Potential of Diffusion Tensor Imaging and Relaxometry for the Detection of Specific Pathological Alterations in Parkinson's Disease (PD)
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{"title"=>"Potential of diffusion tensor imaging and relaxometry for the detection of specific pathological alterations in Parkinson's Disease (PD)", "type"=>"journal", "authors"=>[{"first_name"=>"Regina", "last_name"=>"Esterhammer", "scopus_author_id"=>"6507780113"}, {"first_name"=>"Klaus", "last_name"=>"Seppi", "scopus_author_id"=>"7004725975"}, {"first_name"=>"Eva", "last_name"=>"Reiter", "scopus_author_id"=>"56200008600"}, {"first_name"=>"Bernadette", "last_name"=>"Pinter", "scopus_author_id"=>"55868796600"}, {"first_name"=>"Christoph", "last_name"=>"Mueller", "scopus_author_id"=>"16689898100"}, {"first_name"=>"Christian", "last_name"=>"Kremser", "scopus_author_id"=>"7003338106"}, {"first_name"=>"Tanja", "last_name"=>"Zitzelsberger", "scopus_author_id"=>"57034269600"}, {"first_name"=>"Michael", "last_name"=>"Nocker", "scopus_author_id"=>"24328558100"}, {"first_name"=>"Christoph", "last_name"=>"Scherfler", "scopus_author_id"=>"6602530679"}, {"first_name"=>"Werner", "last_name"=>"Poewe", "scopus_author_id"=>"35373337300"}, {"first_name"=>"Michael", "last_name"=>"Schocke", "scopus_author_id"=>"7003795511"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84958025663", "pmid"=>"26713760", "sgr"=>"84958025663", "doi"=>"10.1371/journal.pone.0145493", "issn"=>"19326203", "pui"=>"608080522"}, "id"=>"d452e7b8-6738-3545-b1fc-de3a81709ce9", "abstract"=>"The purpose of the present study was to evaluate the potential of multimodal MR imaging including mean diffusivity (MD), fractional anisotropy (FA), relaxation rates R2 and R2* to detect disease specific alterations in Parkinson's Disease (PD). We enrolled 82 PD patients (PD-all) with varying disease durations (<5 years: PD<5, n = 43; >5 years: PD>5, n = 39) and 38 matched healthy controls (HC), receiving diffusion tensor imaging as well as R2 and R2* relaxometry calculated from multi-echo T2*-weighted and dual-echo TSE imaging, respectively. ROIs were drawn to delineate caudate nucleus (CN), putamen (PU), globus pallidus (GP) and substantia nigra (SN) on the co-registered maps. The SN was divided in 3 descending levels (SL 1-3). The most significant parameters were used for a flexible discrimination analysis (FDA) in a training collective consisting of 25 randomized subjects from each group in order to predict the classification of remaining subjects. PD-all showed significant increases in MD, R2 and R2* within SN and its subregions as well as in MD and R2* within different basal ganglia regions. Compared to the HC group, the PD<5 and the PD>5 group showed significant MD increases within the SN and its lower two subregions, while the PD<5 group exhibited significant increases in R2 and R2* within SN and its subregions, and tended to elevation within the basal ganglia. The PD>5 group had significantly increased MD in PU and GP, whereas the PD<5 group presented normal MD within the basal ganglia. FDA achieved right classification in 84{%} of study participants. Micro-structural damage affects primarily the SN of PD patients and in later disease stages the basal ganglia. Iron contents of PU, GP and SN are increased at early disease stages of PD.", "link"=>"http://www.mendeley.com/research/potential-diffusion-tensor-imaging-relaxometry-detection-specific-pathological-alterations-parkinson", "reader_count"=>13, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>1, "Other"=>2, "Lecturer > Senior Lecturer"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>1, "Other"=>2, "Lecturer > Senior Lecturer"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2618226"], "description"=>"<p>The disease durations are marked on the upper margin of the R2* maps. The corresponding MD maps are just below the R2* maps. The high signals on the R2* maps within the basal ganglia indicate high iron concentrations and pointed out by white arrows. PD patients with longer disease durations show less signal on R2* maps compared to PD patients at early disease stage. Differences in MD can be hardly detected visually, but with the help of a ROI analysis.</p>", "links"=>[], "tags"=>["gp", "fda", "tse", "hc", "roi", "pu", "r 2", "82 PD patients", "md", "25 randomized subjects", "fa", "Diffusion tensor imaging", "cn", "sn", "sl", "disease stages", "Specific Pathological Alterations", "multimodal MR imaging", "Basal Ganglia", "basal ganglia regions"], "article_id"=>1631265, "categories"=>["Biological Sciences"], "users"=>["Regina Esterhammer", "Klaus Seppi", "Eva Reiter", "Bernadette Pinter", "Christoph Mueller", "Christian Kremser", "Tanja Zitzelsberger", "Michael Nocker", "Christoph Scherfler", "Werner Poewe", "Michael Schocke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145493.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_R2_and_the_MD_maps_of_the_basal_ganglia_indicate_relatively_high_iron_concentrations_in_patients_at_early_stages_of_Parkinson_s_disease_PD_/1631265", "title"=>"The R2* and the MD maps of the basal ganglia indicate relatively high iron concentrations in patients at early stages of Parkinson's disease (PD).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2618228"], "description"=>"<p>The white arrows point out increased signals on MD maps. With increasing disease duration the areas of elevated MD grow, which is also supported by a significant correlation.</p>", "links"=>[], "tags"=>["gp", "fda", "tse", "hc", "roi", "pu", "r 2", "82 PD patients", "md", "25 randomized subjects", "fa", "Diffusion tensor imaging", "cn", "sn", "sl", "disease stages", "Specific Pathological Alterations", "multimodal MR imaging", "Basal Ganglia", "basal ganglia regions"], "article_id"=>1631267, "categories"=>["Biological Sciences"], "users"=>["Regina Esterhammer", "Klaus Seppi", "Eva Reiter", "Bernadette Pinter", "Christoph Mueller", "Christian Kremser", "Tanja Zitzelsberger", "Michael Nocker", "Christoph Scherfler", "Werner Poewe", "Michael Schocke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145493.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_MD_maps_are_derived_from_the_substantia_nigra_of_a_representative_healthy_control_and_several_PD_patients_with_increasing_disease_duration_as_given_on_the_upper_margin_of_each_image_/1631267", "title"=>"The MD maps are derived from the substantia nigra of a representative healthy control and several PD patients with increasing disease duration as given on the upper margin of each image.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2618232"], "description"=>"<p>Images belong to the same subjects included in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145493#pone.0145493.g005\" target=\"_blank\">Fig 5</a>. The white arrows point out increased signals on R2* maps, indicating iron overload. With increasing disease duration the areas of elevated R2* become inhomogeneous.</p>", "links"=>[], "tags"=>["gp", "fda", "tse", "hc", "roi", "pu", "r 2", "82 PD patients", "md", "25 randomized subjects", "fa", "Diffusion tensor imaging", "cn", "sn", "sl", "disease stages", "Specific Pathological Alterations", "multimodal MR imaging", "Basal Ganglia", "basal ganglia regions"], "article_id"=>1631271, "categories"=>["Biological Sciences"], "users"=>["Regina Esterhammer", "Klaus Seppi", "Eva Reiter", "Bernadette Pinter", "Christoph Mueller", "Christian Kremser", "Tanja Zitzelsberger", "Michael Nocker", "Christoph Scherfler", "Werner Poewe", "Michael Schocke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145493.g006", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_R2_maps_are_derived_from_the_substantia_nigra_of_a_representative_healthy_control_and_several_PD_patients_with_increasing_disease_duration_as_given_on_the_upper_margin_of_each_image_/1631271", "title"=>"The R2* maps are derived from the substantia nigra of a representative healthy control and several PD patients with increasing disease duration as given on the upper margin of each image.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2618234"], "description"=>"<p>The FDA bases on the most significant MR parameters including MD of NC, PU, GP, SN and SL 1–3 as well as R2 of GP, SN, SL 1 and SL 2 as well as R2* of GP, SN, SL 1 SL 2 and SL 3. The misclassification error is 0.13.</p>", "links"=>[], "tags"=>["gp", "fda", "tse", "hc", "roi", "pu", "r 2", "82 PD patients", "md", "25 randomized subjects", "fa", "Diffusion tensor imaging", "cn", "sn", "sl", "disease stages", "Specific Pathological Alterations", "multimodal MR imaging", "Basal Ganglia", "basal ganglia regions"], "article_id"=>1631273, "categories"=>["Biological Sciences"], "users"=>["Regina Esterhammer", "Klaus Seppi", "Eva Reiter", "Bernadette Pinter", "Christoph Mueller", "Christian Kremser", "Tanja Zitzelsberger", "Michael Nocker", "Christoph Scherfler", "Werner Poewe", "Michael Schocke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145493.g007", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_scatter_plot_shows_the_results_of_the_flexible_discriminant_analysis_FDA_in_the_training_collective_consisting_of_25_subjects_from_each_group_1_HC_2_PD_8804_5_3_PD_gt_5_/1631273", "title"=>"The scatter plot shows the results of the flexible discriminant analysis (FDA) in the training collective consisting of 25 subjects from each group (1, HC; 2, PD≤5; 3, PD>5).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2618236"], "description"=>"<div><p>The purpose of the present study was to evaluate the potential of multimodal MR imaging including mean diffusivity (MD), fractional anisotropy (FA), relaxation rates R2 and R2* to detect disease specific alterations in Parkinson's Disease (PD). We enrolled 82 PD patients (PD-all) with varying disease durations (≤5 years: PD≤5, n = 43; >5 years: PD>5, n = 39) and 38 matched healthy controls (HC), receiving diffusion tensor imaging as well as R2 and R2* relaxometry calculated from multi-echo T2*-weighted and dual-echo TSE imaging, respectively. ROIs were drawn to delineate caudate nucleus (CN), putamen (PU), globus pallidus (GP) and substantia nigra (SN) on the co-registered maps. The SN was divided in 3 descending levels (SL 1–3). The most significant parameters were used for a flexible discrimination analysis (FDA) in a training collective consisting of 25 randomized subjects from each group in order to predict the classification of remaining subjects. PD-all showed significant increases in MD, R2 and R2* within SN and its subregions as well as in MD and R2* within different basal ganglia regions. Compared to the HC group, the PD≤5 and the PD>5 group showed significant MD increases within the SN and its lower two subregions, while the PD≤5 group exhibited significant increases in R2 and R2* within SN and its subregions, and tended to elevation within the basal ganglia. The PD>5 group had significantly increased MD in PU and GP, whereas the PD≤5 group presented normal MD within the basal ganglia. FDA achieved right classification in 84% of study participants. Micro-structural damage affects primarily the SN of PD patients and in later disease stages the basal ganglia. Iron contents of PU, GP and SN are increased at early disease stages of PD.</p></div>", "links"=>[], "tags"=>["gp", "fda", "tse", "hc", "roi", "pu", "r 2", "82 PD patients", "md", "25 randomized subjects", "fa", "Diffusion tensor imaging", "cn", "sn", "sl", "disease stages", "Specific Pathological Alterations", "multimodal MR imaging", "Basal Ganglia", "basal ganglia regions"], "article_id"=>1631275, "categories"=>["Biological Sciences"], "users"=>["Regina Esterhammer", "Klaus Seppi", "Eva Reiter", "Bernadette Pinter", "Christoph Mueller", "Christian Kremser", "Tanja Zitzelsberger", "Michael Nocker", "Christoph Scherfler", "Werner Poewe", "Michael Schocke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145493", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Potential_of_Diffusion_Tensor_Imaging_and_Relaxometry_for_the_Detection_of_Specific_Pathological_Alterations_in_Parkinson_s_Disease_PD_/1631275", "title"=>"Potential of Diffusion Tensor Imaging and Relaxometry for the Detection of Specific Pathological Alterations in Parkinson's Disease (PD)", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-01-05 14:55:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/2618211"], "description"=>"<p>In four subjects the R2* maps showed distinct signal loss near to the base of the skull as demonstrated in B.</p>", "links"=>[], "tags"=>["gp", "fda", "tse", "hc", "roi", "pu", "r 2", "82 PD patients", "md", "25 randomized subjects", "fa", "Diffusion tensor imaging", "cn", "sn", "sl", "disease stages", "Specific Pathological Alterations", "multimodal MR imaging", "Basal Ganglia", "basal ganglia regions"], "article_id"=>1631250, "categories"=>["Biological Sciences"], "users"=>["Regina Esterhammer", "Klaus Seppi", "Eva Reiter", "Bernadette Pinter", "Christoph Mueller", "Christian Kremser", "Tanja Zitzelsberger", "Michael Nocker", "Christoph Scherfler", "Werner Poewe", "Michael Schocke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145493.g001", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_sagittal_reconstructions_of_the_co_registered_maps_show_the_excellent_coherence_in_one_normal_control_A_and_in_two_PD_patients_B_and_C_/1631250", "title"=>"The sagittal reconstructions of the co-registered maps show the excellent coherence in one normal control (A) and in two PD patients (B and C).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/2618217"], "description"=>"<p>For that purpose, the maps of ADC, FA, R2 and R2* as well as the proton-density weighted images were first co-registered. The ROIs were segmented by syncing the b 1000 images, averaged for all measured directions, the FA maps and the proton-density weighted images in ImageJ. The ROIs were stored in the ROI manager and transferred to the co-registered maps. The segmented brain regions were highlighted in different colors: CN—black; PU—red; GP—green; TH—white; SN—blue; CC—cyan.</p>", "links"=>[], "tags"=>["gp", "fda", "tse", "hc", "roi", "pu", "r 2", "82 PD patients", "md", "25 randomized subjects", "fa", "Diffusion tensor imaging", "cn", "sn", "sl", "disease stages", "Specific Pathological Alterations", "multimodal MR imaging", "Basal Ganglia", "basal ganglia regions"], "article_id"=>1631256, "categories"=>["Biological Sciences"], "users"=>["Regina Esterhammer", "Klaus Seppi", "Eva Reiter", "Bernadette Pinter", "Christoph Mueller", "Christian Kremser", "Tanja Zitzelsberger", "Michael Nocker", "Christoph Scherfler", "Werner Poewe", "Michael Schocke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145493.g002", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_regions_of_interest_ROIs_were_manually_drawn_by_an_experienced_radiologist_by_using_the_b_1000_images_averaged_for_all_measured_directions_the_FA_maps_and_the_proton_density_weighted_images_/1631256", "title"=>"The regions-of-interest (ROIs) were manually drawn by an experienced radiologist by using the b 1000 images, averaged for all measured directions, the FA maps and the proton-density weighted images.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/2618221"], "description"=>"<p>The delineation of the substantia nigra was poor on the maps of mean diffusivity, given by the mean apparent diffusion coefficient (ADC) in 12 directions as well as on the maps of the relaxation rates R2 and R2*. However, the mean b 1000 images, the FA maps and the proton-density weighted images provided the best contrast for the accurate demarcation of the substantia nigra (SN), which is marked by white arrows. These three different modalities were used for the segmentation of SN.</p>", "links"=>[], "tags"=>["gp", "fda", "tse", "hc", "roi", "pu", "r 2", "82 PD patients", "md", "25 randomized subjects", "fa", "Diffusion tensor imaging", "cn", "sn", "sl", "disease stages", "Specific Pathological Alterations", "multimodal MR imaging", "Basal Ganglia", "basal ganglia regions"], "article_id"=>1631260, "categories"=>["Biological Sciences"], "users"=>["Regina Esterhammer", "Klaus Seppi", "Eva Reiter", "Bernadette Pinter", "Christoph Mueller", "Christian Kremser", "Tanja Zitzelsberger", "Michael Nocker", "Christoph Scherfler", "Werner Poewe", "Michael Schocke"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145493.g003", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_substantia_nigra_was_evaluated_on_three_levels_as_shown_here_in_a_normal_control_male_61_years_old_/1631260", "title"=>"The substantia nigra was evaluated on three levels as shown here in a normal control (male, 61 years old).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:55:04"}

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{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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