Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model
Publication Date
September 25, 2015
Journal
PLOS ONE
Authors
Chun Yan Yeung, Wai Tao Chan, Chun Bin Jiang, Mei Lien Cheng, et al
Volume
10
Issue
9
Pages
e0138746
DOI
https://dx.plos.org/10.1371/journal.pone.0138746
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0138746
Scopus
84947762368
Mendeley
http://www.mendeley.com/research/amelioration-chemotherapyinduced-intestinal-mucositis-orally-administered-probiotics-mouse-model
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Mendeley | Further Information

{"title"=>"Amelioration of chemotherapy-induced intestinal mucositis by orally administered probiotics in a mouse model", "type"=>"journal", "authors"=>[{"first_name"=>"Chun Yan", "last_name"=>"Yeung", "scopus_author_id"=>"7201354161"}, {"first_name"=>"Wai Tao", "last_name"=>"Chan", "scopus_author_id"=>"56426711000"}, {"first_name"=>"Chun Bin", "last_name"=>"Jiang", "scopus_author_id"=>"57133315400"}, {"first_name"=>"Mei Lien", "last_name"=>"Cheng", "scopus_author_id"=>"36833893600"}, {"first_name"=>"Chia Yuan", "last_name"=>"Liu", "scopus_author_id"=>"8711670500"}, {"first_name"=>"Szu Wen", "last_name"=>"Chang", "scopus_author_id"=>"14007901300"}, {"first_name"=>"Jen Shiu Chiang", "last_name"=>"Chiau", "scopus_author_id"=>"36081548500"}, {"first_name"=>"Hung Chang", "last_name"=>"Lee", "scopus_author_id"=>"8833493200"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84947762368", "sgr"=>"84947762368", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0138746", "pmid"=>"26406888", "pui"=>"606939479"}, "id"=>"178118d1-fe1b-393b-a673-0c6dbe621a30", "abstract"=>"BACKGROUND AND AIMS: Intestinal mucositis is a frequently encountered side effect in oncology patients undergoing chemotherapy. No well-established or up to date therapeutic strategies are available. To study a novel way to alleviate mucositis, we investigate the effects and safety of probiotic supplementation in ameliorating 5-FU-induced intestinal mucositis in a mouse model. METHODS: Seventy-two mice were injected saline or 5-Fluorouracil (5-FU) intraperitoneally daily. Mice were either orally administrated daily saline, probiotic suspension of Lactobacillus casei variety rhamnosus (Lcr35) or Lactobacillus acidophilus and Bifidobacterium bifidum (LaBi). Diarrhea score, pro-inflammatory cytokines serum levels, intestinal villus height and crypt depth and total RNA from tissue were assessed. Samples of blood, liver and spleen tissues were assessed for translocation. RESULTS: Marked diarrhea developed in the 5-FU groups but was attenuated after oral Lcr35 and LaBi administrations. Diarrhea scores decreased significantly from 2.64 to 1.45 and 0.80, respectively (P<0.001). Those mice in 5-FU groups had significantly higher proinflammatory cytokine levels (TNF-α: 234.80 vs. 29.10, P<0.001, IL-6: 25.13 vs. 7.43, P<0.001, IFN-γ: 22.07 vs. 17.06, P = 0.137). A repairing of damage in jejunal villi was observed following probiotics administration. We also found TNF-α, IL-1β and IL-6 mRNA expressions were up-regulated in intestinal mucositis tissues following 5-FU treatment (TNF-α: 4.35 vs. 1.18, IL-1β: 2.29 vs. 1.07, IL-6: 1.49 vs. 1.02) and that probiotics treatment suppressed this up-regulation (P<0.05). No bacterial translocation was found in this study. CONCLUSIONS: In conclusion, our results show that oral administration of probiotics Lcr35 and LaBi can ameliorate chemotherapy-induced intestinal mucositis in a mouse model. This suggests probiotics may serve as an alternative therapeutic strategy for the prevention or management of chemotherapy-induced mucositis in the future.", "link"=>"http://www.mendeley.com/research/amelioration-chemotherapyinduced-intestinal-mucositis-orally-administered-probiotics-mouse-model", "reader_count"=>46, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>12, "Other"=>2, "Student > Bachelor"=>4, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>12, "Other"=>2, "Student > Bachelor"=>4, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>4, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>11, "Veterinary Science and Veterinary Medicine"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Immunology and Microbiology"=>5, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>0}

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Scopus | Further Information

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