Epigenetic DNA Methylation Linked to Social Dominance
Publication Date
December 30, 2015
Journal
PLOS ONE
Authors
Kapa Lenkov, Mi H. Lee, Olga D. Lenkov, Andrew Swafford, et al
Volume
10
Issue
12
Pages
e0144750
DOI
https://dx.plos.org/10.1371/journal.pone.0144750
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0144750
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26717574
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696829
Europe PMC
http://europepmc.org/abstract/MED/26717574
Web of Science
000367510500014
Scopus
84957564162
Mendeley
http://www.mendeley.com/research/epigenetic-dna-methylation-linked-social-dominance
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2616258"], "description"=>"<p>(A) Animals that had never been socially dominant were divided into three groups of size matched pairs. (B) In control animals, both members of the pair received vehicle injections (N = 10 pairs), in experimental animals, in one group (left) one member of the group received L-methionine (N = 12) and the other received vehicle control (N = 12), while in the other group (right), one member of the pair received zebularine, (N = 11) and the other received vehicle control (N = 11). (C) Animals injected with L-methionine were significantly more likely to become socially dominant, while those injected with zebularine were significantly more likely to remain non-dominant.</p>", "links"=>[], "tags"=>["rank", "dna methylation", "Epigenetic DNA Methylation", "African cichlid fish", "DNA methylation state", "Injecting DNA methylating", "Social Dominance Social status hierarchies"], "article_id"=>1629852, "categories"=>["Uncategorised"], "users"=>["Kapa Lenkov", "Mi H. Lee", "Olga D. Lenkov", "Andrew Swafford", "Russell D. Fernald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144750.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Epigenetic_DNA_Methylation_Linked_to_Social_Dominance_Fig_1_/1629852", "title"=>"Epigenetic DNA Methylation Linked to Social Dominance - Fig 1", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:53:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/2616259"], "description"=>"<p>(A) Paired L-methionine (blue line) and vehicle-injected (gray dashed line) animals (2N = 24). There is a significant difference between methionine-injected and control-injected animals F(1,110) = 59.28, p = 6.37 x 10<sup>−12</sup>. There was no significant difference in behavior between individual observation days (F(4,110) = 2.32, p = 0.062) or significant interaction between injection treatment and individual days (F(4,110) = 1.52, p = 0.20). (B) Paired zebularine (red line) and vehicle injected (gray dashed line) animals (2N = 22). There was a significant difference between zebularine-injected and control-injected animals F(1,100) = 29.60, p = 3.79 x 10<sup>−7</sup>. There was no significant difference in behavior between individual days (F(4,100) = 1.76, p = 0.14), or significant interaction between injection treatment and individual days (F(4,100) = 0.70, p = 0.59).</p>", "links"=>[], "tags"=>["rank", "dna methylation", "Epigenetic DNA Methylation", "African cichlid fish", "DNA methylation state", "Injecting DNA methylating", "Social Dominance Social status hierarchies"], "article_id"=>1629853, "categories"=>["Uncategorised"], "users"=>["Kapa Lenkov", "Mi H. Lee", "Olga D. Lenkov", "Andrew Swafford", "Russell D. Fernald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144750.g002", "stats"=>{"downloads"=>2, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_number_of_territorial_acts_with_non_territorial_behavioral_acts_subtracted_per_5_min_of_dominant_upper_line_in_each_graph_and_non_dominant_animals_lower_line_in_each_graph_/1629853", "title"=>"Average number of territorial acts with non-territorial behavioral acts subtracted (per 5 min) of dominant (upper line in each graph) and non-dominant animals (lower line in each graph).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:53:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/2616260"], "description"=>"<p><b>A</b>. Methylation was assayed in two locations on the <i>GnRH1</i> gene; in the promoter region within the binding site of <i>egr1</i> (3 CpG sites indicated by single vertical bars within the green rectangle) and in the coding region in the sequence of the signal peptide (2 CpG sites indicated by single bars within the yellow rectangle). <b>B</b>. Average methylation levels in <i>GnRH1</i> genomic regions of zebularine-injected ND males that show significantly higher average methylation levels than control-injected ND males in the <i>egr-1</i> binding site located in promoter region of <i>GnRH1</i>. (*q-value < 0.05; n = 3–4 per group). <b>C</b>. Average methylation levels in <i>GnRH1</i> genomic regions of methionine-injected ND males are not significantly different from those of control injected animals (q-value > 0.05 for all groups; n = 3–8 per group). Statistical significance for each of these regions was calculated by determining combined Fisher’s p values and then calculating q values estimating the multiple-testing-corrected false discovery rate (see Methods in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0144750#pone.0144750.s001\" target=\"_blank\">S1 File</a> for complete description). Error bars represent s.e.m.</p>", "links"=>[], "tags"=>["rank", "dna methylation", "Epigenetic DNA Methylation", "African cichlid fish", "DNA methylation state", "Injecting DNA methylating", "Social Dominance Social status hierarchies"], "article_id"=>1629854, "categories"=>["Uncategorised"], "users"=>["Kapa Lenkov", "Mi H. Lee", "Olga D. Lenkov", "Andrew Swafford", "Russell D. Fernald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144750.g003", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_methylation_at_CpG_sites_within_functional_genomic_regions_of_GnRH1_in_the_pre_optic_area_POA_in_zebularine_injected_L_methionine_injected_and_control_injected_dominant_D_and_non_dominant_ND_males_5_days_after_initial_injection_/1629854", "title"=>"Differential methylation at CpG sites within functional genomic regions of <i>GnRH1</i> in the pre-optic area (POA) in zebularine-injected, L-methionine-injected and control-injected dominant (D) and non-dominant (ND) males 5 days after initial injection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:53:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/2616261"], "description"=>"<div><p>Social status hierarchies are ubiquitous in vertebrate social systems, including humans. It is well known that social rank can influence quality of life dramatically among members of social groups. For example, high-ranking individuals have greater access to resources, including food and mating prerogatives that, in turn, have a positive impact on their reproductive success and health. In contrast low ranking individuals typically have limited reproductive success and may experience lasting social and physiological costs. Ultimately, social rank and behavior are regulated by changes in gene expression. However, little is known about mechanisms that transduce social cues into transcriptional changes. Since social behavior is a dynamic process, we hypothesized that a molecular mechanism such as DNA methylation might play a role these changes. To test this hypothesis, we used an African cichlid fish, <i>Astatotilapia burtoni</i>, in which social rank dictates reproductive access. We show that manipulating global DNA methylation state strongly biases the outcomes of social encounters. Injecting DNA methylating and de-methylating agents in low status animals competing for status, we found that animals with chemically increased methylation states were statistically highly likely to ascend in rank. In contrast, those with inhibited methylation processes and thus lower methylation levels were statistically highly unlikely to ascend in rank. This suggests that among its many roles, DNA methylation may be linked to social status and more generally to social behavior.</p></div>", "links"=>[], "tags"=>["rank", "dna methylation", "Epigenetic DNA Methylation", "African cichlid fish", "DNA methylation state", "Injecting DNA methylating", "Social Dominance Social status hierarchies"], "article_id"=>1629855, "categories"=>["Uncategorised"], "users"=>["Kapa Lenkov", "Mi H. Lee", "Olga D. Lenkov", "Andrew Swafford", "Russell D. Fernald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0144750", "stats"=>{"downloads"=>6, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Epigenetic_DNA_Methylation_Linked_to_Social_Dominance_/1629855", "title"=>"Epigenetic DNA Methylation Linked to Social Dominance", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-01-05 14:53:34"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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