Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice
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{"title"=>"Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Radhika V.", "last_name"=>"Seimon", "scopus_author_id"=>"26633325500"}, {"first_name"=>"Yan Chuan", "last_name"=>"Shi", "scopus_author_id"=>"35325529100"}, {"first_name"=>"Katy", "last_name"=>"Slack", "scopus_author_id"=>"12766503400"}, {"first_name"=>"Kailun", "last_name"=>"Lee", "scopus_author_id"=>"56879586400"}, {"first_name"=>"Hamish A.", "last_name"=>"Fernando", "scopus_author_id"=>"55774473500"}, {"first_name"=>"Amy D.", "last_name"=>"Nguyen", "scopus_author_id"=>"35325061300"}, {"first_name"=>"Lei", "last_name"=>"Zhang", "scopus_author_id"=>"56127244500"}, {"first_name"=>"Shu", "last_name"=>"Lin", "scopus_author_id"=>"35748789600"}, {"first_name"=>"Ronaldo F.", "last_name"=>"Enriquez", "scopus_author_id"=>"7004774977"}, {"first_name"=>"Jackie", "last_name"=>"Lau", "scopus_author_id"=>"54407111400"}, {"first_name"=>"Herbert", "last_name"=>"Herzog", "scopus_author_id"=>"55584141200"}, {"first_name"=>"Amanda", "last_name"=>"Sainsbury", "scopus_author_id"=>"57192420799"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0145157", "sgr"=>"84958214683", "scopus"=>"2-s2.0-84958214683", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"26784324", "pui"=>"608240624"}, "id"=>"2b82ab1c-700b-391a-b9f2-51ab1bf3dd64", "abstract"=>"BACKGROUND: Intermittent severe energy restriction is popular for weight management. To investigate whether intermittent moderate energy restriction may improve this approach by enhancing weight loss efficiency, we conducted a study in mice, where energy intake can be controlled.\\n\\nMETHODS: Male C57/Bl6 mice that had been rendered obese by an ad libitum diet high in fat and sugar for 22 weeks were then fed one of two energy-restricted normal chow diets for a 12-week weight loss phase. The continuous diet (CD) provided 82% of the energy intake of age-matched ad libitum chow-fed controls. The intermittent diet (ID) provided cycles of 82% of control intake for 5-6 consecutive days, and ad libitum intake for 1-3 days. Weight loss efficiency during this phase was calculated as (total weight change) ÷ [(total energy intake of mice on CD or ID)-(total average energy intake of controls)]. Subsets of mice then underwent a 3-week weight regain phase involving ad libitum re-feeding.\\n\\nRESULTS: Mice on the ID showed transient hyperphagia relative to controls during each 1-3-day ad libitum feeding period, and overall ate significantly more than CD mice (91.1±1.0 versus 82.2±0.5% of control intake respectively, n = 10, P<0.05). There were no significant differences between CD and ID groups at the end of the weight loss or weight regain phases with respect to body weight, fat mass, circulating glucose or insulin concentrations, or the insulin resistance index. Weight loss efficiency was significantly greater with ID than with CD (0.042±0.007 versus 0.018±0.001 g/kJ, n = 10, P<0.01). Mice on the CD exhibited significantly greater hypothalamic mRNA expression of proopiomelanocortin (POMC) relative to ID and control mice, with no differences in neuropeptide Y or agouti-related peptide mRNA expression between energy-restricted groups.\\n\\nCONCLUSION: Intermittent moderate energy restriction may offer an advantage over continuous moderate energy restriction, because it induces significantly greater weight loss relative to energy deficit in mice.", "link"=>"http://www.mendeley.com/research/intermittent-moderate-energy-restriction-improves-weight-loss-efficiency-dietinduced-obese-mice", "reader_count"=>60, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Researcher"=>8, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>6, "Other"=>3, "Student > Master"=>8, "Student > Bachelor"=>14, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Researcher"=>8, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>6, "Other"=>3, "Student > Master"=>8, "Student > Bachelor"=>14, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>8, "Nursing and Health Professions"=>5, "Materials Science"=>1, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>18, "Neuroscience"=>1, "Sports and Recreations"=>3, "Psychology"=>3}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>18}, "Neuroscience"=>{"Neuroscience"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>3}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>7}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Sweden"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2630012"], "description"=>"<p>CAC, continuous <i>ad libitum</i> chow; CAF, continuous <i>ad libitum</i> high fat; CD, continuous diet; ID, intermittent diet.</p>", "links"=>[], "tags"=>["Weight loss", "energy restriction", "Weight Loss Efficiency", "ad libitum diet", "energy intake", "pomc", "ad libitum intake", "control intake", "insulin resistance index", "phase", "id"], "article_id"=>1639377, "categories"=>["Biological Sciences"], "users"=>["Radhika V. Seimon", "Yan-Chuan Shi", "Katy Slack", "Kailun Lee", "Hamish A. Fernando", "Amy D. Nguyen", "Lei Zhang", "Shu Lin", "Ronaldo F. Enriquez", "Jackie Lau", "Herbert Herzog", "Amanda Sainsbury"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145157.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_flow_chart_/1639377", "title"=>"Study flow chart.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-28 12:38:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/2630013"], "description"=>"<p>CAC, continuous <i>ad libitum</i> chow; CAF, continuous <i>ad libitum</i> high fat diet; CD, continuous diet; ID, intermittent diet. Data are means ± SEM of 3–10 mice per group as shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145157#pone.0145157.g001\" target=\"_blank\">Fig 1</a>.</p>", "links"=>[], "tags"=>["Weight loss", "energy restriction", "Weight Loss Efficiency", "ad libitum diet", "energy intake", "pomc", "ad libitum intake", "control intake", "insulin resistance index", "phase", "id"], "article_id"=>1639378, "categories"=>["Biological Sciences"], "users"=>["Radhika V. Seimon", "Yan-Chuan Shi", "Katy Slack", "Kailun Lee", "Hamish A. Fernando", "Amy D. Nguyen", "Lei Zhang", "Shu Lin", "Ronaldo F. Enriquez", "Jackie Lau", "Herbert Herzog", "Amanda Sainsbury"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145157.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Energy_intake_A_and_body_weight_B_during_the_weight_gain_loss_and_regain_phases_/1639378", "title"=>"Energy intake (A) and body weight (B) during the weight gain, loss and regain phases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-28 12:38:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/2630015"], "description"=>"<p>(A) Fat mass (g), (B) fat mass (% of body weight) and (C) lean mass (g) at the end of the weight loss and weight regain phases. CAC, continuous <i>ad libitum</i> chow; CAF, continuous <i>ad libitum</i> high fat diet; CD, continuous diet; ID, intermittent diet. Data are means ± SEM of 3–10 mice per group as shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145157#pone.0145157.g001\" target=\"_blank\">Fig 1</a>. * P<0.05, ** P<0.01, *** P<0.001 versus CAC. §§ P<0.01, §§§ P<0.001 versus CAF.</p>", "links"=>[], "tags"=>["Weight loss", "energy restriction", "Weight Loss Efficiency", "ad libitum diet", "energy intake", "pomc", "ad libitum intake", "control intake", "insulin resistance index", "phase", "id"], "article_id"=>1639380, "categories"=>["Biological Sciences"], "users"=>["Radhika V. Seimon", "Yan-Chuan Shi", "Katy Slack", "Kailun Lee", "Hamish A. Fernando", "Amy D. Nguyen", "Lei Zhang", "Shu Lin", "Ronaldo F. Enriquez", "Jackie Lau", "Herbert Herzog", "Amanda Sainsbury"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145157.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_composition_as_determined_by_dual_energy_X_ray_absorptiometry_/1639380", "title"=>"Body composition as determined by dual energy X-ray absorptiometry.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-28 12:38:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/2630016"], "description"=>"<p>White adipose tissue (WAT) and brown adipose tissue (BAT) depot masses are presented in absolute weights (g) and as a percent of body weight (%) at the end of the weight loss (A and B) and weight regain (C and D) phases. CAC, continuous <i>ad libitum</i> chow; CAF, continuous <i>ad libitum</i> high fat diet; CD, continuous diet; ID, intermittent diet; WATi, inguinal WAT; WATe, epididymal WAT; WATr, retroperitoneal WAT; WATm, mesenteric WAT; WATt, sum of the above 4 WAT depot masses. Data are means ± SEM of 3–10 mice per group as shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145157#pone.0145157.g001\" target=\"_blank\">Fig 1</a>. * P<0.05, ** P<0.01, *** P<0.001 versus CAC. §§§ P<0.001 versus CAF.</p>", "links"=>[], "tags"=>["Weight loss", "energy restriction", "Weight Loss Efficiency", "ad libitum diet", "energy intake", "pomc", "ad libitum intake", "control intake", "insulin resistance index", "phase", "id"], "article_id"=>1639381, "categories"=>["Biological Sciences"], "users"=>["Radhika V. Seimon", "Yan-Chuan Shi", "Katy Slack", "Kailun Lee", "Hamish A. Fernando", "Amy D. Nguyen", "Lei Zhang", "Shu Lin", "Ronaldo F. Enriquez", "Jackie Lau", "Herbert Herzog", "Amanda Sainsbury"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145157.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_composition_as_determined_by_adipose_tissue_dissection_/1639381", "title"=>"Body composition as determined by adipose tissue dissection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-28 12:38:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/2630017"], "description"=>"<p>Whole hypothalamic blocks were used for the determination of (A) neuropeptide Y (NPY), (B) agouti related peptide (AgRP) and (C) proopiomelanocortin (POMC) mRNA expression levels by quantitative PCR. Values are expressed as fold-change in expression relative to that of the housekeeping gene, ribosomal protein L19 and as a percentage of CAC mice (open bars). CAC, continuous <i>ad libitum</i> chow; CAF, continuous <i>ad libitum</i> high fat diet; CD, continuous diet; ID, intermittent diet. Data are means ± SEM of 4 mice per group. * P<0.05, ** P<0.01 versus CAC. § P<0.05 versus CAF.</p>", "links"=>[], "tags"=>["Weight loss", "energy restriction", "Weight Loss Efficiency", "ad libitum diet", "energy intake", "pomc", "ad libitum intake", "control intake", "insulin resistance index", "phase", "id"], "article_id"=>1639382, "categories"=>["Biological Sciences"], "users"=>["Radhika V. Seimon", "Yan-Chuan Shi", "Katy Slack", "Kailun Lee", "Hamish A. Fernando", "Amy D. Nguyen", "Lei Zhang", "Shu Lin", "Ronaldo F. Enriquez", "Jackie Lau", "Herbert Herzog", "Amanda Sainsbury"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145157.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hypothalamic_expression_of_regulators_of_energy_balance_at_the_end_of_the_weight_loss_phase_/1639382", "title"=>"Hypothalamic expression of regulators of energy balance at the end of the weight loss phase.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-28 12:38:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/2630019"], "description"=>"<div><p>Background</p><p>Intermittent severe energy restriction is popular for weight management. To investigate whether intermittent moderate energy restriction may improve this approach by enhancing weight loss efficiency, we conducted a study in mice, where energy intake can be controlled.</p><p>Methods</p><p>Male C57/Bl6 mice that had been rendered obese by an <i>ad libitum</i> diet high in fat and sugar for 22 weeks were then fed one of two energy-restricted normal chow diets for a 12-week weight loss phase. The continuous diet (CD) provided 82% of the energy intake of age-matched <i>ad libitum</i> chow-fed controls. The intermittent diet (ID) provided cycles of 82% of control intake for 5–6 consecutive days, and <i>ad libitum</i> intake for 1–3 days. Weight loss efficiency during this phase was calculated as (total weight change) ÷ [(total energy intake of mice on CD or ID)–(total average energy intake of controls)]. Subsets of mice then underwent a 3-week weight regain phase involving <i>ad libitum</i> re-feeding.</p><p>Results</p><p>Mice on the ID showed transient hyperphagia relative to controls during each 1–3-day <i>ad libitum</i> feeding period, and overall ate significantly more than CD mice (91.1±1.0 versus 82.2±0.5% of control intake respectively, <i>n</i> = 10, P<0.05). There were no significant differences between CD and ID groups at the end of the weight loss or weight regain phases with respect to body weight, fat mass, circulating glucose or insulin concentrations, or the insulin resistance index. Weight loss efficiency was significantly greater with ID than with CD (0.042±0.007 versus 0.018±0.001 g/kJ, <i>n</i> = 10, P<0.01). Mice on the CD exhibited significantly greater hypothalamic mRNA expression of proopiomelanocortin (POMC) relative to ID and control mice, with no differences in neuropeptide Y or agouti-related peptide mRNA expression between energy-restricted groups.</p><p>Conclusion</p><p>Intermittent moderate energy restriction may offer an advantage over continuous moderate energy restriction, because it induces significantly greater weight loss relative to energy deficit in mice.</p></div>", "links"=>[], "tags"=>["Weight loss", "energy restriction", "Weight Loss Efficiency", "ad libitum diet", "energy intake", "pomc", "ad libitum intake", "control intake", "insulin resistance index", "phase", "id"], "article_id"=>1639384, "categories"=>["Biological Sciences"], "users"=>["Radhika V. Seimon", "Yan-Chuan Shi", "Katy Slack", "Kailun Lee", "Hamish A. Fernando", "Amy D. Nguyen", "Lei Zhang", "Shu Lin", "Ronaldo F. Enriquez", "Jackie Lau", "Herbert Herzog", "Amanda Sainsbury"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145157", "stats"=>{"downloads"=>2, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intermittent_Moderate_Energy_Restriction_Improves_Weight_Loss_Efficiency_in_Diet_Induced_Obese_Mice_/1639384", "title"=>"Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-01-28 12:38:09"}

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{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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