Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula
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{"title"=>"Identification of target genes involved in wound healing angiogenesis of endothelial cells with the treatment of a Chinese 2-herb formula", "type"=>"journal", "authors"=>[{"first_name"=>"Jacqueline Chor Wing", "last_name"=>"Tam", "scopus_author_id"=>"49964705900"}, {"first_name"=>"Chun Hay", "last_name"=>"Ko", "scopus_author_id"=>"55550029200"}, {"first_name"=>"Chi Man", "last_name"=>"Koon", "scopus_author_id"=>"24172511000"}, {"first_name"=>"Zhang", "last_name"=>"Cheng", "scopus_author_id"=>"56963163900"}, {"first_name"=>"Wong Hing", "last_name"=>"Lok", "scopus_author_id"=>"56964159200"}, {"first_name"=>"Ching Po", "last_name"=>"Lau", "scopus_author_id"=>"24172781500"}, {"first_name"=>"Ping Chung", "last_name"=>"Leung", "scopus_author_id"=>"55085136200"}, {"first_name"=>"Kwok Pui", "last_name"=>"Fung", "scopus_author_id"=>"7202934739"}, {"first_name"=>"Wai Yee", "last_name"=>"Chan", "scopus_author_id"=>"7403918043"}, {"first_name"=>"Clara Bik San", "last_name"=>"Lau", "scopus_author_id"=>"8982873200"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84947246992", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0139342", "pui"=>"606879445", "sgr"=>"84947246992", "issn"=>"19326203", "pmid"=>"26430762"}, "id"=>"fc9079ea-96d9-37bb-92ba-72b5be870701", "abstract"=>"Angiogenesis is vitally important in diabetic wound healing. We had previously demonstrated that a Chinese 2-herb formula (NF3) significantly stimulated angiogenesis of HUVEC in wound healing. However, the molecular mechanism has not yet been elucidated. In line with this, global expression profiling of NF3-treated HUVEC was performed so as to assess the regulatory role of NF3 involved in the underlying signaling pathways in wound healing angiogenesis. The microarray results illustrated that different panels of differentially expressed genes were strictly governed in NF3-treated HUVEC in a time-regulated manner. The microarray analysis followed by qRT-PCR and western blotting verification of NF3-treated HUVEC at 6 h revealed the involvement of various genes in diverse biological process, e.g., MAP3K14 in anti-inflammation; SLC5A8 in anti-tumorogenesis; DNAJB7 in protein translation; BIRC5, EPCAM, INSL4, MMP8 and NPR3 in cell proliferation; CXCR7, EPCAM, HAND1 and MMP8 in migration; CXCR7, EPCAM and MMP8 in tubular formation; and BIRC5, CXCR7, EPCAM, HAND1, MMP8 and UBD in angiogenesis. After 16 h incubation of NF3, other sets of genes were shown with differential expression in HUVEC, e.g., IL1RAPL2 and NR1H4 in anti-inflammation; miR28 in anti-tumorogenesis; GRIN1 and LCN1 in anti-oxidation; EPB41 in intracellular signal transduction; PRL and TFAP2A in cell proliferation; miR28, PRL and SCG2 in cell migration; PRL in tubular formation; and miR28, NR1H4 and PRL in angiogenesis. This study provided concrete scientific evidence in support of the regulatory role of NF3 on endothelial cells involved in wound healing angiogenesis.", "link"=>"http://www.mendeley.com/research/identification-target-genes-involved-wound-healing-angiogenesis-endothelial-cells-treatment-chinese-1", "reader_count"=>10, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Master"=>2, "Other"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Master"=>2, "Other"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>3, "Chemistry"=>2, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>2}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/2297228"], "description"=>"<p>Values are means ± SD from three individual experiments.</p><p>RNA from new preparation of HUVEC samples were used for confirmation of microarray analysis.</p>", "links"=>[], "tags"=>["MMP 8", "5a", "2a", "16 h incubation", "ubd", "npr", "3k", "epb", "scg", "birc", "NF 3", "prl", "LCN", "cxcr", "TfAP", "1h", "dnajb", "wound healing", "Cell proliferation", "nr", "INSL", "1RAPL", "wound healing angiogenesis", "intracellular signal transduction", "huvec", "mir", "il", "epcam", "GRIN", "slc"], "article_id"=>1563046, "categories"=>["Uncategorised"], "users"=>["Jacqueline Chor Wing Tam", "Chun Hay Ko", "Chi Man Koon", "Zhang Cheng", "Wong Hing Lok", "Ching Po Lau", "Ping Chung Leung", "Kwok Pui Fung", "Wai Yee Chan", "Clara Bik San Lau"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0139342.t005", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_qRT_PCR_analysis_of_the_relative_gene_expression_level_of_NF3_treated_HUVEC_versus_control_HUVEC_at_6_h_/1563046", "title"=>"qRT-PCR analysis of the relative gene expression level of NF3-treated HUVEC versus control HUVEC at 6 h.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-02 03:26:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297229"], "description"=>"<p>Values are means ± SD from three individual experiments.</p><p>RNA from new preparation of HUVEC samples were used for confirmation of microarray analysis.</p>", "links"=>[], "tags"=>["MMP 8", "5a", "2a", "16 h incubation", "ubd", "npr", "3k", "epb", "scg", "birc", "NF 3", "prl", "LCN", "cxcr", "TfAP", "1h", "dnajb", "wound healing", "Cell proliferation", "nr", "INSL", "1RAPL", "wound healing angiogenesis", "intracellular signal transduction", "huvec", "mir", "il", "epcam", "GRIN", "slc"], "article_id"=>1563047, "categories"=>["Uncategorised"], "users"=>["Jacqueline Chor Wing Tam", "Chun Hay Ko", "Chi Man Koon", "Zhang Cheng", "Wong Hing Lok", "Ching Po Lau", "Ping Chung Leung", "Kwok Pui Fung", "Wai Yee Chan", "Clara Bik San Lau"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0139342.t006", "stats"=>{"downloads"=>6, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_qRT_PCR_analysis_of_the_relative_gene_expression_level_of_NF3_treated_HUVEC_versus_control_HUVEC_at_16_h_/1563047", "title"=>"qRT-PCR analysis of the relative gene expression level of NF3-treated HUVEC versus control HUVEC at 16 h.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-02 03:26:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297230", "https://ndownloader.figshare.com/files/2297231", "https://ndownloader.figshare.com/files/2297232", "https://ndownloader.figshare.com/files/2297233"], "description"=>"<div><p>Angiogenesis is vitally important in diabetic wound healing. We had previously demonstrated that a Chinese 2-herb formula (NF3) significantly stimulated angiogenesis of HUVEC in wound healing. However, the molecular mechanism has not yet been elucidated. In line with this, global expression profiling of NF3-treated HUVEC was performed so as to assess the regulatory role of NF3 involved in the underlying signaling pathways in wound healing angiogenesis. The microarray results illustrated that different panels of differentially expressed genes were strictly governed in NF3-treated HUVEC in a time-regulated manner. The microarray analysis followed by qRT-PCR and western blotting verification of NF3-treated HUVEC at 6 h revealed the involvement of various genes in diverse biological process, e.g., MAP3K14 in anti-inflammation; SLC5A8 in anti-tumorogenesis; DNAJB7 in protein translation; BIRC5, EPCAM, INSL4, MMP8 and NPR3 in cell proliferation; CXCR7, EPCAM, HAND1 and MMP8 in migration; CXCR7, EPCAM and MMP8 in tubular formation; and BIRC5, CXCR7, EPCAM, HAND1, MMP8 and UBD in angiogenesis. After 16 h incubation of NF3, other sets of genes were shown with differential expression in HUVEC, e.g., IL1RAPL2 and NR1H4 in anti-inflammation; miR28 in anti-tumorogenesis; GRIN1 and LCN1 in anti-oxidation; EPB41 in intracellular signal transduction; PRL and TFAP2A in cell proliferation; miR28, PRL and SCG2 in cell migration; PRL in tubular formation; and miR28, NR1H4 and PRL in angiogenesis. This study provided concrete scientific evidence in support of the regulatory role of NF3 on endothelial cells involved in wound healing angiogenesis.</p></div>", "links"=>[], "tags"=>["MMP 8", "5a", "2a", "16 h incubation", "ubd", "npr", "3k", "epb", "scg", "birc", "NF 3", "prl", "LCN", "cxcr", "TfAP", "1h", "dnajb", "wound healing", "Cell proliferation", "nr", "INSL", "1RAPL", "wound healing angiogenesis", "intracellular signal transduction", "huvec", "mir", "il", "epcam", "GRIN", "slc"], "article_id"=>1563048, "categories"=>["Uncategorised"], "users"=>["Jacqueline Chor Wing Tam", "Chun Hay Ko", "Chi Man Koon", "Zhang Cheng", "Wong Hing Lok", "Ching Po Lau", "Ping Chung Leung", "Kwok Pui Fung", "Wai Yee Chan", "Clara Bik San Lau"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0139342.s001", "https://dx.doi.org/10.1371/journal.pone.0139342.s002", "https://dx.doi.org/10.1371/journal.pone.0139342.s003", "https://dx.doi.org/10.1371/journal.pone.0139342.s004"], "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Identification_of_Target_Genes_Involved_in_Wound_Healing_Angiogenesis_of_Endothelial_Cells_with_the_Treatment_of_a_Chinese_2_Herb_Formula_/1563048", "title"=>"Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-10-02 03:26:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297209"], "description"=>"<p>Microarray hybridizations were performed using total RNA from HUVEC treated with 75 μg/ml NF3 for 16 h. The gene expression profiles of 3 pools of control cells (red) and 3 pools of NF3-treated cells (blue) were compared using PCA. The red or blue ball located at the central position within the cluster represented the mean of gene expression profiles of 3 pools of control or NF3-treated cells. The two distinct clusters of three red and blue balls represented the intra-experimental variation of control cells and NF3-treated cells, respectively. The three-dimensional plot view of gene expression data (including all probe sets on human GeneChip 1.0 ST) were shown with respect to their correlation to the first three principal components.</p>", "links"=>[], "tags"=>["MMP 8", "5a", "2a", "16 h incubation", "ubd", "npr", "3k", "epb", "scg", "birc", "NF 3", "prl", "LCN", "cxcr", "TfAP", "1h", "dnajb", "wound healing", "Cell proliferation", "nr", "INSL", "1RAPL", "wound healing angiogenesis", "intracellular signal transduction", "huvec", "mir", "il", "epcam", "GRIN", "slc"], "article_id"=>1563027, "categories"=>["Uncategorised"], "users"=>["Jacqueline Chor Wing Tam", "Chun Hay Ko", "Chi Man Koon", "Zhang Cheng", "Wong Hing Lok", "Ching Po Lau", "Ping Chung Leung", "Kwok Pui Fung", "Wai Yee Chan", "Clara Bik San Lau"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0139342.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Supervised_principal_component_analysis_PCA_/1563027", "title"=>"Supervised principal component analysis (PCA).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 03:26:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297212"], "description"=>"<p>The molecular functions of differentially expressed genes in HUVEC after (A) 6 h and (B) 16 h of NF3 treatment.</p>", "links"=>[], "tags"=>["MMP 8", "5a", "2a", "16 h incubation", "ubd", "npr", "3k", "epb", "scg", "birc", "NF 3", "prl", "LCN", "cxcr", "TfAP", "1h", "dnajb", "wound healing", "Cell proliferation", "nr", "INSL", "1RAPL", "wound healing angiogenesis", "intracellular signal transduction", "huvec", "mir", "il", "epcam", "GRIN", "slc"], "article_id"=>1563030, "categories"=>["Uncategorised"], "users"=>["Jacqueline Chor Wing Tam", "Chun Hay Ko", "Chi Man Koon", "Zhang Cheng", "Wong Hing Lok", "Ching Po Lau", "Ping Chung Leung", "Kwok Pui Fung", "Wai Yee Chan", "Clara Bik San Lau"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0139342.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_molecular_functions_of_differentially_expressed_genes_in_HUVEC_after_A_6_h_and_B_16_h_of_NF3_treatment_/1563030", "title"=>"The molecular functions of differentially expressed genes in HUVEC after (A) 6 h and (B) 16 h of NF3 treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 03:26:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297216"], "description"=>"<p>(A) Differentially expressed genes with frequent co-citations and interactions in NF3 treated HUVEC at 6 h. (B) Differentially expressed genes with frequent co-citations and interactions in NF3 treated HUVEC at 16 h. Genes were identified by their gene symbols (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0139342#pone.0139342.s001\" target=\"_blank\">S1</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0139342#pone.0139342.s002\" target=\"_blank\">S2</a> Tables). Dashed lines indicated association by co-citation. Up arrow and down arrow corresponded to up- or down-regulation, respectively.</p>", "links"=>[], "tags"=>["MMP 8", "5a", "2a", "16 h incubation", "ubd", "npr", "3k", "epb", "scg", "birc", "NF 3", "prl", "LCN", "cxcr", "TfAP", "1h", "dnajb", "wound healing", "Cell proliferation", "nr", "INSL", "1RAPL", "wound healing angiogenesis", "intracellular signal transduction", "huvec", "mir", "il", "epcam", "GRIN", "slc"], "article_id"=>1563034, "categories"=>["Uncategorised"], "users"=>["Jacqueline Chor Wing Tam", "Chun Hay Ko", "Chi Man Koon", "Zhang Cheng", "Wong Hing Lok", "Ching Po Lau", "Ping Chung Leung", "Kwok Pui Fung", "Wai Yee Chan", "Clara Bik San Lau"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0139342.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Network_connectivity_of_identified_genes_in_NF3_treated_HUVEC_by_GePS_/1563034", "title"=>"Network connectivity of identified genes in NF3-treated HUVEC by GePS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 03:26:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297219"], "description"=>"<p>Immunobloting was performed three times using independent cell lysates and representative blots of (A) 6 h and (B) 16 h were shown.</p>", "links"=>[], "tags"=>["MMP 8", "5a", "2a", "16 h incubation", "ubd", "npr", "3k", "epb", "scg", "birc", "NF 3", "prl", "LCN", "cxcr", "TfAP", "1h", "dnajb", "wound healing", "Cell proliferation", "nr", "INSL", "1RAPL", "wound healing angiogenesis", "intracellular signal transduction", "huvec", "mir", "il", "epcam", "GRIN", "slc"], "article_id"=>1563037, "categories"=>["Uncategorised"], "users"=>["Jacqueline Chor Wing Tam", "Chun Hay Ko", "Chi Man Koon", "Zhang Cheng", "Wong Hing Lok", "Ching Po Lau", "Ping Chung Leung", "Kwok Pui Fung", "Wai Yee Chan", "Clara Bik San Lau"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0139342.g004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blotting_of_NF3_on_HUVEC_for_6_and_16_h_/1563037", "title"=>"Western blotting of NF3 on HUVEC for 6 and 16 h.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 03:26:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/2297221"], "description"=>"<p>The molecular gene targets, respective signaling pathways and molecule mediators associated with the biological responses was demonstrated in NF3-treated HUVEC at 6 h. Yellow molecules represented differentially expressed genes identified from microarray analysis. Blue box represented the suggested signaling pathway. Purple box represented the molecular mediators. Green box represented the biological responses. + indicated as positive regulation and–indicated negative regulation.</p>", "links"=>[], "tags"=>["MMP 8", "5a", "2a", "16 h incubation", "ubd", "npr", "3k", "epb", "scg", "birc", "NF 3", "prl", "LCN", "cxcr", "TfAP", "1h", "dnajb", "wound healing", "Cell proliferation", "nr", "INSL", "1RAPL", "wound healing angiogenesis", "intracellular signal transduction", "huvec", "mir", "il", "epcam", "GRIN", "slc"], "article_id"=>1563039, "categories"=>["Uncategorised"], "users"=>["Jacqueline Chor Wing Tam", "Chun Hay Ko", "Chi Man Koon", "Zhang Cheng", "Wong Hing Lok", "Ching Po Lau", "Ping Chung Leung", "Kwok Pui Fung", "Wai Yee Chan", "Clara Bik San Lau"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0139342.g005", "stats"=>{"downloads"=>3, "page_views"=>140, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hypothetical_diagram_of_mechanistic_actions_of_NF3_on_HUVEC_at_6_h_/1563039", "title"=>"Hypothetical diagram of mechanistic actions of NF3 on HUVEC at 6 h.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-02 03:26:26"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"32", "full-text"=>"36", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"47", "full-text"=>"60", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"30", "full-text"=>"29", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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