circles (grey = control group, black = fish oil group) represent individual data for each animal from densitometric analysis. Black lines represent means of individual data for each group (n = 7–9 sows per group). The mean of the control group is set to 1. The mean of the fish oil group is expressed as fold of the control group and numerically indicated next to the black line. Superscript symbol indicates difference from control group (<sup>#</sup>p<0.1).</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538404, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g010", "stats"=>{"downloads"=>9, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_fish_oil_on_phosphorylation_of_PERK_and_PERK_mediated_phosphorylation_of_eIF2_945_and_I_954_B_in_the_liver_of_lactating_sows_/1538404", "title"=>"Effect of fish oil on phosphorylation of PERK and PERK-mediated phosphorylation of eIF2α and IκB in the liver of lactating sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256683"], "description"=>"<p><sup>1</sup>Abbreviations: <i>ATF4</i>, activating transcription factor 4; <i>BAK1</i>, BCL2-antagonist/killer 1; <i>BAX</i>, BCL2-associated X protein; <i>BCL2L1</i>, BCL2-like 1; <i>CASP</i>, caspase, apoptosis-related cysteine peptidase; <i>CCL2</i>, chemokine (C-C motif) ligand 2; <i>CYP1A1</i>, cytochrome P450, family 1, subfamily A, polypeptide 1; <i>DDIT3</i>, DNA-damage-inducible transcript 3; <i>DNAJC3</i>, DnaJ (Hsp40) homolog, subfamily C, member 3; <i>EDEM1</i>, ER degradation enhancer, mannosidase alpha-like 1; <i>GPX1</i>, glutathione peroxidase 1; <i>HMOX1</i>, heme oxygenase 1; <i>HP</i>, haptoglobin; <i>HSP90B1</i>, heat shock protein 90kDa beta (Grp94), member 1; <i>HSPA5</i>, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); <i>ICAM1</i>, intercellular adhesion molecule 1; <i>IL1B</i>, interleukin 1, beta; <i>LBP</i>, lipopolysaccharide binding protein; <i>NLRP3</i>, NLR family, pyrin domain containing 3; <i>NQO1</i>, NAD(P)H dehydrogenase, quinone 1; <i>PPP1R15A</i>, protein phosphatase 1, regulatory subunit 15A; <i>PTGS2</i>, prostaglandin-endoperoxide synthase 2; <i>PRDX6</i>, peroxiredoxin 6; <i>PYCARD</i>, PYD and CARD domain containing; <i>SAA2</i>, serum amyloid A2; <i>SOD1</i>, superoxide dismutase 1, soluble; <i>TNF</i>, tumor necrosis factor; <i>TP53</i>, tumor protein p53; <i>TXNRD1</i>, thioredoxin reductase 1.</p><p>Characteristics of gene-specific primers used for qPCR.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538405, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.t001", "stats"=>{"downloads"=>3, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_gene_specific_primers_used_for_qPCR_/1538405", "title"=>"Characteristics of gene-specific primers used for qPCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256667"], "description"=>"<p>Relative mRNA concentrations of genes involved in the unfolded protein response (UPR) in the liver of lactating and non-lactating sows on day 20 of lactation. Filled circles (grey = non-lactating group, black = lactating group) represent individual data for each animal. Black lines represent means of individual data for each group (n = 6–10 sows per group). The mean of the non-lactating group is set to 1. The mean of the lactating group is expressed as fold of the non-lactating group and numerically indicated next to the black line. Superscript symbol indicates difference from non-lactating group (*p<0.05, <sup>#</sup>p<0.1). Abbreviations: ATF4, activating transcription factor 4; BAK1, BCL2-antagonist/killer 1; BAX, BCL2-associated X protein; BCL2L1, BCL2-like 1; CASP, caspase, apoptosis-related cysteine peptidase; DDIT3, DNA-damage-inducible transcript 3; DNAJC3, DnaJ (Hsp40) homolog, subfamily C, member 3; EDEM1, ER degradation enhancer, mannosidase alpha-like 1; HSP90B1, heat shock protein 90kDa beta (Grp94), member 1; HSPA5, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); PDIA4, protein disulfide isomerase family A, member 4; PPP1R15A, protein phosphatase 1, regulatory subunit 15A; TP53, tumor protein p53.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538389, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g001", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_lactation_on_mRNA_concentrations_of_genes_involved_in_the_UPR_in_the_liver_of_sows_/1538389", "title"=>"Effect of lactation on mRNA concentrations of genes involved in the UPR in the liver of sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256668"], "description"=>"<p>Relative mRNA concentrations of genes involved in the UPR in the skeletal muscle of lactating and non-lactating sows on day 20 of lactation. Filled circles (grey = non-lactating group, black = lactating group) represent individual data for each animal. Black lines represent means of individual data for each group (n = 8–10 sows per group). The mean of the non-lactating group is set to 1. The mean of the lactating group is expressed as fold of the non-lactating group and numerically indicated next to the black line. Superscript symbol indicates difference from non-lactating group (*p<0.05). Abbreviations: ATF4, activating transcription factor 4; BAX, BCL2-associated X protein; BCL2L1, BCL2-like 1; CASP, caspase, apoptosis-related cysteine peptidase; DDIT3, DNA-damage-inducible transcript 3; DNAJC3, DnaJ (Hsp40) homolog, subfamily C, member 3; EDEM1, ER degradation enhancer, mannosidase alpha-like 1; HSP90B1, heat shock protein 90kDa beta (Grp94), member 1; HSPA5, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); PDIA4, protein disulfide isomerase family A, member 4; PPP1R15A, protein phosphatase 1, regulatory subunit 15A; TP53, tumor protein p53.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538390, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g002", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_lactation_on_mRNA_concentrations_of_genes_involved_in_the_UPR_in_the_skeletal_muscle_of_sows_/1538390", "title"=>"Effect of lactation on mRNA concentrations of genes involved in the UPR in the skeletal muscle of sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256669"], "description"=>"<p>Relative mRNA concentrations of genes involved in the NOD-like receptor P3 (NLRP3) inflammasome the liver (A) and the skeletal muscle (B) of lactating and non-lactating sows on day 20 of lactation. Filled circles (grey = non-lactating group, black = lactating group) represent individual data for each animal. Black lines represent means of individual data for each group (n = 8–10 sows per group). The mean of the non-lactating group is set to 1. The mean of the lactating group is expressed as fold of the non-lactating group and numerically indicated next to the black line. Superscript symbol indicates difference from non-lactating group (<sup>#</sup>p<0.1). Abbreviations: CASP1, caspase 1, apoptosis-related cysteine peptidase; IL1B, interleukin 1, beta; NLRP3, NLR family, pyrin domain containing 3; PYCARD, PYD and CARD domain containing.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538391, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g003", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_lactation_on_mRNA_concentrations_of_genes_involved_in_the_NLRP3_inflammasome_in_the_liver_and_skeletal_muscle_of_sows_/1538391", "title"=>"Effect of lactation on mRNA concentrations of genes involved in the NLRP3 inflammasome in the liver and skeletal muscle of sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256670"], "description"=>"<p>Relative protein concentrations of phosphorylated and total PKR-like ER kinase (PERK), eukaryotic translation initiation factor 2α (eIF2α) and inhibitor of κB (IκB) in the liver of lactating and non-lactating sows on day 20 of lactation. Representative immunoblots specific to phosphorylated and total PERK, eIF2α and IκB and α-Tubulin as internal control are shown for one animal per group; immunoblots for the other animals revealed similar results. Filled circles (grey = non-lactating group, black = lactating group) represent individual data for each animal from densitometric analysis. Black lines represent means of individual data for each group (n = 6–8 sows per group). The mean of the non-lactating group is set to 1. The mean of the lactating group is expressed as fold of the non-lactating group and numerically indicated next to the black line.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538392, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_lactation_on_phosphorylation_of_PERK_and_PERK_mediated_phosphorylation_of_eIF2_945_and_I_954_B_in_the_liver_of_sows_/1538392", "title"=>"Effect of lactation on phosphorylation of PERK and PERK-mediated phosphorylation of eIF2α and IκB in the liver of sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256672"], "description"=>"<p>Relative mRNA concentrations of nuclear factor κB (NF-κB) target genes in the liver (A) and the skeletal muscle (B) of lactating sows with or without fish oil supplementation on day 20 of lactation. Filled circles (grey = control group, black = fish oil group) represent individual data for each animal. Black lines represent means of individual data for each group (n = 6–10 sows per group). The mean of the control group is set to 1. The mean of the fish oil group is expressed as fold of the control group and numerically indicated next to the black line. Superscript symbol indicates difference from control group (*p<0.05, <sup>#</sup>p<0.1). Abbreviations: CCL2, chemokine (C-C motif) ligand 2; HP, haptoglobin; ICAM1, intercellular adhesion molecule 1; IL8, interleukin 8; LBP, lipopolysaccharide binding protein; PTGS2, prostaglandin-endoperoxide synthase 2; SAA2, serum amyloid A2; TNF, tumor necrosis factor.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538394, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g005", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_fish_oil_on_mRNA_concentrations_of_NF_954_B_target_genes_in_the_liver_and_skeletal_muscle_of_lactating_sows_/1538394", "title"=>"Effect of fish oil on mRNA concentrations of NF-κB target genes in the liver and skeletal muscle of lactating sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256673"], "description"=>"<p>Relative mRNA concentrations of genes involved in the unfolded protein response (UPR) in the liver of lactating sows with or without fish oil supplementation on day 20 of lactation. Filled circles (grey = control group, black = fish oil group) represent individual data for each animal. Black lines represent means of individual data for each group (n = 6–10 sows per group). The mean of the control group is set to 1. The mean of the fish oil group is expressed as fold of the control group and numerically indicated next to the black line. Superscript symbol indicates difference from control group (*p<0.05, <sup>#</sup>p<0.1). Abbreviations: ATF4, activating transcription factor 4; BAK1, BCL2-antagonist/killer 1; BAX, BCL2-associated X protein; BCL2L1, BCL2-like 1; CASP, caspase, apoptosis-related cysteine peptidase; DDIT3, DNA-damage-inducible transcript 3; DNAJC3, DnaJ (Hsp40) homolog, subfamily C, member 3; EDEM1, ER degradation enhancer, mannosidase alpha-like 1; HSP90B1, heat shock protein 90kDa beta (Grp94), member 1; HSPA5, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); PDIA4, protein disulfide isomerase family A, member 4; PPP1R15A, protein phosphatase 1, regulatory subunit 15A; TP53, tumor protein p53.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538395, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g006", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_fish_oil_on_mRNA_concentrations_of_genes_involved_in_the_UPR_in_the_liver_of_lactating_sows_/1538395", "title"=>"Effect of fish oil on mRNA concentrations of genes involved in the UPR in the liver of lactating sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2256674"], "description"=>"<p>Relative mRNA concentrations of genes involved in the unfolded protein response (UPR) in the skeletal muscle of lactating sows with or without fish oil supplementation on day 20 of lactation. Filled circles (grey = control group, black = fish oil group) represent individual data for each animal. Black lines represent means of individual data for each group (n = 7–10 sows per group). The mean of the control group is set to 1. The mean of the fish oil group is expressed as fold of the control group and numerically indicated next to the black line. Abbreviations: ATF4, activating transcription factor 4; BAX, BCL2-associated X protein; BCL2L1, BCL2-like 1; CASP, caspase, apoptosis-related cysteine peptidase; DDIT3, DNA-damage-inducible transcript 3; DNAJC3, DnaJ (Hsp40) homolog, subfamily C, member 3; EDEM1, ER degradation enhancer, mannosidase alpha-like 1; HSP90B1, heat shock protein 90kDa beta (Grp94), member 1; HSPA5, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); PDIA4, protein disulfide isomerase family A, member 4; PPP1R15A, protein phosphatase 1, regulatory subunit 15A; TP53, tumor protein p53.</p>", "links"=>[], "tags"=>["perk", "phase proteins", "pufa", "phosphorylation", "attenuate hepatic inflammation", "upr", "mRNA levels", "fish oil group", "fish oil", "ER Stress Signalling Pathways"], "article_id"=>1538396, "categories"=>["Uncategorised"], "users"=>["Denise K. Gessner", "Birthe Gröne", "Aline Couturier", "Susann Rosenbaum", "Sonja Hillen", "Sabrina Becker", "Georg Erhardt", "Gerald Reiner", "Robert Ringseis", "Klaus Eder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137684.g007", "stats"=>{"downloads"=>6, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_fish_oil_on_mRNA_concentrations_of_genes_involved_in_the_UPR_in_the_skeletal_muscle_of_lactating_sows_/1538396", "title"=>"Effect of fish oil on mRNA concentrations of genes involved in the UPR in the skeletal muscle of lactating sows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-09 04:29:31"}

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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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