Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett’s Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium
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{"title"=>"Polymorphisms in genes of relevance for oestrogen and oxytocin pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma: A pooled analysis from the BEACON consortium", "type"=>"journal", "authors"=>[{"first_name"=>"Katarina", "last_name"=>"Lagergren", "scopus_author_id"=>"54684384700"}, {"first_name"=>"Weronica E.", "last_name"=>"Ek", "scopus_author_id"=>"36100005400"}, {"first_name"=>"David", "last_name"=>"Levine", "scopus_author_id"=>"7403166224"}, {"first_name"=>"Wong Ho", "last_name"=>"Chow", "scopus_author_id"=>"7402281015"}, {"first_name"=>"Leslie", "last_name"=>"Bernstein", "scopus_author_id"=>"55513990000"}, {"first_name"=>"Alan G.", "last_name"=>"Casson", "scopus_author_id"=>"56526540900"}, {"first_name"=>"Harvey A.", "last_name"=>"Risch", "scopus_author_id"=>"7006408721"}, {"first_name"=>"Nicholas J.", "last_name"=>"Shaheen", "scopus_author_id"=>"7005212160"}, {"first_name"=>"Nigel C.", "last_name"=>"Bird", "scopus_author_id"=>"7005136683"}, {"first_name"=>"Brian J.", "last_name"=>"Reid", "scopus_author_id"=>"7202316393"}, {"first_name"=>"Douglas A.", "last_name"=>"Corley", "scopus_author_id"=>"7006039762"}, {"first_name"=>"Laura J.", "last_name"=>"Hardie", "scopus_author_id"=>"7004421708"}, {"first_name"=>"Anna H.", "last_name"=>"Wu", "scopus_author_id"=>"13609501200"}, {"first_name"=>"Rebecca C.", "last_name"=>"Fitzgerald", "scopus_author_id"=>"7202577507"}, {"first_name"=>"Paul", "last_name"=>"Pharoah", "scopus_author_id"=>"7102929844"}, {"first_name"=>"Carlos", "last_name"=>"Caldas", "scopus_author_id"=>"7006688992"}, {"first_name"=>"Yvonne", "last_name"=>"Romero", "scopus_author_id"=>"6603795889"}, {"first_name"=>"Thomas L.", "last_name"=>"Vaughan", "scopus_author_id"=>"7103008911"}, {"first_name"=>"Stuart", "last_name"=>"Macgregor", "scopus_author_id"=>"56591946800"}, {"first_name"=>"David", "last_name"=>"Whiteman", "scopus_author_id"=>"14024933500"}, {"first_name"=>"Lars", "last_name"=>"Westberg", "scopus_author_id"=>"56216855300"}, {"first_name"=>"Olof", "last_name"=>"Nyren", "scopus_author_id"=>"7005933245"}, {"first_name"=>"Jesper", "last_name"=>"Lagergren", "scopus_author_id"=>"7005124006"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"26406593", "doi"=>"10.1371/journal.pone.0138738", "sgr"=>"84947795687", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84947795687", "issn"=>"19326203", "pui"=>"606939482"}, "id"=>"137e0563-16a4-3c47-96b7-b31d569c761f", "abstract"=>"Background", "link"=>"http://www.mendeley.com/research/polymorphisms-genes-relevance-oestrogen-oxytocin-pathways-risk-barretts-oesophagus-oesophageal-adeno", "reader_count"=>16, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Australia"=>1}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2290303"], "description"=>"<p><sup>1</sup> Chromosome number</p><p><sup>a</sup> 575 cases and 466 controls</p><p><sup>b</sup> 175 cases and 466 controls</p><p><sup>c</sup> 751 cases and 466 controls</p><p><sup>d</sup> 1808 cases and 1703 controls</p><p><sup>e</sup> 1333 cases and 1704 controls, and</p><p><sup>f</sup> 3141 cases and 1702 controls.</p><p>P-values in bold are statistically significant after correction for multiple testing.</p>", "links"=>[], "tags"=>["oac", "oxytocin receptor", "BEACON Consortium BackgroundThe", "2383 BO patients", "oxt", "gene", "19a", "vegas", "oxtr", "cyp", "oestrogen", "cyclic ADP ribose hydrolase glycoprotein", "esr", "males only.ConclusionGenetic variants"], "article_id"=>1557632, "categories"=>["Biological Sciences"], "users"=>["Katarina Lagergren", "Weronica E. Ek", "David Levine", "Wong-Ho Chow", "Leslie Bernstein", "Alan G. Casson", "Harvey A. Risch", "Nicholas J. Shaheen", "Nigel C. Bird", "Brian J. Reid", "Douglas A. Corley", "Laura J. Hardie", "Anna H. Wu", "Rebecca C. Fitzgerald", "Paul Pharoah", "Carlos Caldas", "Yvonne Romero", "Thomas L. Vaughan", "Stuart Macgregor", "David Whiteman", "Lars Westberg", "Olof Nyrén", "Jesper Lagergren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0138738.t005", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_specific_gene_based_analysis_of_top_90_single_nucleotide_polymorphisms_SNPs_in_genes_known_to_regulate_oestrogen_levels_and_oxytocin_levels_and_risk_of_Barrett_8217_s_oesophagus_BO_oesophageal_adenocarcinoma_OAC_and_these_conditions_combined_OAC_BO_/1557632", "title"=>"Sex-specific gene-based analysis of top 90% single nucleotide polymorphisms (SNPs) in genes known to regulate oestrogen levels and oxytocin levels and risk of Barrett’s oesophagus (BO), oesophageal adenocarcinoma (OAC), and these conditions combined (OAC+BO).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-25 05:01:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2290304", "https://ndownloader.figshare.com/files/2290305", "https://ndownloader.figshare.com/files/2290306", "https://ndownloader.figshare.com/files/2290307", "https://ndownloader.figshare.com/files/2290308", "https://ndownloader.figshare.com/files/2290309", "https://ndownloader.figshare.com/files/2290310"], "description"=>"<div><p>Background</p><p>The strong male predominance in oesophageal adenocarcinoma (OAC) and Barrett’s oesophagus (BO) continues to puzzle. Hormonal influence, e.g. oestrogen or oxytocin, might contribute.</p><p>Methods</p><p>This genetic-epidemiological study pooled 14 studies from three continents, Australia, Europe, and North America. Polymorphisms in 3 key genes coding for the oestrogen pathway (receptor alpha (<i>ESR1</i>), receptor beta (<i>ESR2</i>), and aromatase (<i>CYP19A1</i>)), and 3 key genes of the oxytocin pathway (the oxytocin receptor (<i>OXTR</i>), oxytocin protein (<i>OXT</i>), and cyclic ADP ribose hydrolase glycoprotein (<i>CD38</i>)), were analysed using a gene-based approach, versatile gene-based test association study (VEGAS).</p><p>Results</p><p>Among 1508 OAC patients, 2383 BO patients, and 2170 controls, genetic variants within <i>ESR1</i> were associated with BO in males (p = 0.0058) and an increased risk of OAC and BO combined in males (p = 0.0023). Genetic variants within <i>OXTR</i> were associated with an increased risk of BO in both sexes combined (p = 0.0035) and in males (p = 0.0012). We followed up these suggestive findings in a further smaller data set, but found no replication. There were no significant associations between the other 4 genes studied and risk of OAC, BO, separately on in combination, in males and females combined or in males only.</p><p>Conclusion</p><p>Genetic variants in the oestrogen receptor alpha and the oxytocin receptor may be associated with an increased risk of BO or OAC, but replication in other large samples are needed.</p></div>", "links"=>[], "tags"=>["oac", "oxytocin receptor", "BEACON Consortium BackgroundThe", "2383 BO patients", "oxt", "gene", "19a", "vegas", "oxtr", "cyp", "oestrogen", "cyclic ADP ribose hydrolase glycoprotein", "esr", "males only.ConclusionGenetic variants"], "article_id"=>1557633, "categories"=>["Biological Sciences"], "users"=>["Katarina Lagergren", "Weronica E. Ek", "David Levine", "Wong-Ho Chow", "Leslie Bernstein", "Alan G. Casson", "Harvey A. Risch", "Nicholas J. Shaheen", "Nigel C. Bird", "Brian J. Reid", "Douglas A. Corley", "Laura J. Hardie", "Anna H. Wu", "Rebecca C. Fitzgerald", "Paul Pharoah", "Carlos Caldas", "Yvonne Romero", "Thomas L. Vaughan", "Stuart Macgregor", "David Whiteman", "Lars Westberg", "Olof Nyrén", "Jesper Lagergren"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0138738.s001", "https://dx.doi.org/10.1371/journal.pone.0138738.s002", "https://dx.doi.org/10.1371/journal.pone.0138738.s003", "https://dx.doi.org/10.1371/journal.pone.0138738.s004", "https://dx.doi.org/10.1371/journal.pone.0138738.s005", "https://dx.doi.org/10.1371/journal.pone.0138738.s006", "https://dx.doi.org/10.1371/journal.pone.0138738.s007"], "stats"=>{"downloads"=>19, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Polymorphisms_in_Genes_of_Relevance_for_Oestrogen_and_Oxytocin_Pathways_and_Risk_of_Barrett_8217_s_Oesophagus_and_Oesophageal_Adenocarcinoma_A_Pooled_Analysis_from_the_BEACON_Consortium_/1557633", "title"=>"Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett’s Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-09-25 05:01:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2290299"], "description"=>"<p>Characteristics of oesophageal adenocarcinoma cases (OAC), Barrett’s oesophagus cases (BO), either of these (OAC+BO) and control subjects.</p>", "links"=>[], "tags"=>["oac", "oxytocin receptor", "BEACON Consortium BackgroundThe", "2383 BO patients", "oxt", "gene", "19a", "vegas", "oxtr", "cyp", "oestrogen", "cyclic ADP ribose hydrolase glycoprotein", "esr", "males only.ConclusionGenetic variants"], "article_id"=>1557628, "categories"=>["Biological Sciences"], "users"=>["Katarina Lagergren", "Weronica E. Ek", "David Levine", "Wong-Ho Chow", "Leslie Bernstein", "Alan G. Casson", "Harvey A. Risch", "Nicholas J. Shaheen", "Nigel C. Bird", "Brian J. Reid", "Douglas A. Corley", "Laura J. Hardie", "Anna H. Wu", "Rebecca C. Fitzgerald", "Paul Pharoah", "Carlos Caldas", "Yvonne Romero", "Thomas L. Vaughan", "Stuart Macgregor", "David Whiteman", "Lars Westberg", "Olof Nyrén", "Jesper Lagergren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0138738.t001", "stats"=>{"downloads"=>4, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_oesophageal_adenocarcinoma_cases_OAC_Barrett_8217_s_oesophagus_cases_BO_either_of_these_OAC_BO_and_control_subjects_/1557628", "title"=>"Characteristics of oesophageal adenocarcinoma cases (OAC), Barrett’s oesophagus cases (BO), either of these (OAC+BO) and control subjects.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-25 05:01:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2290300"], "description"=>"<p><sup>1</sup> Chromosome number</p><p><sup>2</sup> base pair.</p><p>P-values in bold are statistically significant after correction for multiple testing.</p>", "links"=>[], "tags"=>["oac", "oxytocin receptor", "BEACON Consortium BackgroundThe", "2383 BO patients", "oxt", "gene", "19a", "vegas", "oxtr", "cyp", "oestrogen", "cyclic ADP ribose hydrolase glycoprotein", "esr", "males only.ConclusionGenetic variants"], "article_id"=>1557629, "categories"=>["Biological Sciences"], "users"=>["Katarina Lagergren", "Weronica E. Ek", "David Levine", "Wong-Ho Chow", "Leslie Bernstein", "Alan G. Casson", "Harvey A. Risch", "Nicholas J. Shaheen", "Nigel C. Bird", "Brian J. Reid", "Douglas A. Corley", "Laura J. Hardie", "Anna H. Wu", "Rebecca C. Fitzgerald", "Paul Pharoah", "Carlos Caldas", "Yvonne Romero", "Thomas L. Vaughan", "Stuart Macgregor", "David Whiteman", "Lars Westberg", "Olof Nyrén", "Jesper Lagergren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0138738.t002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_based_analysis_of_genes_known_to_regulate_oestrogen_levels_and_oxytocin_levels_and_risk_of_Barrett_8217_s_oesophagus_BO_oesophageal_adenocarcinoma_OAC_and_these_conditions_combined_OAC_BO_/1557629", "title"=>"Gene-based analysis of genes known to regulate oestrogen levels and oxytocin levels and risk of Barrett’s oesophagus (BO), oesophageal adenocarcinoma (OAC), and these conditions combined (OAC+BO).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-25 05:01:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2290301"], "description"=>"<p><sup>1</sup> Chromosome number</p><p><sup>a</sup> 575 cases and 466 controls</p><p><sup>b</sup> 175 cases and 466 controls</p><p><sup>c</sup> 751 cases and 466 controls</p><p><sup>d</sup> 1808 cases and 1703 controls</p><p><sup>e</sup> 1333 cases and 1704 controls, and</p><p><sup>f</sup> 3141 cases and 1702 controls.</p><p>P-values in bold are statistically significant.</p>", "links"=>[], "tags"=>["oac", "oxytocin receptor", "BEACON Consortium BackgroundThe", "2383 BO patients", "oxt", "gene", "19a", "vegas", "oxtr", "cyp", "oestrogen", "cyclic ADP ribose hydrolase glycoprotein", "esr", "males only.ConclusionGenetic variants"], "article_id"=>1557630, "categories"=>["Biological Sciences"], "users"=>["Katarina Lagergren", "Weronica E. Ek", "David Levine", "Wong-Ho Chow", "Leslie Bernstein", "Alan G. Casson", "Harvey A. Risch", "Nicholas J. Shaheen", "Nigel C. Bird", "Brian J. Reid", "Douglas A. Corley", "Laura J. Hardie", "Anna H. Wu", "Rebecca C. Fitzgerald", "Paul Pharoah", "Carlos Caldas", "Yvonne Romero", "Thomas L. Vaughan", "Stuart Macgregor", "David Whiteman", "Lars Westberg", "Olof Nyrén", "Jesper Lagergren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0138738.t003", "stats"=>{"downloads"=>6, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_specific_gene_based_analysis_for_genes_known_to_regulate_oestrogen_levels_and_oxytocin_levels_and_risk_of_Barrett_8217_s_oesophagus_BO_oesophageal_adenocarcinoma_OAC_and_these_conditions_combined_OAC_BO_/1557630", "title"=>"Sex-specific gene-based analysis for genes known to regulate oestrogen levels and oxytocin levels and risk of Barrett’s oesophagus (BO), oesophageal adenocarcinoma (OAC), and these conditions combined (OAC+BO).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-25 05:01:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/2290302"], "description"=>"<p><sup>1</sup> Chromosome number</p><p><sup>2</sup> base pair.</p><p>P-values in bold are statistically significant after correction for multiple testing.</p>", "links"=>[], "tags"=>["oac", "oxytocin receptor", "BEACON Consortium BackgroundThe", "2383 BO patients", "oxt", "gene", "19a", "vegas", "oxtr", "cyp", "oestrogen", "cyclic ADP ribose hydrolase glycoprotein", "esr", "males only.ConclusionGenetic variants"], "article_id"=>1557631, "categories"=>["Biological Sciences"], "users"=>["Katarina Lagergren", "Weronica E. Ek", "David Levine", "Wong-Ho Chow", "Leslie Bernstein", "Alan G. Casson", "Harvey A. Risch", "Nicholas J. Shaheen", "Nigel C. Bird", "Brian J. Reid", "Douglas A. Corley", "Laura J. Hardie", "Anna H. Wu", "Rebecca C. Fitzgerald", "Paul Pharoah", "Carlos Caldas", "Yvonne Romero", "Thomas L. Vaughan", "Stuart Macgregor", "David Whiteman", "Lars Westberg", "Olof Nyrén", "Jesper Lagergren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0138738.t004", "stats"=>{"downloads"=>4, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_based_analysis_of_top_90_single_nucleotide_polymorphisms_SNPs_in_genes_known_to_regulate_oestrogen_levels_and_oxytocin_levels_and_risk_of_Barrett_8217_s_oesophagus_BO_oesophageal_adenocarcinoma_OAC_and_these_conditions_combined_OAC_BO_/1557631", "title"=>"Gene-based analysis of top 90% single nucleotide polymorphisms (SNPs) in genes known to regulate oestrogen levels and oxytocin levels and risk of Barrett’s oesophagus (BO), oesophageal adenocarcinoma (OAC), and these conditions combined (OAC+BO).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-25 05:01:44"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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