Helicobacter pylori Infection Induces Anemia, Depletes Serum Iron Storage, and Alters Local Iron-Related and Adult Brain Gene Expression in Male INS-GAS Mice
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{"title"=>"Helicobacter pylori infection induces anemia, depletes serum iron storage, and alters local iron-related and adult brain gene expression in male INS-GAS mice", "type"=>"journal", "authors"=>[{"first_name"=>"Monika", "last_name"=>"Burns", "scopus_author_id"=>"57089822400"}, {"first_name"=>"Sureshkumar", "last_name"=>"Muthupalani", "scopus_author_id"=>"26534624500"}, {"first_name"=>"Zhongming", "last_name"=>"Ge", "scopus_author_id"=>"7202139983"}, {"first_name"=>"Timothy C.", "last_name"=>"Wang", "scopus_author_id"=>"35199244700"}, {"first_name"=>"Vasudevan", "last_name"=>"Bakthavatchalu", "scopus_author_id"=>"57192311617"}, {"first_name"=>"Catriona", "last_name"=>"Cunningham", "scopus_author_id"=>"57193090268"}, {"first_name"=>"Kathleen", "last_name"=>"Ennis", "scopus_author_id"=>"16063177300"}, {"first_name"=>"Michael", "last_name"=>"Georgieff", "scopus_author_id"=>"35449178300"}, {"first_name"=>"James G.", "last_name"=>"Fox", "scopus_author_id"=>"36048292500"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84956625893", "doi"=>"10.1371/journal.pone.0142630", "pmid"=>"26575645", "issn"=>"19326203", "scopus"=>"2-s2.0-84956625893", "pui"=>"608007761"}, "id"=>"5bd03982-990d-30e2-9364-991c86985876", "abstract"=>"Iron deficiency anemia (IDA) affects > 500 million people worldwide, and is linked to impaired cognitive development and function in children. Helicobacter pylori, a class 1 carcinogen, infects about half of the world's population, thus creating a high likelihood of overlapping risk. This study determined the effect of H. pylori infection on iron homeostasis in INS-GAS mice. Two replicates of INS-GAS/FVB male mice (n = 9-12/group) were dosed with H. pylori (Hp) strain SS1 or sham dosed at 6-9 weeks of age, and were necropsied at 27-29 weeks of age. Hematologic and serum iron parameters were evaluated, as was gene expression in gastric and brain tissues. Serum ferritin was lower in Hp SS1-infected mice than uninfected mice (p < 0.0001). Infected mice had a lower red blood cell count (p<0.0001), hematocrit (p < 0.001), and hemoglobin concentration (p <0.0001) than uninfected mice. Relative expression of gastric hepcidin antimicrobial peptide (Hamp) was downregulated in mice infected with Hp SS1 compared to sham-dosed controls (p<0.001). Expression of bone morphogenic protein 4 (Bmp4), a growth factor upstream of hepcidin, was downregulated in gastric tissue of Hp SS1-infected mice (p<0.001). Hp SS1-infected mice had downregulated brain expression of tyrosine hydroxylase (Th) (p = 0.02). Expression of iron-responsive genes involved in myelination (myelin basic protein (Mbp) and proteolipid protein 2 (Plp2)) was downregulated in infected mice (p = 0.001 and p = 0.02). Expression of synaptic plasticity markers (brain derived neurotrophic factor 3 (Bdnf3), Psd95 (a membrane associated guanylate kinase), and insulin-like growth factor 1 (Igf1)) was also downregulated in Hp SS1-infected mice (p = 0.09, p = 0.04, p = 0.02 respectively). Infection of male INS-GAS mice with Hp SS1, without concurrent dietary iron deficiency, depleted serum ferritin, deregulated gastric and hepatic expression of iron regulatory genes, and altered iron-dependent neural processes. The use of Hp SS1-infected INS-GAS mice will be an appropriate animal model for further study of the effects of concurrent H. pylori infection and anemia on iron homeostasis and adult iron-dependent brain gene expression.", "link"=>"http://www.mendeley.com/research/helicobacter-pylori-infection-induces-anemia-depletes-serum-iron-storage-alters-local-ironrelated-ad", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Other"=>3, "Student > Bachelor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Other"=>3, "Student > Bachelor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>4, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Thailand"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2444505"], "description"=>"<p>Mean hematocrit (A) of <i>H</i>. <i>pylori</i>-infected mice was lower than sham-dosed mice, as was red blood cell count (B) and hemoglobin concentration(C). (***) = p<0.001, (****) = p<0.0001.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606048, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g007", "stats"=>{"downloads"=>3, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_C_H_pylori_infected_mice_have_lower_red_blood_cell_indices_than_uninfected_mice_6_7_months_post_infection_/1606048", "title"=>"(A-C). <i>H</i>. <i>pylori</i>-infected mice have lower red blood cell indices than uninfected mice 6–7 months post infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444506"], "description"=>"<p>(****) = p<0.0001.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606049, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g008", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_cellular_volume_of_red_blood_cells_is_higher_in_mice_infected_with_H_pylori_than_sham_dosed_mice_/1606049", "title"=>"Mean cellular volume of red blood cells is higher in mice infected with <i>H</i>. <i>pylori</i> than sham-dosed mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444507"], "description"=>"<p><i>H</i>. <i>pylori</i> SS1 infection decreased myeloid:erythroid precursor cell ratio on bone marrow cytology.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606050, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g009", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_H_pylori_SS1_infection_decreased_myeloid_erythroid_precursor_cell_ratio_on_bone_marrow_cytology_/1606050", "title"=>"<i>H</i>. <i>pylori</i> SS1 infection decreased myeloid:erythroid precursor cell ratio on bone marrow cytology.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444508"], "description"=>"<p>Both mean serum erythropoietin (A) and spleen weight (B) were higher in <i>H</i>. <i>pylori</i>-infected mice than sham-dosed control mice. (**) = p<0.01.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606051, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g010", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_B_Serum_erythropoietin_concentration_and_spleen_weight_are_elevated_in_mice_chronically_infected_with_H_pylori_SS1_/1606051", "title"=>"(A&B). Serum erythropoietin concentration and spleen weight are elevated in mice chronically infected with <i>H</i>. <i>pylori</i> SS1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444509", "https://ndownloader.figshare.com/files/2444510", "https://ndownloader.figshare.com/files/2444511"], "description"=>"<div><p>Iron deficiency anemia (IDA) affects > 500 million people worldwide, and is linked to impaired cognitive development and function in children. <i>Helicobacter pylori</i>, a class 1 carcinogen, infects about half of the world’s population, thus creating a high likelihood of overlapping risk. This study determined the effect of <i>H</i>. <i>pylori</i> infection on iron homeostasis in INS-GAS mice. Two replicates of INS-GAS/FVB male mice (n = 9-12/group) were dosed with <i>H</i>. <i>pylori</i> (<i>Hp</i>) strain SS1 or sham dosed at 6–9 weeks of age, and were necropsied at 27–29 weeks of age. Hematologic and serum iron parameters were evaluated, as was gene expression in gastric and brain tissues. Serum ferritin was lower in <i>Hp</i> SS1-infected mice than uninfected mice (p < 0.0001). Infected mice had a lower red blood cell count (p<0.0001), hematocrit (p < 0.001), and hemoglobin concentration (p <0.0001) than uninfected mice. Relative expression of gastric hepcidin antimicrobial peptide (<i>Hamp</i>) was downregulated in mice infected with <i>Hp</i> SS1 compared to sham-dosed controls (p<0.001). Expression of bone morphogenic protein 4 (<i>Bmp4)</i>, a growth factor upstream of hepcidin, was downregulated in gastric tissue of <i>Hp</i> SS1-infected mice (p<0.001). <i>Hp</i> SS1-infected mice had downregulated brain expression of tyrosine hydroxylase (<i>Th)</i> (p = 0.02). Expression of iron-responsive genes involved in myelination (myelin basic protein (<i>Mbp)</i> and proteolipid protein 2 (<i>Plp2</i>)) was downregulated in infected mice (p = 0.001 and p = 0.02). Expression of synaptic plasticity markers (brain derived neurotrophic factor 3 (<i>Bdnf3)</i>, <i>Psd95</i> (a membrane associated guanylate kinase), and insulin-like growth factor 1 (<i>Igf1</i>)) was also downregulated in <i>Hp</i> SS1-infected mice (p = 0.09, p = 0.04, p = 0.02 respectively). Infection of male INS-GAS mice with <i>Hp</i> SS1, without concurrent dietary iron deficiency, depleted serum ferritin, deregulated gastric and hepatic expression of iron regulatory genes, and altered iron-dependent neural processes. The use of <i>Hp</i> SS1-infected INS-GAS mice will be an appropriate animal model for further study of the effects of concurrent <i>H</i>. <i>pylori</i> infection and anemia on iron homeostasis and adult iron-dependent brain gene expression.</p></div>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606052, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0142630.s001", "https://dx.doi.org/10.1371/journal.pone.0142630.s002", "https://dx.doi.org/10.1371/journal.pone.0142630.s003"], "stats"=>{"downloads"=>9, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Helicobacter_pylori_Infection_Induces_Anemia_Depletes_Serum_Iron_Storage_and_Alters_Local_Iron_Related_and_Adult_Brain_Gene_Expression_in_Male_INS_GAS_Mice/1606052", "title"=>"<i>Helicobacter pylori</i> Infection Induces Anemia, Depletes Serum Iron Storage, and Alters Local Iron-Related and Adult Brain Gene Expression in Male INS-GAS Mice", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444499"], "description"=>"<p>Serum ferritin concentration was significantly lower in mice infected with <i>H</i>. <i>pylori</i> SS1 when compared to sham-dosed controls. (****) = p<0.0001.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606042, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_INS_GAS_FVB_mice_chronically_infected_with_H_pylori_have_lower_serum_ferritin_than_uninfected_mice_/1606042", "title"=>"INS-GAS/FVB mice chronically infected with <i>H</i>. <i>pylori</i> have lower serum ferritin than uninfected mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444500"], "description"=>"<p>Gastric tissue expression of bone morphogenic protein 4 (<i>Bmp4)</i> and hepcidin antimicrobial peptide (<i>Hamp)</i> mRNA was significantly downregulated, while Lipocalin 2 (<i>Lcn2)</i> expression was upregulated, in mice infected with <i>H</i>. <i>pylori</i> SS1. (***) = p<0.001; (****) = p<0.0001.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606043, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g002", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_gastric_iron_regulatory_genes_was_downregulated_in_INS_GAS_mice_chronically_infected_with_H_pylori_/1606043", "title"=>"Expression of gastric iron regulatory genes was downregulated in INS-GAS mice chronically infected with <i>H</i>. <i>pylori</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444501"], "description"=>"<p>Expression of hepcidin antimicrobial peptide (<i>Hamp)</i> was lower in <i>H</i>. <i>pylori—</i>infected mice. (****) = p<0.0001.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606044, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_hepcidin_is_downregulated_in_hepatic_tissue_isolated_from_H_pylori_infected_mice_/1606044", "title"=>"Expression of hepcidin is downregulated in hepatic tissue isolated from <i>H</i>. <i>pylori</i> -infected mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444502"], "description"=>"<p>Expression of interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), and interleukin one beta (IL1β) was significantly upregulated in <i>H</i>. <i>pylori</i>-infected mice compared to uninfected mice. (*) = p<0.05; (****) = p<0.0001.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606045, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g004", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Infection_with_H_pylori_upregulated_gastric_inflammatory_cytokine_expression_/1606045", "title"=>"Infection with <i>H</i>. <i>pylori</i> upregulated gastric inflammatory cytokine expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444503"], "description"=>"<p>(A) genes related to myelination (B) synaptic plasticity genes (C) genes involved in dopamine metabolism, (*) = p<0.05, (**) = p<0.01.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606046, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g005", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Chronic_infection_of_male_INS_GAS_mice_with_H_pylori_SS1_reduces_expression_of_genes_involved_in_dopamine_metabolism_myelination_and_synaptic_plasticity_without_significantly_altering_expression_of_iron_transport_genes_/1606046", "title"=>"Chronic infection of male INS-GAS mice with <i>H</i>. <i>pylori</i> SS1 reduces expression of genes involved in dopamine metabolism, myelination, and synaptic plasticity without significantly altering expression of iron transport genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/2444504"], "description"=>"<p>Chronic infection of male INS-GAS mice with <i>H</i>. <i>pylori</i> SS1 reduces brain protein levels of BDNF and MBP.</p>", "links"=>[], "tags"=>["strain SS 1", "Adult Brain Gene Expression", "iron homeostasis", "Depletes Serum Iron Storage", "hepcidin antimicrobial peptide", "pylori infection", "downregulated brain expression", "ida", "blood cell count", "Helicobacter pylori Infection Induces Anemia", "Hp SS 1", "neurotrophic factor 3", "bone morphogenic protein 4", "synaptic plasticity markers", "class 1 carcinogen", "proteolipid protein 2", "serum iron parameters"], "article_id"=>1606047, "categories"=>["Biological Sciences"], "users"=>["Monika Burns", "Sureshkumar Muthupalani", "Zhongming Ge", "Timothy C. Wang", "Vasudevan Bakthavatchalu", "Catriona Cunningham", "Kathleen Ennis", "Michael Georgieff", "James G. Fox"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0142630.g006", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Chronic_infection_of_male_INS_GAS_mice_with_H_pylori_SS1_reduces_brain_protein_levels_of_BDNF_and_MBP_/1606047", "title"=>"Chronic infection of male INS-GAS mice with <i>H</i>. <i>pylori</i> SS1 reduces brain protein levels of BDNF and MBP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-11-17 15:44:18"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"65", "full-text"=>"69", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"49", "full-text"=>"52", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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