Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs
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{"title"=>"Perinatal asphyxia may influence the level of beta-amyloid (1-42) in cerebrospinal fluid: An experimental study on newborn pigs", "type"=>"journal", "authors"=>[{"first_name"=>"Torkil", "last_name"=>"Benterud", "scopus_author_id"=>"26031917100"}, {"first_name"=>"Leonid", "last_name"=>"Pankratov", "scopus_author_id"=>"57003102500"}, {"first_name"=>"Rønnaug", "last_name"=>"Solberg", "scopus_author_id"=>"23091896100"}, {"first_name"=>"Nils", "last_name"=>"Bolstad", "scopus_author_id"=>"16243952500"}, {"first_name"=>"Anders", "last_name"=>"Skinningsrud", "scopus_author_id"=>"14619689800"}, {"first_name"=>"Lars", "last_name"=>"Baumbusch", "scopus_author_id"=>"6506586336"}, {"first_name"=>"Leiv", "last_name"=>"Sandvik", "scopus_author_id"=>"16414937900"}, {"first_name"=>"Ola Didrik", "last_name"=>"Saugstad", "scopus_author_id"=>"35485416300"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84949843770", "scopus"=>"2-s2.0-84949843770", "issn"=>"19326203", "pui"=>"607159165", "doi"=>"10.1371/journal.pone.0140966"}, "id"=>"f281c789-c1f5-374a-9c8c-e1e8e8897f29", "abstract"=>"© 2015 Benterud et al.Objective: Total tau (T-tau), phosphorylated tau (p-Tau) and Beta-Amyloid 1-42 (AB42) in Cerebrospinal Fluid (CSF) are useful biomarkers in neurodegenerative diseases. The aim of the study was to investigate the role of these and other CSF biomarkers (T-tau, p-Tau, AB42, S100B and NSE), during hypoxia-reoxygenation in a newborn pig model. Design: Thirty newborn pigs were included in a study of moderate or severe hypoxia. The moderate hypoxia group (n = 12) was exposed to global hypoxia (8% O2) until Base excess (BE) reached -15 mmol/l. The pigs in the group exposed to severe hypoxia (n = 12) received 8% O2 until BE reached -20 mmol/l or mean Blood Pressure fell below 20 mm Hg, The control group (n = 6) was kept at room air. For all treatments, the CSF was collected at 9.5 hours after the intervention. Results: The level of AB42 in CSF was significantly lower in the pigs exposed to severe hypoxia compared with the control group, 922(SD +/-445)pg/ml versus. 1290(SD +/-143) pg/ml (p<0.05), respectively. Further, a non-significant reduction of AB42 was observed in the group exposed to moderate hypoxia T-tau and p-Tau revealed no significant differences between the intervention groups and the control group, however a significantly higher level of S100B was seen in the CSF of pigs receiving hypoxia in comparison to the level in the control group. Further on, there was a moderate negative correlation between the levels of AB42 and S100B in CSF, as well as a moderate negative correlation between Lactate in blood at end of hypoxia and AB42 in CSF. Interpretation: This is the first study to our knowledge that demonstrated a significant drop in AB42 in CSF after neonatal hypoxia. Whether or not this has an etiological basis for adult neurodegenerative disorders needs to be studied with additional experiments and epidemiological studies. AB42 and S100B are significantly changed in neonatal pigs subjected to hypoxia compared to controls and thus may be valuable biomarkers of perinatal asphyxia.", "link"=>"http://www.mendeley.com/research/perinatal-asphyxia-influence-level-betaamyloid-142-cerebrospinal-fluid-experimental-study-newborn-pi", "reader_count"=>5, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>3, "Neuroscience"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2376663"], "description"=>"<p>Mean and (SD) for arterial blood gases (BE, pH, PaCO2, Lactate and Glucose) at end of hypoxia, 30, 90, 270 and 570 minutes after end of hypoxia. For the Control group the arterial blood gases stayed stable throughout the experiment. For the control group the described time points are corresponding time points.</p><p>BE, pH, PaCO2, Lactate and Glucose at 5 different time points after hypoxia.</p>", "links"=>[], "tags"=>["Newborn Pigs ObjectiveTotal tau", "AB 42", "hypoxia", "csf", "control group", "Cerebrospinal fluid", "Perinatal Asphyxia May Influence", "sd", "nse", "20 mm Hg", "S 100B", "adult neurodegenerative disorders"], "article_id"=>1585280, "categories"=>["Uncategorised"], "users"=>["Torkil Benterud", "Leonid Pankratov", "Rønnaug Solberg", "Nils Bolstad", "Anders Skinningsrud", "Lars Baumbusch", "Leiv Sandvik", "Ola Didrik Saugstad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140966.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BE_pH_PaCO2_Lactate_and_Glucose_at_5_different_time_points_after_hypoxia_/1585280", "title"=>"BE, pH, PaCO2, Lactate and Glucose at 5 different time points after hypoxia.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-26 02:50:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2376661"], "description"=>"<p>Fig 5 describes the correlation between the logarithmic values of NSE and S100B in CSF. It was a high correlation between logNSE and logS100B measured in CSF at the end of the experiment, R = 0.86, p<0.001. The values are depicted as log-values because there was a relatively wide range in the concentration of NSE and S100B.</p>", "links"=>[], "tags"=>["Newborn Pigs ObjectiveTotal tau", "AB 42", "hypoxia", "csf", "control group", "Cerebrospinal fluid", "Perinatal Asphyxia May Influence", "sd", "nse", "20 mm Hg", "S 100B", "adult neurodegenerative disorders"], "article_id"=>1585278, "categories"=>["Uncategorised"], "users"=>["Torkil Benterud", "Leonid Pankratov", "Rønnaug Solberg", "Nils Bolstad", "Anders Skinningsrud", "Lars Baumbusch", "Leiv Sandvik", "Ola Didrik Saugstad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140966.g005", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_NSE_and_S100B_in_CSF_/1585278", "title"=>"Correlation between NSE and S100B in CSF.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-26 02:50:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2376644"], "description"=>"<p>(A): Correlation between Log S100B and AB42 in CSF. There was a moderate negative correlation between LogS100B and AB42 in CSF, R = -0.418, p<0.05. (B): Correlation between Arterial Lactate and AB42 in CSF. Arterial Lactate at end of Hypoxia had a moderate negative correlation with AB42, R = -0.419, p = 0.03</p>", "links"=>[], "tags"=>["Newborn Pigs ObjectiveTotal tau", "AB 42", "hypoxia", "csf", "control group", "Cerebrospinal fluid", "Perinatal Asphyxia May Influence", "sd", "nse", "20 mm Hg", "S 100B", "adult neurodegenerative disorders"], "article_id"=>1585274, "categories"=>["Uncategorised"], "users"=>["Torkil Benterud", "Leonid Pankratov", "Rønnaug Solberg", "Nils Bolstad", "Anders Skinningsrud", "Lars Baumbusch", "Leiv Sandvik", "Ola Didrik Saugstad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140966.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Perinatal_Asphyxia_May_Influence_the_Level_of_Beta_Amyloid_1_42_in_Cerebrospinal_Fluid_An_Experimental_Study_on_Newborn_Pigs_Fig_3_/1585274", "title"=>"Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs - Fig 3", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-26 02:50:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2376658"], "description"=>"<p>(A) shows the Log-values of S100B in CSF for both intervention groups and the Control group, Log-S100B was significantly higher in the group exposed to hypoxia than in the control group, 1.0 (SD +/-0.3) pg/ml vs. 1.4 (SD +/-0.4) pg/ml, p<0.05. Mean difference was 0.4 (95% CI: 0.2–0.9). (B) depicts the Delta-Value from End of Hypoxia to End of experiment, p = 0.05. There was no difference between the group exposed to moderate vs. severe hypoxia regarding the levels of S100B, neither in CSF nor in blood, therefore we decided to combine both hypoxia groups into one intervention group.</p>", "links"=>[], "tags"=>["Newborn Pigs ObjectiveTotal tau", "AB 42", "hypoxia", "csf", "control group", "Cerebrospinal fluid", "Perinatal Asphyxia May Influence", "sd", "nse", "20 mm Hg", "S 100B", "adult neurodegenerative disorders"], "article_id"=>1585276, "categories"=>["Uncategorised"], "users"=>["Torkil Benterud", "Leonid Pankratov", "Rønnaug Solberg", "Nils Bolstad", "Anders Skinningsrud", "Lars Baumbusch", "Leiv Sandvik", "Ola Didrik Saugstad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140966.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_S100B_in_CSF_and_serum_/1585276", "title"=>"S100B in CSF and serum.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-26 02:50:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2376642"], "description"=>"<p>AB42 was significantly lower in the group exposed to severe hypoxia * compared with the control group, 922 (SD +/-445) pg/ml vs. 1290 (SD +/-143) pg/ml, p<0.05. Mean difference was 368 (95% CI: 61–675). The concentration of AB42 in the group exposed to moderate asphyxia was 1059 (SD+/-75) pg/mg, p = 0.07, when compared with the control group.</p>", "links"=>[], "tags"=>["Newborn Pigs ObjectiveTotal tau", "AB 42", "hypoxia", "csf", "control group", "Cerebrospinal fluid", "Perinatal Asphyxia May Influence", "sd", "nse", "20 mm Hg", "S 100B", "adult neurodegenerative disorders"], "article_id"=>1585273, "categories"=>["Uncategorised"], "users"=>["Torkil Benterud", "Leonid Pankratov", "Rønnaug Solberg", "Nils Bolstad", "Anders Skinningsrud", "Lars Baumbusch", "Leiv Sandvik", "Ola Didrik Saugstad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140966.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_values_of_the_concentrations_of_AB42_with_standard_deviations_SD_/1585273", "title"=>"Mean values of the concentrations of AB42 with standard deviations (SD).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-26 02:50:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2376641"], "description"=>"<p>Twelve pigs were included in each experimental group and six pigs in the control group. The pigs in the first experimental group were exposed to global hypoxia (8% O2 in Nitrogen) until Base Excess (BE) reached -15 mmol/l (moderate hypoxia). The animals in the second experimental group (severe hypoxia) were exposed to 8% O2 until BE reached -20 mmol/l and/ or mean blood pressure fell below 20 mmHg. Thereafter the pigs were reoxygenated with air for 9.5 hours. CSF was collected 9.5 hours after end of hypoxia.</p>", "links"=>[], "tags"=>["Newborn Pigs ObjectiveTotal tau", "AB 42", "hypoxia", "csf", "control group", "Cerebrospinal fluid", "Perinatal Asphyxia May Influence", "sd", "nse", "20 mm Hg", "S 100B", "adult neurodegenerative disorders"], "article_id"=>1585272, "categories"=>["Uncategorised"], "users"=>["Torkil Benterud", "Leonid Pankratov", "Rønnaug Solberg", "Nils Bolstad", "Anders Skinningsrud", "Lars Baumbusch", "Leiv Sandvik", "Ola Didrik Saugstad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140966.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_design_/1585272", "title"=>"Study design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-26 02:50:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2376664", "https://ndownloader.figshare.com/files/2376665"], "description"=>"<div><p>Objective</p><p>Total tau (T-tau), phosphorylated tau (p-Tau) and Beta-Amyloid 1–42 (AB42) in Cerebrospinal Fluid (CSF) are useful biomarkers in neurodegenerative diseases. The aim of the study was to investigate the role of these and other CSF biomarkers (T-tau, p-Tau, AB42, S100B and NSE), during hypoxia-reoxygenation in a newborn pig model.</p><p>Design</p><p>Thirty newborn pigs were included in a study of moderate or severe hypoxia. The moderate hypoxia group (n = 12) was exposed to global hypoxia (8% O<sub>2</sub>) until Base excess (BE) reached -15 mmol/l. The pigs in the group exposed to severe hypoxia (n = 12) received 8% O<sub>2</sub> until BE reached -20 mmol/l or mean Blood Pressure fell below 20 mm Hg, The control group (n = 6) was kept at room air. For all treatments, the CSF was collected at 9.5 hours after the intervention.</p><p>Results</p><p>The level of AB42 in CSF was significantly lower in the pigs exposed to severe hypoxia compared with the control group, 922(SD +/-445)pg/ml versus. 1290(SD +/-143) pg/ml (p<0.05), respectively. Further, a non-significant reduction of AB42 was observed in the group exposed to moderate hypoxia T-tau and p-Tau revealed no significant differences between the intervention groups and the control group, however a significantly higher level of S100B was seen in the CSF of pigs receiving hypoxia in comparison to the level in the control group. Further on, there was a moderate negative correlation between the levels of AB42 and S100B in CSF, as well as a moderate negative correlation between Lactate in blood at end of hypoxia and AB42 in CSF.</p><p>Interpretation</p><p>This is the first study to our knowledge that demonstrated a significant drop in AB42 in CSF after neonatal hypoxia. Whether or not this has an etiological basis for adult neurodegenerative disorders needs to be studied with additional experiments and epidemiological studies. AB42 and S100B are significantly changed in neonatal pigs subjected to hypoxia compared to controls and thus may be valuable biomarkers of perinatal asphyxia.</p></div>", "links"=>[], "tags"=>["Newborn Pigs ObjectiveTotal tau", "AB 42", "hypoxia", "csf", "control group", "Cerebrospinal fluid", "Perinatal Asphyxia May Influence", "sd", "nse", "20 mm Hg", "S 100B", "adult neurodegenerative disorders"], "article_id"=>1585281, "categories"=>["Uncategorised"], "users"=>["Torkil Benterud", "Leonid Pankratov", "Rønnaug Solberg", "Nils Bolstad", "Anders Skinningsrud", "Lars Baumbusch", "Leiv Sandvik", "Ola Didrik Saugstad"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0140966.s001", "https://dx.doi.org/10.1371/journal.pone.0140966.s002"], "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Perinatal_Asphyxia_May_Influence_the_Level_of_Beta_Amyloid_1_42_in_Cerebrospinal_Fluid_An_Experimental_Study_on_Newborn_Pigs_/1585281", "title"=>"Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-10-26 02:50:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/2376662"], "description"=>"<p>Between the different groups of the study cohort, there were no significant differences in weight, Hb level, age, BE, PaCO2 or glucose at start. Values are presented as mean (+/- SD) BE: base excess.</p><p>Physiological parameters in the animals of the different groups at start.</p>", "links"=>[], "tags"=>["Newborn Pigs ObjectiveTotal tau", "AB 42", "hypoxia", "csf", "control group", "Cerebrospinal fluid", "Perinatal Asphyxia May Influence", "sd", "nse", "20 mm Hg", "S 100B", "adult neurodegenerative disorders"], "article_id"=>1585279, "categories"=>["Uncategorised"], "users"=>["Torkil Benterud", "Leonid Pankratov", "Rønnaug Solberg", "Nils Bolstad", "Anders Skinningsrud", "Lars Baumbusch", "Leiv Sandvik", "Ola Didrik Saugstad"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0140966.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Physiological_parameters_in_the_animals_of_the_different_groups_at_start_/1585279", "title"=>"Physiological parameters in the animals of the different groups at start.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-26 02:50:58"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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