A Cluster Randomised Trial on the Impact of Integrating Early Infant HIV Diagnosis with the Expanded Programme on Immunization on Immunization and HIV Testing Rates in Rural Health Facilities in Southern Zambia
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{"title"=>"A cluster randomised trial on the impact of integrating early infant HIV diagnosis with the expanded programme on immunization on immunization and HIV testing rates in rural health facilities in southern Zambia", "type"=>"journal", "authors"=>[{"first_name"=>"Paul C.", "last_name"=>"Wang", "scopus_author_id"=>"57157486100"}, {"first_name"=>"Albert", "last_name"=>"Mwango", "scopus_author_id"=>"14065299200"}, {"first_name"=>"Sarah", "last_name"=>"Moberley", "scopus_author_id"=>"22135428800"}, {"first_name"=>"Benjamin J.", "last_name"=>"Brockman", "scopus_author_id"=>"57004726200"}, {"first_name"=>"Alison L.", "last_name"=>"Connor", "scopus_author_id"=>"57004517100"}, {"first_name"=>"Penelope", "last_name"=>"Kalesha-Masumbu", "scopus_author_id"=>"57004860200"}, {"first_name"=>"Simon", "last_name"=>"Mutembo", "scopus_author_id"=>"55193549700"}, {"first_name"=>"Maximillian", "last_name"=>"Bweupe", "scopus_author_id"=>"35408500800"}, {"first_name"=>"Pascalina", "last_name"=>"Chanda-Kapata", "scopus_author_id"=>"53982461600"}, {"first_name"=>"Godfrey", "last_name"=>"Biemba", "scopus_author_id"=>"6602246415"}, {"first_name"=>"Davidson H.", "last_name"=>"Hamer", "scopus_author_id"=>"35433232300"}, {"first_name"=>"Benjamin", "last_name"=>"Chibuye", "scopus_author_id"=>"57004834300"}, {"first_name"=>"Elizabeth", "last_name"=>"McCarthy", "scopus_author_id"=>"57004417100"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"607232327", "sgr"=>"84949998022", "scopus"=>"2-s2.0-84949998022", "pmid"=>"26513240", "doi"=>"10.1371/journal.pone.0141455", "isbn"=>"1932-6203"}, "id"=>"58e00885-fff7-3527-aaef-ed4506e69733", "abstract"=>"BACKGROUND We assessed the integration of early infant HIV diagnosis with the expanded programme for immunization in a rural Zambian setting with the aim of determining whether infant and postpartum maternal HIV testing rates would increase without harming immunization uptake. METHODS In an unblinded, location stratified, cluster randomised controlled trial, 60 facilities in Zambia's Southern Province were equally allocated to a control group, Simple Intervention group that received a sensitization meeting and the resupply of HIV testing commodities in the event of a stock-out, and a Comprehensive Intervention group that received the Simple Intervention as well as on-site operational support to facilitate the integration of HIV testing services with EPI. FINDINGS The average change in number of first dose diphtheria, pertussis, and tetanus vaccine (DPT1) provided per month, per facility was approximately 0.86 doses higher [90% confidence interval (CI) -1.40, 3.12] in Comprehensive Intervention facilities compared to the combined average change in the Simple Intervention and control facilities. The interventions resulted in a 16.6% [90% CI: -7%, 46%, P-value = 0.26] and 10% [90% CI: -10%, 36%, P-value = 0.43] greater change in average monthly infant DBS testing compared to control for the Simple and Comprehensive facilities respectively. We also found 15.76 (90% CI: 7.12, 24.41, P-value < 0.01) and 10.93 (90% CI: 1.52, 20.33, P-value = 0.06) additional total maternal re-tests over baseline for the Simple and Comprehensive Facilities respectively. CONCLUSIONS This study provides strong evidence to support Zambia's policy of integration of HIV testing and EPI services. Actions in line with the interventions, including HIV testing material supply reinforcement, can increase HIV testing rates without harming immunization uptake. In response, Zambia's Ministry of Health issued a memo to remind health facilities to provide HIV testing at under-five clinics and to include under-five HIV testing as part of district performance assessments. TRIAL REGISTRATION ClinicalTrials.gov REGISTRATION NUMBER NCT02479659.", "link"=>"http://www.mendeley.com/research/cluster-randomised-trial-impact-integrating-early-infant-hiv-diagnosis-expanded-programme-immunizati", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>1, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>1, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Nursing and Health Professions"=>6, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>14, "Business, Management and Accounting"=>1, "Social Sciences"=>2, "Psychology"=>1, "Economics, Econometrics and Finance"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>6}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Ethiopia"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2388905"], "description"=>"<p>Health facilities were used as the unit of sampling, randomization, follow-up and analysis.</p>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589168, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141455.g001", "stats"=>{"downloads"=>4, "page_views"=>34, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flowchart_of_facility_inclusion_and_sampling_/1589168", "title"=>"Flowchart of facility inclusion and sampling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-29 03:16:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2388906"], "description"=>"<p>The blue bars represent the average number of infant DBS tests per facility in each study arm at baseline. The red bars represent the corresponding average number of infant DBS tests during the six month intervention period.</p>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589169, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141455.g002", "stats"=>{"downloads"=>1, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_average_number_of_infant_DBS_testing_during_baseline_and_intervention_periods_per_facility_by_intervention_/1589169", "title"=>"The average number of infant DBS testing during baseline and intervention periods per facility, by intervention.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-29 03:16:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2388907"], "description"=>"<p>The bar chart displays the average number of monthly maternal retests both done at the six week under-five visit, as well as the total number of monthly maternal retests during the baseline and the intervention periods across the three intervention arms. The bars in blue represent values at baseline, while bars in red represent values during the six month intervention period.</p>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589170, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141455.g003", "stats"=>{"downloads"=>2, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_average_number_of_monthly_maternal_retests_during_baseline_and_intervention_per_facility_by_intervention_arm_/1589170", "title"=>"The average number of monthly maternal retests during baseline and intervention per facility, by intervention arm.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-10-29 03:16:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2388908"], "description"=>"<p>* The intervention arms were regressed as indicator variables on each outcome. After the regression, an F-test was used to test for equality between the three evaluation arms. At the time of sampling, all samples with p-values of less than 0.90 for DBS, DPT, and ANC averages were removed from consideration. Since that time, more complete data are available, explaining the 0.89 p-value for the DBS tests at the final sample.</p><p>Summary and baseline characteristics by intervention arm.</p>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589171, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141455.t001", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_and_baseline_characteristics_by_intervention_arm_/1589171", "title"=>"Summary and baseline characteristics by intervention arm.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-29 03:16:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2388909"], "description"=>"<p>Multivariate linear regression estimated that the average change in number of DPT1 doses provided per month, per facility was approximately 0.86 doses higher [90% confidence interval (CI) -1.40, 3.12] in Comprehensive Intervention facilities compared to the combined average change in the Simple Intervention and control facilities (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141455#pone.0141455.t003\" target=\"_blank\">Table 3</a>). This average change was not statistically significant (p-value 0.53). A similar multivariate linear regression was run to estimate the combined impact of the Comprehensive and Simple Interventions versus control on the monthly number of DPT1 doses administered, with an average -0.51 fewer doses administered (90% CI -3.59, 2.56, p value 0.78) (data not shown).</p><p>Average number of DPT1 doses administered per month by randomisation group.</p>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589172, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141455.t002", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_number_of_DPT1_doses_administered_per_month_by_randomisation_group_/1589172", "title"=>"Average number of DPT1 doses administered per month by randomisation group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-29 03:16:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2388910"], "description"=>"<p>Multivariate Linear Regression Results for the Montly Average Number of DPT1 Doses Comparing Comprehensive Group to Combined Control & Simple Groups.</p>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589173, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141455.t003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_Linear_Regression_Results_for_the_Montly_Average_Number_of_DPT1_Doses_Comparing_Comprehensive_Group_to_Combined_Control_amp_Simple_Groups_/1589173", "title"=>"Multivariate Linear Regression Results for the Montly Average Number of DPT1 Doses Comparing Comprehensive Group to Combined Control & Simple Groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-29 03:16:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2388911"], "description"=>"<p>Linear Regression Results of Intervention Arm on Logged Outcome (Number of DBS Tests per Facility per Month).</p>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589174, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141455.t004", "stats"=>{"downloads"=>1, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Linear_Regression_Results_of_Intervention_Arm_on_Logged_Outcome_Number_of_DBS_Tests_per_Facility_per_Month_/1589174", "title"=>"Linear Regression Results of Intervention Arm on Logged Outcome (Number of DBS Tests per Facility per Month).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-29 03:16:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2388912"], "description"=>"<p>Multivariate Linear Regression Results for 6 Week Retests and Total Number of Retests.</p>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589175, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0141455.t005", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_Linear_Regression_Results_for_6_Week_Retests_and_Total_Number_of_Retests_/1589175", "title"=>"Multivariate Linear Regression Results for 6 Week Retests and Total Number of Retests.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-10-29 03:16:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2388914", "https://ndownloader.figshare.com/files/2388915", "https://ndownloader.figshare.com/files/2388916", "https://ndownloader.figshare.com/files/2388917"], "description"=>"<div><p>Background</p><p>We assessed the integration of early infant HIV diagnosis with the expanded programme for immunization in a rural Zambian setting with the aim of determining whether infant and postpartum maternal HIV testing rates would increase without harming immunization uptake.</p><p>Methods</p><p>In an unblinded, location stratified, cluster randomised controlled trial, 60 facilities in Zambia’s Southern Province were equally allocated to a control group, Simple Intervention group that received a sensitization meeting and the resupply of HIV testing commodities in the event of a stock-out, and a Comprehensive Intervention group that received the Simple Intervention as well as on-site operational support to facilitate the integration of HIV testing services with EPI.</p><p>Findings</p><p>The average change in number of first dose diphtheria, pertussis, and tetanus vaccine (DPT1) provided per month, per facility was approximately 0.86 doses higher [90% confidence interval (CI) -1.40, 3.12] in Comprehensive Intervention facilities compared to the combined average change in the Simple Intervention and control facilities. The interventions resulted in a 16.6% [90% CI: -7%, 46%, P-value = 0.26] and 10% [90% CI: -10%, 36%, P-value = 0.43] greater change in average monthly infant DBS testing compared to control for the Simple and Comprehensive facilities respectively. We also found 15.76 (90% CI: 7.12, 24.41, P-value < 0.01) and 10.93 (90% CI: 1.52, 20.33, P-value = 0.06) additional total maternal re-tests over baseline for the Simple and Comprehensive Facilities respectively.</p><p>Conclusions</p><p>This study provides strong evidence to support Zambia’s policy of integration of HIV testing and EPI services. Actions in line with the interventions, including HIV testing material supply reinforcement, can increase HIV testing rates without harming immunization uptake. In response, Zambia’s Ministry of Health issued a memo to remind health facilities to provide HIV testing at under-five clinics and to include under-five HIV testing as part of district performance assessments.</p><p>Trial Registration</p><p>ClinicalTrials.gov Registration Number: <a href=\"https://clinicaltrials.gov/ct2/show/study/NCT02479659?term=early+infant+diagnosis+and+HIV+and+Zambia&rank=1\" target=\"_blank\">NCT02479659</a></p></div>", "links"=>[], "tags"=>["Simple Intervention group", "infant DBS testing", "epi", "HIV testing material supply reinforcement", "Comprehensive Intervention group", "Comprehensive Facilities respectively.ConclusionsThis study", "Comprehensive Intervention facilities", "HIV testing rates", "Simple Intervention", "HIV testing", "cluster randomised trial", "facility", "Infant HIV Diagnosis", "ci", "Rural Health Facilities", "dpt", "Southern Zambia BackgroundWe", "HIV testing services", "HIV testing commodities", "nct", "district performance assessments.Trial RegistrationClinicalTrials.gov Registration Number"], "article_id"=>1589176, "categories"=>["Uncategorised"], "users"=>["Paul C. Wang", "Albert Mwango", "Sarah Moberley", "Benjamin J. Brockman", "Alison L. Connor", "Penelope Kalesha-Masumbu", "Simon Mutembo", "Maximillian Bweupe", "Pascalina Chanda-Kapata", "Godfrey Biemba", "Davidson H. Hamer", "Benjamin Chibuye", "Elizabeth McCarthy"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0141455.s001", "https://dx.doi.org/10.1371/journal.pone.0141455.s002", "https://dx.doi.org/10.1371/journal.pone.0141455.s003", "https://dx.doi.org/10.1371/journal.pone.0141455.s004"], "stats"=>{"downloads"=>6, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_Cluster_Randomised_Trial_on_the_Impact_of_Integrating_Early_Infant_HIV_Diagnosis_with_the_Expanded_Programme_on_Immunization_on_Immunization_and_HIV_Testing_Rates_in_Rural_Health_Facilities_in_Southern_Zambia_/1589176", "title"=>"A Cluster Randomised Trial on the Impact of Integrating Early Infant HIV Diagnosis with the Expanded Programme on Immunization on Immunization and HIV Testing Rates in Rural Health Facilities in Southern Zambia", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-10-29 03:16:51"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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