Potential for Drug-Drug Interactions between Antiretrovirals and HCV Direct Acting Antivirals in a Large Cohort of HIV/HCV Coinfected Patients
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{"title"=>"Potential for drug-drug interactions between antiretrovirals and HCV direct acting antivirals in a large cohort of HIV/HCV coinfected patients", "type"=>"journal", "authors"=>[{"first_name"=>"Isabelle", "last_name"=>"Poizot-Martin", "scopus_author_id"=>"34977375900"}, {"first_name"=>"Alissa", "last_name"=>"Naqvi", "scopus_author_id"=>"56808882300"}, {"first_name"=>"Véronique", "last_name"=>"Obry-Roguet", "scopus_author_id"=>"26040933500"}, {"first_name"=>"Marc Antoine", "last_name"=>"Valantin", "scopus_author_id"=>"6602847542"}, {"first_name"=>"Lise", "last_name"=>"Cuzin", "scopus_author_id"=>"35358231300"}, {"first_name"=>"Eric", "last_name"=>"Billaud", "scopus_author_id"=>"7006382956"}, {"first_name"=>"Antoine", "last_name"=>"Cheret", "scopus_author_id"=>"8699906900"}, {"first_name"=>"David", "last_name"=>"Rey", "scopus_author_id"=>"36847199500"}, {"first_name"=>"Christine", "last_name"=>"Jacomet", "scopus_author_id"=>"7004035387"}, {"first_name"=>"Claudine", "last_name"=>"Duvivier", "scopus_author_id"=>"7005656659"}, {"first_name"=>"Pascal", "last_name"=>"Pugliese", "scopus_author_id"=>"7006410951"}, {"first_name"=>"Pierre", "last_name"=>"Pradat", "scopus_author_id"=>"7006166673"}, {"first_name"=>"Laurent", "last_name"=>"Cotte", "scopus_author_id"=>"57198339374"}, {"first_name"=>"S.", "last_name"=>"Brégigeon", "scopus_author_id"=>"26665927100"}, {"first_name"=>"O.", "last_name"=>"Faucher", "scopus_author_id"=>"55317487800"}, {"first_name"=>"V.", "last_name"=>"Obry-Roguet", "scopus_author_id"=>"57190767693"}, {"first_name"=>"M.", "last_name"=>"Orticoni", "scopus_author_id"=>"6505480033"}, {"first_name"=>"M. J.", "last_name"=>"Soavi", "scopus_author_id"=>"6506463259"}, {"first_name"=>"I.", "last_name"=>"Luquet-Besson", "scopus_author_id"=>"16637953900"}, {"first_name"=>"E.", "last_name"=>"Ressiot", "scopus_author_id"=>"23393787700"}, {"first_name"=>"I.", "last_name"=>"Pinot", "scopus_author_id"=>"57003411400"}, {"first_name"=>"M. J.", "last_name"=>"Ducassou", "scopus_author_id"=>"57188766757"}, {"first_name"=>"H.", "last_name"=>"Bertone", "scopus_author_id"=>"57003519800"}, {"first_name"=>"S.", "last_name"=>"Galie", "scopus_author_id"=>"57003662500"}, {"first_name"=>"S.", "last_name"=>"Trijau", "scopus_author_id"=>"23026013500"}, {"first_name"=>"A. S.", "last_name"=>"Ritleng", "scopus_author_id"=>"56764659200"}, {"first_name"=>"A.", "last_name"=>"Ivanova", "scopus_author_id"=>"57002420100"}, {"first_name"=>"M.", "last_name"=>"Guignard", "scopus_author_id"=>"57002944600"}, {"first_name"=>"C. E.", "last_name"=>"Cano", "scopus_author_id"=>"16041409300"}, {"first_name"=>"I.", "last_name"=>"Poizot-Martin", "scopus_author_id"=>"7003773720"}, {"first_name"=>"B.", "last_name"=>"Marchou", "scopus_author_id"=>"7006171494"}, {"first_name"=>"P.", "last_name"=>"Massip", "scopus_author_id"=>"16138315600"}, {"first_name"=>"E.", "last_name"=>"Bonnet", "scopus_author_id"=>"7005940881"}, {"first_name"=>"M.", "last_name"=>"Obadia", "scopus_author_id"=>"6602096249"}, {"first_name"=>"M.", "last_name"=>"Alvarez", "scopus_author_id"=>"14044580300"}, {"first_name"=>"L.", "last_name"=>"Porte", "scopus_author_id"=>"7005806026"}, {"first_name"=>"A.", "last_name"=>"Debard", "scopus_author_id"=>"55737186800"}, {"first_name"=>"L.", "last_name"=>"Cuzin", "scopus_author_id"=>"6603819961"}, {"first_name"=>"P.", "last_name"=>"Delobel", "scopus_author_id"=>"6602513635"}, {"first_name"=>"M.", "last_name"=>"Chauveau", "scopus_author_id"=>"56086789400"}, {"first_name"=>"D.", "last_name"=>"Garipuy", "scopus_author_id"=>"14424213100"}, {"first_name"=>"I.", "last_name"=>"Lepain", "scopus_author_id"=>"55817554200"}, {"first_name"=>"M.", "last_name"=>"Marcel", "scopus_author_id"=>"57003147200"}, {"first_name"=>"E.", "last_name"=>"Puntis", "scopus_author_id"=>"57003398200"}, {"first_name"=>"K.", "last_name"=>"Sauné", "scopus_author_id"=>"12241467900"}, {"first_name"=>"P.", "last_name"=>"Pugliese", "scopus_author_id"=>"36187142900"}, {"first_name"=>"C.", "last_name"=>"Ceppi", "scopus_author_id"=>"6505901669"}, {"first_name"=>"E.", "last_name"=>"Cua", "scopus_author_id"=>"6603657312"}, {"first_name"=>"J.", "last_name"=>"Cottalorda", "scopus_author_id"=>"7005274240"}, {"first_name"=>"P.", "last_name"=>"Dellamonica", "scopus_author_id"=>"7102264890"}, {"first_name"=>"E.", "last_name"=>"Demonchy", "scopus_author_id"=>"35168825800"}, {"first_name"=>"B.", "last_name"=>"Dunais", "scopus_author_id"=>"6603056137"}, {"first_name"=>"J.", "last_name"=>"Durant", "scopus_author_id"=>"7102025746"}, {"first_name"=>"C.", "last_name"=>"Etienne", "scopus_author_id"=>"57003006300"}, {"first_name"=>"S.", "last_name"=>"Ferrando", "scopus_author_id"=>"55613229073"}, {"first_name"=>"J. G.", "last_name"=>"Fuzibet", "scopus_author_id"=>"7004842644"}, {"first_name"=>"R.", "last_name"=>"Garraffo", "scopus_author_id"=>"7006419356"}, {"first_name"=>"K.", "last_name"=>"Risso", "scopus_author_id"=>"35280493900"}, {"first_name"=>"V.", "last_name"=>"Mondain", "scopus_author_id"=>"7004329672"}, {"first_name"=>"A.", "last_name"=>"Naqvi", "scopus_author_id"=>"56719238000"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84949818279", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84949818279", "pui"=>"607159301", "pmid"=>"26488159", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0141164"}, "id"=>"97df38a8-b558-3c97-aef0-0f2143f3f328", "abstract"=>"OBJECTIVES: Development of direct acting antivirals (DAA) offers new benefits for patients with chronic hepatitis C. The combination of these drugs with antiretroviral treatment (cART) is a real challenge in HIV/HCV coinfected patients. The aim of this study was to describe potential drug-drug interactions between DAAs and antiretroviral drugs in a cohort of HIV/HCV coinfected patients. METHODS: Cross-sectional study of all HIV/HCV coinfected patients attending at least one visit in 2012 in the multicenter French Dat'AIDS cohort. A simulation of drug-drug interactions between antiretroviral treatment and DAAs available in 2015 was performed. RESULTS: Of 16,634 HIV-infected patients, 2,511 had detectable anti-HCV antibodies, of whom 1,196 had a detectable HCV-RNA and were not receiving HCV treatment at the time of analysis. 97.1% of these patients were receiving cART and 81.2% had a plasma HIV RNA <50 copies/mL. cART included combinations of nucleoside reverse transcriptase inhibitors with a boosted protease inhibitor in 43.6%, a non-nucleoside reverse transcriptase inhibitor in 17.3%, an integrase inhibitor in 15.4% and various combinations or antiretroviral drugs in 23.7% of patients. A previous treatment against HCV had been administered in 64.4% of patients. Contraindicated associations/potential interactions were expected between cART and respectively sofosbuvir (0.2%/0%), sofosbuvir/ledipasvir (0.2%/67.6%), daclatasvir (0%/49.4%), ombitasvir/boosted paritaprevir (with or without dasabuvir) (34.4%/52.2%) and simeprevir (78.8%/0%). CONCLUSIONS: Significant potential drug-drug interactions are expected between cART and the currently available DAAs in the majority of HIV/HCV coinfected patients. Sofosbuvir/ledipasvir and sofosbuvir/daclatasvir with or without ribavirin appeared the most suitable combinations in our population. A close collaboration between hepatologists and HIV/AIDS specialists appears necessary for the management of HCV treatment concomitantly to cART.", "link"=>"http://www.mendeley.com/research/potential-drugdrug-interactions-between-antiretrovirals-hcv-direct-acting-antivirals-large-cohort-hi", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Student > Master"=>2, "Other"=>4, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Student > Master"=>2, "Other"=>4, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Chemistry"=>{"Chemistry"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Czech Republic"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2367845"], "description"=>"<p>Adapted from <a href=\"http://www.hep-druginteractions.org/\" target=\"_blank\">www.hep-druginteractions.org</a> (Abbreviations: ABC abacavir; ddI didanosine; FTC emtricitabine; LAM lamivudine; TDF tenofovir; ZDV zidovudine; EFV efavirenz; ETV etravirine; NVP nevirapine; RPV rilpivirine; DLG dolutegravir; EVGc cobicistat boosted elvitegravir; MRV maraviroc; RAL raltegravir; ATV atazanavir; ATVr ritonavir boosted atazanavir; DRVr ritonavir boosted darunavir; fAPVr ritonavir boosted fosamprenavir; IDVr ritonavir boosted indinavir; LPVr ritonavir boosted lopinavir; SQVr ritonavir boosted saquinavir; TPVr ritonavir boosted tipranavir; BOC boceprevir; DCV daclatasvir; LED Ledipasvir; OBV ombitasvir; PTVr ritonavir boosted paritaprevir; DSV dasabuvir; SMV simeprevir; SOF sofosbuvir; TVR telaprevir; PegIFN Peg interferon alpha; RBV ribavirin.)</p>", "links"=>[], "tags"=>["combination", "plasma HIV RNA", "antiretroviral treatment", "antiretroviral drugs", "interaction", "inhibitor", "daa", "HCV treatment", "Sofosbuvir", "coinfected"], "article_id"=>1581701, "categories"=>["Biological Sciences"], "users"=>["Isabelle Poizot-Martin", "Alissa Naqvi", "Véronique Obry-Roguet", "Marc-Antoine Valantin", "Lise Cuzin", "Eric Billaud", "Antoine Chéret", "David Rey", "Christine Jacomet", "Claudine Duvivier", "Pascal Pugliese", "Pierre Pradat", "Laurent Cotte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141164.g002", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_antiretroviral_drugs_received_in_1161_HIV_HCV_coinfected_patients_under_cART_and_potential_drug_drug_interactions_between_antiretrovirals_and_currently_available_DAAs_patients_not_under_antiretroviral_treatment_patients_under_HCV_treatmen/1581701", "title"=>"Distribution of antiretroviral drugs received in 1161 HIV/HCV coinfected patients under cART and potential drug-drug interactions between antiretrovirals and currently available DAAs (patients not under antiretroviral treatment, patients under HCV treatment at the time of analysis and patients with HCV reinfection excluded).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-21 02:47:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/2367846"], "description"=>"<p>CDC: Centers for Disease Control; IQR: interquartile range; ART: antiretroviral treatment; NRTI: nucleoside/nucleotide reverse transcriptase inhibitor; bPI: ritonavir-boosted protease inhibitor; NNRTI: non-nucleoside reverse transcriptase inhibitor; INSTI: integrase strand transfer inhibitor.</p><p>* Creatinine clearance estimated using the Cockcroft-Gault Equation: creatinine clearance = (140 –age (years)) / weight (kg) * 1.23 (male) or * 1.04 (female)</p><p>Characteristics of 1196 patients with a detectable HCV-RNA, according to HCV-treatment status (patients under HCV treatment at the time of analysis and patients with HCV reinfection excluded).</p>", "links"=>[], "tags"=>["combination", "plasma HIV RNA", "antiretroviral treatment", "antiretroviral drugs", "interaction", "inhibitor", "daa", "HCV treatment", "Sofosbuvir", "coinfected"], "article_id"=>1581702, "categories"=>["Biological Sciences"], "users"=>["Isabelle Poizot-Martin", "Alissa Naqvi", "Véronique Obry-Roguet", "Marc-Antoine Valantin", "Lise Cuzin", "Eric Billaud", "Antoine Chéret", "David Rey", "Christine Jacomet", "Claudine Duvivier", "Pascal Pugliese", "Pierre Pradat", "Laurent Cotte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141164.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_1196_patients_with_a_detectable_HCV_RNA_according_to_HCV_treatment_status_patients_under_HCV_treatment_at_the_time_of_analysis_and_patients_with_HCV_reinfection_excluded_/1581702", "title"=>"Characteristics of 1196 patients with a detectable HCV-RNA, according to HCV-treatment status (patients under HCV treatment at the time of analysis and patients with HCV reinfection excluded).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-21 02:47:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/2367844"], "description"=>"<p>Flow chart of patient analysis.</p>", "links"=>[], "tags"=>["combination", "plasma HIV RNA", "antiretroviral treatment", "antiretroviral drugs", "interaction", "inhibitor", "daa", "HCV treatment", "Sofosbuvir", "coinfected"], "article_id"=>1581700, "categories"=>["Biological Sciences"], "users"=>["Isabelle Poizot-Martin", "Alissa Naqvi", "Véronique Obry-Roguet", "Marc-Antoine Valantin", "Lise Cuzin", "Eric Billaud", "Antoine Chéret", "David Rey", "Christine Jacomet", "Claudine Duvivier", "Pascal Pugliese", "Pierre Pradat", "Laurent Cotte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141164.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_of_patient_analysis_/1581700", "title"=>"Flow chart of patient analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-21 02:47:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/2367849", "https://ndownloader.figshare.com/files/2367850"], "description"=>"<div><p>Objectives</p><p>Development of direct acting antivirals (DAA) offers new benefits for patients with chronic hepatitis C. The combination of these drugs with antiretroviral treatment (cART) is a real challenge in HIV/HCV coinfected patients. The aim of this study was to describe potential drug-drug interactions between DAAs and antiretroviral drugs in a cohort of HIV/HCV coinfected patients.</p><p>Methods</p><p>Cross-sectional study of all HIV/HCV coinfected patients attending at least one visit in 2012 in the multicenter French Dat’AIDS cohort. A simulation of drug-drug interactions between antiretroviral treatment and DAAs available in 2015 was performed.</p><p>Results</p><p>Of 16,634 HIV-infected patients, 2,511 had detectable anti-HCV antibodies, of whom 1,196 had a detectable HCV-RNA and were not receiving HCV treatment at the time of analysis. 97.1% of these patients were receiving cART and 81.2% had a plasma HIV RNA <50 copies/mL. cART included combinations of nucleoside reverse transcriptase inhibitors with a boosted protease inhibitor in 43.6%, a non-nucleoside reverse transcriptase inhibitor in 17.3%, an integrase inhibitor in 15.4% and various combinations or antiretroviral drugs in 23.7% of patients. A previous treatment against HCV had been administered in 64.4% of patients. Contraindicated associations/potential interactions were expected between cART and respectively sofosbuvir (0.2%/0%), sofosbuvir/ledipasvir (0.2%/67.6%), daclatasvir (0%/49.4%), ombitasvir/boosted paritaprevir (with or without dasabuvir) (34.4%/52.2%) and simeprevir (78.8%/0%).</p><p>Conclusions</p><p>Significant potential drug-drug interactions are expected between cART and the currently available DAAs in the majority of HIV/HCV coinfected patients. Sofosbuvir/ledipasvir and sofosbuvir/daclatasvir with or without ribavirin appeared the most suitable combinations in our population. A close collaboration between hepatologists and HIV/AIDS specialists appears necessary for the management of HCV treatment concomitantly to cART.</p></div>", "links"=>[], "tags"=>["combination", "plasma HIV RNA", "antiretroviral treatment", "antiretroviral drugs", "interaction", "inhibitor", "daa", "HCV treatment", "Sofosbuvir", "coinfected"], "article_id"=>1581705, "categories"=>["Biological Sciences"], "users"=>["Isabelle Poizot-Martin", "Alissa Naqvi", "Véronique Obry-Roguet", "Marc-Antoine Valantin", "Lise Cuzin", "Eric Billaud", "Antoine Chéret", "David Rey", "Christine Jacomet", "Claudine Duvivier", "Pascal Pugliese", "Pierre Pradat", "Laurent Cotte"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0141164.s001", "https://dx.doi.org/10.1371/journal.pone.0141164.s002"], "stats"=>{"downloads"=>7, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Potential_for_Drug_Drug_Interactions_between_Antiretrovirals_and_HCV_Direct_Acting_Antivirals_in_a_Large_Cohort_of_HIV_HCV_Coinfected_Patients_/1581705", "title"=>"Potential for Drug-Drug Interactions between Antiretrovirals and HCV Direct Acting Antivirals in a Large Cohort of HIV/HCV Coinfected Patients", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-10-21 02:47:42"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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