Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS)
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{"title"=>"Epidemiology and heritability of major depressive disorder, stratified by age of onset, sex, and illness course in generation Scotland: Scottish family health study (GS: SFHS)", "type"=>"journal", "authors"=>[{"first_name"=>"Ana Maria", "last_name"=>"Fernandez-Pujals", "scopus_author_id"=>"56543725800"}, {"first_name"=>"Mark James", "last_name"=>"Adams", "scopus_author_id"=>"55454016200"}, {"first_name"=>"Pippa", "last_name"=>"Thomson", "scopus_author_id"=>"8774136900"}, {"first_name"=>"Andrew G.", "last_name"=>"McKechanie", "scopus_author_id"=>"8521071700"}, {"first_name"=>"Douglas H.R.", "last_name"=>"Blackwood", "scopus_author_id"=>"7006606466"}, {"first_name"=>"Blair H.", "last_name"=>"Smith", "scopus_author_id"=>"7501688408"}, {"first_name"=>"Anna F.", "last_name"=>"Dominiczak", "scopus_author_id"=>"7005462773"}, {"first_name"=>"Andrew D.", "last_name"=>"Morris", "scopus_author_id"=>"7403404521"}, {"first_name"=>"Keith", "last_name"=>"Matthews", "scopus_author_id"=>"56009674200"}, {"first_name"=>"Archie", "last_name"=>"Campbell", "scopus_author_id"=>"19642129200"}, {"first_name"=>"Pamela", "last_name"=>"Linksted", "scopus_author_id"=>"10144953200"}, {"first_name"=>"Chris S.", "last_name"=>"Haley", "scopus_author_id"=>"35477845200"}, {"first_name"=>"Ian J.", "last_name"=>"Deary", "scopus_author_id"=>"56705691500"}, {"first_name"=>"David J.", "last_name"=>"Porteous", "scopus_author_id"=>"7006940003"}, {"first_name"=>"Donald J.", "last_name"=>"MacIntyre", "scopus_author_id"=>"8947146700"}, {"first_name"=>"Andrew M.", "last_name"=>"McIntosh", "scopus_author_id"=>"56208173500"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84957111265", "sgr"=>"84957111265", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0142197", "pmid"=>"26571028", "pui"=>"607987941"}, "id"=>"549c514c-952a-388e-8c14-11e6e9d74b67", "abstract"=>"The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently, the heritability of MDD has been estimated on large populations from registries such as the Swedish, Finnish, and Chinese cohorts. Family-based designs utilise a number of different relationships and provide an alternative means of estimating heritability. Generation Scotland: Scottish Family Health Study (GS:SFHS) is a large (n = 20,198), family-based population study designed to identify the genetic determinants of common diseases, including Major Depressive Disorder. Two thousand seven hundred and six individuals were SCID diagnosed with MDD, 13.5% of the cohort, from which we inferred a population prevalence of 12.2% (95% credible interval: 11.4% to 13.1%). Increased risk of MDD was associated with being female, unemployed due to a disability, current smokers, former drinkers, and living in areas of greater social deprivation. The heritability of MDD in GS:SFHS was between 28% and 44%, estimated from a pedigree model. The genetic correlation of MDD between sexes, age of onset, and illness course were examined and showed strong genetic correlations. The genetic correlation between males and females with MDD was 0.75 (0.43 to 0.99); between earlier (≤ age 40) and later (> age 40) onset was 0.85 (0.66 to 0.98); and between single and recurrent episodic illness course was 0.87 (0.72 to 0.98). We found that the heritability of recurrent MDD illness course was significantly greater than the heritability of single MDD illness course. The study confirms a moderate genetic contribution to depression, with a small contribution of the common family environment (variance proportion = 0.07, CI: 0.01 to 0.15), and supports the relationship of MDD with previously identified risk factors. This study did not find robust support for genetic differences in MDD due to sex, age of onset, or illness course. However, we found an intriguing difference in heritability between recurrent and single MDD illness course. These findings establish GS:SFHS as a valuable cohort for the genetic investigation of MDD.", "link"=>"http://www.mendeley.com/research/epidemiology-heritability-major-depressive-disorder-stratified-age-onset-sex-illness-course-generati", "reader_count"=>71, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>4, "Other"=>2, "Student > Master"=>11, "Student > Bachelor"=>12, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>4, "Other"=>2, "Student > Master"=>11, "Student > Bachelor"=>12, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>9, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>13, "Neuroscience"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>20, "Social Sciences"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Neuroscience"=>{"Neuroscience"=>5}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>20}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>9}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1, "Thailand"=>1}, "group_count"=>7}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/2442383"], "description"=>"<p>h<sup>2</sup> = heritability, r<sub>G</sub> = genetic correlation, c<sup>2</sup> = shared family environment, r<sub>C</sub> = shared family environment correlation.</p>", "links"=>[], "tags"=>["gs", "major depressive disorder", "Scottish Family Health Study", "MDD illness course", "ci", "illness course", "heritability", "scid"], "article_id"=>1604374, "categories"=>["Uncategorised"], "users"=>["Ana Maria Fernandez-Pujals", "Mark james Adams", "Pippa Thomson", "Andrew G. McKechanie", "Douglas H. R. Blackwood", "Blair H. Smith", "Anna F. Dominiczak", "Andrew D. Morris", "Keith Matthews", "Archie Campbell", "Pamela Linksted", "Chris S. Haley", "Ian J. Deary", "David J. Porteous", "Donald J. MacIntyre", "Andrew M. McIntosh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142197.t003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heritability_variance_proportions_and_stratified_correlations_of_MDD_/1604374", "title"=>"Heritability, variance proportions, and stratified correlations of MDD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-11-16 03:48:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/2442384"], "description"=>"<p>The effects of social and demographic variables on MDD risk.</p>", "links"=>[], "tags"=>["gs", "major depressive disorder", "Scottish Family Health Study", "MDD illness course", "ci", "illness course", "heritability", "scid"], "article_id"=>1604375, "categories"=>["Uncategorised"], "users"=>["Ana Maria Fernandez-Pujals", "Mark james Adams", "Pippa Thomson", "Andrew G. McKechanie", "Douglas H. R. Blackwood", "Blair H. Smith", "Anna F. Dominiczak", "Andrew D. Morris", "Keith Matthews", "Archie Campbell", "Pamela Linksted", "Chris S. Haley", "Ian J. Deary", "David J. Porteous", "Donald J. MacIntyre", "Andrew M. McIntosh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142197.t004", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_social_and_demographic_variables_on_MDD_risk_/1604375", "title"=>"The effects of social and demographic variables on MDD risk.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-11-16 03:48:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/2442385", "https://ndownloader.figshare.com/files/2442386", "https://ndownloader.figshare.com/files/2442387", "https://ndownloader.figshare.com/files/2442388"], "description"=>"<div><p>The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently, the heritability of MDD has been estimated on large populations from registries such as the Swedish, Finnish, and Chinese cohorts. Family-based designs utilise a number of different relationships and provide an alternative means of estimating heritability. Generation Scotland: Scottish Family Health Study (GS:SFHS) is a large (n = 20,198), family-based population study designed to identify the genetic determinants of common diseases, including Major Depressive Disorder. Two thousand seven hundred and six individuals were SCID diagnosed with MDD, 13.5% of the cohort, from which we inferred a population prevalence of 12.2% (95% credible interval: 11.4% to 13.1%). Increased risk of MDD was associated with being female, unemployed due to a disability, current smokers, former drinkers, and living in areas of greater social deprivation. The heritability of MDD in GS:SFHS was between 28% and 44%, estimated from a pedigree model. The genetic correlation of MDD between sexes, age of onset, and illness course were examined and showed strong genetic correlations. The genetic correlation between males and females with MDD was 0.75 (0.43 to 0.99); between earlier (≤ age 40) and later (> age 40) onset was 0.85 (0.66 to 0.98); and between single and recurrent episodic illness course was 0.87 (0.72 to 0.98). We found that the heritability of recurrent MDD illness course was significantly greater than the heritability of single MDD illness course. The study confirms a moderate genetic contribution to depression, with a small contribution of the common family environment (variance proportion = 0.07, CI: 0.01 to 0.15), and supports the relationship of MDD with previously identified risk factors. This study did not find robust support for genetic differences in MDD due to sex, age of onset, or illness course. However, we found an intriguing difference in heritability between recurrent and single MDD illness course. These findings establish GS:SFHS as a valuable cohort for the genetic investigation of MDD.</p></div>", "links"=>[], "tags"=>["gs", "major depressive disorder", "Scottish Family Health Study", "MDD illness course", "ci", "illness course", "heritability", "scid"], "article_id"=>1604376, "categories"=>["Uncategorised"], "users"=>["Ana Maria Fernandez-Pujals", "Mark james Adams", "Pippa Thomson", "Andrew G. McKechanie", "Douglas H. R. Blackwood", "Blair H. Smith", "Anna F. Dominiczak", "Andrew D. Morris", "Keith Matthews", "Archie Campbell", "Pamela Linksted", "Chris S. Haley", "Ian J. Deary", "David J. Porteous", "Donald J. MacIntyre", "Andrew Mcintosh"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0142197.s001", "https://dx.doi.org/10.1371/journal.pone.0142197.s002", "https://dx.doi.org/10.1371/journal.pone.0142197.s003", "https://dx.doi.org/10.1371/journal.pone.0142197.s004"], "stats"=>{"downloads"=>4, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Epidemiology_and_Heritability_of_Major_Depressive_Disorder_Stratified_by_Age_of_Onset_Sex_and_Illness_Course_in_Generation_Scotland_Scottish_Family_Health_Study_GS_SFHS_/1604376", "title"=>"Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS)", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-11-16 03:48:46"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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