Imaging Surrogates of Disease Activity in Neuromyelitis Optica Allow Distinction from Multiple Sclerosis
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{"title"=>"Imaging surrogates of disease activity in neuromyelitis optica allow distinction from multiple sclerosis", "type"=>"journal", "authors"=>[{"first_name"=>"Lucy", "last_name"=>"Matthews", "scopus_author_id"=>"24512589900"}, {"first_name"=>"Shannon", "last_name"=>"Kolind", "scopus_author_id"=>"13104405000"}, {"first_name"=>"Alix", "last_name"=>"Brazier", "scopus_author_id"=>"56950390200"}, {"first_name"=>"Maria Isabel", "last_name"=>"Leite", "scopus_author_id"=>"8974534800"}, {"first_name"=>"Jonathan", "last_name"=>"Brooks", "scopus_author_id"=>"8635505600"}, {"first_name"=>"Anthony", "last_name"=>"Traboulsee", "scopus_author_id"=>"6602953194"}, {"first_name"=>"Mark", "last_name"=>"Jenkinson", "scopus_author_id"=>"7004366857"}, {"first_name"=>"Heidi", "last_name"=>"Johansen-Berg", "scopus_author_id"=>"6701480981"}, {"first_name"=>"Jacqueline", "last_name"=>"Palace", "scopus_author_id"=>"7003371998"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84946593873", "sgr"=>"84946593873", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0137715", "pmid"=>"26381510", "isbn"=>"1932-6203", "pui"=>"606742940"}, "id"=>"be3bca76-2c1f-3718-a897-6ed9e8e243af", "abstract"=>"Inflammatory demyelinating lesions of the central nervous system are a common feature of both neuromyelitis optica and multiple sclerosis. Despite this similarity, it is evident clinically that the accumulation of disability in patients with neuromyelitis optica is relapse related and that a progressive phase is very uncommon. This poses the question whether there is any pathological evidence of disease activity or neurodegeneration in neuromyelitis optica between relapses. To investigate this we conducted a longitudinal advanced MRI study of the brain and spinal cord in neuromyelitis optica patients, comparing to patients with multiple sclerosis and controls. We found both cross-sectional and longitudinal evidence of diffusely distributed neurodegenerative surrogates in the multiple sclerosis group (including thalamic atrophy, cervical cord atrophy and progressive widespread diffusion and myelin water imaging abnormalities in the normal appearing white matter) but not in those with neuromyelitis optica, where localised abnormalities in the optic radiations of those with severe visual impairment were noted. In addition, between relapses, there were no new silent brain lesions in the neuromyelitis optica group. These findings indicate that global central nervous system neurodegeneration is not a feature of neuromyelitis optica. The work also questions the theory that neurodegeneration in multiple sclerosis is a chronic sequela to prior inflammatory and demyelinating pathology, as this has not been found to be the case in neuromyelitis optica where the lesions are often more destructive.", "link"=>"http://www.mendeley.com/research/imaging-surrogates-disease-activity-neuromyelitis-optica-allow-distinction-multiple-sclerosis", "reader_count"=>27, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>3, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>3, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>9, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2277947"], "description"=>"<p>Histogram showing the frequency of subjects (x axis) classified into each group by their discriminant function score (y axis).</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549197, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.g008", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histogram_showing_the_frequency_of_subjects_x_axis_classified_into_each_group_by_their_discriminant_function_score_y_axis_/1549197", "title"=>"Histogram showing the frequency of subjects (x axis) classified into each group by their discriminant function score (y axis).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277946"], "description"=>"<p>Voxelwise paired comparison of baseline and one year scans for each subject group showed significant areas within the TBSS white matter skeletons of the multiple sclerosis group of (A) reduction in fractional anisotropy shown in red/yellow, and (B) reduction in myelin water fraction shown in green.</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549196, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.g007", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Longitudinal_measures_of_the_integrity_of_the_normal_appearing_white_matter_/1549196", "title"=>"Longitudinal measures of the integrity of the normal appearing white matter.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277943"], "description"=>"<p>Voxelwise analysis of MWF in the white matter skeleton created with TBSS where significantly lower MWF is shown in red for (A) multiple sclerosis group versus control group, and (B) multiple sclerosis group MWF versus neuromyelitis optica group.</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549193, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.g004", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cross_sectional_myelin_water_fraction_MWF_of_the_normal_appearing_white_matter_/1549193", "title"=>"Cross-sectional myelin water fraction (MWF) of the normal appearing white matter.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277941"], "description"=>"<p>Showed relative atrophy of the thalami and caudate nuclei.</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549191, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Voxel_based_morphometry_of_the_multiple_sclerosis_group_compared_to_controls_/1549191", "title"=>"Voxel-based morphometry of the multiple sclerosis group compared to controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277942"], "description"=>"<p>Voxelwise comparison of fractional anisotropy (FA) within white matter skeletons created with TBSS where significantly lower FA is shown in yellow for (A) neuromyelitis optica group versus control group, (B) multiple sclerosis group versus control group, and (C) multiple sclerosis group versus neuromyelitis optica group.</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549192, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cross_sectional_fractional_anisotropy_of_the_normal_appearing_white_matter_/1549192", "title"=>"Cross-sectional fractional anisotropy of the normal appearing white matter.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277940"], "description"=>"<p>The dots show individual patient results and the bars the group mean. Individual and mean results have not been normalised for age. (A) Whole brain volume normalised for intracranial volume. (B) Thalamic volume normalised for intracranial volume. (C) Cervical spinal cord volume. NS = not significant, * = significant difference (corrected p< 0.05).</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549190, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_cross_sectional_volumetric_analyses_/1549190", "title"=>"Results of the cross-sectional volumetric analyses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277949"], "description"=>"<p>Abbreviations:</p><p>ANCOVA: analysis of co-variance</p><p>DTI: diffusion tensor imaging</p><p>MTSCF: Magnetisation transfer contrast normalized by CSF signal</p><p>MWI: myelin water imaging</p><p>NAT: Normal appearing tissue</p><p>NAWM: normal appearing white matter</p><p>NS: not significant</p><p>SD: standard deviation</p><p>*: significant difference (p<0.05).</p><p>Group comparisons of quantitative imaging measures.</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549199, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.t002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Group_comparisons_of_quantitative_imaging_measures_/1549199", "title"=>"Group comparisons of quantitative imaging measures.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277950", "https://ndownloader.figshare.com/files/2277951"], "description"=>"<div><p>Inflammatory demyelinating lesions of the central nervous system are a common feature of both neuromyelitis optica and multiple sclerosis. Despite this similarity, it is evident clinically that the accumulation of disability in patients with neuromyelitis optica is relapse related and that a progressive phase is very uncommon. This poses the question whether there is any pathological evidence of disease activity or neurodegeneration in neuromyelitis optica between relapses. To investigate this we conducted a longitudinal advanced MRI study of the brain and spinal cord in neuromyelitis optica patients, comparing to patients with multiple sclerosis and controls. We found both cross-sectional and longitudinal evidence of diffusely distributed neurodegenerative surrogates in the multiple sclerosis group (including thalamic atrophy, cervical cord atrophy and progressive widespread diffusion and myelin water imaging abnormalities in the normal appearing white matter) but not in those with neuromyelitis optica, where localised abnormalities in the optic radiations of those with severe visual impairment were noted. In addition, between relapses, there were no new silent brain lesions in the neuromyelitis optica group. These findings indicate that global central nervous system neurodegeneration is not a feature of neuromyelitis optica. The work also questions the theory that neurodegeneration in multiple sclerosis is a chronic sequela to prior inflammatory and demyelinating pathology, as this has not been found to be the case in neuromyelitis optica where the lesions are often more destructive.</p></div>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549200, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0137715.s001", "https://dx.doi.org/10.1371/journal.pone.0137715.s002"], "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Imaging_Surrogates_of_Disease_Activity_in_Neuromyelitis_Optica_Allow_Distinction_from_Multiple_Sclerosis_/1549200", "title"=>"Imaging Surrogates of Disease Activity in Neuromyelitis Optica Allow Distinction from Multiple Sclerosis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277948"], "description"=>"<p>Abbreviations:</p><p>Aza: Azathioprine</p><p>Glt: Glatiramer</p><p>Inf: β-Interferon</p><p>Mtx: Methotrexate</p><p>MS: Multiple sclerosis</p><p>NMO: Neuromyelitis optica</p><p>Pred: Prednisolone</p><p>VA: Visual Acuity.</p><p>Subject Characteristics.</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549198, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.t001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_Characteristics_/1549198", "title"=>"Subject Characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277945"], "description"=>"<p>(A) Percentage change in brain volume over one year in subject groups. (B) Voxelwise within-group analysis found a small significant area of atrophy in the region of the insula cortex within the multiple sclerosis group (shown) but not the neuromyelitis optica or control groups over the course of one year. (C) Change in thalamic volume over one year. NS = not significant, * = significant difference (corrected p< 0.05).</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549195, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.g006", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Longitudinal_volumetric_measures_/1549195", "title"=>"Longitudinal volumetric measures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-18 03:46:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/2277944"], "description"=>"<p>Error bars are +/- 2 standard errors of the mean.</p>", "links"=>[], "tags"=>["neurodegeneration", "relapse", "neuromyelitis optica group", "myelin water imaging abnormalities", "lesion", "neuromyelitis optica patients", "sclerosis", "neuromyelitis optica", "mri"], "article_id"=>1549194, "categories"=>["Biological Sciences"], "users"=>["Lucy Matthews", "Shannon Kolind", "Alix Brazier", "Maria Isabel Leite", "Jonathan Brooks", "Anthony Traboulsee", "Mark Jenkinson", "Heidi Johansen-Berg", "Jacqueline Palace"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0137715.g005", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bar_graph_showing_average_spinal_cord_MTCSF_white_grey_matter_ratio_in_each_patient_group_/1549194", "title"=>"Bar graph showing average spinal cord MTCSF white:grey matter ratio in each patient group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-18 03:46:31"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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