Hypothyroidism Side Effect in Patients Treated with Sunitinib or Sorafenib: Clinical and Structural Analyses
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{"title"=>"Hypothyroidism side effect in patients treated with sunitinib or sorafenib: Clinical and structural analyses", "type"=>"journal", "authors"=>[{"first_name"=>"Mao", "last_name"=>"Shu", "scopus_author_id"=>"23470576000"}, {"first_name"=>"Xiaoli", "last_name"=>"Zai", "scopus_author_id"=>"56979188200"}, {"first_name"=>"Beina", "last_name"=>"Zhang", "scopus_author_id"=>"57116738500"}, {"first_name"=>"Rui", "last_name"=>"Wang", "scopus_author_id"=>"56822377400"}, {"first_name"=>"Zhihua", "last_name"=>"Lin", "scopus_author_id"=>"7404229537"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84958214033", "sgr"=>"84958214033", "doi"=>"10.1371/journal.pone.0147048", "pui"=>"608240445", "pmid"=>"26784451", "issn"=>"19326203"}, "id"=>"c31e4950-5a4f-3529-be77-6b0d6899ea7d", "abstract"=>"Tyrosine kinase inhibitors (TKIs) provide more effective targeted treatments for cancer, but are subject to a variety of adverse effects, such as hypothyroidism. TKI-induced hypothyroidism is a highly complicated issue, because of not only the unrealized toxicological mechanisms, but also different incidences of individual TKI drugs. While sunitinib is suspected for causing thyroid dysfunction more often than other TKIs, sorafenib is believed to be less risky. Here we integrated clinical data and in silico drug-protein interactions to examine the pharmacological distinction between sunitinib and sorafenib. Statistical analysis on the FDA Adverse Event Reporting System (FAERS) confirmed that sunitinib is more concurrent with hypothyroidism than sorafenib, which was observed in both female and male patients. Then, we used docking method and identified 3 proteins specifically binding to sunitinib but not sorafenib, i.e., retinoid X receptor alpha, retinoic acid receptors beta and gamma. As potential off-targets of sunitinib, these proteins are well known to assemble with thyroid hormone receptors, which can explain the profound impact of sunitinib on thyroid function. Taken together, we established a strategy of integrated analysis on clinical records and drug off-targets, which can be applied to explore the molecular basis of various adverse drug reactions. ", "link"=>"http://www.mendeley.com/research/hypothyroidism-side-effect-patients-treated-sunitinib-sorafenib-clinical-structural-analyses", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>6, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2629654"], "description"=>"<p>(A) The rationale of the comparison between sunitinib and sorafenib. Simulated binding affinity is measured by docking scores. We pay particular attention to those targets (as indicated by the arrow) showing much higher affinity with sunitinib than with sorafenib. (B) The comparability between sunitinib and sorafenib is verified by their positively correlated Z’-score vectors. (C) The whole molecule of sunitinib binds deep into the pockets of retinoic acid receptors (RXRA has two structure models in Protein Data Bank for docking, while RARB and RARG have one). In contrast, the sorafenib molecule is less well accommodated in the pockets due to steric hindrance in different directions. As suggested by docking scores, the binding strengths of sunitinib towards retinoic acid receptors tend to be higher than those of sorafenib. The figures are produced by DRAR-CPI server.</p>", "links"=>[], "tags"=>["Hypothyroidism Side Effect", "Patients Treated", "drug reactions", "3 proteins", "toxicological mechanisms", "sunitinib", "hypothyroidism", "statistical analysis", "thyroid function", "retinoic acid receptors beta", "sorafenib", "TKI drugs", "thyroid dysfunction", "thyroid hormone receptors", "Structural Analyses Tyrosine kinase inhibitors", "docking method", "FAERS", "fda", "Event Reporting System"], "article_id"=>1639129, "categories"=>["Biological Sciences"], "users"=>["Mao Shu", "Xiaoli Zai", "Beina Zhang", "Rui Wang", "Zhihua Lin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0147048.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Structural_comparison_of_sunitinib_and_sorafenib_towards_potential_off_targets_/1639129", "title"=>"Structural comparison of sunitinib and sorafenib towards potential off-targets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-28 12:37:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/2629657"], "description"=>"<div><p>Tyrosine kinase inhibitors (TKIs) provide more effective targeted treatments for cancer, but are subject to a variety of adverse effects, such as hypothyroidism. TKI-induced hypothyroidism is a highly complicated issue, because of not only the unrealized toxicological mechanisms, but also different incidences of individual TKI drugs. While sunitinib is suspected for causing thyroid dysfunction more often than other TKIs, sorafenib is believed to be less risky. Here we integrated clinical data and <i>in silico</i> drug-protein interactions to examine the pharmacological distinction between sunitinib and sorafenib. Statistical analysis on the FDA Adverse Event Reporting System (FAERS) confirmed that sunitinib is more concurrent with hypothyroidism than sorafenib, which was observed in both female and male patients. Then, we used docking method and identified 3 proteins specifically binding to sunitinib but not sorafenib, i.e., retinoid X receptor alpha, retinoic acid receptors beta and gamma. As potential off-targets of sunitinib, these proteins are well known to assemble with thyroid hormone receptors, which can explain the profound impact of sunitinib on thyroid function. Taken together, we established a strategy of integrated analysis on clinical records and drug off-targets, which can be applied to explore the molecular basis of various adverse drug reactions.</p></div>", "links"=>[], "tags"=>["Hypothyroidism Side Effect", "Patients Treated", "drug reactions", "3 proteins", "toxicological mechanisms", "sunitinib", "hypothyroidism", "statistical analysis", "thyroid function", "retinoic acid receptors beta", "sorafenib", "TKI drugs", "thyroid dysfunction", "thyroid hormone receptors", "Structural Analyses Tyrosine kinase inhibitors", "docking method", "FAERS", "fda", "Event Reporting System"], "article_id"=>1639132, "categories"=>["Biological Sciences"], "users"=>["Mao Shu", "Xiaoli Zai", "Beina Zhang", "Rui Wang", "Zhihua Lin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0147048", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hypothyroidism_Side_Effect_in_Patients_Treated_with_Sunitinib_or_Sorafenib_Clinical_and_Structural_Analyses_/1639132", "title"=>"Hypothyroidism Side Effect in Patients Treated with Sunitinib or Sorafenib: Clinical and Structural Analyses", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-01-28 12:37:50"}

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  • {"unique-ip"=>"15", "full-text"=>"7", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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