Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier
Publication Date
November 04, 2015
Journal
PLOS ONE
Authors
Evelien Wynendaele, Frederick Verbeke, Sofie Stalmans, Bert Gevaert, et al
Volume
10
Issue
11
Pages
e0142071
DOI
https://dx.plos.org/10.1371/journal.pone.0142071
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0142071
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26536593
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633044
Europe PMC
http://europepmc.org/abstract/MED/26536593
Web of Science
000364298400128
Scopus
84951114083
Mendeley
http://www.mendeley.com/research/quorum-sensing-peptides-selectively-penetrate-bloodbrain-barrier
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Mendeley | Further Information

{"title"=>"Quorum sensing peptides selectively penetrate the blood-brain barrier", "type"=>"journal", "authors"=>[{"first_name"=>"Evelien", "last_name"=>"Wynendaele", "scopus_author_id"=>"37050233000"}, {"first_name"=>"Frederick", "last_name"=>"Verbeke", "scopus_author_id"=>"55498683900"}, {"first_name"=>"Sofie", "last_name"=>"Stalmans", "scopus_author_id"=>"54793516000"}, {"first_name"=>"Bert", "last_name"=>"Gevaert", "scopus_author_id"=>"55815470900"}, {"first_name"=>"Yorick", "last_name"=>"Janssens", "scopus_author_id"=>"57015129000"}, {"first_name"=>"Christophe", "last_name"=>"Van De Wiele", "scopus_author_id"=>"56233872200"}, {"first_name"=>"Kathelijne", "last_name"=>"Peremans", "scopus_author_id"=>"6701733653"}, {"first_name"=>"Christian", "last_name"=>"Burvenich", "scopus_author_id"=>"7005206847"}, {"first_name"=>"Bart", "last_name"=>"De Spiegeleer", "scopus_author_id"=>"12140513300"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84951114083", "pui"=>"607325420", "doi"=>"10.1371/journal.pone.0142071", "isbn"=>"1932-6203", "sgr"=>"84951114083", "pmid"=>"26536593"}, "id"=>"384638b4-1890-30e4-b620-817d261288f0", "abstract"=>"Bacteria communicate with each other by the use of signaling molecules, a process called 'quorum sensing'. One group of quorum sensing molecules includes the oligopeptides, which are mainly produced by Gram-positive bacteria. Recently, these quorum sensing peptides were found to biologically influence mammalian cells, promoting i.a. metastasis of cancer cells. Moreover, it was found that bacteria can influence different central nervous system related disorders as well, e.g. anxiety, depression and autism. Research currently focuses on the role of bacterial metabolites in this bacteria-brain interaction, with the role of the quorum sensing peptides not yet known. Here, three chemically diverse quorum sensing peptides were investigated for their brain influx (multiple time regression technique) and efflux properties in an in vivo mouse model (ICR-CD-1) to determine blood-brain transfer properties: PhrCACET1 demonstrated comparatively a very high initial influx into the mouse brain (Kin = 20.87 μl/(g×min)), while brain penetrabilities of BIP-2 and PhrANTH2 were found to be low (Kin = 2.68 μl/(g×min)) and very low (Kin = 0.18 μl/(g×min)), respectively. All three quorum sensing peptides were metabolically stable in plasma (in vitro) during the experimental time frame and no significant brain efflux was observed. Initial tissue distribution data showed remarkably high liver accumulation of BIP-2 as well. Our results thus support the potential role of some quorum sensing peptides in different neurological disorders, thereby enlarging our knowledge about the microbiome-brain axis.", "link"=>"http://www.mendeley.com/research/quorum-sensing-peptides-selectively-penetrate-bloodbrain-barrier", "reader_count"=>43, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>4, "Other"=>1, "Student > Master"=>6, "Student > Bachelor"=>8, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>4, "Other"=>1, "Student > Master"=>6, "Student > Bachelor"=>8, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>21, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>4, "Chemistry"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>2}, "Psychology"=>{"Psychology"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Luxembourg"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2406266"], "description"=>"<p>The amount of peptide that is effectively transferred into the brain shows a higher brain parenchyma versus a relatively low capillary distribution for the three peptides. The capillary and parenchyma fraction (%) are indicated above the histogram.</p>", "links"=>[], "tags"=>["brain efflux", "peptide", "cancer cells", "Peptides Selectively Penetrate", "PhrANTH 2", "liver accumulation", "time regression technique", "time frame", "efflux properties", "brain influx", "role", "kin", "bip", "mouse brain", "Initial tissue distribution data", "quorum", "Vivo Mouse Model", "brain penetrabilities", "PhrCACET 1"], "article_id"=>1593352, "categories"=>["Biological Sciences"], "users"=>["Evelien Wynendaele", "Frederick Verbeke", "Sofie Stalmans", "Bert Gevaert", "Yorick Janssens", "Christophe Van De Wiele", "Kathelijne Peremans", "Christian Burvenich", "Bart De Spiegeleer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142071.g003", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Capillary_depletion_results_of_the_quorum_sensing_peptides_/1593352", "title"=>"Capillary depletion results of the quorum sensing peptides.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-04 02:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2406262"], "description"=>"<p>The selected peptides are indicated by the rectangles, <i>i</i>.<i>e</i>. Quorumpeps ID 102 (BIP-2), ID 206 (PhrCACET1) and ID 186 (PhrANTH2).</p>", "links"=>[], "tags"=>["brain efflux", "peptide", "cancer cells", "Peptides Selectively Penetrate", "PhrANTH 2", "liver accumulation", "time regression technique", "time frame", "efflux properties", "brain influx", "role", "kin", "bip", "mouse brain", "Initial tissue distribution data", "quorum", "Vivo Mouse Model", "brain penetrabilities", "PhrCACET 1"], "article_id"=>1593350, "categories"=>["Biological Sciences"], "users"=>["Evelien Wynendaele", "Frederick Verbeke", "Sofie Stalmans", "Bert Gevaert", "Yorick Janssens", "Christophe Van De Wiele", "Kathelijne Peremans", "Christian Burvenich", "Bart De Spiegeleer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142071.g001", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Score_plot_of_the_PCA_analysis_distinguishing_3_main_clusters_/1593350", "title"=>"Score plot of the PCA analysis, distinguishing 3 main clusters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-04 02:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2406269"], "description"=>"<p>BSA shows a higher spleen and liver distribution, while dermorphin is massively accumulated in the mice duodenum. PhrANTH2 shows no clear tissue distribution, while PhrCACET1 and BIP-2 are mainly distributed to the kidneys/duodenum and liver, respectively.</p>", "links"=>[], "tags"=>["brain efflux", "peptide", "cancer cells", "Peptides Selectively Penetrate", "PhrANTH 2", "liver accumulation", "time regression technique", "time frame", "efflux properties", "brain influx", "role", "kin", "bip", "mouse brain", "Initial tissue distribution data", "quorum", "Vivo Mouse Model", "brain penetrabilities", "PhrCACET 1"], "article_id"=>1593353, "categories"=>["Biological Sciences"], "users"=>["Evelien Wynendaele", "Frederick Verbeke", "Sofie Stalmans", "Bert Gevaert", "Yorick Janssens", "Christophe Van De Wiele", "Kathelijne Peremans", "Christian Burvenich", "Bart De Spiegeleer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142071.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tissue_distribution_of_the_quorum_sensing_peptides_15_minutes_after_IV_administration_/1593353", "title"=>"Tissue distribution of the quorum sensing peptides, 15 minutes after IV administration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-04 02:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2406270"], "description"=>"<p><sup>a</sup> N/A (V<sub>0</sub>): V<sub>0</sub> was set to be equal to the V<sub>0</sub> of PhrANTH2</p><p><sup>b</sup> N/A (V<sub>g</sub>): not applicable</p><p>Overview of the multiple time regression results using both the linear as the biphasic model (mean ± 1 standard error).</p>", "links"=>[], "tags"=>["brain efflux", "peptide", "cancer cells", "Peptides Selectively Penetrate", "PhrANTH 2", "liver accumulation", "time regression technique", "time frame", "efflux properties", "brain influx", "role", "kin", "bip", "mouse brain", "Initial tissue distribution data", "quorum", "Vivo Mouse Model", "brain penetrabilities", "PhrCACET 1"], "article_id"=>1593354, "categories"=>["Biological Sciences"], "users"=>["Evelien Wynendaele", "Frederick Verbeke", "Sofie Stalmans", "Bert Gevaert", "Yorick Janssens", "Christophe Van De Wiele", "Kathelijne Peremans", "Christian Burvenich", "Bart De Spiegeleer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142071.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_the_multiple_time_regression_results_using_both_the_linear_as_the_biphasic_model_mean_177_1_standard_error_/1593354", "title"=>"Overview of the multiple time regression results using both the linear as the biphasic model (mean ± 1 standard error).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-11-04 02:49:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2406264"], "description"=>"<p>BSA and dermorphin were used as the negative and positive controls, respectively. PhrANTH2 shows no significant brain influx, while the results of PhrCACET1 and BIP-2 indicate BBB permeability, which is the highest for PhrCACET1.</p>", "links"=>[], "tags"=>["brain efflux", "peptide", "cancer cells", "Peptides Selectively Penetrate", "PhrANTH 2", "liver accumulation", "time regression technique", "time frame", "efflux properties", "brain influx", "role", "kin", "bip", "mouse brain", "Initial tissue distribution data", "quorum", "Vivo Mouse Model", "brain penetrabilities", "PhrCACET 1"], "article_id"=>1593351, "categories"=>["Biological Sciences"], "users"=>["Evelien Wynendaele", "Frederick Verbeke", "Sofie Stalmans", "Bert Gevaert", "Yorick Janssens", "Christophe Van De Wiele", "Kathelijne Peremans", "Christian Burvenich", "Bart De Spiegeleer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142071.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_influx_of_the_selected_quorum_sensing_peptides_using_the_simple_linear_regression_method_for_BSA_and_PhrANTH2_and_biphasic_model_for_dermorphin_PhrCACET1_and_BIP_2_/1593351", "title"=>"Brain influx of the selected quorum sensing peptides, using the simple linear regression method for BSA and PhrANTH2 and biphasic model for dermorphin, PhrCACET1 and BIP-2.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-04 02:49:33"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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