Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion
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{"title"=>"Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion", "type"=>"journal", "authors"=>[{"first_name"=>"Benjamin Toby", "last_name"=>"Wall", "scopus_author_id"=>"36983428600"}, {"first_name"=>"Stefan H.", "last_name"=>"Gorissen", "scopus_author_id"=>"54683786100"}, {"first_name"=>"Bart", "last_name"=>"Pennings", "scopus_author_id"=>"23490281100"}, {"first_name"=>"René", "last_name"=>"Koopman", "scopus_author_id"=>"7007112978"}, {"first_name"=>"Bart B.L.", "last_name"=>"Groen", "scopus_author_id"=>"53063603900"}, {"first_name"=>"Lex B.", "last_name"=>"Verdijk", "scopus_author_id"=>"15023690400"}, {"first_name"=>"Luc J.C.", "last_name"=>"Van Loon", "scopus_author_id"=>"7006194281"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84951051432", "sgr"=>"84951051432", "issn"=>"19326203", "isbn"=>"10.1371/journal.pone.0140903", "pmid"=>"26536130", "doi"=>"10.1371/journal.pone.0140903", "pui"=>"607325374"}, "id"=>"bd9a636c-5f45-318f-a225-5e6e841a18bf", "abstract"=>"PURPOSE Progressive loss of skeletal muscle mass with aging (sarcopenia) forms a global health concern. It has been suggested that an impaired capacity to increase muscle protein synthesis rates in response to protein intake is a key contributor to sarcopenia. We assessed whether differences in post-absorptive and/or post-prandial muscle protein synthesis rates exist between large cohorts of healthy young and older men. PROCEDURES We performed a cross-sectional, retrospective study comparing in vivo post-absorptive muscle protein synthesis rates determined with stable isotope methodologies between 34 healthy young (22±1 y) and 72 older (75±1 y) men, and post-prandial muscle protein synthesis rates between 35 healthy young (22±1 y) and 40 older (74±1 y) men. FINDINGS Post-absorptive muscle protein synthesis rates did not differ significantly between the young and older group. Post-prandial muscle protein synthesis rates were 16% lower in the older subjects when compared with the young. Muscle protein synthesis rates were >3 fold more responsive to dietary protein ingestion in the young. Irrespective of age, there was a strong negative correlation between post-absorptive muscle protein synthesis rates and the increase in muscle protein synthesis rate following protein ingestion. CONCLUSIONS Aging is associated with the development of muscle anabolic inflexibility which represents a key physiological mechanism underpinning sarcopenia.", "link"=>"http://www.mendeley.com/research/aging-accompanied-blunted-muscle-protein-synthetic-response-protein-ingestion", "reader_count"=>65, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>14, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>11, "Student > Bachelor"=>9, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>14, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>11, "Student > Bachelor"=>9, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Environmental Science"=>1, "Nursing and Health Professions"=>6, "Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>15, "Medicine and Dentistry"=>16, "Neuroscience"=>1, "Sports and Recreations"=>11, "Business, Management and Accounting"=>1, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Neuroscience"=>{"Neuroscience"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>11}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>6}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"New Zealand"=>1, "Netherlands"=>1, "United States"=>1, "Denmark"=>1, "Mexico"=>1, "Spain"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2407023"], "description"=>"<p>Delta increases from post-absorptive to post-prandial were analyzed between groups using an unpaired <i>t</i>-test (significantly different; <i>P</i><0.01). Individual responses are reported in the inset figure only in those subjects for whom post-absorptive and post-prandial muscle protein synthesis rates were assessed within the same experiment (<i>n</i> = 55 [22 young and 23 elderly]).</p>", "links"=>[], "tags"=>["muscle protein synthesis rate", "protein intake", "health concern", "protein ingestion.ConclusionsAging", "increase muscle protein synthesis rates", "muscle protein synthesis rates", "retrospective study", "Blunted Muscle Protein", "Protein Ingestion PurposeProgressive loss", "mechanism underpinning sarcopenia", "muscle mass", "muscle anabolic inflexibility", "isotope methodologies", "protein ingestion"], "article_id"=>1593616, "categories"=>["Biological Sciences"], "users"=>["Benjamin Toby Wall", "Stefan H. Gorissen", "Bart Pennings", "René Koopman", "Bart B. L. Groen", "Lex B. Verdijk", "Luc J. C. van Loon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140903.g002", "stats"=>{"downloads"=>6, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fractional_mixed_muscle_protein_synthesis_rates_FSR_calculated_using_plasma_L_ring_2_H_5_phenylalanine_enrichments_as_the_precursor_pool_in_healthy_young_and_elderly_men_in_the_post_absorptive_state_n_34_young_and_n_72_elderly_and_following_the_ingestion/1593616", "title"=>"Fractional mixed muscle protein synthesis rates (FSR), calculated using plasma L-[<i>ring</i>-<sup>2</sup>H<sub>5</sub>] phenylalanine enrichments as the precursor pool, in healthy young and elderly men in the post-absorptive state (<i>n</i> = 34 young and <i>n</i> = 72 elderly) and following the ingestion of 20 g protein (post-prandial; <i>n</i> = 35 young and <i>n</i> = 40 elderly.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-04 03:25:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/2407025"], "description"=>"<p>Graphical representation of the individual values for fractional mixed muscle protein synthesis rates (FSR), calculated using plasma L-[<i>ring</i>-<sup>2</sup>H<sub>5</sub>]phenylalanine enrichments as the precursor pool, in healthy young and elderly men in the post-absorptive state (<i>n</i> = 34 young and <i>n</i> = 72 elderly) and following the ingestion of 20 g protein (post-prandial; <i>n</i> = 35 young and <i>n</i> = 40 elderly).</p>", "links"=>[], "tags"=>["muscle protein synthesis rate", "protein intake", "health concern", "protein ingestion.ConclusionsAging", "increase muscle protein synthesis rates", "muscle protein synthesis rates", "retrospective study", "Blunted Muscle Protein", "Protein Ingestion PurposeProgressive loss", "mechanism underpinning sarcopenia", "muscle mass", "muscle anabolic inflexibility", "isotope methodologies", "protein ingestion"], "article_id"=>1593617, "categories"=>["Biological Sciences"], "users"=>["Benjamin Toby Wall", "Stefan H. Gorissen", "Bart Pennings", "René Koopman", "Bart B. L. Groen", "Lex B. Verdijk", "Luc J. C. van Loon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140903.g003", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Graphical_representation_of_the_individual_values_for_fractional_mixed_muscle_protein_synthesis_rates_FSR_calculated_using_plasma_L_ring_2_H_5_phenylalanine_enrichments_as_the_precursor_pool_in_healthy_young_and_elderly_men_in_the_post_absorptive_state_n/1593617", "title"=>"Graphical representation of the individual values for fractional mixed muscle protein synthesis rates (FSR), calculated using plasma L-[<i>ring</i>-<sup>2</sup>H<sub>5</sub>]phenylalanine enrichments as the precursor pool, in healthy young and elderly men in the post-absorptive state (<i>n</i> = 34 young and <i>n</i> = 72 elderly) and following the ingestion of 20 g protein (post-prandial; <i>n</i> = 35 young and <i>n</i> = 40 elderly).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-04 03:25:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/2407028"], "description"=>"<p>Data were analyzed with 2-tailed tests of significance by using Pearson's correlation coefficients.</p>", "links"=>[], "tags"=>["muscle protein synthesis rate", "protein intake", "health concern", "protein ingestion.ConclusionsAging", "increase muscle protein synthesis rates", "muscle protein synthesis rates", "retrospective study", "Blunted Muscle Protein", "Protein Ingestion PurposeProgressive loss", "mechanism underpinning sarcopenia", "muscle mass", "muscle anabolic inflexibility", "isotope methodologies", "protein ingestion"], "article_id"=>1593618, "categories"=>["Biological Sciences"], "users"=>["Benjamin Toby Wall", "Stefan H. Gorissen", "Bart Pennings", "René Koopman", "Bart B. L. Groen", "Lex B. Verdijk", "Luc J. C. van Loon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140903.g004", "stats"=>{"downloads"=>4, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_post_absorptive_fractional_mixed_muscle_protein_synthesis_rates_FSR_and_the_delta_increase_in_FSR_following_the_ingestion_dietary_protein_post_prandial_in_healthy_young_n_22_and_elderly_n_68_men_/1593618", "title"=>"Correlation between post-absorptive fractional mixed muscle protein synthesis rates (FSR) and the delta increase in FSR following the ingestion dietary protein (post-prandial) in healthy young (<i>n</i> = 22) and elderly (<i>n</i> = 68) men.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-04 03:25:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/2407030"], "description"=>"<p>Values are means±SEM. Abbreviations: HOMA-IR; Homeostatic Model Assessment of Insulin Resistance [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140903#pone.0140903.ref057\" target=\"_blank\">57</a>].</p><p>Subjects’ characteristics for comparisons of muscle protein synthesis rates.</p>", "links"=>[], "tags"=>["muscle protein synthesis rate", "protein intake", "health concern", "protein ingestion.ConclusionsAging", "increase muscle protein synthesis rates", "muscle protein synthesis rates", "retrospective study", "Blunted Muscle Protein", "Protein Ingestion PurposeProgressive loss", "mechanism underpinning sarcopenia", "muscle mass", "muscle anabolic inflexibility", "isotope methodologies", "protein ingestion"], "article_id"=>1593619, "categories"=>["Biological Sciences"], "users"=>["Benjamin Toby Wall", "Stefan H. Gorissen", "Bart Pennings", "René Koopman", "Bart B. L. Groen", "Lex B. Verdijk", "Luc J. C. van Loon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140903.t001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subjects_8217_characteristics_for_comparisons_of_muscle_protein_synthesis_rates_/1593619", "title"=>"Subjects’ characteristics for comparisons of muscle protein synthesis rates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-11-04 03:25:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/2407031"], "description"=>"<div><p>Purpose</p><p>Progressive loss of skeletal muscle mass with aging (sarcopenia) forms a global health concern. It has been suggested that an impaired capacity to increase muscle protein synthesis rates in response to protein intake is a key contributor to sarcopenia. We assessed whether differences in post-absorptive and/or post-prandial muscle protein synthesis rates exist between large cohorts of healthy young and older men.</p><p>Procedures</p><p>We performed a cross-sectional, retrospective study comparing <i>in vivo</i> post-absorptive muscle protein synthesis rates determined with stable isotope methodologies between 34 healthy young (22±1 y) and 72 older (75±1 y) men, and post-prandial muscle protein synthesis rates between 35 healthy young (22±1 y) and 40 older (74±1 y) men.</p><p>Findings</p><p>Post-absorptive muscle protein synthesis rates did not differ significantly between the young and older group. Post-prandial muscle protein synthesis rates were 16% lower in the older subjects when compared with the young. Muscle protein synthesis rates were >3 fold more responsive to dietary protein ingestion in the young. Irrespective of age, there was a strong negative correlation between post-absorptive muscle protein synthesis rates and the increase in muscle protein synthesis rate following protein ingestion.</p><p>Conclusions</p><p>Aging is associated with the development of muscle anabolic inflexibility which represents a key physiological mechanism underpinning sarcopenia.</p></div>", "links"=>[], "tags"=>["muscle protein synthesis rate", "protein intake", "health concern", "protein ingestion.ConclusionsAging", "increase muscle protein synthesis rates", "muscle protein synthesis rates", "retrospective study", "Blunted Muscle Protein", "Protein Ingestion PurposeProgressive loss", "mechanism underpinning sarcopenia", "muscle mass", "muscle anabolic inflexibility", "isotope methodologies", "protein ingestion"], "article_id"=>1593620, "categories"=>["Biological Sciences"], "users"=>["Benjamin Toby Wall", "Stefan H. Gorissen", "Bart Pennings", "René Koopman", "Bart B. L. Groen", "Lex B. Verdijk", "Luc J. C. van Loon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140903", "stats"=>{"downloads"=>6, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aging_Is_Accompanied_by_a_Blunted_Muscle_Protein_Synthetic_Response_to_Protein_Ingestion_/1593620", "title"=>"Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-11-04 03:25:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/2407021"], "description"=>"<p>Data were analyzed with multiple unpaired <i>t</i>-tests. Significantly different between corresponding post-absorptive and post-prandial values = ** (<i>P</i><0.01), *** (<i>P</i><0.001). Significantly different compared to corresponding values in the young = †† (P<0.01).</p>", "links"=>[], "tags"=>["muscle protein synthesis rate", "protein intake", "health concern", "protein ingestion.ConclusionsAging", "increase muscle protein synthesis rates", "muscle protein synthesis rates", "retrospective study", "Blunted Muscle Protein", "Protein Ingestion PurposeProgressive loss", "mechanism underpinning sarcopenia", "muscle mass", "muscle anabolic inflexibility", "isotope methodologies", "protein ingestion"], "article_id"=>1593615, "categories"=>["Biological Sciences"], "users"=>["Benjamin Toby Wall", "Stefan H. Gorissen", "Bart Pennings", "René Koopman", "Bart B. L. Groen", "Lex B. Verdijk", "Luc J. C. van Loon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140903.g001", "stats"=>{"downloads"=>5, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fractional_mixed_muscle_protein_synthesis_rates_FSR_calculated_using_plasma_L_ring_2_H_5_phenylalanine_enrichments_as_the_precursor_pool_in_healthy_young_and_elderly_men_in_the_post_absorptive_state_n_34_young_and_n_72_elderly_and_following_the_ingestion/1593615", "title"=>"Fractional mixed muscle protein synthesis rates (FSR), calculated using plasma L-[<i>ring</i>-<sup>2</sup>H<sub>5</sub>] phenylalanine enrichments as the precursor pool, in healthy young and elderly men in the post-absorptive state (<i>n</i> = 34 young and <i>n</i> = 72 elderly) and following the ingestion of 20 g protein (post-prandial; <i>n</i> = 35 young and <i>n</i> = 40 elderly).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-04 03:25:10"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

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