Iron and Oxidative Stress in Parkinson’s Disease: An Observational Study of Injury Biomarkers
Publication Date
January 11, 2016
Journal
PLOS ONE
Authors
Marcio S. Medeiros, Arthur Schumacher Schuh, Andreia Machado Cardoso, Guilherme Vargas Bochi, et al
Volume
11
Issue
1
Pages
e0146129
DOI
https://dx.plos.org/10.1371/journal.pone.0146129
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0146129
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26751079
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709097
Europe PMC
http://europepmc.org/abstract/MED/26751079
Web of Science
000367888100047
Scopus
84954488860
Mendeley
http://www.mendeley.com/research/iron-oxidative-stress-parkinsons-disease-observational-study-injury-biomarkers
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Mendeley | Further Information

{"title"=>"Iron and oxidative stress in Parkinson's disease: An observational study of injury biomarkers", "type"=>"journal", "authors"=>[{"first_name"=>"Marcio S.", "last_name"=>"Medeiros", "scopus_author_id"=>"57061928200"}, {"first_name"=>"Arthur", "last_name"=>"Schumacher-Schuh", "scopus_author_id"=>"55502929400"}, {"first_name"=>"Andreia Machado", "last_name"=>"Cardoso", "scopus_author_id"=>"49862799100"}, {"first_name"=>"Guilherme Vargas", "last_name"=>"Bochi", "scopus_author_id"=>"35755432300"}, {"first_name"=>"Jucimara", "last_name"=>"Baldissarelli", "scopus_author_id"=>"39361193900"}, {"first_name"=>"Aline", "last_name"=>"Kegler", "scopus_author_id"=>"36171816900"}, {"first_name"=>"Daniel", "last_name"=>"Santana", "scopus_author_id"=>"57062214100"}, {"first_name"=>"Carolina Maria Martins Behle Soares", "last_name"=>"Chaves", "scopus_author_id"=>"57062183100"}, {"first_name"=>"Maria Rosa Chitolina", "last_name"=>"Schetinger", "scopus_author_id"=>"6701672606"}, {"first_name"=>"Rafael Noal", "last_name"=>"Moresco", "scopus_author_id"=>"7003832342"}, {"first_name"=>"Carlos R.M.", "last_name"=>"Rieder", "scopus_author_id"=>"7102036208"}, {"first_name"=>"Michele Rechia", "last_name"=>"Fighera", "scopus_author_id"=>"6507031753"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84954488860", "pmid"=>"26751079", "pui"=>"607726682", "scopus"=>"2-s2.0-84954488860", "doi"=>"10.1371/journal.pone.0146129", "issn"=>"19326203"}, "id"=>"9dc355f7-53fb-3672-acc3-32872d5facb2", "abstract"=>"Parkinson's disease (PD) is characterized by progressive motor impairment attributed to progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. In addition to an accumulation of iron, there is also an increased production of reactive oxygen/nitrogen species (ROS/RNS) and inflammatory markers. These observations suggest that iron dyshomeostasis may be playing a key role in neurodegeneration. However, the mechanisms underlying this metal-associated oxidative stress and neuronal damage have not been fully elucidated. To determine peripheral levels of iron, ferritin, and transferrin in PD patients and its possible relation with oxidative/nitrosative parameters, whilst attempting to identify a profile of peripheral biomarkers in this neurological condition. Forty PD patients and 46 controls were recruited to compare serum levels of iron, ferritin, transferrin, oxidative stress markers (superoxide dismutase (SOD), catalase (CAT), nitrosative stress marker (NOx), thiobarbituric acid reactive substances (TBARS), non-protein thiols (NPSH), advanced oxidation protein products (AOPP), ferric reducing ability of plasma (FRAP) and vitamin C) as well as inflammatory markers (NTPDases, ecto-5'-nucleotidase, adenosine deaminase (ADA), ischemic-modified albumin (IMA) and myeloperoxidase). Iron levels were lower in PD patients, whereas there was no difference in ferritin and transferrin. Oxidative stress (TBARS and AOPP) and inflammatory markers (NTPDases, IMA, and myeloperoxidase) were significantly higher in PD, while antioxidants FRAP, vitamin C, and non-protein thiols were significantly lower in PD. The enzymes SOD, CAT, and ecto-5'-nucleotidase were not different among the groups, although NOx and ADA levels were significantly higher in the controls. Our data corroborate the idea that ROS/RNS production and neuroinflammation may dysregulate iron homeostasis and collaborate to reduce the periphery levels of this ion, contributing to alterations observed in the pathophysiology of PD.", "link"=>"http://www.mendeley.com/research/iron-oxidative-stress-parkinsons-disease-observational-study-injury-biomarkers", "reader_count"=>43, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>11, "Student > Bachelor"=>12, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>11, "Student > Bachelor"=>12, "Other"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>8, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>7, "Neuroscience"=>8, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Immunology and Microbiology"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>8}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>4}

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Scopus | Further Information

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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