Relationship between Fungal Colonisation of the Respiratory Tract in Lung Transplant Recipients and Fungal Contamination of the Hospital Environment
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{"title"=>"Relationship between fungal colonisation of the respiratory tract in lung transplant recipients and fungal contamination of the hospital environment", "type"=>"journal", "authors"=>[{"first_name"=>"Christine", "last_name"=>"Bonnal", "scopus_author_id"=>"22957347000"}, {"first_name"=>"Christopher", "last_name"=>"Leleu", "scopus_author_id"=>"55362704800"}, {"first_name"=>"Olivier", "last_name"=>"Brugière", "scopus_author_id"=>"6701522392"}, {"first_name"=>"Christian", "last_name"=>"Chochillon", "scopus_author_id"=>"6601996390"}, {"first_name"=>"Raphael", "last_name"=>"Porcher", "scopus_author_id"=>"55682557800"}, {"first_name"=>"Pierre Yves", "last_name"=>"Boelle", "scopus_author_id"=>"7003593801"}, {"first_name"=>"Jean", "last_name"=>"Menotti", "scopus_author_id"=>"6603039692"}, {"first_name"=>"Sandrine", "last_name"=>"Houze", "scopus_author_id"=>"24830420000"}, {"first_name"=>"Jean Christophe", "last_name"=>"Lucet", "scopus_author_id"=>"7006655229"}, {"first_name"=>"Francis", "last_name"=>"Derouin", "scopus_author_id"=>"14051759200"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203", "pmid"=>"26629994", "doi"=>"10.1371/journal.pone.0144044", "pui"=>"607884193", "issn"=>"19326203", "sgr"=>"84955461502", "scopus"=>"2-s2.0-84955461502"}, "id"=>"ae37a816-1899-3163-83ad-8a6dbe6ef3ef", "abstract"=>"BACKGROUND: Aspergillus colonisation is frequently reported after lung transplantation. The question of whether aspergillus colonisation is related to the hospital environment is crucial to prevention.\\n\\nMETHOD: To elucidate this question, a prospective study of aspergillus colonisation after lung transplantation, along with a mycological survey of the patient environment, was performed.\\n\\nRESULTS: Forty-four consecutive patients were included from the day of lung transplantation and then examined weekly for aspergillus colonisation until hospital discharge. Environmental fungal contamination of each patient was followed weekly via air and surface sampling. Twelve patients (27%) had transient aspergillus colonisation, occurring 1-13 weeks after lung transplantation, without associated manifestation of aspergillosis. Responsible Aspergillus species were A. fumigatus (6), A. niger (3), A. sydowii (1), A. calidoustus (1) and Aspergillus sp. (1). In the environment, contamination by Penicillium and Aspergillus was predominant. Multivariate analysis showed a significant association between occurrence of aspergillus colonisation and fungal contamination of the patient's room, either by Aspergillus spp. in the air or by A.fumigatus on the floor. Related clinical and environmental isolates were genotyped in 9 cases of aspergillus colonisation. For A. fumigatus (4 cases), two identical microsatellite profiles were found between clinical and environmental isolates collected on distant dates or locations. For other Aspergillus species, isolates were different in 2 cases; in 3 cases of aspergillus colonisation by A. sydowii, A. niger and A. calidoustus, similarity between clinical and environmental internal transcribed spacer and tubulin sequences was >99%.\\n\\nCONCLUSION: Taken together, these results support the hypothesis of environmental risk of hospital acquisition of aspergillus colonisation in lung transplant recipients.", "link"=>"http://www.mendeley.com/research/relationship-between-fungal-colonisation-respiratory-tract-lung-transplant-recipients-fungal-contami", "reader_count"=>22, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>2, "Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>4, "Social Sciences"=>1, "Immunology and Microbiology"=>1, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"France"=>1, "Spain"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2596718"], "description"=>"<p>All values are n (%), unless indicated</p><p>Abbreviations: SD, standard deviation; Idiop. pulm. Fibrosis, idiopathic pulmonary fibrosis; COPD, chronic obstructive pulmonary disease, CMV, cytomegalovirus; Ab, antibody</p><p>Eight patients (18%) died during their post-operative hospital stay, but none from fungal infection. Non-colonised patients had a higher mortality than colonised patients (p = 0,06).</p><p>No patient developed invasive aspergillosis during the study period. Twelve patients (27%) had transient AC (certain: 2, probable: 10), without associated manifestation of aspergillosis. All colonised patients had single species colonisation. Their clinical and biological characteristics are presented in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0144044#pone.0144044.t002\" target=\"_blank\">Table 2</a>. AC occurred 1 to 13 weeks after transplant (median, 5 weeks); it lasted from 1 to 2 weeks. AC occurred in the SICU and LTU in 4 and 8 cases, respectively.</p><p>Patient characteristics.</p>", "links"=>[], "tags"=>["lung transplant recipients", "aspergillus colonisation", "Hospital Environment BackgroundAspergillus colonisation", "Responsible Aspergillus species", "lung transplantation"], "article_id"=>1616011, "categories"=>["Biological Sciences"], "users"=>["Christine Bonnal", "Christopher Leleu", "Olivier Brugière", "Christian Chochillon", "Raphael Porcher", "Pierre-Yves Boëlle", "Jean Menotti", "Sandrine Houze", "Jean-Christophe Lucet", "Francis Derouin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144044.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_characteristics_/1616011", "title"=>"Patient characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-12-02 02:46:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/2596719"], "description"=>"<p>*Duration expressed in weeks</p><p>Abbreviations: COPD, chronic obstructive pulmonary disease; LTU, lung transplant unit; SICU, surgical intensive care unit</p><p>Characteristics of 12 patients with <i>Aspergillus</i> spp. colonisation after transplantation.</p>", "links"=>[], "tags"=>["lung transplant recipients", "aspergillus colonisation", "Hospital Environment BackgroundAspergillus colonisation", "Responsible Aspergillus species", "lung transplantation"], "article_id"=>1616012, "categories"=>["Biological Sciences"], "users"=>["Christine Bonnal", "Christopher Leleu", "Olivier Brugière", "Christian Chochillon", "Raphael Porcher", "Pierre-Yves Boëlle", "Jean Menotti", "Sandrine Houze", "Jean-Christophe Lucet", "Francis Derouin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144044.t002", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_12_patients_with_Aspergillus_spp_colonisation_after_transplantation_/1616012", "title"=>"Characteristics of 12 patients with <i>Aspergillus</i> spp. colonisation after transplantation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-12-02 02:46:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/2596720"], "description"=>"<p>Results are expressed in number of single nucleotide polymorphisms (or deletion when indicated), compared with the sequence of the clinical isolate</p><p>*Deletion of one nucleotide; D: sequence with more than three single nucleotide polymorphisms; ND: not determined</p><p>Comparison of ITS, beta-tubulin and actin sequences of clinical isolates of <i>Aspergillus</i> and isolates of the same species collected from the environment.</p>", "links"=>[], "tags"=>["lung transplant recipients", "aspergillus colonisation", "Hospital Environment BackgroundAspergillus colonisation", "Responsible Aspergillus species", "lung transplantation"], "article_id"=>1616013, "categories"=>["Biological Sciences"], "users"=>["Christine Bonnal", "Christopher Leleu", "Olivier Brugière", "Christian Chochillon", "Raphael Porcher", "Pierre-Yves Boëlle", "Jean Menotti", "Sandrine Houze", "Jean-Christophe Lucet", "Francis Derouin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144044.t003", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_ITS_beta_tubulin_and_actin_sequences_of_clinical_isolates_of_Aspergillus_and_isolates_of_the_same_species_collected_from_the_environment_/1616013", "title"=>"Comparison of ITS, beta-tubulin and actin sequences of clinical isolates of <i>Aspergillus</i> and isolates of the same species collected from the environment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-12-02 02:46:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/2596721"], "description"=>"<p>Univariate and multivariate analysis of relationships between fungal contamination and <i>Aspergillus</i> colonisation (Cox proportional hazards model).</p>", "links"=>[], "tags"=>["lung transplant recipients", "aspergillus colonisation", "Hospital Environment BackgroundAspergillus colonisation", "Responsible Aspergillus species", "lung transplantation"], "article_id"=>1616014, "categories"=>["Biological Sciences"], "users"=>["Christine Bonnal", "Christopher Leleu", "Olivier Brugière", "Christian Chochillon", "Raphael Porcher", "Pierre-Yves Boëlle", "Jean Menotti", "Sandrine Houze", "Jean-Christophe Lucet", "Francis Derouin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144044.t004", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_and_multivariate_analysis_of_relationships_between_fungal_contamination_and_Aspergillus_colonisation_Cox_proportional_hazards_model_/1616014", "title"=>"Univariate and multivariate analysis of relationships between fungal contamination and <i>Aspergillus</i> colonisation (Cox proportional hazards model).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-12-02 02:46:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/2596722", "https://ndownloader.figshare.com/files/2596723", "https://ndownloader.figshare.com/files/2596724"], "description"=>"<div><p>Background</p><p>Aspergillus colonisation is frequently reported after lung transplantation. The question of whether aspergillus colonisation is related to the hospital environment is crucial to prevention.</p><p>Method</p><p>To elucidate this question, a prospective study of aspergillus colonisation after lung transplantation, along with a mycological survey of the patient environment, was performed.</p><p>Results</p><p>Forty-four consecutive patients were included from the day of lung transplantation and then examined weekly for aspergillus colonisation until hospital discharge. Environmental fungal contamination of each patient was followed weekly via air and surface sampling. Twelve patients (27%) had transient aspergillus colonisation, occurring 1–13 weeks after lung transplantation, without associated manifestation of aspergillosis. Responsible <i>Aspergillus</i> species were <i>A</i>. <i>fumigatus</i> (6), <i>A</i>. <i>niger</i> (3), <i>A</i>. <i>sydowii</i> (1), <i>A</i>. <i>calidoustus</i> (1) and <i>Aspergillus sp</i>. (1). In the environment, contamination by <i>Penicillium</i> and <i>Aspergillus</i> was predominant. Multivariate analysis showed a significant association between occurrence of aspergillus colonisation and fungal contamination of the patient’s room, either by <i>Aspergillus</i> spp. in the air or by <i>A</i>.<i>fumigatus</i> on the floor. Related clinical and environmental isolates were genotyped in 9 cases of aspergillus colonisation. For <i>A</i>. <i>fumigatus</i> (4 cases), two identical microsatellite profiles were found between clinical and environmental isolates collected on distant dates or locations. For other <i>Aspergillus</i> species, isolates were different in 2 cases; in 3 cases of aspergillus colonisation by <i>A</i>. <i>sydowii</i>, <i>A</i>. <i>niger</i> and <i>A</i>. <i>calidoustus</i>, similarity between clinical and environmental internal transcribed spacer and tubulin sequences was >99%.</p><p>Conclusion</p><p>Taken together, these results support the hypothesis of environmental risk of hospital acquisition of aspergillus colonisation in lung transplant recipients.</p></div>", "links"=>[], "tags"=>["lung transplant recipients", "aspergillus colonisation", "Hospital Environment BackgroundAspergillus colonisation", "Responsible Aspergillus species", "lung transplantation"], "article_id"=>1616015, "categories"=>["Biological Sciences"], "users"=>["Christine Bonnal", "Christopher Leleu", "Olivier Brugière", "Christian Chochillon", "Raphael Porcher", "Pierre-Yves Boëlle", "Jean Menotti", "Sandrine Houze", "Jean-Christophe Lucet", "Francis Derouin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0144044.s001", "https://dx.doi.org/10.1371/journal.pone.0144044.s002", "https://dx.doi.org/10.1371/journal.pone.0144044.s003"], "stats"=>{"downloads"=>5, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_Fungal_Colonisation_of_the_Respiratory_Tract_in_Lung_Transplant_Recipients_and_Fungal_Contamination_of_the_Hospital_Environment_/1616015", "title"=>"Relationship between Fungal Colonisation of the Respiratory Tract in Lung Transplant Recipients and Fungal Contamination of the Hospital Environment", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-12-02 02:46:45"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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