Neuropeptidergic Signaling in the American Lobster Homarus americanus: New Insights from High-Throughput Nucleotide Sequencing
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{"title"=>"Neuropeptidergic signaling in the American Lobster Homarus Americanus: New insights from high-throughput nucleotide sequencing", "type"=>"journal", "authors"=>[{"first_name"=>"Andrew E.", "last_name"=>"Christie", "scopus_author_id"=>"7103003926"}, {"first_name"=>"Megan", "last_name"=>"Chi", "scopus_author_id"=>"56545174100"}, {"first_name"=>"Tess J.", "last_name"=>"Lameyer", "scopus_author_id"=>"55214991600"}, {"first_name"=>"Micah G.", "last_name"=>"Pascual", "scopus_author_id"=>"57093185100"}, {"first_name"=>"Devlin N.", "last_name"=>"Shea", "scopus_author_id"=>"57093346500"}, {"first_name"=>"Meredith E.", "last_name"=>"Stanhope", "scopus_author_id"=>"57093487900"}, {"first_name"=>"David J.", "last_name"=>"Schulz", "scopus_author_id"=>"7201870255"}, {"first_name"=>"Patsy S.", "last_name"=>"Dickinson", "scopus_author_id"=>"7006444748"}], "year"=>2015, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"8089565212", "pmid"=>"26716450", "scopus"=>"2-s2.0-84956901834", "pui"=>"608056688", "doi"=>"10.1371/journal.pone.0145964", "sgr"=>"84956901834"}, "id"=>"ba38e5f6-34de-3056-90bc-294b4efc7aa2", "abstract"=>"Peptides are the largest and most diverse class of molecules used for neurochemical communication, playing key roles in the control of essentially all aspects of physiology and behavior. The American lobster, Homarus americanus, is a crustacean of commercial and biomedical importance; lobster growth and reproduction are under neuropeptidergic control, and portions of the lobster nervous system serve as models for understanding the general principles underlying rhythmic motor behavior (including peptidergic neuromodulation). While a number of neuropeptides have been identified from H. americanus, and the effects of some have been investigated at the cellular/systems levels, little is currently known about the molecular components of neuropeptidergic signaling in the lobster. Here, a H. americanus neural transcriptome was generated and mined for sequences encoding putative peptide precursors and receptors; 35 precursor- and 41 receptor-encoding transcripts were identified. We predicted 194 distinct neuropeptides from the deduced precursor proteins, including members of the adipokinetic hormone-corazonin-like peptide, allatostatin A, allatostatin C, bursicon, CCHamide, corazonin, crustacean cardioactive peptide, crustacean hyperglycemic hormone (CHH), CHH precursor-related peptide, diuretic hormone 31, diuretic hormone 44, eclosion hormone, FLRFamide, GSEFLamide, insulin-like peptide, intocin, leucokinin, myosuppressin, neuroparsin, neuropeptide F, orcokinin, pigment dispersing hormone, proctolin, pyrokinin, SIFamide, sulfakinin and tachykinin-related peptide families. While some of the predicted peptides are known H. americanus isoforms, most are novel identifications, more than doubling the extant lobster neuropeptidome. The deduced receptor proteins are the first descriptions of H. americanus neuropeptide receptors, and include ones for most of the peptide groups mentioned earlier, as well as those for ecdysis-triggering hormone, red pigment concentrating hormone and short neuropeptide F. Multiple receptors were identified for most peptide families. These data represent the most complete description of the molecular underpinnings of peptidergic signaling in H. americanus, and will serve as a foundation for future gene-based studies of neuropeptidergic control in the lobster.", "link"=>"http://www.mendeley.com/research/neuropeptidergic-signaling-american-lobster-homarus-americanus-new-insights-highthroughput-nucleotid", "reader_count"=>20, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>4, "Professor"=>4}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>4, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>7, "Neuroscience"=>3, "Chemistry"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2616717"], "description"=>"<p>(A) Alignment of allatostatin-C receptor (AST-CR) I and II. (B) Alignment of pigment dispersing hormone receptor (PDHR) I and II. In each panel, “*” located beneath each line of the alignment indicates residues that are identical in the two sequences, while “:” and “.” indicate highly conservative and conservative substituted (similar) amino acids, respectively, shared between the two proteins. In this figure, the rhodopsin-like G protein-coupled receptor (GPCR) seven transmembrane domains identified by InterPro in each of the two AST-CRs are highlighted in black, while the GPCR family 2 extracellular hormone receptor domain and the GPCR family 2-like seven transmembrane region identified by InterPro in the each PDHR are highlighted in red and dark blue, respectively.</p>", "links"=>[], "tags"=>["American Lobster Homarus americanus", "chh", "neuropeptide F", "americanus neuropeptide receptors", "neuropeptidergic control", "crustacean cardioactive peptide", "crustacean hyperglycemic hormone"], "article_id"=>1630201, "categories"=>["Biological Sciences"], "users"=>["Andrew E. Christie", "Megan Chi", "Tess J. Lameyer", "Micah G. Pascual", "Devlin N. Shea", "Meredith E. Stanhope", "David J. Schulz", "Patsy S. Dickinson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145964.g003", "stats"=>{"downloads"=>4, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Amino_acid_sequence_alignment_of_selected_Homarus_americanus_receptors_for_peptide_families_in_which_multiple_full_length_receptors_were_identified_/1630201", "title"=>"Amino acid sequence alignment of selected <i>Homarus americanus</i> receptors for peptide families in which multiple full-length receptors were identified.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:53:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/2616718", "https://ndownloader.figshare.com/files/2616719", "https://ndownloader.figshare.com/files/2616720", "https://ndownloader.figshare.com/files/2616721", "https://ndownloader.figshare.com/files/2616722", "https://ndownloader.figshare.com/files/2616723", "https://ndownloader.figshare.com/files/2616724", "https://ndownloader.figshare.com/files/2616725"], "description"=>"<div><p>Peptides are the largest and most diverse class of molecules used for neurochemical communication, playing key roles in the control of essentially all aspects of physiology and behavior. The American lobster, <i>Homarus americanus</i>, is a crustacean of commercial and biomedical importance; lobster growth and reproduction are under neuropeptidergic control, and portions of the lobster nervous system serve as models for understanding the general principles underlying rhythmic motor behavior (including peptidergic neuromodulation). While a number of neuropeptides have been identified from <i>H</i>. <i>americanus</i>, and the effects of some have been investigated at the cellular/systems levels, little is currently known about the molecular components of neuropeptidergic signaling in the lobster. Here, a <i>H</i>. <i>americanus</i> neural transcriptome was generated and mined for sequences encoding putative peptide precursors and receptors; 35 precursor- and 41 receptor-encoding transcripts were identified. We predicted 194 distinct neuropeptides from the deduced precursor proteins, including members of the adipokinetic hormone-corazonin-like peptide, allatostatin A, allatostatin C, bursicon, CCHamide, corazonin, crustacean cardioactive peptide, crustacean hyperglycemic hormone (CHH), CHH precursor-related peptide, diuretic hormone 31, diuretic hormone 44, eclosion hormone, FLRFamide, GSEFLamide, insulin-like peptide, intocin, leucokinin, myosuppressin, neuroparsin, neuropeptide F, orcokinin, pigment dispersing hormone, proctolin, pyrokinin, SIFamide, sulfakinin and tachykinin-related peptide families. While some of the predicted peptides are known <i>H</i>. <i>americanus</i> isoforms, most are novel identifications, more than doubling the extant lobster neuropeptidome. The deduced receptor proteins are the first descriptions of <i>H</i>. <i>americanus</i> neuropeptide receptors, and include ones for most of the peptide groups mentioned earlier, as well as those for ecdysis-triggering hormone, red pigment concentrating hormone and short neuropeptide F. Multiple receptors were identified for most peptide families. These data represent the most complete description of the molecular underpinnings of peptidergic signaling in <i>H</i>. <i>americanus</i>, and will serve as a foundation for future gene-based studies of neuropeptidergic control in the lobster.</p></div>", "links"=>[], "tags"=>["American Lobster Homarus americanus", "chh", "neuropeptide F", "americanus neuropeptide receptors", "neuropeptidergic control", "crustacean cardioactive peptide", "crustacean hyperglycemic hormone"], "article_id"=>1630202, "categories"=>["Biological Sciences"], "users"=>["Andrew E. Christie", "Megan Chi", "Tess J. Lameyer", "Micah G. Pascual", "Devlin N. Shea", "Meredith E. Stanhope", "David J. Schulz", "Patsy S. Dickinson"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0145964.s001", "https://dx.doi.org/10.1371/journal.pone.0145964.s002", "https://dx.doi.org/10.1371/journal.pone.0145964.s003", "https://dx.doi.org/10.1371/journal.pone.0145964.s004", "https://dx.doi.org/10.1371/journal.pone.0145964.s005", "https://dx.doi.org/10.1371/journal.pone.0145964.s006", "https://dx.doi.org/10.1371/journal.pone.0145964.s007", "https://dx.doi.org/10.1371/journal.pone.0145964.s008"], "stats"=>{"downloads"=>6, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Neuropeptidergic_Signaling_in_the_American_Lobster_Homarus_americanus_New_Insights_from_High_Throughput_Nucleotide_Sequencing/1630202", "title"=>"Neuropeptidergic Signaling in the American Lobster <i>Homarus americanus</i>: New Insights from High-Throughput Nucleotide Sequencing", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2016-01-05 14:53:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/2616712"], "description"=>"<p>(A) Predicted processing scheme for prepro-adipokinetic hormone-corazonin-like peptide (ACP). The structure of the mature ACP isoform is shown in red, with the structures of two mature linker/precursor-related peptides shown in blue. In this schematic, the presence of a pyroglutamic acid in the putative mature ACP isoform is indicated by “pQ”. (B) Predicted processing scheme for prepro-FLRFamide. In this schematic, the structures of nine mature FLRFamide-like peptides are shown in red, with those of nine mature linker/precursor-related peptides shown in blue. Sulfated tyrosine residues in two of the linker/precursor-related sequences are indicated by “Y<sub>(SO3H)</sub>”. The presence of a disulfide bond between the cysteine residues in another of the linker/precursor-related peptides is indicated by an inverted blue bracket.</p>", "links"=>[], "tags"=>["American Lobster Homarus americanus", "chh", "neuropeptide F", "americanus neuropeptide receptors", "neuropeptidergic control", "crustacean cardioactive peptide", "crustacean hyperglycemic hormone"], "article_id"=>1630196, "categories"=>["Biological Sciences"], "users"=>["Andrew E. Christie", "Megan Chi", "Tess J. Lameyer", "Micah G. Pascual", "Devlin N. Shea", "Meredith E. Stanhope", "David J. Schulz", "Patsy S. Dickinson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145964.g001", "stats"=>{"downloads"=>5, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_examples_of_the_in_silico_workflow_used_for_the_prediction_of_putative_mature_Homarus_americanus_peptide_structures_/1630196", "title"=>"Two examples of the <i>in silico</i> workflow used for the prediction of putative mature <i>Homarus americanus</i> peptide structures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:53:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/2616714"], "description"=>"<p>(A) Allatostatin A receptor. In this schematic, the single rhodopsin-like G protein-coupled receptor (GPCR) seven transmembrane domain identified by InterPro is highlighted in black. (B) Diuretic hormone 44 receptor I. In this schematic, the GPCR family 2 extracellular hormone receptor domain identified by InterPro is highlighted in red while the GPCR family 2-like seven transmembrane region identified by InterPro is highlighted in dark blue. (C) Insulin-like peptide receptor I. In this schematic, the two receptor L-domains are highlighted in light blue and green, the one furin-like cysteine-rich domain is highlighted in green and yellow, the two immunoglobulin-like fold domains are highlighted in pink and one protein kinase-like domain is highlighted in gray.</p>", "links"=>[], "tags"=>["American Lobster Homarus americanus", "chh", "neuropeptide F", "americanus neuropeptide receptors", "neuropeptidergic control", "crustacean cardioactive peptide", "crustacean hyperglycemic hormone"], "article_id"=>1630198, "categories"=>["Biological Sciences"], "users"=>["Andrew E. Christie", "Megan Chi", "Tess J. Lameyer", "Micah G. Pascual", "Devlin N. Shea", "Meredith E. Stanhope", "David J. Schulz", "Patsy S. Dickinson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0145964.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Three_examples_of_putative_full_length_Homarus_americanus_neuropeptide_receptor_proteins_and_the_functional_domains_identified_within_them_using_the_online_program_InterPro_/1630198", "title"=>"Three examples of putative full-length <i>Homarus americanus</i> neuropeptide receptor proteins and the functional domains identified within them using the online program InterPro.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-05 14:53:51"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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